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TCF7L2 Gene Record

  • Summary
  • Interactions
  • Claims
  • TCF7L2 6934 Clinically Actionable

    Alternate Names:

    6934
    TRANSCRIPTION FACTOR 7 LIKE 2
    TCF7L2
    TCF-4
    TCF4
    602228
    11641
    ENSG00000148737
    OTTHUMG00000019070
    PA36394
    Transcription factor 7-like 2
    Q9NQB0

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    CLINICALLY ACTIONABLE
    TRANSCRIPTION FACTOR

    Publications:

    Ling Q et al., 2013, Association between donor and recipient TCF7L2 gene polymorphisms and the risk of new-onset diabetes mellitus after liver transplantation in a Han Chinese population., J Hepatol
    Kurzawski M et al., 2011, Association of transcription factor 7-like 2 (TCF7L2) gene polymorphism with posttransplant diabetes mellitus in kidney transplant patients medicated with tacrolimus., Pharmacol Rep
    Yu M et al., 2010, KCNJ11 Lys23Glu and TCF7L2 rs290487(C/T) polymorphisms affect therapeutic efficacy of repaglinide in Chinese patients with type 2 diabetes., Clin Pharmacol Ther
  • REPAGLINIDE   TCF7L2

    Interaction Score: 1.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20054294


    Sources:
    PharmGKB

  • TACROLIMUS   TCF7L2

    Interaction Score: 1.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23041303 21857094


    Sources:
    PharmGKB

  • SIROLIMUS   TCF7L2

    Interaction Score: 0.66

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23041303 21857094


    Sources:
    PharmGKB

  • CYCLOSPORINE   TCF7L2

    Interaction Score: 0.6

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23041303 21857094


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   TCF7L2

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000148737

    • Version: 101_38

    Alternate Names:
    TCF7L2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: TCF7L2

    • Version: 18-August-2020

    Alternate Names:
    PA36394 PharmGKB ID

    Gene Info:

    Publications:
    Yu M et al., 2010, KCNJ11 Lys23Glu and TCF7L2 rs290487(C/T) polymorphisms affect therapeutic efficacy of repaglinide in Chinese patients with type 2 diabetes., Clin Pharmacol Ther
    Schroner Z et al., 2011, Effect of sulphonylurea treatment on glycaemic control is related to TCF7L2 genotype in patients with type 2 diabetes., Diabetes Obes Metab
    Pearson ER et al., 2007, Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study., Diabetes

  • Tempus: TCF7L2

    • Version: 11-November-2018

    Alternate Names:
    TCF7L2 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Pharos: TCF7L2

    • Version: 01-February-2022

    Alternate Names:
    Transcription factor 7-like 2 Gene Name
    Q9NQB0 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR

    Publications:

  • CarisMolecularIntelligence: TCF7L2

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21