DGIdb - TDO2 Gene Record

TDO2 6999 Druggable Genome

Alternate Names:

6999
TRYPTOPHAN 2,3-DIOXYGENASE
TDO2
TDO
TO
TPH2
TRPO
191070
11708
ENSG00000151790
OTTHUMG00000161838
2887
P48775
T44818
NM_005651\|NM_019911
NP_005642
HYPTRP

Gene Info:

Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	1.13.11.- Dioxygenases
GuideToPharmacology Gene Category ID	899

(3 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Grote et al., 1983, No correlation between binding of glucocorticosteroids to specific cytoplasmic proteins in vivo and enzyme induction in the rat liver., Biochem. J.
Schubart, 1986, Regulation of gene expression in rat hepatocytes and hepatoma cells by insulin: quantitation of messenger ribonucleic acid's coding for tyrosine aminotransferase, tryptophan oxygenase, and phosphoenolpyruvate carboxykinase., Endocrinology

NAVOXIMOD TDO2

Interaction Score: 7.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
INSULIN TDO2

Interaction Score: 0.83

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2875868

Sources:
NCI
DEXAMETHASONE TDO2

Interaction Score: 0.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6136271

Sources:
NCI

Ensembl: ENSG00000151790
- Version: 101_38
Alternate Names:

TDO2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
GuideToPharmacology: 6999
- Version: 29-September-2020
Alternate Names:

11708 HUGO Gene ID

11708 HUGO Gene Symbol

tryptophan 2,3-dioxygenase HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name 1.13.11.- Dioxygenases

GuideToPharmacology Gene Category ID 899

Gene Categories:

ENZYME

Publications:

NCI: TDO2

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Grote et al., 1983, No correlation between binding of glucocorticosteroids to specific cytoplasmic proteins in vivo and enzyme induction in the rat liver., Biochem. J.

Li et al., 1995, Subchronic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and their reversibility in male Sprague-Dawley rats., Toxicology

Schubart, 1986, Regulation of gene expression in rat hepatocytes and hepatoma cells by insulin: quantitation of messenger ribonucleic acid's coding for tyrosine aminotransferase, tryptophan oxygenase, and phosphoenolpyruvate carboxykinase., Endocrinology

HingoraniCasas: ENSG00000151790
- Version: 31-May-2017
Alternate Names:

ENSG00000151790 Gene Symbol

TDO2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: TDO2
- Version: 19.3
Alternate Names:

ENSG00000151790 Ensembl Gene ID

TDO Human Protein Atlas Gene Synonym

TPH2 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
TTD: Tryptophan 2,3-dioxygenase
- Version: 2020.06.01
Alternate Names:

TDO TTD Gene Abbreviation

T44818 TTD Target ID

Gene Info:

Publications:
Pharos: TDO2
- Version: 01-May-2021
Alternate Names:

Tryptophan 2,3-dioxygenase Gene Name

P48775 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

11708	HUGO Gene ID
11708	HUGO Gene Symbol
tryptophan 2,3-dioxygenase	HUGO Gene Name

ENSG00000151790	Ensembl Gene ID
TDO	Human Protein Atlas Gene Synonym
TPH2	Human Protein Atlas Gene Synonym

TDO	TTD Gene Abbreviation
T44818	TTD Target ID

TDO2 Gene Record

TDO2 6999 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

NAVOXIMOD TDO2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

INSULIN TDO2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2875868

Sources: NCI

DEXAMETHASONE TDO2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6136271

Sources: NCI

Ensembl: ENSG00000151790

Alternate Names: TDO2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

GuideToPharmacology: 6999

Alternate Names: 11708 HUGO Gene ID 11708 HUGO Gene Symbol tryptophan 2,3-dioxygenase HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name 1.13.11.- Dioxygenases GuideToPharmacology Gene Category ID 899

Gene Categories: ENZYME

Publications:

NCI: TDO2

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000151790

Alternate Names: ENSG00000151790 Gene Symbol TDO2 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

HumanProteinAtlas: TDO2

Alternate Names: ENSG00000151790 Ensembl Gene ID TDO Human Protein Atlas Gene Synonym TPH2 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories: ENZYME

Publications:

TTD: Tryptophan 2,3-dioxygenase

Alternate Names: TDO TTD Gene Abbreviation T44818 TTD Target ID

Gene Info:

Publications:

Pharos: TDO2

Alternate Names: Tryptophan 2,3-dioxygenase Gene Name P48775 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
2875868

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6136271

Sources:
NCI

Alternate Names:

TDO2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

11708 HUGO Gene ID

11708 HUGO Gene Symbol

tryptophan 2,3-dioxygenase HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name 1.13.11.- Dioxygenases

GuideToPharmacology Gene Category ID 899

Gene Categories:

ENZYME

Alternate Names:

ENSG00000151790 Gene Symbol

TDO2 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000151790 Ensembl Gene ID

TDO Human Protein Atlas Gene Synonym

TPH2 Human Protein Atlas Gene Synonym

Gene Categories:

ENZYME

Alternate Names:

TDO TTD Gene Abbreviation

T44818 TTD Target ID

Alternate Names:

Tryptophan 2,3-dioxygenase Gene Name

P48775 UniProt ID

Gene Categories:

ENZYME