• TEK 7010 Druggable GenomeClinically Actionable

    Alternate Names:

    7010
    TEK RECEPTOR TYROSINE KINASE
    TEK
    CD202B
    GLC3E
    TIE-2
    TIE2
    VMCM
    VMCM1
    600221
    11724
    ENSG00000120156
    OTTHUMG00000019712
    Tyrosine-protein kinase receptor TIE-2
    p140 TEK
    CD_antigen=CD202b
    hTIE2
    Angiopoietin-1 receptor
    Tyrosine-protein kinase receptor TEK
    Endothelial tyrosine kinase
    Tunica interna endothelial cell kinase
    Tyrosine kinase with Ig and EGF homology domains-2
    ANGIOPOIETIN 1 RECEPTOR PRECURSOR (EC 2.7.1.112) (TYROSINE-PROTEIN KINASE RECEPTOR TIE-2) (TYROSINE-PROTEIN KINASE RECEPTOR TEK) (P140 TEK) (TUNICA INTERNA ENDOTHELIAL CELL KINASE) (CD202B ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q02763]
    Q02763
    ANGIOPOIETIN 1 RECEPTOR
    1842
    TIE2_HUMAN
    NM_000459
    NP_000450
    T92144

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Target Subclass EC:2.7.10.1
    Target Class Receptors
    Human Readable Name KINASE
    Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Interpro Acc IPR001245
    Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain
    GuideToPharmacology Gene Category Name Type XII RTKs: TIE family of angiopoietin receptors
    GuideToPharmacology Gene Category ID 330
    Gene Biotype PROTEIN_CODING
    (13 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    KINASE
    TYROSINE KINASE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
  • Interaction Score: 3.54

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tyrosine-protein kinase TIE-2 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 1.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 1.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17884497


    Sources:
    DTC

  • Interaction Score: 1.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22406116


    Sources:
    DTC

  • Interaction Score: 1.33

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tyrosine-protein kinase TIE-2 inhibitor
    Direct Interaction yes
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


  • Interaction Score: 0.89

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Novel Target
    Trial Name MGCD265
    Notes

    PMIDs:
    None found


  • Interaction Score: 0.71

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tyrosine-protein kinase TIE-2 inhibitor
    Direct Interaction yes
    Specific Action of the Ligand Inhibition

  • Interaction Score: 0.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 0.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22406116


    Sources:
    DTC

  • Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22406116


    Sources:
    DTC

  • Interaction Score: 0.59

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tyrosine-protein kinase TIE-2 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.59

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tyrosine-protein kinase TIE-2 inhibitor
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


  • Interaction Score: 0.51

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name regorafenib, BAY 73-4506
    Novel drug target Novel Target
    Notes

  • Interaction Score: 0.44

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Inhibition of <i>in vitro</i> biochemical activity by EMD Millipore assay.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.27

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tyrosine-protein kinase TIE-2 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


  • Interaction Score: 0.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name ABT-869, Linifanib
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


  • Interaction Score: 0.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tyrosine-protein kinase TIE-2 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    • Version: 101_38

    Alternate Names:
    TEK Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    7010 Entrez Gene Id
    Q02763 Uniprot Accession
    TEK Uniprot Gene Name

    Gene Info:
    Human Readable Name KINASE
    Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000120156 Ensembl Gene Id
    TEK Display Id
    ANGIOPOIETIN 1 RECEPTOR PRECURSOR (EC 2.7.1.112) (TYROSINE-PROTEIN KINASE RECEPTOR TIE-2) (TYROSINE-PROTEIN KINASE RECEPTOR TEK) (P140 TEK) (TUNICA INTERNA ENDOTHELIAL CELL KINASE) (CD202B ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q02763] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: January-2014

    Alternate Names:
    TIE2 Gene Symbol
    TEK Gene Symbol

    Gene Info:
    Target Subclass EC:2.7.10.1
    Target Class Receptors

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    11724 HUGO Gene ID
    11724 HUGO Gene Symbol
    TEK receptor tyrosine kinase HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Type XII RTKs: TIE family of angiopoietin receptors
    GuideToPharmacology Gene Category ID 330

    Publications:

  • DTC: TEK

    • Version: 02-September-2020
    • Version: 12-May-2016

    Alternate Names:
    TIE2 Gene Symbol

    Gene Info:

    Publications:

    • Version: 12-May-2016

    Alternate Names:
    TIE-2 Gene Symbol

    Gene Info:

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000120156 Gene Symbol
    TEK Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    VMCM GENE_SYMBOL
    VMCM1 GENE_SYMBOL
    TEK GENE_SYMBOL

    Gene Info:

    Publications:

    • Version: 27-Jun-2013

    Alternate Names:
    7010 Gene ID
    CD202B dGene Synonym
    TIE-2 dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, TYROSINE KINASE

    Publications:

    • Version: 2020.06.01

    Alternate Names:
    TEK TTD Gene Abbreviation
    T92144 TTD Target ID

    Gene Info:

    Publications:

  • GO: TEK

    • Version: 01-May-2021

    Alternate Names:
    TIE2 GO Gene Synonym
    VMCM GO Gene Synonym
    VMCM1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, TYROSINE KINASE

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    Angiopoietin-1 receptor Gene Name
    Q02763 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

    • Version: 30-February-2014

    Alternate Names:

    Gene Info:

    Publications:

    • Version: 15-June-2013

    Alternate Names:

    Gene Info:

    Publications:

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications: