DGIdb - TGM2 Gene Record

TGM2 7052 Druggable Genome

Alternate Names:

7052
TRANSGLUTAMINASE 2
TGM2
TG(C)
TGC
190196
11778
ENSG00000198959
OTTHUMG00000032437
P21980
TGM2_HUMAN
PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 2
TISSUE TRANSGLUTAMINASE
PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE (EC 2.3.2.13) (TISSUE TRANSGLUTAMINASE) (TGASE C) (TGC) (TG(C)) (TRANGLUTAMINASE 2) (TGASE- H). [SOURCE:UNIPROT/SWISSPROT;ACC:P21980]
TG2
T05387
G(h)
hTG2
tTG

Gene Info:

Interpro Type	Domain
Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	Transglutaminase_N
Interpro Name	Transglutaminase, N-terminal
Uniprot Status	Swiss-Prot
Interpro Acc	IPR001102
Uniprot Evidence	1: Evidence at protein level
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

PROTEASE
DRUGGABLE GENOME
ENZYME

Publications:

Zhang et al., 1997, Pharmacologic inhibition of transglutaminase-induced cross-linking of Alzheimer's amyloid beta-peptide., Life Sci.
Nardacci et al., 2005, Characterization of cell death pathways in human immunodeficiency virus-associated encephalitis., Am. J. Pathol.
Hausch et al., 2003, Design, synthesis, and evaluation of gluten peptide analogs as selective inhibitors of human tissue transglutaminase., Chem. Biol.
Nakano et al., 2007, ATP-mediated mineralization of MC3T3-E1 osteoblast cultures., Bone
Tschirch et al., 2007, Low-dose intranasal versus oral midazolam for routine body MRI of claustrophobic patients., Eur Radiol
Ai et al., 2008, The transglutaminase 2 gene (TGM2), a potential molecular marker for chemotherapeutic drug sensitivity, is epigenetically silenced in breast cancer., Carcinogenesis
Balasenthil et al., 2002, Apoptosis induction by S-allylcysteine, a garlic constituent, during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis., Cell Biochem. Funct.
Osborne et al., 1997, Minor products of reaction of DNA with alpha-acetoxytamoxifen., Carcinogenesis
Soehnlein et al., 2004, Atorvastatin induces tissue transglutaminase in human endothelial cells., Biochem. Biophys. Res. Commun.
Kitahara et al., 1987, Specific localization of tissue-type transglutaminase in adrenocorticotropin-producing cells of the human pituitary gland as demonstrated by immunohistochemistry., J. Clin. Endocrinol. Metab.
Waldron et al., 1997, Store-operated Ca2+ entry and coupling to Ca2+ pool depletion in thapsigargin-resistant cells., J. Biol. Chem.
Cao et al., 2008, Tissue transglutaminase protects epithelial ovarian cancer cells from cisplatin-induced apoptosis by promoting cell survival signaling., Carcinogenesis
Lin et al., 1998, Camptothecin induces differentiation, tissue transglutaminase and apoptosis in cultured keratinocytes., Exp. Dermatol.
Wu et al., 2000, Roles of tissue transglutaminase in ethanol-induced inhibition of hepatocyte proliferation and alpha 1-adrenergic signal transduction., J. Biol. Chem.
Adel Moallem et al., 1996, Transglutaminase and clusterin induction during normal and abnormal limb development in the mouse., Biol. Reprod.
Zeng et al., 2005, [Enhancement of NMDA receptor sensitivity by thrombin and its relationship with tissue transglutaminase]., Zhonghua Nei Ke Za Zhi
Gambetti et al., 2005, Interaction with heparin protects tissue transglutaminase against inactivation by heating and by proteolysis., Biochimie
Ando et al., 1996, Induction of tissue transglutaminase in rat superior cervical sympathetic ganglia following in vitro stimulation of retinoic acid., Neurosci. Res.
Fujimoto et al., 1996, Requirement for transglutaminase in progesterone-induced decidualization of human endometrial stromal cells., Endocrinology
Verma et al., 2006, Increased expression of tissue transglutaminase in pancreatic ductal adenocarcinoma and its implications in drug resistance and metastasis., Cancer Res.
Rittmaster et al., 1995, Evidence for atrophy and apoptosis in the ventral prostate of rats given the 5 alpha-reductase inhibitor finasteride., Endocrinology

LEVAMISOLE TGM2

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17669706

Sources:
NCI
ACIVICIN TGM2

Interaction Score: 1.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12670536

Sources:
NCI
PERFOSFAMIDE TGM2

Interaction Score: 0.98

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8828830

Sources:
NCI
IONOMYCIN TGM2

Interaction Score: 0.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9045668

Sources:
NCI
CORTICOTROPIN TGM2

Interaction Score: 0.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2444616

Sources:
NCI
GARLIC TGM2

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12125104

Sources:
NCI
FINASTERIDE TGM2

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7835306

Sources:
NCI
DEFEROXAMINE TGM2

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9194688

Sources:
NCI
GENTAMICIN TGM2

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8861105

Sources:
NCI
THROMBIN TGM2

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16202257

Sources:
NCI
HEPARIN TGM2

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15935280

Sources:
NCI
CAMPTOTHECIN TGM2

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9758415

Sources:
NCI
MIDAZOLAM TGM2

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17093965

Sources:
NCI
SIROLIMUS TGM2

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16127150

Sources:
NCI
TAMOXIFEN TGM2

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9067554

Sources:
NCI
ATORVASTATIN TGM2

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15313180

Sources:
NCI
PROGESTERONE TGM2

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8603579

Sources:
NCI
GEMCITABINE TGM2

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17079475

Sources:
NCI
ALCOHOL TGM2

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10801782

Sources:
NCI
DOXORUBICIN TGM2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18174247

Sources:
NCI
CISPLATIN TGM2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18667446

Sources:
NCI

Ensembl: ENSG00000198959
- Version: 101_38
Alternate Names:

TGM2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000198959

Version: 26-July-2011

Alternate Names:

TGM2 Display Id

PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE (EC 2.3.2.13) (TISSUE TRANSGLUTAMINASE) (TGASE C) (TGC) (TG(C)) (TRANGLUTAMINASE 2) (TGASE- H). [SOURCE:UNIPROT/SWISSPROT;ACC:P21980] Description

ENSG00000198959 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P21980
- Version: 11-September-2012
Alternate Names:

TGM2 Uniprot Gene Name

PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 2 Uniprot Protein Name

TGM2_HUMAN Uniprot Id

Gene Info:

Interpro Type Domain

Human Readable Name DRUGGABLE GENOME

Interpro Short Name Transglutaminase_N

Gene Categories:

DRUGGABLE GENOME

Publications:

NCI: TGM2

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Zhang et al., 1997, Pharmacologic inhibition of transglutaminase-induced cross-linking of Alzheimer's amyloid beta-peptide., Life Sci.

Nardacci et al., 2005, Characterization of cell death pathways in human immunodeficiency virus-associated encephalitis., Am. J. Pathol.

Nakano et al., 2007, ATP-mediated mineralization of MC3T3-E1 osteoblast cultures., Bone

HingoraniCasas: ENSG00000198959
- Version: 31-May-2017
Alternate Names:

ENSG00000198959 Gene Symbol

TGM2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Tissue transglutaminase
- Version: 2020.06.01
Alternate Names:

TG2 TTD Gene Abbreviation

T05387 TTD Target ID

Gene Info:

Publications:
Pharos: TGM2
- Version: 01-February-2022
Alternate Names:

Protein-glutamine gamma-glutamyltransferase 2 Gene Name

P21980 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
GO: TGM2
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

PROTEASE

Publications:

TGM2	Display Id
PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE (EC 2.3.2.13) (TISSUE TRANSGLUTAMINASE) (TGASE C) (TGC) (TG(C)) (TRANGLUTAMINASE 2) (TGASE- H). [SOURCE:UNIPROT/SWISSPROT;ACC:P21980]	Description
ENSG00000198959	Ensembl Gene Id

TGM2	Uniprot Gene Name
PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 2	Uniprot Protein Name
TGM2_HUMAN	Uniprot Id

Protein-glutamine gamma-glutamyltransferase 2	Gene Name
P21980	UniProt ID

TGM2 Gene Record

TGM2 7052 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17669706

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12670536

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8828830

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9045668

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2444616

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12125104

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7835306

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9194688

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8861105

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16202257

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15935280

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9758415

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17093965

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16127150

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9067554

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15313180

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8603579

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17079475

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
17669706

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12670536

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8828830

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9045668

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2444616

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12125104

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7835306

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9194688

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8861105

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16202257

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15935280

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9758415

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17093965

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16127150

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9067554

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15313180

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8603579

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17079475

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10801782

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18174247

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18667446

Sources:
NCI

Alternate Names:

TGM2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

TGM2 Display Id

PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE (EC 2.3.2.13) (TISSUE TRANSGLUTAMINASE) (TGASE C) (TGC) (TG(C)) (TRANGLUTAMINASE 2) (TGASE- H). [SOURCE:UNIPROT/SWISSPROT;ACC:P21980] Description

ENSG00000198959 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

TGM2 Uniprot Gene Name

PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 2 Uniprot Protein Name

TGM2_HUMAN Uniprot Id

Gene Info:

Interpro Type Domain

Human Readable Name DRUGGABLE GENOME

Interpro Short Name Transglutaminase_N

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000198959 Gene Symbol

TGM2 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

TG2 TTD Gene Abbreviation

T05387 TTD Target ID

Alternate Names:

Protein-glutamine gamma-glutamyltransferase 2 Gene Name

P21980 UniProt ID

Gene Categories:

ENZYME

Gene Categories:

PROTEASE