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TGM2 Gene Record

  • Summary
  • Interactions
  • Claims
  • TGM2 7052 Druggable Genome

    Alternate Names:

    7052
    TRANSGLUTAMINASE 2
    TGM2
    TG(C)
    TGC
    190196
    11778
    ENSG00000198959
    OTTHUMG00000032437
    P21980
    TGM2_HUMAN
    PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 2
    TISSUE TRANSGLUTAMINASE
    PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE (EC 2.3.2.13) (TISSUE TRANSGLUTAMINASE) (TGASE C) (TGC) (TG(C)) (TRANGLUTAMINASE 2) (TGASE- H). [SOURCE:UNIPROT/SWISSPROT;ACC:P21980]
    TG2
    T05387
    G(h)
    hTG2
    tTG

    Gene Info:

    Interpro Type Domain
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Transglutaminase_N
    Interpro Name Transglutaminase, N-terminal
    Uniprot Status Swiss-Prot
    Interpro Acc IPR001102
    Uniprot Evidence 1: Evidence at protein level
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    PROTEASE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Zhang et al., 1997, Pharmacologic inhibition of transglutaminase-induced cross-linking of Alzheimer's amyloid beta-peptide., Life Sci.
    Nardacci et al., 2005, Characterization of cell death pathways in human immunodeficiency virus-associated encephalitis., Am. J. Pathol.
    Hausch et al., 2003, Design, synthesis, and evaluation of gluten peptide analogs as selective inhibitors of human tissue transglutaminase., Chem. Biol.
    Nakano et al., 2007, ATP-mediated mineralization of MC3T3-E1 osteoblast cultures., Bone
    Tschirch et al., 2007, Low-dose intranasal versus oral midazolam for routine body MRI of claustrophobic patients., Eur Radiol
    Ai et al., 2008, The transglutaminase 2 gene (TGM2), a potential molecular marker for chemotherapeutic drug sensitivity, is epigenetically silenced in breast cancer., Carcinogenesis
    Balasenthil et al., 2002, Apoptosis induction by S-allylcysteine, a garlic constituent, during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis., Cell Biochem. Funct.
    Osborne et al., 1997, Minor products of reaction of DNA with alpha-acetoxytamoxifen., Carcinogenesis
    Soehnlein et al., 2004, Atorvastatin induces tissue transglutaminase in human endothelial cells., Biochem. Biophys. Res. Commun.
    Kitahara et al., 1987, Specific localization of tissue-type transglutaminase in adrenocorticotropin-producing cells of the human pituitary gland as demonstrated by immunohistochemistry., J. Clin. Endocrinol. Metab.
    Waldron et al., 1997, Store-operated Ca2+ entry and coupling to Ca2+ pool depletion in thapsigargin-resistant cells., J. Biol. Chem.
    Cao et al., 2008, Tissue transglutaminase protects epithelial ovarian cancer cells from cisplatin-induced apoptosis by promoting cell survival signaling., Carcinogenesis
    Lin et al., 1998, Camptothecin induces differentiation, tissue transglutaminase and apoptosis in cultured keratinocytes., Exp. Dermatol.
    Wu et al., 2000, Roles of tissue transglutaminase in ethanol-induced inhibition of hepatocyte proliferation and alpha 1-adrenergic signal transduction., J. Biol. Chem.
    Adel Moallem et al., 1996, Transglutaminase and clusterin induction during normal and abnormal limb development in the mouse., Biol. Reprod.
    Zeng et al., 2005, [Enhancement of NMDA receptor sensitivity by thrombin and its relationship with tissue transglutaminase]., Zhonghua Nei Ke Za Zhi
    Gambetti et al., 2005, Interaction with heparin protects tissue transglutaminase against inactivation by heating and by proteolysis., Biochimie
    Ando et al., 1996, Induction of tissue transglutaminase in rat superior cervical sympathetic ganglia following in vitro stimulation of retinoic acid., Neurosci. Res.
    Fujimoto et al., 1996, Requirement for transglutaminase in progesterone-induced decidualization of human endometrial stromal cells., Endocrinology
    Verma et al., 2006, Increased expression of tissue transglutaminase in pancreatic ductal adenocarcinoma and its implications in drug resistance and metastasis., Cancer Res.
    Rittmaster et al., 1995, Evidence for atrophy and apoptosis in the ventral prostate of rats given the 5 alpha-reductase inhibitor finasteride., Endocrinology
  • LEVAMISOLE   TGM2

    Interaction Score: 2.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17669706


    Sources:
    NCI

  • ACIVICIN   TGM2

    Interaction Score: 1.96

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12670536


    Sources:
    NCI

  • PERFOSFAMIDE   TGM2

    Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8828830


    Sources:
    NCI

  • IONOMYCIN   TGM2

    Interaction Score: 0.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9045668


    Sources:
    NCI

  • CORTICOTROPIN   TGM2

    Interaction Score: 0.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2444616


    Sources:
    NCI

  • GARLIC   TGM2

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12125104


    Sources:
    NCI

  • FINASTERIDE   TGM2

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7835306


    Sources:
    NCI

  • DEFEROXAMINE   TGM2

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9194688


    Sources:
    NCI

  • GENTAMICIN   TGM2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8861105


    Sources:
    NCI

  • THROMBIN   TGM2

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16202257


    Sources:
    NCI

  • HEPARIN   TGM2

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15935280


    Sources:
    NCI

  • CAMPTOTHECIN   TGM2

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9758415


    Sources:
    NCI

  • MIDAZOLAM   TGM2

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17093965


    Sources:
    NCI

  • SIROLIMUS   TGM2

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16127150


    Sources:
    NCI

  • TAMOXIFEN   TGM2

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9067554


    Sources:
    NCI

  • ATORVASTATIN   TGM2

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15313180


    Sources:
    NCI

  • PROGESTERONE   TGM2

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8603579


    Sources:
    NCI

  • GEMCITABINE   TGM2

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17079475


    Sources:
    NCI

  • ALCOHOL   TGM2

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10801782


    Sources:
    NCI

  • DOXORUBICIN   TGM2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18174247


    Sources:
    NCI

  • CISPLATIN   TGM2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18667446


    Sources:
    NCI

  • Ensembl: ENSG00000198959

    • Version: 101_38

    Alternate Names:
    TGM2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000198959

    • Version: 26-July-2011

    Alternate Names:
    TGM2 Display Id
    PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE (EC 2.3.2.13) (TISSUE TRANSGLUTAMINASE) (TGASE C) (TGC) (TG(C)) (TRANGLUTAMINASE 2) (TGASE- H). [SOURCE:UNIPROT/SWISSPROT;ACC:P21980] Description
    ENSG00000198959 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P21980

    • Version: 11-September-2012

    Alternate Names:
    TGM2 Uniprot Gene Name
    PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 2 Uniprot Protein Name
    TGM2_HUMAN Uniprot Id

    Gene Info:
    Interpro Type Domain
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Transglutaminase_N

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • NCI: TGM2

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Zhang et al., 1997, Pharmacologic inhibition of transglutaminase-induced cross-linking of Alzheimer's amyloid beta-peptide., Life Sci.
    Nardacci et al., 2005, Characterization of cell death pathways in human immunodeficiency virus-associated encephalitis., Am. J. Pathol.
    Nakano et al., 2007, ATP-mediated mineralization of MC3T3-E1 osteoblast cultures., Bone

  • HingoraniCasas: ENSG00000198959

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000198959 Gene Symbol
    TGM2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Tissue transglutaminase

    • Version: 2020.06.01

    Alternate Names:
    TG2 TTD Gene Abbreviation
    T05387 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: TGM2

    • Version: 01-February-2022

    Alternate Names:
    Protein-glutamine gamma-glutamyltransferase 2 Gene Name
    P21980 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • GO: TGM2

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21