DGIdb - TH Gene Record

TH 7054 Druggable Genome

Alternate Names:

7054
TYROSINE HYDROXYLASE
TH
DYT14
DYT5b
TYH
191290
11782
ENSG00000180176
OTTHUMG00000009559
P07101
TYROSINE 3-MONOOXYGENASE
TY3H_HUMAN
Tyrosine 3-hydroxylase
TYROSINE 3-MONOOXYGENASE (EC 1.14.16.2) (TYROSINE 3-HYDROXYLASE) (TH). [SOURCE:UNIPROT/SWISSPROT;ACC:P07101]
PA351
T62390

Gene Info:

Uniprot Status	Swiss-Prot
Human Readable Name	DRUGGABLE GENOME
Interpro Name	Aromatic amino acid hydroxylase
Interpro Type	Family
Interpro Acc	IPR001273
Interpro Short Name	ArAA_hydroxylase
Uniprot Evidence	1: Evidence at protein level
Target Subclass	1.14.16.2
Target Main Class	Enzymes
Target Class	Enzymes
Target Subclass	EC:1.14.16.2
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Pagerols M et al., 2017, Pharmacogenetics of methylphenidate response and tolerability in attention-deficit/hyperactivity disorder., Pharmacogenomics J
Yoshimoto et al., 2005, L-dopa and dopamine enhance the formation of aggregates under proteasome inhibition in PC12 cells., FEBS Lett.
Shore et al., 1975, On a prime role for newly synthesized dopamine in striatal function., Eur. J. Pharmacol.
Nasrallah et al., 1977, Inhibition of dopamine synthesis in chronic schizophrenia. Clinical ineffectiveness of metyrosine., Arch. Gen. Psychiatry
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Moore et al., 1980, Influence of prolactin on dopaminergic neuronal systems in the hypothalamus., Fed. Proc.
Kanaan et al., 2006, Exogenous erythropoietin provides neuroprotection of grafted dopamine neurons in a rodent model of Parkinson's disease., Brain Res.
Garcia de Yebenes et al., 1995, Effects of dehydroepiandrosterone (DHEA) on pituitary prolactin and arcuate nucleus neuron tyrosine hydroxylase mRNA levels in the rat., J. Neuroendocrinol.
Schallreuter et al., 2003, In situ and in vitro evidence for DCoH/HNF-1 alpha transcription of tyrosinase in human skin melanocytes., Biochem. Biophys. Res. Commun.
Fusetti et al., 1998, Structure of tetrameric human phenylalanine hydroxylase and its implications for phenylketonuria., J. Biol. Chem.
Ogawa et al., 2006, Effect of metals and phenylalanine on the activity of human tryptophan hydroxylase-2: comparison with that on tyrosine hydroxylase activity., Neurosci. Lett.
Fukami et al., 1990, Phenylalanine as substrate for tyrosine hydroxylase in bovine adrenal chromaffin cells., Biochem. J.
McQuade et al., 1983, The effect of various amino acids and drugs on the para- and meta-hydroxyphenylacetic acid concentrations in the mouse caudate nucleus., Neurochem. Res.
Georgievska et al., 2004, Regulated delivery of glial cell line-derived neurotrophic factor into rat striatum, using a tetracycline-dependent lentiviral vector., Hum. Gene Ther.
Xu et al., 2003, Effect of indomethacin on the c-fos expression in AVP and TH neurons in rat brain induced by lipopolysaccharide., Brain Res.
Olsovská et al., 2007, Assay of tyrosine hydroxylase based on high-performance liquid chromatography separation and quantification of L-dopa and L-tyrosine., Biomed. Chromatogr.
Bodnár et al., 2007, Effect of local (intracerebral and intracerebroventricular) administration of tyrosine hydroxylase inhibitor on the neuroendocrine dopaminergic neurons and prolactin release., Ideggyogy Sz
Rostrup et al., 2008, Oxygen dependence of tyrosine hydroxylase., Amino Acids
Richards et al., 2007, EphB1 null mice exhibit neuronal loss in substantia nigra pars reticulata and spontaneous locomotor hyperactivity., Eur. J. Neurosci.
Ugriumov, [Brain neurons partly expressing monoaminergic phenotype: distribution, development, and functional significance]., Usp Fiziol Nauk
Seidler et al., 1982, Delays in growth and biochemical development of rat brain caused by maternal methadone administration: are the alterations in synaptogenesis and cellular maturation independent of reduced maternal food intake?, Dev. Neurosci.
Kritzer et al., 2001, Administration of tamoxifen but not flutamide to hormonally intact, adult male rats mimics the effects of short-term gonadectomy on the catecholamine innervation of the cerebral cortex., J. Comp. Neurol.
Schmidt et al., 1989, Tyrosine hydroxylase activity in sympathetic nervous system of rats with streptozocin-induced diabetes., Diabetes
Steinberg et al., 1984, Effect of triamterene on tyrosine hydroxylase activity., Naunyn Schmiedebergs Arch. Pharmacol.
Lode et al., 1995, Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of monoamine transporters in neuroblastoma cell lines: correlations to meta-iodobenzylguanidine (MIBG) uptake and tyrosine hydroxylase gene expression., Eur. J. Cancer

TYROSINE TH

Interaction Score: 30.91

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
17604359 17451064 11752352 17520326 17561836 17578016

Sources:
TTD
PHENYLALANINE TH

Interaction Score: 10.3

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
12565907 9642259 16581181 11752352 1973034 6621777

Sources:
TTD
METYROSINE TH

Interaction Score: 4.01

Interaction Types & Directionality:

binder

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tyrosine 3-hydroxylase inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
15710413 1168577 17374 11752352 7409209

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD
SAPROPTERIN TH

Interaction Score: 3.31

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Sapropterin

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND TTD
IOBENGUANE TH

Interaction Score: 2.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7576974

Sources:
NCI
DOXYCYCLINE TH

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15585109

Sources:
NCI
TRIAMTERENE TH

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6149469

Sources:
NCI
PRASTERONE TH

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8704732

Sources:
NCI
FLUTAMIDE TH

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11223814

Sources:
NCI
EPOETIN ALFA TH

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16368081

Sources:
NCI
METHADONE TH

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6125371

Sources:
NCI
INDOMETHACIN TH

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12646303

Sources:
NCI
METHYLPHENIDATE TH

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26810137

Sources:
PharmGKB
STREPTOZOCIN TH

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2568957

Sources:
NCI

Ensembl: ENSG00000180176
- Version: 101_38
Alternate Names:

TH Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000180176
- Version: 26-July-2011
Alternate Names:

TH Display Id

TYROSINE 3-MONOOXYGENASE (EC 1.14.16.2) (TYROSINE 3-HYDROXYLASE) (TH). [SOURCE:UNIPROT/SWISSPROT;ACC:P07101] Description

ENSG00000180176 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: P07101
- Version: 11-September-2012
Alternate Names:

P07101 Uniprot Accession

TY3H_HUMAN Uniprot Id

ENSG00000180176 Ensembl Gene Id

Gene Info:

Uniprot Status Swiss-Prot

Human Readable Name DRUGGABLE GENOME

Interpro Name Aromatic amino acid hydroxylase

Gene Categories:

DRUGGABLE GENOME

Publications:
TEND: P07101
- Version: 01-August-2011
Alternate Names:

7054 Entrez Gene Id

TH Gene Symbol

P07101 Uniprot Accession

Gene Info:

Target Subclass 1.14.16.2

Target Main Class Enzymes

Publications:
TdgClinicalTrial: P07101
- Version: January-2014
Alternate Names:

TH Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.14.16.2

Publications:

PharmGKB: TH

Version: 18-August-2020

Alternate Names:

PA351 PharmGKB ID

Gene Info:

Publications:

Pagerols M et al., 2017, Pharmacogenetics of methylphenidate response and tolerability in attention-deficit/hyperactivity disorder., Pharmacogenomics J

Randesi M et al., 2018, Dopamine gene variants in opioid addiction: comparison of dependent patients, nondependent users and healthy controls., Pharmacogenomics

Liu JL et al., 2020, Tyrosine Hydroxylase Gene Polymorphisms Contribute to Opioid Dependence and Addiction by Affecting Promoter Region Function., Neuromolecular Med

NCI: TH

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Garcia de Yebenes et al., 1995, Effects of dehydroepiandrosterone (DHEA) on pituitary prolactin and arcuate nucleus neuron tyrosine hydroxylase mRNA levels in the rat., J. Neuroendocrinol.

Schmidt et al., 1989, Tyrosine hydroxylase activity in sympathetic nervous system of rats with streptozocin-induced diabetes., Diabetes

Steinberg et al., 1984, Effect of triamterene on tyrosine hydroxylase activity., Naunyn Schmiedebergs Arch. Pharmacol.

HingoraniCasas: ENSG00000180176
- Version: 31-May-2017
Alternate Names:

ENSG00000180176 Gene Symbol

TH Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: TYH
- Version: chembl_23
Alternate Names:

TYH GENE_SYMBOL

TH GENE_SYMBOL

Tyrosine 3-monooxygenase UNIPROT

Gene Info:

Publications:
TTD: Tyrosine 3-monooxygenase
- Version: 2020.06.01
Alternate Names:

TH TTD Gene Abbreviation

T62390 TTD Target ID

Gene Info:

Publications:
Pharos: TH
- Version: 01-February-2022
Alternate Names:

Tyrosine 3-monooxygenase Gene Name

P07101 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

Mechanism of Interaction	Tyrosine 3-hydroxylase inhibitor
Direct Interaction	yes
Trial Name	-

TH	Display Id
TYROSINE 3-MONOOXYGENASE (EC 1.14.16.2) (TYROSINE 3-HYDROXYLASE) (TH). [SOURCE:UNIPROT/SWISSPROT;ACC:P07101]	Description
ENSG00000180176	Ensembl Gene Id

P07101	Uniprot Accession
TY3H_HUMAN	Uniprot Id
ENSG00000180176	Ensembl Gene Id

binder
inhibitor (inhibitory)

Trial Name	Sapropterin
Novel drug target	Established target

TH Gene Record

TH 7054 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: binder

Interaction Info:

PMIDs: 17604359 17451064 11752352 17520326 17561836 17578016

Sources: TTD

Interaction Types & Directionality: binder

Interaction Info:

PMIDs: 12565907 9642259 16581181 11752352 1973034 6621777

Sources: TTD

Interaction Types & Directionality: binder inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tyrosine 3-hydroxylase inhibitor Direct Interaction yes Trial Name -

PMIDs: 15710413 1168577 17374 11752352 7409209

Sources: TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Sapropterin Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7576974

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15585109

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6149469

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8704732

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11223814

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16368081

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6125371

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12646303

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26810137

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2568957

Sources: NCI

Ensembl: ENSG00000180176

Alternate Names: TH Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000180176

Alternate Names: TH Display Id TYROSINE 3-MONOOXYGENASE (EC 1.14.16.2) (TYROSINE 3-HYDROXYLASE) (TH). [SOURCE:UNIPROT/SWISSPROT;ACC:P07101] Description ENSG00000180176 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: P07101

Alternate Names: P07101 Uniprot Accession TY3H_HUMAN Uniprot Id ENSG00000180176 Ensembl Gene Id

Gene Info: Uniprot Status Swiss-Prot Human Readable Name DRUGGABLE GENOME Interpro Name Aromatic amino acid hydroxylase

Gene Categories: DRUGGABLE GENOME

Publications:

TEND: P07101

Alternate Names: 7054 Entrez Gene Id TH Gene Symbol P07101 Uniprot Accession

Gene Info: Target Subclass 1.14.16.2 Target Main Class Enzymes

Publications:

Interaction Types & Directionality:

binder

PMIDs:
17604359 17451064 11752352 17520326 17561836 17578016

Sources:
TTD

Interaction Types & Directionality:

binder

PMIDs:
12565907 9642259 16581181 11752352 1973034 6621777

Sources:
TTD

Interaction Types & Directionality:

binder

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tyrosine 3-hydroxylase inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
15710413 1168577 17374 11752352 7409209

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Sapropterin

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
7576974

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15585109

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6149469

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8704732

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11223814

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16368081

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6125371

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12646303

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
26810137

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
2568957

Sources:
NCI

Alternate Names:

TH Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

TH Display Id

TYROSINE 3-MONOOXYGENASE (EC 1.14.16.2) (TYROSINE 3-HYDROXYLASE) (TH). [SOURCE:UNIPROT/SWISSPROT;ACC:P07101] Description

ENSG00000180176 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

P07101 Uniprot Accession

TY3H_HUMAN Uniprot Id

ENSG00000180176 Ensembl Gene Id

Gene Info:

Uniprot Status Swiss-Prot

Human Readable Name DRUGGABLE GENOME

Interpro Name Aromatic amino acid hydroxylase

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

7054 Entrez Gene Id

TH Gene Symbol

P07101 Uniprot Accession

Gene Info:

Target Subclass 1.14.16.2

Target Main Class Enzymes

Alternate Names:

TH Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.14.16.2

Alternate Names:

PA351 PharmGKB ID

Alternate Names:

ENSG00000180176 Gene Symbol

TH Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

TYH GENE_SYMBOL

TH GENE_SYMBOL

Tyrosine 3-monooxygenase UNIPROT

Alternate Names:

TH TTD Gene Abbreviation

T62390 TTD Target ID

Alternate Names:

Tyrosine 3-monooxygenase Gene Name

P07101 UniProt ID

Gene Categories:

ENZYME