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THBD Gene Record

  • Summary
  • Interactions
  • Claims
  • THBD 7056 Druggable Genome

    Alternate Names:

    7056
    THROMBOMODULIN
    THBD
    AHUS6
    BDCA3
    CD141
    THPH12
    THRM
    TM
    188040
    11784
    ENSG00000178726
    OTTHUMG00000032053
    PA36496
    BDCA-3

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME

    Publications:

    Stogowska-Nikiciuk et al., 2008, [The influence of simvastatin on hsCRP and some paramneters of hemostasis in patients with ischemic heart disease]., Prz. Lek.
    Hayakawa et al., 2000, Effects of beraprost and cilostazol and renal function on serum thrombomodulin levels in diabetic patients., Arzneimittelforschung
    Nagasaki et al., 2004, Change in von Willebrand factor and carotid intima-media thickness in hypothyroid patients with normal thyroid function after levothyroxine replacement therapy., Eur. J. Endocrinol.
    An SH et al., 2014, Association of gene polymorphisms with the risk of warfarin bleeding complications at therapeutic INR in patients with mechanical cardiac valves., J Clin Pharm Ther
    Nan et al., 2005, Effects of TNF-alpha and curcumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells., Thromb. Res.
  • LEVOTHYROXINE   THBD

    Interaction Score: 2.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14763909


    Sources:
    NCI

  • CILOSTAZOL   THBD

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10918946


    Sources:
    NCI

  • WARFARIN   THBD

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24602049


    Sources:
    PharmGKB

  • SIMVASTATIN   THBD

    Interaction Score: 0.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18663903


    Sources:
    NCI

  • CURCUMIN   THBD

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15733976


    Sources:
    NCI

  • Ensembl: ENSG00000178726

    • Version: 101_38

    Alternate Names:
    THBD Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: THBD

    • Version: 18-August-2020

    Alternate Names:
    PA36496 PharmGKB ID

    Gene Info:

    Publications:
    An SH et al., 2014, Association of gene polymorphisms with the risk of warfarin bleeding complications at therapeutic INR in patients with mechanical cardiac valves., J Clin Pharm Ther

  • NCI: THBD

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Nan et al., 2005, Effects of TNF-alpha and curcumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells., Thromb. Res.
    Lan et al., 2006, Activity of Ginkgo biloba extract and quercetin on thrombomodulin expression and tissue-type plasminogen activator secretion by human umbilical vein endothelial cells., Biomed. Environ. Sci.
    Archipoff et al., 1993, Role of cyclic AMP in promoting the thromboresistance of human endothelial cells by enhancing thrombomodulin and decreasing tissue factor activities., Br. J. Pharmacol.

  • HingoraniCasas: ENSG00000178726

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000178726 Gene Symbol
    THBD Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: THBD

    • Version: 01-February-2022

    Alternate Names:
    THRM GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21