DGIdb - THRB Gene Record

THRB 7068 Druggable Genome

Alternate Names:

7068
THYROID HORMONE RECEPTOR BETA
THRB
C-ERBA-2
C-ERBA-BETA
ERBA2
GRTH
NR1A2
PRTH
THR1
THRB1
THRB2
190160
11799
ENSG00000151090
OTTHUMG00000130478
P10828
THB_HUMAN
Nuclear receptor subfamily 1 group A member 2
THYROID HORMONE RECEPTOR BETA-1. [SOURCE:UNIPROT/SWISSPROT;ACC:P10828]
T98933
TRbeta

Gene Info:

Human Readable Name	NUCLEAR HORMONE RECEPTOR
Target Class	Receptors
Target Subclass	Nuclear receptor
Uniprot Status	Swiss-Prot
Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	1: Evidence at protein level
Interpro Name	Nuclear hormone receptor, ligand-binding, core
Interpro Type	Domain
Interpro Acc	IPR000536
Interpro Short Name	Nucl_hrmn_rcpt_lig-bd_core
Target Main Class	Receptors
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

NUCLEAR HORMONE RECEPTOR
DRUGGABLE GENOME

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Yen et al., 2003, Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice., EMBO Rep.
Bernal, 2007, Thyroid hormone receptors in brain development and function., Nat Clin Pract Endocrinol Metab
González-Sancho et al., 2003, Thyroid hormone receptors/THR genes in human cancer., Cancer Lett.
Wu et al., 2005, Tissue responses to thyroid hormone in a kindred with resistance to thyroid hormone harboring a commonly occurring mutation in the thyroid hormone receptor beta gene (P453T)., J. Lab. Clin. Med.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Grasberger et al., 2005, Resistance to thyroid hormone in a patient with thyroid dysgenesis., Thyroid
Marazuela et al., 2008, Thyroid hormone resistance and pituitary enlargement after thyroid ablation in a woman on levothyroxine treatment., Thyroid
Sivakumar et al., 2010, Resistance to thyroid hormone in a patient with coexisting Graves' disease., Thyroid
Cheng SY et al., 2010, Molecular aspects of thyroid hormone actions., Endocr Rev
Hwang JY et al., 2012, Synthesis and evaluation of sulfonylnitrophenylthiazoles (SNPTs) as thyroid hormone receptor-coactivator interaction inhibitors., J Med Chem
Kullak-Ublick et al., 2001, Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver., Gastroenterology
Gierach I et al., 2012, Bacterial biosensors for screening isoform-selective ligands for human thyroid receptors α-1 and β-1., FEBS Open Bio

MB07811 THRB

Interaction Score: 2.52

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Thyroid hormone receptor beta-1 agonist

Trial Name MB07811

PMIDs:
10592235

Sources:
TdgClinicalTrial ChemblInteractions TTD
RESMETIROM THRB

Interaction Score: 1.89

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name VIA-3196

Mechanism of Interaction Thyroid hormone receptor beta-1 agonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
EPROTIROME THRB

Interaction Score: 1.89

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name eprotirome, KB2115

Novel drug target Established target

Direct Interaction yes

PMIDs:
10592235

Sources:
TdgClinicalTrial ChemblInteractions
DEXTROTHYROXINE THRB

Interaction Score: 1.68

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Thyroid hormone receptor agonist

Direct Interaction yes

PMIDs:
10592235 12776178 17315033 12668276 16099238 17016423 17139284

Sources:
ChemblInteractions
AXITIROME THRB

Interaction Score: 1.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23667826

Sources:
TTD
SOBETIROME THRB

Interaction Score: 1.26

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name sobetirome, QRX-431

PMIDs:
10592235

Sources:
TdgClinicalTrial
AMMONIA SOLUTION, STRONG THRB

Interaction Score: 1.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22324546

Sources:
DTC
LIOTHYRONINE THRB

Interaction Score: 0.87

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Direct Interaction yes

PMIDs:
11159893 10592235 12776178 17315033 12668276 16099238 17016423 17139284

Sources:
TdgClinicalTrial ChemblInteractions TEND
CHEMBL577415 THRB

Interaction Score: 0.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
4-METHOXYCINNAMIC ACID THRB

Interaction Score: 0.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AZORUBINE THRB

Interaction Score: 0.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL584508 THRB

Interaction Score: 0.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LEVOTHYROXINE THRB

Interaction Score: 0.56

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name levothyroxine sodium,Unithroid

Novel drug target Established target

Trial Name levothyroxine,Levoxyl

PMIDs:
16053391 18816177 20151830 17016423 20051527

Sources:
DTC TdgClinicalTrial TEND
TIRATRICOL THRB

Interaction Score: 0.38

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
17139284 17016423

Sources:
TTD
CHEMBL603024 THRB

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL87568 THRB

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LEVOTHYROXINE SODIUM THRB

Interaction Score: 0.32

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Thyroid hormone receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CIRAZOLINE THRB

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL426404 THRB

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DEXTROTHYROXINE SODIUM THRB

Interaction Score: 0.32

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Thyroid hormone receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PRIMAQUINE PHOSPHATE THRB

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHLOROPHENYLPIPERAZINE THRB

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUINALDINE BLUE THRB

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OXYCARBOXIN THRB

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIENOCHLOR THRB

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
METHYL PARATHIONE THRB

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
3-METHYLCHOLANTHRENE THRB

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OXIDOPAMINE THRB

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIBENZ[A,H]ANTHRACENE THRB

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ANAZOLENE THRB

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUINPIROLE THRB

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PYRACLOSTROBIN THRB

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1397308 THRB

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ORTHO-PHTHALALDEHYDE THRB

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BENZO[B]FLUORANTHENE THRB

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ROSE BENGAL THRB

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HOMIDIUM THRB

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUININE THRB

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ROSMARINIC ACID THRB

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CARUBICIN THRB

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
METHYLENE BLUE THRB

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TETRAIDOFLUORESCEIN THRB

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
3R14S-OCHRATOXIN A THRB

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1493528 THRB

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL601952 THRB

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL581044 THRB

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ERYTHROSINE THRB

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
METHYLENE BLUE THRB

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BENZO(K)FLUORANTHENE THRB

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1341830 THRB

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RHAMNETIN THRB

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SHIKONIN THRB

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
WEDELOLACTONE THRB

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL533293 THRB

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOSANTEL THRB

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ISOTRETINOIN THRB

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHLOROTHALONIL THRB

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
METHACYCLINE HYDROCHLORIDE THRB

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FUMARPROTOCETRARIC ACID THRB

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL602969 THRB

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL211670 THRB

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DITHIAZANINE IODIDE THRB

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ZIRAM THRB

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYPERICIN THRB

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1465049 THRB

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LOMOFUNGIN THRB

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUINALIZARIN THRB

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL297304 THRB

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DACTINOMYCIN THRB

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DYCLONINE HYDROCHLORIDE THRB

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GENTIAN VIOLET THRB

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1451216 THRB

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
INAMRINONE THRB

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIAMTERENE THRB

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OXYTETRACYCLINE THRB

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TOLONIUM CHLORIDE THRB

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ACID BLUE 129 THRB

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SPIRONOLACTONE THRB

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
JUGLONE THRB

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PICEATANNOL THRB

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL578741 THRB

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SLAZINIC ACID THRB

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
METHYLTHIONINIUM CHLORIDE THRB

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BAICALEIN THRB

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DEPHOSTATIN THRB

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROTOPORPHYRIN THRB

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
WORTMANNIN THRB

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HOMIDIUM BROMIDE THRB

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LIOTHYRONINE SODIUM THRB

Interaction Score: 0.02

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Thyroid hormone receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHEMBL592124 THRB

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DAUNORUBICIN HYDROCHLORIDE THRB

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DOXORUBICIN HYDROCHLORIDE THRB

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
IDARUBICIN THRB

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HEXACHLOROPHENE THRB

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL THRB

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL429095 THRB

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIPYRIDAMOLE THRB

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DAUNORUBICIN THRB

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000151090
- Version: 101_38
Alternate Names:

THRB Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000151090
- Version: 26-July-2011
Alternate Names:

THYROID HORMONE RECEPTOR BETA-1. [SOURCE:UNIPROT/SWISSPROT;ACC:P10828] Description

ENSG00000151090 Ensembl Gene Id

THRB Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TEND: P10828
- Version: 01-August-2011
Alternate Names:

THB_HUMAN Uniprot Id

THRB Gene Symbol

ENSG00000151090 Ensembl Gene Id

Gene Info:

Target Main Class Receptors

Target Subclass Nuclear receptor

Publications:
HopkinsGroom: P10828
- Version: 11-September-2012
Alternate Names:

THB_HUMAN Uniprot Id

ENSG00000151090 Ensembl Gene Id

THRB Uniprot Gene Name

Gene Info:

Uniprot Status Swiss-Prot

Human Readable Name DRUGGABLE GENOME

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P10828
- Version: January-2014
Alternate Names:

THRB Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Nuclear receptor

Publications:
TTD: Thyroid hormone receptor beta
- Version: 2020.06.01
Alternate Names:

THRB TTD Gene Abbreviation

T98933 TTD Target ID

Gene Info:

Publications:

Gierach I et al., 2012, Bacterial biosensors for screening isoform-selective ligands for human thyroid receptors α-1 and β-1., FEBS Open Bio
DTC: THRB
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Hwang JY et al., 2012, Synthesis and evaluation of sulfonylnitrophenylthiazoles (SNPTs) as thyroid hormone receptor-coactivator interaction inhibitors., J Med Chem
HingoraniCasas: ENSG00000151090
- Version: 31-May-2017
Alternate Names:

ENSG00000151090 Gene Symbol

THRB Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: ERBA2
- Version: chembl_23
Alternate Names:

NR1A2 GENE_SYMBOL

THR1 GENE_SYMBOL

THRB GENE_SYMBOL

Gene Info:

Publications:
GO: THRB
- Version: 01-February-2022
Alternate Names:

ERBA2 GO Gene Synonym

NR1A2 GO Gene Synonym

THR1 GO Gene Synonym

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
dGene: THRB
- Version: 27-Jun-2013
Alternate Names:

7068 Gene ID

C-ERBA-2 dGene Synonym

C-ERBA-BETA dGene Synonym

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:

Direct Interaction	yes
Mechanism of Interaction	Thyroid hormone receptor beta-1 agonist
Trial Name	MB07811

Novel drug target	Established target
Trial Name	VIA-3196
Mechanism of Interaction	Thyroid hormone receptor beta-1 agonist

Trial Name	eprotirome, KB2115
Novel drug target	Established target
Direct Interaction	yes

Mechanism of Interaction	Thyroid hormone receptor agonist
Direct Interaction	yes

Trial Name	levothyroxine sodium,Unithroid
Novel drug target	Established target
Trial Name	levothyroxine,Levoxyl

THYROID HORMONE RECEPTOR BETA-1. [SOURCE:UNIPROT/SWISSPROT;ACC:P10828]	Description
ENSG00000151090	Ensembl Gene Id
THRB	Display Id

THB_HUMAN	Uniprot Id
THRB	Gene Symbol
ENSG00000151090	Ensembl Gene Id

THRB Gene Record

THRB 7068 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Thyroid hormone receptor beta-1 agonist Trial Name MB07811

PMIDs: 10592235

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name VIA-3196 Mechanism of Interaction Thyroid hormone receptor beta-1 agonist

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name eprotirome, KB2115 Novel drug target Established target Direct Interaction yes

PMIDs: 10592235

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Thyroid hormone receptor agonist Direct Interaction yes

PMIDs: 10592235 12776178 17315033 12668276 16099238 17016423 17139284

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23667826

Sources: TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name sobetirome, QRX-431

PMIDs: 10592235

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22324546

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target Direct Interaction yes

PMIDs: 11159893 10592235 12776178 17315033 12668276 16099238 17016423 17139284

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name levothyroxine sodium,Unithroid Novel drug target Established target Trial Name levothyroxine,Levoxyl

PMIDs: 16053391 18816177 20151830 17016423 20051527

Sources: DTC TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 17139284 17016423

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Thyroid hormone receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Thyroid hormone receptor beta-1 agonist

Trial Name MB07811

PMIDs:
10592235

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name VIA-3196

Mechanism of Interaction Thyroid hormone receptor beta-1 agonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name eprotirome, KB2115

Novel drug target Established target

Direct Interaction yes

PMIDs:
10592235

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Thyroid hormone receptor agonist

Direct Interaction yes

PMIDs:
10592235 12776178 17315033 12668276 16099238 17016423 17139284

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
23667826

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name sobetirome, QRX-431

PMIDs:
10592235

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
22324546

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Direct Interaction yes

PMIDs:
11159893 10592235 12776178 17315033 12668276 16099238 17016423 17139284

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name levothyroxine sodium,Unithroid

Novel drug target Established target

Trial Name levothyroxine,Levoxyl

PMIDs:
16053391 18816177 20151830 17016423 20051527

Sources:
DTC TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

PMIDs:
17139284 17016423

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Thyroid hormone receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Thyroid hormone receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found