7153 |
DNA TOPOISOMERASE II ALPHA |
TOP2A |
TOP2 |
TP2A |
126430 |
11989 |
ENSG00000131747 |
OTTHUMG00000155008 |
DNA topoisomerase II, alpha isozyme |
DNA topoisomerase 2-alpha |
TOPOISOMERASE II ALPHA (FRAGMENT). [SOURCE:UNIPROT/SPTREMBL;ACC:Q71UQ5] |
Q71UN1_HUMAN |
PA354 |
P11388 |
TOP2A_HUMAN |
T17048 |
TOP2alpha |
TOPIIA |
Human Readable Name | DRUGGABLE GENOME |
Target Class | Enzymes |
Target Subclass | EC:5.99.1.3 |
Interpro Name | DNA topoisomerase, type IIA |
Interpro Type | Domain |
Interpro Short Name | Topo_IIA |
Interpro Short Name | Topo_IIA_A/C |
Interpro Type | Family |
Interpro Acc | IPR003594 |
Interpro Name | ATPase-like, ATP-binding domain |
Interpro Name | DNA topoisomerase, type IIA, subunit A/C-terminal |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Acc | IPR001241 |
Interpro Short Name | ATPase-like_ATP-bd |
Uniprot Status | Swiss-Prot |
Interpro Acc | IPR002205 |
Target Subclass | 5.99.1.3 |
Target Main Class | Enzymes |
Gene Biotype | PROTEIN_CODING |
DRUGGABLE GENOME |
CLINICALLY ACTIONABLE |
ENZYME |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | DNA topoisomerase II alpha inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | DNA topoisomerase II alpha inhibitor |
Direct Interaction | yes |
Trial Name | - |
inhibitor (inhibitory) |
Trial Name | INNO-206 |
Novel drug target | Established target |
Mechanism of Interaction | DNA topoisomerase II alpha inhibitor |
inhibitor (inhibitory) |
Novel drug target | Established target |
Trial Name | - |
Mechanism of Interaction | DNA topoisomerase II inhibitor |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | DNA topoisomerase II inhibitor |
Trial Name | - |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | DNA topoisomerase II alpha inhibitor |
n/a |
Trial Name | GPX-100 |
Novel drug target | Established target |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | DNA topoisomerase II alpha inhibitor |
inhibitor (inhibitory) |
Trial Name | Voreloxin |
Novel drug target | Established target |
Mechanism of Interaction | DNA topoisomerase II inhibitor |
inhibitor (inhibitory) |
Trial Name | becatecarin, XL 119, rebeccamycin |
Novel drug target | Established target |
Mechanism of Interaction | DNA topoisomerase II inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | DNA topoisomerase II inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | DNA topoisomerase II alpha inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | DNA topoisomerase II inhibitor |
Trial Name | C-1311, XLS-002,Symadex |
inhibitor (inhibitory) |
Trial Name | liposome encapsulated mitoxantrone (LEM) |
Novel drug target | Established target |
Trial Name | mitoxantrone hydrochloride,Novantrone |
n/a |
inhibitor (inhibitory) |
Trial Name | AEZS-108, AN-152 |
Novel drug target | Established target |
Trial Name | MTC-DOX, MTC-doxorubicin |
inhibitor (inhibitory) |
Mechanism of Interaction | DNA topoisomerase II alpha inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | DNA topoisomerase II alpha inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | DNA topoisomerase II alpha inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | DNA topoisomerase II alpha inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | DNA topoisomerase II alpha inhibitor |
Direct Interaction | yes |
n/a |
Trial Name | liposomal encapsulated paclitaxel (LEP) |
Novel drug target | Established target |
TOP2A | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
Q71UN1_HUMAN | Display Id |
TOPOISOMERASE II ALPHA (FRAGMENT). [SOURCE:UNIPROT/SPTREMBL;ACC:Q71UQ5] | Description |
ENSG00000131747 | Ensembl Gene Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
P11388 | Uniprot Accession |
ENSG00000131747 | Ensembl Gene Id |
TOP2A_HUMAN | Uniprot Id |
Target Subclass | 5.99.1.3 |
Target Main Class | Enzymes |
TOP2A | Gene Symbol |
Target Class | Enzymes |
Target Subclass | EC:5.99.1.3 |
P11388 | Uniprot Accession |
7153 | Entrez Gene Id |
TOP2A | Uniprot Gene Name |
Interpro Name | DNA topoisomerase, type IIA |
Interpro Type | Domain |
Interpro Short Name | Topo_IIA |
DRUGGABLE GENOME |
TOP2 | GENE_SYMBOL |
TOP2A | GENE_SYMBOL |
DNA topoisomerase 2-alpha | UNIPROT |
ENSG00000131747 | Gene Symbol |
TOP2A | Ensembl Id |
DRUGGABLE GENOME |
PA354 | PharmGKB ID |
TOP2A | Gene Symbol |
CLINICALLY ACTIONABLE |
TOP2A | TTD Gene Abbreviation |
T17048 | TTD Target ID |
DNA topoisomerase 2-alpha | Gene Name |
P11388 | UniProt ID |
ENZYME |
CLINICALLY ACTIONABLE |