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TPH1 7166 Druggable Genome
Alternate Names:
7166 TRYPTOPHAN HYDROXYLASE 1 TPH1 TPRH TRPH 191060 12008 ENSG00000129167 OTTHUMG00000166421 P17752 TPH1_HUMAN PA355 TRYPTOPHAN 5-HYDROXYLASE 1 Tryptophan 5-monooxygenase 1 TPH TRYPTOPHAN 5-HYDROXYLASE 1 (EC 1.14.16.4) (TRYPTOPHAN 5-MONOOXYGENASE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P17752] 1241 L-Tryptophan hydroxylase 1 Tryptophan 5-hydroxylase T45083 Tryptophan hydroxylase T51593 T78915 Gene Info:
Target Subclass 1.14.16.4 Target Main Class Enzymes Uniprot Status Swiss-Prot Interpro Type Family Interpro Short Name ArAA_hydroxylase Uniprot Evidence 1: Evidence at protein level Interpro Acc IPR001273 Interpro Name Aromatic amino acid hydroxylase Human Readable Name DRUGGABLE GENOME Target Class Enzymes Target Subclass EC:1.14.16.4 Gene Biotype PROTEIN_CODING GuideToPharmacology Gene Category Name Amino acid hydroxylases GuideToPharmacology Gene Category ID 249 Gene Categories: Category Details
DRUGGABLE GENOME ENZYME Publications:
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Interaction Score: 5.32
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Interaction Score: 5.32
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Novel drug target Established target Trial Name LX1032 Mechanism of Interaction Tryptophan 5-hydroxylase inhibitor -
Interaction Score: 2.66
Interaction Types & Directionality:
n/a Interaction Info:
Trial Name Sapropterin Novel drug target Established target -
Interaction Score: 2.66
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False -
Interaction Score: 2.66
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False -
Interaction Score: 2.66
Interaction Types & Directionality:
antagonist (inhibitory) inhibitor (inhibitory) Interaction Info:
Direct Interaction yes Mechanism of Interaction Tryptophan 5-hydroxylase inhibitor -
Interaction Score: 1.33
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False -
Interaction Score: 1.18
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Interaction Score: 0.85
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Interaction Score: 0.71
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Interaction Score: 0.63
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- Version: 101_38
Alternate Names:
TPH1 Ensembl Gene Name Gene Info:
Gene Biotype PROTEIN_CODING Publications:
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- Version: January-2014
Alternate Names:
TPH1 Gene Symbol Gene Info:
Target Class Enzymes Target Subclass EC:1.14.16.4 Publications:
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Alternate Names:
P17752 Uniprot Accession TPH1 Gene Symbol ENSG00000129167 Ensembl Gene Id Gene Info:
Target Subclass 1.14.16.4 Target Main Class Enzymes Publications:
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- Version: 11-September-2012
Alternate Names:
TPH1 Uniprot Gene Name TRYPTOPHAN 5-HYDROXYLASE 1 Uniprot Protein Name ENSG00000129167 Ensembl Gene Id Gene Info:
Uniprot Status Swiss-Prot Interpro Type Family Interpro Short Name ArAA_hydroxylase Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: 26-July-2011
Alternate Names:
TPH1 Display Id TRYPTOPHAN 5-HYDROXYLASE 1 (EC 1.14.16.4) (TRYPTOPHAN 5-MONOOXYGENASE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P17752] Description ENSG00000129167 Ensembl Gene Id Gene Info:
Human Readable Name DRUGGABLE GENOME Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: 29-September-2020
Alternate Names:
12008 HUGO Gene ID 12008 HUGO Gene Symbol tryptophan hydroxylase 1 HUGO Gene Name Gene Info:
GuideToPharmacology Gene Category Name Amino acid hydroxylases GuideToPharmacology Gene Category ID 249 Gene Categories:
ENZYME Publications:
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Alternate Names:
PA355 PharmGKB ID Gene Info:
Publications:
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- Version: 31-May-2017
Alternate Names:
ENSG00000129167 Gene Symbol TPH1 Ensembl Id Gene Info:
Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: chembl_23
Alternate Names:
TPRH GENE_SYMBOL TRPH GENE_SYMBOL TPH1 GENE_SYMBOL Gene Info:
Publications:
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- Version: 2020.06.01
Alternate Names:
TPH TTD Gene Abbreviation T45083 TTD Target ID Gene Info:
Publications:
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- Version: 2020.06.01
Alternate Names:
TPH1 TTD Gene Abbreviation T78915 TTD Target ID Gene Info:
Publications:
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- Version: 2020.06.01
Alternate Names:
TPH TTD Gene Abbreviation T51593 TTD Target ID Gene Info:
Publications: