DGIdb - TPH1 Gene Record

TPH1 7166 Druggable Genome

Alternate Names:

7166
TRYPTOPHAN HYDROXYLASE 1
TPH1
TPRH
TRPH
191060
12008
ENSG00000129167
OTTHUMG00000166421
BE0000121
P17752
TPH1_HUMAN
PA355
TRYPTOPHAN 5-HYDROXYLASE 1
Tryptophan 5-monooxygenase 1
TPH
TRYPTOPHAN 5-HYDROXYLASE 1 (EC 1.14.16.4) (TRYPTOPHAN 5-MONOOXYGENASE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P17752]
1241
L-Tryptophan hydroxylase 1
Tryptophan 5-hydroxylase
T45083
Tryptophan hydroxylase
T51593
T78915

Gene Info:

Target Subclass	1.14.16.4
Target Main Class	Enzymes
Uniprot Status	Swiss-Prot
Interpro Type	Family
Interpro Short Name	ArAA_hydroxylase
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR001273
Interpro Name	Aromatic amino acid hydroxylase
Human Readable Name	DRUGGABLE GENOME
Target Class	Enzymes
Target Subclass	EC:1.14.16.4
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	Amino acid hydroxylases
GuideToPharmacology Gene Category ID	249

(9 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Niitsu T et al., 2013, Pharmacogenetics in major depression: a comprehensive meta-analysis., Prog Neuropsychopharmacol Biol Psychiatry
Arias B et al., 2013, TPH1, MAOA, serotonin receptor 2A and 2C genes in citalopram response: possible effect in melancholic and psychotic depression., Neuropsychobiology
Illi A et al., 2009, 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression., Neuroreport
Serova et al., 2004, Response of tyrosine hydroxylase and GTP cyclohydrolase I gene expression to estrogen in brain catecholaminergic regions varies with mode of administration., Brain Res.
Martínez et al., 2001, A structural approach into human tryptophan hydroxylase and its implications for the regulation of serotonin biosynthesis., Curr. Med. Chem.
Chamas et al., 1999, Tryptophan hydroxylase mRNA levels are elevated by repeated immobilization stress in rat raphe nuclei but not in pineal gland., Neurosci. Lett.
Ikemoto et al., 2002, Localization of sepiapterin reductase in the human brain., Brain Res.
Haavik, 1989, [From butterflies to neurobiology and the diagnosis of AIDS. The 100th anniversary of the discovery of pteridines]., Tidsskr. Nor. Laegeforen.
McCarthy MJ et al., 2010, Pharmacogenetics of lithium response in bipolar disorder., Pharmacogenomics

SAPROPTERIN TPH1

Interaction Score: 6.55

Interaction Types & Directionality:

cofactor (activating)

Interaction Info:

PMIDs:
15223360 11472242 10381000 12414107 2665179

Sources:
DrugBank
RODATRISTAT ETHYL TPH1

Interaction Score: 4.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TELOTRISTAT ETHYL TPH1

Interaction Score: 4.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name LX1032

Mechanism of Interaction Tryptophan 5-hydroxylase inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
SAPROPTERIN TPH1

Interaction Score: 2.18

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Sapropterin

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
RODATRISTAT TPH1

Interaction Score: 2.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
TELOTRISTAT TPH1

Interaction Score: 2.18

Interaction Types & Directionality:

inhibitor (inhibitory)

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tryptophan 5-hydroxylase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
FENCLONINE TPH1

Interaction Score: 1.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
FENFLURAMINE TPH1

Interaction Score: 0.73

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
ESCITALOPRAM TPH1

Interaction Score: 0.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23733030 23221997 19590397

Sources:
PharmGKB
PAROXETINE TPH1

Interaction Score: 0.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23733030 23221997 19590397

Sources:
PharmGKB
FLUOXETINE TPH1

Interaction Score: 0.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23733030 23221997 19590397

Sources:
PharmGKB
CITALOPRAM TPH1

Interaction Score: 0.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23733030 23221997 19590397

Sources:
PharmGKB
LITHIUM TPH1

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21047205

Sources:
PharmGKB

Ensembl: ENSG00000129167
- Version: 101_38
Alternate Names:

TPH1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P17752
- Version: January-2014
Alternate Names:

TPH1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.14.16.4

Publications:
TEND: P17752
- Version: 01-August-2011
Alternate Names:

P17752 Uniprot Accession

TPH1 Gene Symbol

ENSG00000129167 Ensembl Gene Id

Gene Info:

Target Subclass 1.14.16.4

Target Main Class Enzymes

Publications:
HopkinsGroom: P17752
- Version: 11-September-2012
Alternate Names:

TPH1 Uniprot Gene Name

TRYPTOPHAN 5-HYDROXYLASE 1 Uniprot Protein Name

ENSG00000129167 Ensembl Gene Id

Gene Info:

Uniprot Status Swiss-Prot

Interpro Type Family

Interpro Short Name ArAA_hydroxylase

Gene Categories:

DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000129167
- Version: 26-July-2011
Alternate Names:

TPH1 Display Id

TRYPTOPHAN 5-HYDROXYLASE 1 (EC 1.14.16.4) (TRYPTOPHAN 5-MONOOXYGENASE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P17752] Description

ENSG00000129167 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
GuideToPharmacology: 7166
- Version: 29-September-2020
Alternate Names:

12008 HUGO Gene ID

12008 HUGO Gene Symbol

tryptophan hydroxylase 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Amino acid hydroxylases

GuideToPharmacology Gene Category ID 249

Gene Categories:

ENZYME

Publications:

PharmGKB: TPH1

Version: 18-August-2020

Alternate Names:

PA355 PharmGKB ID

Gene Info:

Publications:

Illi A et al., 2009, 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression., Neuroreport

Arias B et al., 2013, TPH1, MAOA, serotonin receptor 2A and 2C genes in citalopram response: possible effect in melancholic and psychotic depression., Neuropsychobiology

Niitsu T et al., 2013, Pharmacogenetics in major depression: a comprehensive meta-analysis., Prog Neuropsychopharmacol Biol Psychiatry

DrugBank: BE0000121

Version: 5.1.7

Alternate Names:

TPH1 DrugBank Gene Name

P17752 UniProt Accession

7166 Entrez Gene Id

Gene Info:

Publications:

Martínez et al., 2001, A structural approach into human tryptophan hydroxylase and its implications for the regulation of serotonin biosynthesis., Curr. Med. Chem.

Ikemoto et al., 2002, Localization of sepiapterin reductase in the human brain., Brain Res.

Haavik, 1989, [From butterflies to neurobiology and the diagnosis of AIDS. The 100th anniversary of the discovery of pteridines]., Tidsskr. Nor. Laegeforen.

HingoraniCasas: ENSG00000129167
- Version: 31-May-2017
Alternate Names:

ENSG00000129167 Gene Symbol

TPH1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: TPH
- Version: chembl_23
Alternate Names:

TPRH GENE_SYMBOL

TRPH GENE_SYMBOL

TPH1 GENE_SYMBOL

Gene Info:

Publications:
TTD: Tryptophan 5-hydroxylase
- Version: 2020.06.01
Alternate Names:

TPH TTD Gene Abbreviation

T45083 TTD Target ID

Gene Info:

Publications:
TTD: Tryptophan 5-hydroxylase 1
- Version: 2020.06.01
Alternate Names:

TPH1 TTD Gene Abbreviation

T78915 TTD Target ID

Gene Info:

Publications:
TTD: Tryptophan hydroxylase
- Version: 2020.06.01
Alternate Names:

TPH TTD Gene Abbreviation

T51593 TTD Target ID

Gene Info:

Publications:

Novel drug target	Established target
Trial Name	LX1032
Mechanism of Interaction	Tryptophan 5-hydroxylase inhibitor

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

Direct Interaction	yes
Mechanism of Interaction	Tryptophan 5-hydroxylase inhibitor

P17752	Uniprot Accession
TPH1	Gene Symbol
ENSG00000129167	Ensembl Gene Id

TPH1	Uniprot Gene Name
TRYPTOPHAN 5-HYDROXYLASE 1	Uniprot Protein Name
ENSG00000129167	Ensembl Gene Id

TPH1	Display Id
TRYPTOPHAN 5-HYDROXYLASE 1 (EC 1.14.16.4) (TRYPTOPHAN 5-MONOOXYGENASE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P17752]	Description
ENSG00000129167	Ensembl Gene Id

12008	HUGO Gene ID
12008	HUGO Gene Symbol
tryptophan hydroxylase 1	HUGO Gene Name

TPH1	DrugBank Gene Name
P17752	UniProt Accession
7166	Entrez Gene Id

inhibitor (inhibitory)
antagonist (inhibitory)

TPH1 Gene Record

TPH1 7166 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: cofactor (activating)

Interaction Info:

PMIDs: 15223360 11472242 10381000 12414107 2665179

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name LX1032 Mechanism of Interaction Tryptophan 5-hydroxylase inhibitor

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Sapropterin Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory) antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Tryptophan 5-hydroxylase inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23733030 23221997 19590397

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23733030 23221997 19590397

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23733030 23221997 19590397

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23733030 23221997 19590397

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21047205

Sources: PharmGKB

Ensembl: ENSG00000129167

Alternate Names: TPH1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P17752

Alternate Names: TPH1 Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:1.14.16.4

Publications:

TEND: P17752

Alternate Names: P17752 Uniprot Accession TPH1 Gene Symbol ENSG00000129167 Ensembl Gene Id

Gene Info: Target Subclass 1.14.16.4 Target Main Class Enzymes

Publications:

HopkinsGroom: P17752

Alternate Names: TPH1 Uniprot Gene Name TRYPTOPHAN 5-HYDROXYLASE 1 Uniprot Protein Name ENSG00000129167 Ensembl Gene Id

Gene Info: Uniprot Status Swiss-Prot Interpro Type Family Interpro Short Name ArAA_hydroxylase

Gene Categories: DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000129167

Alternate Names: TPH1 Display Id TRYPTOPHAN 5-HYDROXYLASE 1 (EC 1.14.16.4) (TRYPTOPHAN 5-MONOOXYGENASE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P17752] Description ENSG00000129167 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

Interaction Types & Directionality:

cofactor (activating)

PMIDs:
15223360 11472242 10381000 12414107 2665179

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name LX1032

Mechanism of Interaction Tryptophan 5-hydroxylase inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Sapropterin

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tryptophan 5-hydroxylase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
23733030 23221997 19590397

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23733030 23221997 19590397

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23733030 23221997 19590397

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23733030 23221997 19590397

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21047205

Sources:
PharmGKB

Alternate Names:

TPH1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

TPH1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.14.16.4

Alternate Names:

P17752 Uniprot Accession

TPH1 Gene Symbol

ENSG00000129167 Ensembl Gene Id

Gene Info:

Target Subclass 1.14.16.4

Target Main Class Enzymes

Alternate Names:

TPH1 Uniprot Gene Name

TRYPTOPHAN 5-HYDROXYLASE 1 Uniprot Protein Name

ENSG00000129167 Ensembl Gene Id

Gene Info:

Uniprot Status Swiss-Prot

Interpro Type Family

Interpro Short Name ArAA_hydroxylase

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

TPH1 Display Id

TRYPTOPHAN 5-HYDROXYLASE 1 (EC 1.14.16.4) (TRYPTOPHAN 5-MONOOXYGENASE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P17752] Description

ENSG00000129167 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

12008 HUGO Gene ID

12008 HUGO Gene Symbol

tryptophan hydroxylase 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Amino acid hydroxylases

GuideToPharmacology Gene Category ID 249

Gene Categories:

ENZYME

Alternate Names:

PA355 PharmGKB ID

Alternate Names:

TPH1 DrugBank Gene Name

P17752 UniProt Accession

7166 Entrez Gene Id

Alternate Names:

ENSG00000129167 Gene Symbol

TPH1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

TPRH GENE_SYMBOL

TRPH GENE_SYMBOL

TPH1 GENE_SYMBOL

Alternate Names:

TPH TTD Gene Abbreviation

T45083 TTD Target ID

Alternate Names:

TPH1 TTD Gene Abbreviation

T78915 TTD Target ID

Alternate Names:

TPH TTD Gene Abbreviation

T51593 TTD Target ID