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TPH1 Gene Record

  • Summary
  • Interactions
  • Claims
  • TPH1 7166 Druggable Genome

    Alternate Names:

    7166
    TRYPTOPHAN HYDROXYLASE 1
    TPH1
    TPRH
    TRPH
    191060
    12008
    ENSG00000129167
    OTTHUMG00000166421
    P17752
    TPH1_HUMAN
    PA355
    TRYPTOPHAN 5-HYDROXYLASE 1
    Tryptophan 5-monooxygenase 1
    TPH
    TRYPTOPHAN 5-HYDROXYLASE 1 (EC 1.14.16.4) (TRYPTOPHAN 5-MONOOXYGENASE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P17752]
    Tryptophan 5-hydroxylase
    T45083
    Tryptophan hydroxylase
    T51593
    T78915

    Gene Info:

    Target Subclass 1.14.16.4
    Target Main Class Enzymes
    Uniprot Status Swiss-Prot
    Interpro Type Family
    Interpro Short Name ArAA_hydroxylase
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR001273
    Interpro Name Aromatic amino acid hydroxylase
    Human Readable Name DRUGGABLE GENOME
    Target Class Enzymes
    Target Subclass EC:1.14.16.4
    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Niitsu T et al., 2013, Pharmacogenetics in major depression: a comprehensive meta-analysis., Prog Neuropsychopharmacol Biol Psychiatry
    Arias B et al., 2013, TPH1, MAOA, serotonin receptor 2A and 2C genes in citalopram response: possible effect in melancholic and psychotic depression., Neuropsychobiology
    Illi A et al., 2009, 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression., Neuroreport
    McCarthy MJ et al., 2010, Pharmacogenetics of lithium response in bipolar disorder., Pharmacogenomics
  • RODATRISTAT ETHYL   TPH1

    Interaction Score: 6.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TELOTRISTAT ETHYL   TPH1

    Interaction Score: 6.87

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name LX1032
    Mechanism of Interaction Tryptophan 5-hydroxylase inhibitor

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • SAPROPTERIN   TPH1

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Sapropterin
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TEND

  • TELOTRISTAT   TPH1

    Interaction Score: 3.43

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tryptophan 5-hydroxylase inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ESCITALOPRAM   TPH1

    Interaction Score: 1.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23733030 23221997 19590397


    Sources:
    PharmGKB

  • PAROXETINE   TPH1

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23733030 23221997 19590397


    Sources:
    PharmGKB

  • FLUOXETINE   TPH1

    Interaction Score: 1.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23733030 23221997 19590397


    Sources:
    PharmGKB

  • CITALOPRAM   TPH1

    Interaction Score: 0.83

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23733030 23221997 19590397


    Sources:
    PharmGKB

  • LITHIUM   TPH1

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21047205


    Sources:
    PharmGKB

  • Ensembl: ENSG00000129167

    • Version: 101_38

    Alternate Names:
    TPH1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P17752

    • Version: January-2014

    Alternate Names:
    TPH1 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:1.14.16.4

    Publications:

  • TEND: P17752

    • Version: 01-August-2011

    Alternate Names:
    P17752 Uniprot Accession
    TPH1 Gene Symbol
    ENSG00000129167 Ensembl Gene Id

    Gene Info:
    Target Subclass 1.14.16.4
    Target Main Class Enzymes

    Publications:

  • HopkinsGroom: P17752

    • Version: 11-September-2012

    Alternate Names:
    TPH1 Uniprot Gene Name
    TRYPTOPHAN 5-HYDROXYLASE 1 Uniprot Protein Name
    ENSG00000129167 Ensembl Gene Id

    Gene Info:
    Uniprot Status Swiss-Prot
    Interpro Type Family
    Interpro Short Name ArAA_hydroxylase

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000129167

    • Version: 26-July-2011

    Alternate Names:
    TPH1 Display Id
    TRYPTOPHAN 5-HYDROXYLASE 1 (EC 1.14.16.4) (TRYPTOPHAN 5-MONOOXYGENASE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P17752] Description
    ENSG00000129167 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: TPH1

    • Version: 18-August-2020

    Alternate Names:
    PA355 PharmGKB ID

    Gene Info:

    Publications:
    Illi A et al., 2009, 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression., Neuroreport
    Arias B et al., 2013, TPH1, MAOA, serotonin receptor 2A and 2C genes in citalopram response: possible effect in melancholic and psychotic depression., Neuropsychobiology
    Niitsu T et al., 2013, Pharmacogenetics in major depression: a comprehensive meta-analysis., Prog Neuropsychopharmacol Biol Psychiatry

  • HingoraniCasas: ENSG00000129167

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000129167 Gene Symbol
    TPH1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: TPH

    • Version: chembl_23

    Alternate Names:
    TPRH GENE_SYMBOL
    TRPH GENE_SYMBOL
    TPH1 GENE_SYMBOL

    Gene Info:

    Publications:

  • TTD: Tryptophan 5-hydroxylase

    • Version: 2020.06.01

    Alternate Names:
    TPH TTD Gene Abbreviation
    T45083 TTD Target ID

    Gene Info:

    Publications:

  • TTD: Tryptophan 5-hydroxylase 1

    • Version: 2020.06.01

    Alternate Names:
    TPH1 TTD Gene Abbreviation
    T78915 TTD Target ID

    Gene Info:

    Publications:

  • TTD: Tryptophan hydroxylase

    • Version: 2020.06.01

    Alternate Names:
    TPH TTD Gene Abbreviation
    T51593 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21