DGIdb - TPH1 Gene Record

TPH1 7166 Druggable Genome

Alternate Names:

7166
TRYPTOPHAN HYDROXYLASE 1
TPH1
TPRH
TRPH
191060
12008
ENSG00000129167
OTTHUMG00000166421
P17752
TPH1_HUMAN
PA355
TRYPTOPHAN 5-HYDROXYLASE 1
Tryptophan 5-monooxygenase 1
TPH
TRYPTOPHAN 5-HYDROXYLASE 1 (EC 1.14.16.4) (TRYPTOPHAN 5-MONOOXYGENASE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P17752]
Tryptophan 5-hydroxylase
T45083
Tryptophan hydroxylase
T51593
T78915

Gene Info:

Target Subclass	1.14.16.4
Target Main Class	Enzymes
Uniprot Status	Swiss-Prot
Interpro Type	Family
Interpro Short Name	ArAA_hydroxylase
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR001273
Interpro Name	Aromatic amino acid hydroxylase
Human Readable Name	DRUGGABLE GENOME
Target Class	Enzymes
Target Subclass	EC:1.14.16.4
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Niitsu T et al., 2013, Pharmacogenetics in major depression: a comprehensive meta-analysis., Prog Neuropsychopharmacol Biol Psychiatry
Arias B et al., 2013, TPH1, MAOA, serotonin receptor 2A and 2C genes in citalopram response: possible effect in melancholic and psychotic depression., Neuropsychobiology
Illi A et al., 2009, 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression., Neuroreport
McCarthy MJ et al., 2010, Pharmacogenetics of lithium response in bipolar disorder., Pharmacogenomics

RODATRISTAT ETHYL TPH1

Interaction Score: 6.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TELOTRISTAT ETHYL TPH1

Interaction Score: 6.87

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name LX1032

Mechanism of Interaction Tryptophan 5-hydroxylase inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
SAPROPTERIN TPH1

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Sapropterin

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
TELOTRISTAT TPH1

Interaction Score: 3.43

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tryptophan 5-hydroxylase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
ESCITALOPRAM TPH1

Interaction Score: 1.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23733030 23221997 19590397

Sources:
PharmGKB
PAROXETINE TPH1

Interaction Score: 1.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23733030 23221997 19590397

Sources:
PharmGKB
FLUOXETINE TPH1

Interaction Score: 1.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23733030 23221997 19590397

Sources:
PharmGKB
CITALOPRAM TPH1

Interaction Score: 0.83

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23733030 23221997 19590397

Sources:
PharmGKB
LITHIUM TPH1

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21047205

Sources:
PharmGKB

Ensembl: ENSG00000129167
- Version: 101_38
Alternate Names:

TPH1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P17752
- Version: January-2014
Alternate Names:

TPH1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.14.16.4

Publications:
TEND: P17752
- Version: 01-August-2011
Alternate Names:

P17752 Uniprot Accession

TPH1 Gene Symbol

ENSG00000129167 Ensembl Gene Id

Gene Info:

Target Subclass 1.14.16.4

Target Main Class Enzymes

Publications:
HopkinsGroom: P17752
- Version: 11-September-2012
Alternate Names:

TPH1 Uniprot Gene Name

TRYPTOPHAN 5-HYDROXYLASE 1 Uniprot Protein Name

ENSG00000129167 Ensembl Gene Id

Gene Info:

Uniprot Status Swiss-Prot

Interpro Type Family

Interpro Short Name ArAA_hydroxylase

Gene Categories:

DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000129167
- Version: 26-July-2011
Alternate Names:

TPH1 Display Id

TRYPTOPHAN 5-HYDROXYLASE 1 (EC 1.14.16.4) (TRYPTOPHAN 5-MONOOXYGENASE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P17752] Description

ENSG00000129167 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: TPH1

Version: 18-August-2020

Alternate Names:

PA355 PharmGKB ID

Gene Info:

Publications:

Illi A et al., 2009, 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression., Neuroreport

Arias B et al., 2013, TPH1, MAOA, serotonin receptor 2A and 2C genes in citalopram response: possible effect in melancholic and psychotic depression., Neuropsychobiology

Niitsu T et al., 2013, Pharmacogenetics in major depression: a comprehensive meta-analysis., Prog Neuropsychopharmacol Biol Psychiatry

HingoraniCasas: ENSG00000129167
- Version: 31-May-2017
Alternate Names:

ENSG00000129167 Gene Symbol

TPH1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: TPH
- Version: chembl_23
Alternate Names:

TPRH GENE_SYMBOL

TRPH GENE_SYMBOL

TPH1 GENE_SYMBOL

Gene Info:

Publications:
TTD: Tryptophan 5-hydroxylase
- Version: 2020.06.01
Alternate Names:

TPH TTD Gene Abbreviation

T45083 TTD Target ID

Gene Info:

Publications:
TTD: Tryptophan 5-hydroxylase 1
- Version: 2020.06.01
Alternate Names:

TPH1 TTD Gene Abbreviation

T78915 TTD Target ID

Gene Info:

Publications:
TTD: Tryptophan hydroxylase
- Version: 2020.06.01
Alternate Names:

TPH TTD Gene Abbreviation

T51593 TTD Target ID

Gene Info:

Publications:

Novel drug target	Established target
Trial Name	LX1032
Mechanism of Interaction	Tryptophan 5-hydroxylase inhibitor

Direct Interaction	yes
Mechanism of Interaction	Tryptophan 5-hydroxylase inhibitor

P17752	Uniprot Accession
TPH1	Gene Symbol
ENSG00000129167	Ensembl Gene Id

TPH1	Uniprot Gene Name
TRYPTOPHAN 5-HYDROXYLASE 1	Uniprot Protein Name
ENSG00000129167	Ensembl Gene Id

TPH1	Display Id
TRYPTOPHAN 5-HYDROXYLASE 1 (EC 1.14.16.4) (TRYPTOPHAN 5-MONOOXYGENASE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P17752]	Description
ENSG00000129167	Ensembl Gene Id

antagonist (inhibitory)
inhibitor (inhibitory)

TPH1 Gene Record

TPH1 7166 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name LX1032 Mechanism of Interaction Tryptophan 5-hydroxylase inhibitor

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Sapropterin Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Tryptophan 5-hydroxylase inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23733030 23221997 19590397

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23733030 23221997 19590397

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23733030 23221997 19590397

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23733030 23221997 19590397

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21047205

Sources: PharmGKB

Ensembl: ENSG00000129167

Alternate Names: TPH1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P17752

Alternate Names: TPH1 Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:1.14.16.4

Publications:

TEND: P17752

Alternate Names: P17752 Uniprot Accession TPH1 Gene Symbol ENSG00000129167 Ensembl Gene Id

Gene Info: Target Subclass 1.14.16.4 Target Main Class Enzymes

Publications:

HopkinsGroom: P17752

Alternate Names: TPH1 Uniprot Gene Name TRYPTOPHAN 5-HYDROXYLASE 1 Uniprot Protein Name ENSG00000129167 Ensembl Gene Id

Gene Info: Uniprot Status Swiss-Prot Interpro Type Family Interpro Short Name ArAA_hydroxylase

Gene Categories: DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000129167

Alternate Names: TPH1 Display Id TRYPTOPHAN 5-HYDROXYLASE 1 (EC 1.14.16.4) (TRYPTOPHAN 5-MONOOXYGENASE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P17752] Description ENSG00000129167 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

PharmGKB: TPH1

Alternate Names: PA355 PharmGKB ID

Gene Info:

HingoraniCasas: ENSG00000129167

Alternate Names: ENSG00000129167 Gene Symbol TPH1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: TPH

Alternate Names: TPRH GENE_SYMBOL TRPH GENE_SYMBOL TPH1 GENE_SYMBOL

Gene Info:

Publications:

TTD: Tryptophan 5-hydroxylase

Alternate Names: TPH TTD Gene Abbreviation T45083 TTD Target ID

Gene Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name LX1032

Mechanism of Interaction Tryptophan 5-hydroxylase inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Sapropterin

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tryptophan 5-hydroxylase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
23733030 23221997 19590397

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23733030 23221997 19590397

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23733030 23221997 19590397

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23733030 23221997 19590397

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21047205

Sources:
PharmGKB

Alternate Names:

TPH1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

TPH1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.14.16.4

Alternate Names:

P17752 Uniprot Accession

TPH1 Gene Symbol

ENSG00000129167 Ensembl Gene Id

Gene Info:

Target Subclass 1.14.16.4

Target Main Class Enzymes

Alternate Names:

TPH1 Uniprot Gene Name

TRYPTOPHAN 5-HYDROXYLASE 1 Uniprot Protein Name

ENSG00000129167 Ensembl Gene Id

Gene Info:

Uniprot Status Swiss-Prot

Interpro Type Family

Interpro Short Name ArAA_hydroxylase

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

TPH1 Display Id

TRYPTOPHAN 5-HYDROXYLASE 1 (EC 1.14.16.4) (TRYPTOPHAN 5-MONOOXYGENASE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P17752] Description

ENSG00000129167 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PA355 PharmGKB ID

Alternate Names:

ENSG00000129167 Gene Symbol

TPH1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

TPRH GENE_SYMBOL

TRPH GENE_SYMBOL

TPH1 GENE_SYMBOL

Alternate Names:

TPH TTD Gene Abbreviation

T45083 TTD Target ID

Alternate Names:

TPH1 TTD Gene Abbreviation

T78915 TTD Target ID

Alternate Names:

TPH TTD Gene Abbreviation

T51593 TTD Target ID