• Interaction Score: 4.46

    Interaction Types & Directionality:
    inducer (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Direct Interaction yes

  • Interaction Score: 3.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26263397


    Sources:
    DTC

  • Interaction Score: 3.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17684094


    Sources:
    DTC

  • Interaction Score: 1.67

    Interaction Types & Directionality:
    inducer (activating)

    Interaction Info:

  • Interaction Score: 1.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26263397


    Sources:
    DTC

  • Interaction Score: 1.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24484240


    Sources:
    DTC

  • Interaction Score: 1.67

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Transient receptor potential cation channel subfamily A member 1 antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 1.67

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Transient receptor potential cation channel subfamily A member 1 antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 1.67

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Activation
    Details of the Assay for Interaction Patch clamp

    PMIDs:
    None found


  • Interaction Score: 1.67

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Endogenous Drug? False
    Details of Interaction This compound has similar activity at rat and mouse TRPA1
    Specific Action of the Ligand Activation

    PMIDs:
    None found


  • Interaction Score: 1.67

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Endogenous Drug? False
    Details of Interaction This compound also activates mouse TRPA1
    Specific Action of the Ligand Activation

    PMIDs:
    None found


  • Interaction Score: 1.67

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Details of the Assay for Interaction FLIPR calcium influx assay
    Specific Action of the Ligand Activation
    Details of Interaction non-covalent

    PMIDs:
    None found


  • Interaction Score: 1.25

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:


    Sources:
    DrugBank

  • Interaction Score: 1.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26263397


    Sources:
    DTC

  • Interaction Score: 0.84

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Specific Action of the Ligand Activation
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.84

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Details of Interaction covalent

    PMIDs:
    None found


  • Interaction Score: 0.84

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Details of the Assay for Interaction Calcium imaging, patch clamp
    Specific Action of the Ligand Activation
    Details of Interaction This compound has similar activity at mouse and rat TRPA1

    PMIDs:
    None found


  • Interaction Score: 0.67

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    16192383


    Sources:
    DrugBank

  • Interaction Score: 0.56

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    16192383


    Sources:
    DrugBank

  • Interaction Score: 0.56

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Details of the Assay for Interaction Calcium imaging
    Specific Action of the Ligand Activation
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.56

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Details of Interaction covalent
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26263397


    Sources:
    DTC

  • Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    28120232


    Sources:
    DrugBank

  • Interaction Score: 0.42

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    22133806


    Sources:
    DrugBank

  • Interaction Score: 0.42

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Details of the Assay for Interaction Fluorometric Imaging Plate Reader (FLIRP) calcium-influx assay
    Specific Action of the Ligand Agonist
    Details of Interaction non-covalent

    PMIDs:
    None found


  • Interaction Score: 0.33

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Activation
    Details of the Assay for Interaction Calcium imaging

    PMIDs:
    None found


  • Interaction Score: 0.28

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Details of the Assay for Interaction Calcium imaging
    Specific Action of the Ligand Activation
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.17

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Details of the Assay for Interaction FLIPR calcium-influx assay
    Specific Action of the Ligand Activation
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.12

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:


    Sources:
    DrugBank

  • Interaction Score: 0.1

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Endogenous Drug? False
    Details of Interaction This compound is also an activator of mouse TRPA1.
    Specific Action of the Ligand Activation

    PMIDs:
    None found


  • Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • Interaction Score: 0.07

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Details of the Assay for Interaction Calcium imaging, patch clamp
    Specific Action of the Ligand Activation
    Details of Interaction Apomorphine blocks TRPA1 at 100µM

    PMIDs:
    None found


  • Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26263397


    Sources:
    DTC

  • Interaction Score: 0.03

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Details of the Assay for Interaction Patch clamp
    Specific Action of the Ligand Activation
    Details of Interaction non-covalent

    PMIDs:
    None found