• TRPC5 7224 Druggable Genome

    Alternate Names:

    7224
    TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY C MEMBER 5
    TRPC5
    PPP1R159
    TRP5
    300334
    12337
    ENSG00000072315
    OTTHUMG00000022212
    TRPC5_HUMAN
    Q9UL62
    490
    NP_036603
    NM_012471
    SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 5 (TRPC5) (HTRP-5) (HTRP5). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9UL62]
    SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 5
    T00156

    Gene Info:

    Initial Gene Query TRPC5
    Counted Citations from 1950-2000 0
    GuideToPharmacology Gene Category Name Transient Receptor Potential channels
    GuideToPharmacology Gene Category ID 78
    Human Readable Name DRUGGABLE GENOME
    Human Readable Name ION CHANNEL
    Interpro Name Ion transport domain
    Interpro Acc IPR005821
    Interpro Short Name Ion_trans_dom
    Interpro Type Domain
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    KINASE
    ION CHANNEL
    DRUGGABLE GENOME
  • Interaction Score: 7.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16998480


    Sources:
    DTC

  • Interaction Score: 7.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16998480


    Sources:
    DTC

  • Interaction Score: 2.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16998480


    Sources:
    DTC

  • Interaction Score: 1.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16998480


    Sources:
    DTC

  • Interaction Score: 1.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16998480


    Sources:
    DTC

  • Interaction Score: 1.26

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? True
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.47

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Inhibition of lanthanide-evoked calcium entry in HEK 293 cells overexpressing hTRPC5, by patch-clamp recording.
    Specific Action of the Ligand None
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.42

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.24

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Details of the Assay for Interaction Measuring intracellular calcium elevation in HEK293 cells expressing hTRPC5.
    Specific Action of the Ligand Activation
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.16

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Specific Action of the Ligand Activation
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.16

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.12

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Activation

    PMIDs:
    None found


  • Interaction Score: 0.09

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand None

    PMIDs:
    None found


  • Interaction Score: 0.06

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Specific Action of the Ligand None
    Details of Interaction independent of tyrosine kinase inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.05

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


    • Version: 101_38

    Alternate Names:
    TRPC5 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000072315 Ensembl Gene Id
    SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 5 (TRPC5) (HTRP-5) (HTRP5). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9UL62] Description
    TRPC5 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: February-2014

    Alternate Names:
    7224 Entrez Gene ID

    Gene Info:
    Initial Gene Query TRPC5
    Counted Citations from 1950-2000 0

    Gene Categories:
    ION CHANNEL

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000072315 Ensembl Gene Id
    SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 5 Uniprot Protein Name
    TRPC5_HUMAN Uniprot Id

    Gene Info:
    Human Readable Name ION CHANNEL
    Interpro Name Ion transport domain
    Interpro Acc IPR005821

    Gene Categories:
    ION CHANNEL, DRUGGABLE GENOME

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    12337 HUGO Gene ID
    12337 HUGO Gene Symbol
    transient receptor potential cation channel subfamily C member 5 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Transient Receptor Potential channels
    GuideToPharmacology Gene Category ID 78

    Gene Categories:
    ION CHANNEL

    Publications:

    • Version: 02-September-2020
    • Version: 31-May-2017

    Alternate Names:
    ENSG00000072315 Gene Symbol
    TRPC5 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 03-September-2020

    Alternate Names:
    Short transient receptor potential channel 5 Gene Name
    Q9UL62 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, ION CHANNEL

    Publications:

  • Alternate Names:
    TRPC5 TTD Gene Abbreviation
    T00156 TTD Target ID

    Gene Info:

    Publications: