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TUBA3D Gene Record

  • Summary
  • Interactions
  • Claims
  • TUBA3D 113457 Druggable Genome

    Alternate Names:

    113457
    TUBULIN ALPHA 3D
    TUBA3D
    H2-ALPHA
    24071
    ENSG00000075886
    OTTHUMG00000153600
    Q13748
    113457; 7278
    TUBULIN ALPHA-3C/D CHAIN
    TBA3C_HUMAN
    ENSG00000198033
    TUBA2
    Tubulin alpha-2 chain
    Alpha-tubulin 3C/D
    Alpha-tubulin 2
    Detyrosinated tubulin alpha-3C/D chain
    and
    TUBULIN ALPHA-2 CHAIN (ALPHA-TUBULIN 2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13748]
    KTCN9
    617878

    Gene Info:

    Interpro Name Tubulin
    Interpro Acc IPR000217
    Interpro Type Family
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Interpro Short Name Tubulin
    Human Readable Name DRUGGABLE GENOME
    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Field JJ et al., 2009, Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis., J Med Chem
    Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem
    Yi X et al., 2012, Identification of a class of novel tubulin inhibitors., J Med Chem
    Zheng J et al., 2013, Elaboration of thorough simplified vinca alkaloids as antimitotic agents based on pharmacophore similarity., Eur J Med Chem
    Cheng YY et al., 2013, Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl)-6-pyrrolidinylquinolin-4-one as a potent anticancer lead., Bioorg Med Chem Lett
    Reddy MV et al., 2013, Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents., J Med Chem
    Wang F et al., 2015, Synthesis and biological evaluation of diarylthiazole derivatives as antimitotic and antivascular agents with potent antitumor activity., Bioorg Med Chem
    Zhu C et al., 2014, Discovery of potent cytotoxic ortho-aryl chalcones as new scaffold targeting tubulin and mitosis with affinity-based fluorescence., J Med Chem
    Zhang X et al., 2015, Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors., Eur J Med Chem
    Wang XF et al., 2014, Optimization of 4-(N-cycloamino)phenylquinazolines as a novel class of tubulin-polymerization inhibitors targeting the colchicine site., J Med Chem
    Minegishi H et al., 2015, Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate (GN39482) as a tubulin polymerization inhibitor identified by MorphoBase and ChemProteoBase profiling methods., J Med Chem
    Canela MD et al., 2014, Novel colchicine-site binders with a cyclohexanedione scaffold identified through a ligand-based virtual screening approach., J Med Chem
    Bio M et al., 2013, Site-specific and far-red-light-activatable prodrug of combretastatin A-4 using photo-unclick chemistry., J Med Chem
    Vine KL et al., 2007, An investigation into the cytotoxicity and mode of action of some novel N-alkyl-substituted isatins., J Med Chem
    Asami Y et al., 2012, Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells., Bioorg Med Chem
    O'Boyle NM et al., 2014, β-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand., J Med Chem
    Sathish Kumar B et al., 2014, Synthesis of neolignans as microtubule stabilisers., Bioorg Med Chem
    Zhao Y et al., 2013, Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation., J Med Chem
    Kamal A et al., 2014, Synthesis and biological evaluation of 4-aza-2,3-dihydropyridophenanthrolines as tubulin polymerization inhibitors., Bioorg Med Chem Lett
    Kumar AS et al., 2013, Design and synthesis of biaryl aryl stilbenes/ethylenes as antimicrotubule agents., Eur J Med Chem
    Parrino B et al., 2015, Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: in vitro antiproliferative activity and molecular mechanism(s) of action., Eur J Med Chem
    Tu HY et al., 2009, Ursolic acid derivatives induce cell cycle arrest and apoptosis in NTUB1 cells associated with reactive oxygen species., Bioorg Med Chem
    Kumar M et al., 2013, Tubulin inhibitors from an endophytic fungus isolated from Cedrus deodara., J Nat Prod
    Kawaratani Y et al., 2011, New microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group., Bioorg Med Chem
    Kamal A et al., 2011, Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents., Eur J Med Chem
    Kuroiwa K et al., 2015, Synthesis and Structure-Activity Relationship Study of 1-Phenyl-1-(quinazolin-4-yl)ethanols as Anticancer Agents., ACS Med Chem Lett
    Guan Q et al., 2014, Synthesis and evaluation of benzimidazole carbamates bearing indole moieties for antiproliferative and antitubulin activities., Eur J Med Chem
    Kamal A et al., 2011, Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents., Bioorg Med Chem
    Imperio D et al., 2007, Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry., Bioorg Med Chem
    Kamal A et al., 2012, Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents., Bioorg Med Chem
    Buey RM et al., 2007, Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites., Nat Chem Biol
    Kupchan SM et al., 1978, Structural requirements for antileukemic activity among the naturally occurring and semisynthetic maytansinoids., J Med Chem
    Arslanian RL et al., 2002, A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus., J Nat Prod
    Gasparotto V et al., 2006, Synthesis and biological activity of 7-phenyl-6,9-dihydro-3H-pyrrolo[3,2-f]quinolin-9-ones: a new class of antimitotic agents devoid of aromatase activity., J Med Chem
    Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem
    Pirali T et al., 2006, Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents., J Med Chem
    Galli U et al., 2015, Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents., J Med Chem
    Zheng S et al., 2014, Design, synthesis, and biological evaluation of novel pyridine-bridged analogues of combretastatin-A4 as anticancer agents., J Med Chem
    Kamal A et al., 2014, Synthesis and biological evaluation of 1,2,3-triazole linked aminocombretastatin conjugates as mitochondrial mediated apoptosis inducers., Bioorg Med Chem
    Kamal A et al., 2014, Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents., Bioorg Med Chem
  • COMBRETASTATIN A4   TUBA3D

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23631389 16913727 22543234 25584687 24669888 17765552 25192811


    Sources:
    DTC

  • NOCODAZOLE   TUBA3D

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25369367 21194809 25815147 23313639 25262051


    Sources:
    DTC

  • COLCHICINE   TUBA3D

    Interaction Score: 0.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    23750455 25937236 25061803 25805446 24502232 25938266 24773591


    Sources:
    DTC ChemblInteractions

  • PODOFILOX   TUBA3D

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21402478 17765552 24953821


    Sources:
    DTC

  • PACLITAXEL   TUBA3D

    Interaction Score: 0.2

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    23631389 17887662 22595423 25369367 24457094 23725535 24953821 23313639 25768699 19758808 23387901


    Sources:
    DTC ChemblInteractions

  • MAYTANSINE   TUBA3D

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    563462


    Sources:
    DTC

  • CHEMBL453818   TUBA3D

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12141877


    Sources:
    DTC

  • CHEMBL2036124   TUBA3D

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22543234


    Sources:
    DTC

  • MAYTANSINOL   TUBA3D

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    563462


    Sources:
    DTC

  • CYCLOSTREPTIN   TUBA3D

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17206139


    Sources:
    DTC

  • CHEMBL2036119   TUBA3D

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22543234


    Sources:
    DTC

  • CHEMBL1795737   TUBA3D

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21664138


    Sources:
    DTC

  • ZAMPANOLIDE   TUBA3D

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19877653


    Sources:
    DTC

  • CHEMBL1935538   TUBA3D

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22435708


    Sources:
    DTC

  • ABT-751   TUBA3D

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25468039


    Sources:
    DTC

  • VINBLASTINE   TUBA3D

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23708010 23916255


    Sources:
    DTC

  • VINORELBINE   TUBA3D

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25768699


    Sources:
    DTC

  • DAVUNETIDE   TUBA3D

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Tubulin stabiliser
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FOSBRETABULIN DISODIUM   TUBA3D

    Interaction Score: 0.11

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CROLIBULIN   TUBA3D

    Interaction Score: 0.11

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VERUBULIN   TUBA3D

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Tubulin disrupting agent
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PACLITAXEL POLIGLUMEX   TUBA3D

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tubulin stabiliser

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LEXIBULIN   TUBA3D

    Interaction Score: 0.11

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PLINABULIN   TUBA3D

    Interaction Score: 0.11

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VINFLUNINE   TUBA3D

    Interaction Score: 0.11

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SAGOPILONE   TUBA3D

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tubulin stabiliser

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FOSBRETABULIN TROMETHAMINE   TUBA3D

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Tubulin disrupting agent
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DOCETAXEL   TUBA3D

    Interaction Score: 0.11

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VINCRISTINE   TUBA3D

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21664138 23916255 16539377


    Sources:
    DTC

  • LARGAZOLE   TUBA3D

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20491440


    Sources:
    DTC

  • BRENTUXIMAB VEDOTIN   TUBA3D

    Interaction Score: 0.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TRASTUZUMAB EMTANSINE   TUBA3D

    Interaction Score: 0.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INDIBULIN   TUBA3D

    Interaction Score: 0.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tubulin inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ERIBULIN MESYLATE   TUBA3D

    Interaction Score: 0.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tubulin inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VINORELBINE TARTRATE   TUBA3D

    Interaction Score: 0.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tubulin inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VINCRISTINE SULFATE   TUBA3D

    Interaction Score: 0.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CABAZITAXEL   TUBA3D

    Interaction Score: 0.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VINBLASTINE SULFATE   TUBA3D

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tubulin inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • IXABEPILONE   TUBA3D

    Interaction Score: 0.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VORINOSTAT   TUBA3D

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20491440


    Sources:
    DTC

  • CURCUMIN   TUBA3D

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23830698


    Sources:
    DTC

  • Ensembl: ENSG00000075886

    • Version: 101_38

    Alternate Names:
    TUBA3D Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: Q13748

    • Version: 11-September-2012

    Alternate Names:
    Q13748 Uniprot Accession
    TUBA3D Uniprot Gene Name
    113457; 7278 Entrez Gene Id

    Gene Info:
    Interpro Name Tubulin
    Interpro Acc IPR000217
    Interpro Type Family

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000075886

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000075886 Ensembl Gene Id
    TUBA2 Display Id
    TUBULIN ALPHA-2 CHAIN (ALPHA-TUBULIN 2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13748] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • DTC: TUBA3D

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Field JJ et al., 2009, Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis., J Med Chem
    Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem
    Zheng J et al., 2013, Elaboration of thorough simplified vinca alkaloids as antimitotic agents based on pharmacophore similarity., Eur J Med Chem

  • ChemblInteractions: TUBA2

    • Version: chembl_23

    Alternate Names:
    TUBA2 GENE_SYMBOL
    and GENE_SYMBOL
    TUBA3D GENE_SYMBOL

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000075886

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000075886 Gene Symbol
    TUBA3D Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21