DGIdb - TUBB1 Gene Record

TUBB1 81027 Druggable Genome

Alternate Names:

81027
TUBULIN BETA 1 CLASS VI
TUBB1
612901
16257
ENSG00000101162
OTTHUMG00000032860
Tubulin beta-1 chain
Q9H4B7
TBB1
TBB1_HUMAN
TUBULIN BETA-1 CHAIN. [SOURCE:UNIPROT/SWISSPROT;ACC:Q9H4B7]
PA38100
T84397

Gene Info:

Target Class	Miscellaneous
Target Subclass	StructuralAndAdhesion
Target Subclass	Cytoskeleton
Target Class	Other
Target Main Class	Other
Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	Tubulin
Interpro Name	Tubulin
Uniprot Status	Swiss-Prot
Interpro Acc	IPR000217
Interpro Type	Family
Uniprot Evidence	1: Evidence at protein level
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Bio M et al., 2013, Site-specific and far-red-light-activatable prodrug of combretastatin A-4 using photo-unclick chemistry., J Med Chem
Vine KL et al., 2007, An investigation into the cytotoxicity and mode of action of some novel N-alkyl-substituted isatins., J Med Chem
Asami Y et al., 2012, Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells., Bioorg Med Chem
O'Boyle NM et al., 2014, β-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand., J Med Chem
Sathish Kumar B et al., 2014, Synthesis of neolignans as microtubule stabilisers., Bioorg Med Chem
Zhao Y et al., 2013, Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation., J Med Chem
Kamal A et al., 2014, Synthesis and biological evaluation of 4-aza-2,3-dihydropyridophenanthrolines as tubulin polymerization inhibitors., Bioorg Med Chem Lett
Kumar AS et al., 2013, Design and synthesis of biaryl aryl stilbenes/ethylenes as antimicrotubule agents., Eur J Med Chem
Parrino B et al., 2015, Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: in vitro antiproliferative activity and molecular mechanism(s) of action., Eur J Med Chem
Tu HY et al., 2009, Ursolic acid derivatives induce cell cycle arrest and apoptosis in NTUB1 cells associated with reactive oxygen species., Bioorg Med Chem
Kumar M et al., 2013, Tubulin inhibitors from an endophytic fungus isolated from Cedrus deodara., J Nat Prod
Cheung et al., 2009, Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers., Mol. Cancer
Kovács et al., 2007, Effects of taxol treatment on the microtubular system and mitochondria of Tetrahymena., Cell Biol. Int.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Horwitz, 1992, Mechanism of action of taxol., Trends Pharmacol. Sci.
Buey RM et al., 2007, Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites., Nat Chem Biol
Kawaratani Y et al., 2011, New microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group., Bioorg Med Chem
Cheng YY et al., 2013, Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl)-6-pyrrolidinylquinolin-4-one as a potent anticancer lead., Bioorg Med Chem Lett
Gasparotto V et al., 2006, Synthesis and biological activity of 7-phenyl-6,9-dihydro-3H-pyrrolo[3,2-f]quinolin-9-ones: a new class of antimitotic agents devoid of aromatase activity., J Med Chem
Kamal A et al., 2011, Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents., Bioorg Med Chem
Imperio D et al., 2007, Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry., Bioorg Med Chem
Kamal A et al., 2011, Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents., Eur J Med Chem
Kuroiwa K et al., 2015, Synthesis and Structure-Activity Relationship Study of 1-Phenyl-1-(quinazolin-4-yl)ethanols as Anticancer Agents., ACS Med Chem Lett
Guan Q et al., 2014, Synthesis and evaluation of benzimidazole carbamates bearing indole moieties for antiproliferative and antitubulin activities., Eur J Med Chem
Dabydeen et al., 2006, Comparison of the activities of the truncated halichondrin B analog NSC 707389 (E7389) with those of the parent compound and a proposed binding site on tubulin., Mol. Pharmacol.
Yoshida et al., Antiproliferating activity of the mitotic inhibitor pironetin against vindesine- and paclitaxel-resistant human small cell lung cancer H69 cells., Anticancer Res.
Fiebig et al., Gene signatures developed from patient tumor explants grown in nude mice to predict tumor response to 11 cytotoxic drugs., Cancer Genomics Proteomics
Natsume et al., 2000, Characterization of the interaction of TZT-1027, a potent antitumor agent, with tubulin., Jpn. J. Cancer Res.
Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem
Kamal A et al., 2014, Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents., Bioorg Med Chem
Field JJ et al., 2009, Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis., J Med Chem
Reddy MV et al., 2013, Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents., J Med Chem
Wang F et al., 2015, Synthesis and biological evaluation of diarylthiazole derivatives as antimitotic and antivascular agents with potent antitumor activity., Bioorg Med Chem
Zhu C et al., 2014, Discovery of potent cytotoxic ortho-aryl chalcones as new scaffold targeting tubulin and mitosis with affinity-based fluorescence., J Med Chem
Zhang X et al., 2015, Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors., Eur J Med Chem
Wang XF et al., 2014, Optimization of 4-(N-cycloamino)phenylquinazolines as a novel class of tubulin-polymerization inhibitors targeting the colchicine site., J Med Chem
Minegishi H et al., 2015, Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate (GN39482) as a tubulin polymerization inhibitor identified by MorphoBase and ChemProteoBase profiling methods., J Med Chem
Canela MD et al., 2014, Novel colchicine-site binders with a cyclohexanedione scaffold identified through a ligand-based virtual screening approach., J Med Chem
Acharya et al., 2009, Vitamin K3 disrupts the microtubule networks by binding to tubulin: a novel mechanism of its antiproliferative activity., Biochemistry
Finkelstein et al., 2010, Colchicine poisoning: the dark side of an ancient drug., Clin Toxicol (Phila)
Cerquaglia et al., 2005, Pharmacological and clinical basis of treatment of Familial Mediterranean Fever (FMF) with colchicine or analogues: an update., Curr Drug Targets Inflamm Allergy
Li et al., 2010, Competitive mass spectrometry binding assay for characterization of three binding sites of tubulin., J Mass Spectrom
Hari M et al., 2006, Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules., Mol Cancer Ther
Kamal A et al., 2012, Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents., Bioorg Med Chem
Kupchan SM et al., 1978, Structural requirements for antileukemic activity among the naturally occurring and semisynthetic maytansinoids., J Med Chem
Gligorov et al., 2004, Preclinical pharmacology of the taxanes: implications of the differences., Oncologist
Matesanz et al., 2008, Optimization of taxane binding to microtubules: binding affinity dissection and incremental construction of a high-affinity analog of paclitaxel., Chem. Biol.
Snyder et al., 2001, The binding conformation of Taxol in beta-tubulin: a model based on electron crystallographic density., Proc. Natl. Acad. Sci. U.S.A.
Belani et al., 2004, Development of docetaxel in advanced non-small-cell lung cancer., Lung Cancer
Arslanian RL et al., 2002, A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus., J Nat Prod
Liu M et al., 2014, Aromatase inhibitor-associated bone fractures: a case-cohort GWAS and functional genomics., Mol Endocrinol
Zheng J et al., 2013, Elaboration of thorough simplified vinca alkaloids as antimitotic agents based on pharmacophore similarity., Eur J Med Chem
Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem
Yi X et al., 2012, Identification of a class of novel tubulin inhibitors., J Med Chem
Galli U et al., 2015, Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents., J Med Chem
Kamal A et al., 2014, Synthesis and biological evaluation of 1,2,3-triazole linked aminocombretastatin conjugates as mitochondrial mediated apoptosis inducers., Bioorg Med Chem
Zheng S et al., 2014, Design, synthesis, and biological evaluation of novel pyridine-bridged analogues of combretastatin-A4 as anticancer agents., J Med Chem
Pirali T et al., 2006, Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents., J Med Chem

VINDESINE TUBB1

Interaction Score: 2.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17465195 17878523 17016423 17139284 10920282

Sources:
TdgClinicalTrial TEND
TASIDOTIN TUBB1

Interaction Score: 1.19

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ILX-651, tasidotin,Synthadotin

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
OMBRABULIN TUBB1

Interaction Score: 1.19

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name ombrabulin

PMIDs:
None found

Sources:
TdgClinicalTrial
MILATAXEL TUBB1

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name milataxel, MAC-321

Novel drug target Established target

PMIDs:
16505100

Sources:
TdgClinicalTrial
TESETAXEL TUBB1

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name tesetaxel

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
ANG1005 TUBB1

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ANG1005

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
COMBRETASTATIN A4 TUBB1

Interaction Score: 0.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23631389 25584687 17765552 25192811 24669888 22543234 16913727

Sources:
DTC
COLCHICINE TUBB1

Interaction Score: 0.39

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591 19527023 20586571 15720245 20814887 17016423 17139284

Sources:
DTC ChemblInteractions
ORTATAXEL TUBB1

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ortataxel

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
NOCODAZOLE TUBB1

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25369367 21194809 25815147 23313639 25262051

Sources:
DTC
PACLITAXEL TUBB1

Interaction Score: 0.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name oral paclitaxel

Novel drug target Established target

Trial Name Abraxane

PMIDs:
23631389 17887662 22595423 25369367 24457094 23725535 24953821 23313639 25768699 19758808 23387901 19575780 17314054 17016423 17139284 1350385

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND
CABAZITAXEL TUBB1

Interaction Score: 0.21

Interaction Types & Directionality:

binder

inhibitor (inhibitory)

Interaction Info:

Trial Name cabazitaxel, XRP6258,Jevtana

Novel drug target Established target

Mechanism of Interaction Tubulin inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND
PODOFILOX TUBB1

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21402478 17765552 24953821

Sources:
DTC
ANASTROZOLE TUBB1

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25148458

Sources:
PharmGKB
EXEMESTANE TUBB1

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25148458

Sources:
PharmGKB
ERIBULIN MESYLATE TUBB1

Interaction Score: 0.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
16940412

Sources:
ChemblInteractions
MAYTANSINOL TUBB1

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
563462

Sources:
DTC
CHEMBL1795737 TUBB1

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21664138

Sources:
DTC
CHEMBL453818 TUBB1

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12141877

Sources:
DTC
CHEMBL2036119 TUBB1

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22543234

Sources:
DTC
MAYTANSINE TUBB1

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
563462

Sources:
DTC
CHEMBL2036124 TUBB1

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22543234

Sources:
DTC
ZAMPANOLIDE TUBB1

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19877653

Sources:
DTC
CYCLOSTREPTIN TUBB1

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17206139

Sources:
DTC
CHEMBL1935538 TUBB1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22435708

Sources:
DTC
ABT-751 TUBB1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25468039

Sources:
DTC
VINBLASTINE TUBB1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23708010 23916255

Sources:
DTC
IXABEPILONE TUBB1

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
None found

Sources:
ChemblInteractions TEND
DOCETAXEL TUBB1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ANX-514, lyophilized docetaxel

Novel drug target Established target

Trial Name ATI-1123

PMIDs:
15161985 18559268 11309480 15698529

Sources:
TdgClinicalTrial TEND
VINORELBINE TUBB1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25768699

Sources:
DTC
LEXIBULIN TUBB1

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DOCETAXEL TUBB1

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VINFLUNINE TUBB1

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PLINABULIN TUBB1

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DAVUNETIDE TUBB1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin stabiliser

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FOSBRETABULIN DISODIUM TUBB1

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
FOSBRETABULIN TROMETHAMINE TUBB1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin disrupting agent

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PACLITAXEL POLIGLUMEX TUBB1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin stabiliser

PMIDs:
None found

Sources:
ChemblInteractions
SAGOPILONE TUBB1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin stabiliser

PMIDs:
None found

Sources:
ChemblInteractions
CROLIBULIN TUBB1

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
VERUBULIN TUBB1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin disrupting agent

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LARGAZOLE TUBB1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440

Sources:
DTC
VINCRISTINE TUBB1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21664138 23916255 16539377

Sources:
DTC
INDIBULIN TUBB1

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BRENTUXIMAB VEDOTIN TUBB1

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TRASTUZUMAB EMTANSINE TUBB1

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VINORELBINE TARTRATE TUBB1

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VINCRISTINE SULFATE TUBB1

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
VINBLASTINE SULFATE TUBB1

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
VORINOSTAT TUBB1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440

Sources:
DTC
ENMD-981693 TUBB1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name MKC-1

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
CURCUMIN TUBB1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23830698

Sources:
DTC

Ensembl: ENSG00000101162
- Version: 101_38
Alternate Names:

TUBB1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: Q9H4B7
- Version: 11-September-2012
Alternate Names:

TBB1_HUMAN Uniprot Id

Q9H4B7 Uniprot Accession

ENSG00000101162 Ensembl Gene Id

Gene Info:

Interpro Short Name Tubulin

Interpro Name Tubulin

Uniprot Status Swiss-Prot

Gene Categories:

DRUGGABLE GENOME

Publications:
TEND: Q9H4B7
- Version: 01-August-2011
Alternate Names:

Q9H4B7 Uniprot Accession

81027 Entrez Gene Id

ENSG00000101162 Ensembl Gene Id

Gene Info:

Target Subclass Cytoskeleton

Target Subclass StructuralAndAdhesion

Target Main Class Other

Publications:
TdgClinicalTrial: Q9H4B7
- Version: January-2014
Alternate Names:

TUBB1 Gene Symbol

TBB1 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass StructuralAndAdhesion

Target Subclass Cytoskeleton

Publications:
RussLampel: ENSG00000101162
- Version: 26-July-2011
Alternate Names:

TUBULIN BETA-1 CHAIN. [SOURCE:UNIPROT/SWISSPROT;ACC:Q9H4B7] Description

TUBB1 Display Id

ENSG00000101162 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
PharmGKB: TUBB1
- Version: 18-August-2020
Alternate Names:

PA38100 PharmGKB ID

Gene Info:

Publications:

Liu M et al., 2014, Aromatase inhibitor-associated bone fractures: a case-cohort GWAS and functional genomics., Mol Endocrinol

DTC: TUBB1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Gasparotto V et al., 2006, Synthesis and biological activity of 7-phenyl-6,9-dihydro-3H-pyrrolo[3,2-f]quinolin-9-ones: a new class of antimitotic agents devoid of aromatase activity., J Med Chem

Kawaratani Y et al., 2011, New microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group., Bioorg Med Chem

Cheng YY et al., 2013, Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl)-6-pyrrolidinylquinolin-4-one as a potent anticancer lead., Bioorg Med Chem Lett

HingoraniCasas: ENSG00000101162
- Version: 31-May-2017
Alternate Names:

ENSG00000101162 Gene Symbol

TUBB1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: TUBB1
- Version: chembl_23
Alternate Names:

TUBB1 GENE_SYMBOL

Tubulin beta-1 chain UNIPROT

Gene Info:

Publications:
TTD: Tubulin beta-1 chain
- Version: 2020.06.01
Alternate Names:

TUBB1 TTD Gene Abbreviation

T84397 TTD Target ID

Gene Info:

Publications:

Trial Name	ILX-651, tasidotin,Synthadotin
Novel drug target	Established target

Trial Name	milataxel, MAC-321
Novel drug target	Established target

Mechanism of Interaction	Tubulin inhibitor
Direct Interaction	yes

Trial Name	oral paclitaxel
Novel drug target	Established target
Trial Name	Abraxane

Trial Name	cabazitaxel, XRP6258,Jevtana
Novel drug target	Established target
Mechanism of Interaction	Tubulin inhibitor

Trial Name	ANX-514, lyophilized docetaxel
Novel drug target	Established target
Trial Name	ATI-1123

Mechanism of Interaction	Tubulin stabiliser
Direct Interaction	yes

Mechanism of Interaction	Tubulin disrupting agent
Direct Interaction	yes

TBB1_HUMAN	Uniprot Id
Q9H4B7	Uniprot Accession
ENSG00000101162	Ensembl Gene Id

TUBULIN BETA-1 CHAIN. [SOURCE:UNIPROT/SWISSPROT;ACC:Q9H4B7]	Description
TUBB1	Display Id
ENSG00000101162	Ensembl Gene Id

binder
inhibitor (inhibitory)

TUBB1 Gene Record

TUBB1 81027 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17465195 17878523 17016423 17139284 10920282

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info: Trial Name ILX-651, tasidotin,Synthadotin Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name ombrabulin

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name milataxel, MAC-321 Novel drug target Established target

PMIDs: 16505100

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name tesetaxel Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name ANG1005 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23631389 25584687 17765552 25192811 24669888 22543234 16913727

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tubulin inhibitor Direct Interaction yes

PMIDs: 23750455 25937236 25061803 25805446 24502232 25938266 24773591 19527023 20586571 15720245 20814887 17016423 17139284

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name ortataxel Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25369367 21194809 25815147 23313639 25262051

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name oral paclitaxel Novel drug target Established target Trial Name Abraxane

PMIDs: 23631389 17887662 22595423 25369367 24457094 23725535 24953821 23313639 25768699 19758808 23387901 19575780 17314054 17016423 17139284 1350385

Sources: DTC TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: binder inhibitor (inhibitory)

Interaction Info: Trial Name cabazitaxel, XRP6258,Jevtana Novel drug target Established target Mechanism of Interaction Tubulin inhibitor

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21402478 17765552 24953821

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25148458

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25148458

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Tubulin inhibitor

PMIDs: 16940412

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 563462

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21664138

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17465195 17878523 17016423 17139284 10920282

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ILX-651, tasidotin,Synthadotin

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name ombrabulin

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name milataxel, MAC-321

Novel drug target Established target

PMIDs:
16505100

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name tesetaxel

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ANG1005

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
23631389 25584687 17765552 25192811 24669888 22543234 16913727

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591 19527023 20586571 15720245 20814887 17016423 17139284

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ortataxel

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
25369367 21194809 25815147 23313639 25262051

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name oral paclitaxel

Novel drug target Established target

Trial Name Abraxane

PMIDs:
23631389 17887662 22595423 25369367 24457094 23725535 24953821 23313639 25768699 19758808 23387901 19575780 17314054 17016423 17139284 1350385

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

binder

inhibitor (inhibitory)

Interaction Info:

Trial Name cabazitaxel, XRP6258,Jevtana

Novel drug target Established target

Mechanism of Interaction Tubulin inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
21402478 17765552 24953821

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25148458

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
25148458

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
16940412

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
563462

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21664138

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
12141877

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22543234

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
563462

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22543234

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19877653

Sources:
DTC