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TUBB1 Gene Record

  • Summary
  • Interactions
  • Claims
  • TUBB1 81027 Druggable Genome

    Alternate Names:

    81027
    TUBULIN BETA 1 CLASS VI
    TUBB1
    612901
    16257
    ENSG00000101162
    OTTHUMG00000032860
    Tubulin beta-1 chain
    Q9H4B7
    TBB1
    TBB1_HUMAN
    TUBULIN BETA-1 CHAIN. [SOURCE:UNIPROT/SWISSPROT;ACC:Q9H4B7]
    PA38100
    T84397

    Gene Info:

    Target Class Miscellaneous
    Target Subclass StructuralAndAdhesion
    Target Subclass Cytoskeleton
    Target Class Other
    Target Main Class Other
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Tubulin
    Interpro Name Tubulin
    Uniprot Status Swiss-Prot
    Interpro Acc IPR000217
    Interpro Type Family
    Uniprot Evidence 1: Evidence at protein level
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Bio M et al., 2013, Site-specific and far-red-light-activatable prodrug of combretastatin A-4 using photo-unclick chemistry., J Med Chem
    Vine KL et al., 2007, An investigation into the cytotoxicity and mode of action of some novel N-alkyl-substituted isatins., J Med Chem
    Asami Y et al., 2012, Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells., Bioorg Med Chem
    O'Boyle NM et al., 2014, β-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand., J Med Chem
    Sathish Kumar B et al., 2014, Synthesis of neolignans as microtubule stabilisers., Bioorg Med Chem
    Zhao Y et al., 2013, Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation., J Med Chem
    Kamal A et al., 2014, Synthesis and biological evaluation of 4-aza-2,3-dihydropyridophenanthrolines as tubulin polymerization inhibitors., Bioorg Med Chem Lett
    Kumar AS et al., 2013, Design and synthesis of biaryl aryl stilbenes/ethylenes as antimicrotubule agents., Eur J Med Chem
    Parrino B et al., 2015, Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: in vitro antiproliferative activity and molecular mechanism(s) of action., Eur J Med Chem
    Tu HY et al., 2009, Ursolic acid derivatives induce cell cycle arrest and apoptosis in NTUB1 cells associated with reactive oxygen species., Bioorg Med Chem
    Kumar M et al., 2013, Tubulin inhibitors from an endophytic fungus isolated from Cedrus deodara., J Nat Prod
    Cheung et al., 2009, Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers., Mol. Cancer
    Kovács et al., 2007, Effects of taxol treatment on the microtubular system and mitochondria of Tetrahymena., Cell Biol. Int.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Horwitz, 1992, Mechanism of action of taxol., Trends Pharmacol. Sci.
    Buey RM et al., 2007, Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites., Nat Chem Biol
    Kawaratani Y et al., 2011, New microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group., Bioorg Med Chem
    Cheng YY et al., 2013, Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl)-6-pyrrolidinylquinolin-4-one as a potent anticancer lead., Bioorg Med Chem Lett
    Gasparotto V et al., 2006, Synthesis and biological activity of 7-phenyl-6,9-dihydro-3H-pyrrolo[3,2-f]quinolin-9-ones: a new class of antimitotic agents devoid of aromatase activity., J Med Chem
    Kamal A et al., 2011, Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents., Bioorg Med Chem
    Imperio D et al., 2007, Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry., Bioorg Med Chem
    Kamal A et al., 2011, Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents., Eur J Med Chem
    Kuroiwa K et al., 2015, Synthesis and Structure-Activity Relationship Study of 1-Phenyl-1-(quinazolin-4-yl)ethanols as Anticancer Agents., ACS Med Chem Lett
    Guan Q et al., 2014, Synthesis and evaluation of benzimidazole carbamates bearing indole moieties for antiproliferative and antitubulin activities., Eur J Med Chem
    Dabydeen et al., 2006, Comparison of the activities of the truncated halichondrin B analog NSC 707389 (E7389) with those of the parent compound and a proposed binding site on tubulin., Mol. Pharmacol.
    Yoshida et al., Antiproliferating activity of the mitotic inhibitor pironetin against vindesine- and paclitaxel-resistant human small cell lung cancer H69 cells., Anticancer Res.
    Fiebig et al., Gene signatures developed from patient tumor explants grown in nude mice to predict tumor response to 11 cytotoxic drugs., Cancer Genomics Proteomics
    Natsume et al., 2000, Characterization of the interaction of TZT-1027, a potent antitumor agent, with tubulin., Jpn. J. Cancer Res.
    Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem
    Kamal A et al., 2014, Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents., Bioorg Med Chem
    Field JJ et al., 2009, Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis., J Med Chem
    Reddy MV et al., 2013, Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents., J Med Chem
    Wang F et al., 2015, Synthesis and biological evaluation of diarylthiazole derivatives as antimitotic and antivascular agents with potent antitumor activity., Bioorg Med Chem
    Zhu C et al., 2014, Discovery of potent cytotoxic ortho-aryl chalcones as new scaffold targeting tubulin and mitosis with affinity-based fluorescence., J Med Chem
    Zhang X et al., 2015, Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors., Eur J Med Chem
    Wang XF et al., 2014, Optimization of 4-(N-cycloamino)phenylquinazolines as a novel class of tubulin-polymerization inhibitors targeting the colchicine site., J Med Chem
    Minegishi H et al., 2015, Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate (GN39482) as a tubulin polymerization inhibitor identified by MorphoBase and ChemProteoBase profiling methods., J Med Chem
    Canela MD et al., 2014, Novel colchicine-site binders with a cyclohexanedione scaffold identified through a ligand-based virtual screening approach., J Med Chem
    Acharya et al., 2009, Vitamin K3 disrupts the microtubule networks by binding to tubulin: a novel mechanism of its antiproliferative activity., Biochemistry
    Finkelstein et al., 2010, Colchicine poisoning: the dark side of an ancient drug., Clin Toxicol (Phila)
    Cerquaglia et al., 2005, Pharmacological and clinical basis of treatment of Familial Mediterranean Fever (FMF) with colchicine or analogues: an update., Curr Drug Targets Inflamm Allergy
    Li et al., 2010, Competitive mass spectrometry binding assay for characterization of three binding sites of tubulin., J Mass Spectrom
    Hari M et al., 2006, Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules., Mol Cancer Ther
    Kamal A et al., 2012, Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents., Bioorg Med Chem
    Kupchan SM et al., 1978, Structural requirements for antileukemic activity among the naturally occurring and semisynthetic maytansinoids., J Med Chem
    Gligorov et al., 2004, Preclinical pharmacology of the taxanes: implications of the differences., Oncologist
    Matesanz et al., 2008, Optimization of taxane binding to microtubules: binding affinity dissection and incremental construction of a high-affinity analog of paclitaxel., Chem. Biol.
    Snyder et al., 2001, The binding conformation of Taxol in beta-tubulin: a model based on electron crystallographic density., Proc. Natl. Acad. Sci. U.S.A.
    Belani et al., 2004, Development of docetaxel in advanced non-small-cell lung cancer., Lung Cancer
    Arslanian RL et al., 2002, A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus., J Nat Prod
    Liu M et al., 2014, Aromatase inhibitor-associated bone fractures: a case-cohort GWAS and functional genomics., Mol Endocrinol
    Zheng J et al., 2013, Elaboration of thorough simplified vinca alkaloids as antimitotic agents based on pharmacophore similarity., Eur J Med Chem
    Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem
    Yi X et al., 2012, Identification of a class of novel tubulin inhibitors., J Med Chem
    Galli U et al., 2015, Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents., J Med Chem
    Kamal A et al., 2014, Synthesis and biological evaluation of 1,2,3-triazole linked aminocombretastatin conjugates as mitochondrial mediated apoptosis inducers., Bioorg Med Chem
    Zheng S et al., 2014, Design, synthesis, and biological evaluation of novel pyridine-bridged analogues of combretastatin-A4 as anticancer agents., J Med Chem
    Pirali T et al., 2006, Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents., J Med Chem
  • VINDESINE   TUBB1

    Interaction Score: 2.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17465195 17878523 17016423 17139284 10920282


    Sources:
    TdgClinicalTrial TEND

  • TASIDOTIN   TUBB1

    Interaction Score: 1.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name ILX-651, tasidotin,Synthadotin
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • OMBRABULIN   TUBB1

    Interaction Score: 1.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name ombrabulin

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • MILATAXEL   TUBB1

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name milataxel, MAC-321
    Novel drug target Established target

    PMIDs:
    16505100


    Sources:
    TdgClinicalTrial

  • TESETAXEL   TUBB1

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name tesetaxel
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • ANG1005   TUBB1

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name ANG1005
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • COMBRETASTATIN A4   TUBB1

    Interaction Score: 0.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23631389 25584687 17765552 25192811 24669888 22543234 16913727


    Sources:
    DTC

  • COLCHICINE   TUBB1

    Interaction Score: 0.39

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    23750455 25937236 25061803 25805446 24502232 25938266 24773591 19527023 20586571 15720245 20814887 17016423 17139284


    Sources:
    DTC ChemblInteractions

  • ORTATAXEL   TUBB1

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name ortataxel
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • NOCODAZOLE   TUBB1

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25369367 21194809 25815147 23313639 25262051


    Sources:
    DTC

  • PACLITAXEL   TUBB1

    Interaction Score: 0.25

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name oral paclitaxel
    Novel drug target Established target
    Trial Name Abraxane

    PMIDs:
    23631389 17887662 22595423 25369367 24457094 23725535 24953821 23313639 25768699 19758808 23387901 19575780 17314054 17016423 17139284 1350385


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND

  • CABAZITAXEL   TUBB1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    binder
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name cabazitaxel, XRP6258,Jevtana
    Novel drug target Established target
    Mechanism of Interaction Tubulin inhibitor

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • PODOFILOX   TUBB1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21402478 17765552 24953821


    Sources:
    DTC

  • ANASTROZOLE   TUBB1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25148458


    Sources:
    PharmGKB

  • EXEMESTANE   TUBB1

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25148458


    Sources:
    PharmGKB

  • ERIBULIN MESYLATE   TUBB1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tubulin inhibitor

    PMIDs:
    16940412


    Sources:
    ChemblInteractions

  • MAYTANSINOL   TUBB1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    563462


    Sources:
    DTC

  • CHEMBL1795737   TUBB1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21664138


    Sources:
    DTC

  • CHEMBL453818   TUBB1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12141877


    Sources:
    DTC

  • CHEMBL2036119   TUBB1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22543234


    Sources:
    DTC

  • MAYTANSINE   TUBB1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    563462


    Sources:
    DTC

  • CHEMBL2036124   TUBB1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22543234


    Sources:
    DTC

  • ZAMPANOLIDE   TUBB1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19877653


    Sources:
    DTC

  • CYCLOSTREPTIN   TUBB1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17206139


    Sources:
    DTC

  • CHEMBL1935538   TUBB1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22435708


    Sources:
    DTC

  • ABT-751   TUBB1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25468039


    Sources:
    DTC

  • VINBLASTINE   TUBB1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23708010 23916255


    Sources:
    DTC

  • IXABEPILONE   TUBB1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tubulin inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions TEND

  • DOCETAXEL   TUBB1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name ANX-514, lyophilized docetaxel
    Novel drug target Established target
    Trial Name ATI-1123

    PMIDs:
    15161985 18559268 11309480 15698529


    Sources:
    TdgClinicalTrial TEND

  • VINORELBINE   TUBB1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25768699


    Sources:
    DTC

  • LEXIBULIN   TUBB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DOCETAXEL   TUBB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VINFLUNINE   TUBB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PLINABULIN   TUBB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DAVUNETIDE   TUBB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Tubulin stabiliser
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FOSBRETABULIN DISODIUM   TUBB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tubulin inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FOSBRETABULIN TROMETHAMINE   TUBB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Tubulin disrupting agent
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PACLITAXEL POLIGLUMEX   TUBB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tubulin stabiliser

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SAGOPILONE   TUBB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tubulin stabiliser

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CROLIBULIN   TUBB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tubulin inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VERUBULIN   TUBB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Tubulin disrupting agent
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LARGAZOLE   TUBB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20491440


    Sources:
    DTC

  • VINCRISTINE   TUBB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21664138 23916255 16539377


    Sources:
    DTC

  • INDIBULIN   TUBB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BRENTUXIMAB VEDOTIN   TUBB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TRASTUZUMAB EMTANSINE   TUBB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VINORELBINE TARTRATE   TUBB1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VINCRISTINE SULFATE   TUBB1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tubulin inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VINBLASTINE SULFATE   TUBB1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tubulin inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VORINOSTAT   TUBB1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20491440


    Sources:
    DTC

  • ENMD-981693   TUBB1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name MKC-1
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • CURCUMIN   TUBB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23830698


    Sources:
    DTC

  • Ensembl: ENSG00000101162

    • Version: 101_38

    Alternate Names:
    TUBB1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: Q9H4B7

    • Version: 11-September-2012

    Alternate Names:
    TBB1_HUMAN Uniprot Id
    Q9H4B7 Uniprot Accession
    ENSG00000101162 Ensembl Gene Id

    Gene Info:
    Interpro Short Name Tubulin
    Interpro Name Tubulin
    Uniprot Status Swiss-Prot

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TEND: Q9H4B7

    • Version: 01-August-2011

    Alternate Names:
    Q9H4B7 Uniprot Accession
    81027 Entrez Gene Id
    ENSG00000101162 Ensembl Gene Id

    Gene Info:
    Target Subclass Cytoskeleton
    Target Subclass StructuralAndAdhesion
    Target Main Class Other

    Publications:

  • TdgClinicalTrial: Q9H4B7

    • Version: January-2014

    Alternate Names:
    TUBB1 Gene Symbol
    TBB1 Gene Symbol

    Gene Info:
    Target Class Miscellaneous
    Target Subclass StructuralAndAdhesion
    Target Subclass Cytoskeleton

    Publications:

  • RussLampel: ENSG00000101162

    • Version: 26-July-2011

    Alternate Names:
    TUBULIN BETA-1 CHAIN. [SOURCE:UNIPROT/SWISSPROT;ACC:Q9H4B7] Description
    TUBB1 Display Id
    ENSG00000101162 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: TUBB1

    • Version: 18-August-2020

    Alternate Names:
    PA38100 PharmGKB ID

    Gene Info:

    Publications:
    Liu M et al., 2014, Aromatase inhibitor-associated bone fractures: a case-cohort GWAS and functional genomics., Mol Endocrinol

  • DTC: TUBB1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Gasparotto V et al., 2006, Synthesis and biological activity of 7-phenyl-6,9-dihydro-3H-pyrrolo[3,2-f]quinolin-9-ones: a new class of antimitotic agents devoid of aromatase activity., J Med Chem
    Kawaratani Y et al., 2011, New microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group., Bioorg Med Chem
    Cheng YY et al., 2013, Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl)-6-pyrrolidinylquinolin-4-one as a potent anticancer lead., Bioorg Med Chem Lett

  • HingoraniCasas: ENSG00000101162

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000101162 Gene Symbol
    TUBB1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: TUBB1

    • Version: chembl_23

    Alternate Names:
    TUBB1 GENE_SYMBOL
    Tubulin beta-1 chain UNIPROT

    Gene Info:

    Publications:

  • TTD: Tubulin beta-1 chain

    • Version: 2020.06.01

    Alternate Names:
    TUBB1 TTD Gene Abbreviation
    T84397 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21