DGIdb - TUBB3 Gene Record

TUBB3 10381 Druggable Genome

Alternate Names:

10381
TUBULIN BETA 3 CLASS III
TUBB3
CDCBM
CDCBM1
CFEOM3
CFEOM3A
FEOM3
TUBB4
beta-4
602661
20772
ENSG00000258947
OTTHUMG00000138985
Tubulin beta-4 chain
Tubulin beta-3 chain
Tubulin beta-III
Q13509
ENSG00000198211
TUBULIN BETA-3 CHAIN (TUBULIN BETA-III) (TUBULIN BETA-4). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13509]

TBB3_HUMAN

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Target Class	Miscellaneous
Target Subclass	StructuralAndAdhesion
Target Subclass	Tubulin
Interpro Name	Tubulin
Interpro Type	Family
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Short Name	Tubulin
Interpro Acc	IPR000217
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Kamal A et al., 2011, Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents., Bioorg Med Chem
Imperio D et al., 2007, Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry., Bioorg Med Chem
Kamal A et al., 2014, Synthesis and biological evaluation of 4-aza-2,3-dihydropyridophenanthrolines as tubulin polymerization inhibitors., Bioorg Med Chem Lett
Bio M et al., 2013, Site-specific and far-red-light-activatable prodrug of combretastatin A-4 using photo-unclick chemistry., J Med Chem
Vine KL et al., 2007, An investigation into the cytotoxicity and mode of action of some novel N-alkyl-substituted isatins., J Med Chem
Asami Y et al., 2012, Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells., Bioorg Med Chem
O'Boyle NM et al., 2014, β-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand., J Med Chem
Sathish Kumar B et al., 2014, Synthesis of neolignans as microtubule stabilisers., Bioorg Med Chem
Zhao Y et al., 2013, Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation., J Med Chem
Kumar AS et al., 2013, Design and synthesis of biaryl aryl stilbenes/ethylenes as antimicrotubule agents., Eur J Med Chem
Parrino B et al., 2015, Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: in vitro antiproliferative activity and molecular mechanism(s) of action., Eur J Med Chem
Tu HY et al., 2009, Ursolic acid derivatives induce cell cycle arrest and apoptosis in NTUB1 cells associated with reactive oxygen species., Bioorg Med Chem
Kumar M et al., 2013, Tubulin inhibitors from an endophytic fungus isolated from Cedrus deodara., J Nat Prod
Yi X et al., 2012, Identification of a class of novel tubulin inhibitors., J Med Chem
Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem
Vahdat, 2008, Ixabepilone: a novel antineoplastic agent with low susceptibility to multiple tumor resistance mechanisms., Oncologist
Goodin, 2008, Ixabepilone: a novel microtubule-stabilizing agent for the treatment of metastatic breast cancer., Am J Health Syst Pharm
Denduluri et al., 2008, Ixabepilone for the treatment of solid tumors: a review of clinical data., Expert Opin Investig Drugs
Arslanian RL et al., 2002, A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus., J Nat Prod
Kupchan SM et al., 1978, Structural requirements for antileukemic activity among the naturally occurring and semisynthetic maytansinoids., J Med Chem
Kamal A et al., 2012, Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents., Bioorg Med Chem
Reddy MV et al., 2013, Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents., J Med Chem
Wang F et al., 2015, Synthesis and biological evaluation of diarylthiazole derivatives as antimitotic and antivascular agents with potent antitumor activity., Bioorg Med Chem
Zhu C et al., 2014, Discovery of potent cytotoxic ortho-aryl chalcones as new scaffold targeting tubulin and mitosis with affinity-based fluorescence., J Med Chem
Zhang X et al., 2015, Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors., Eur J Med Chem
Wang XF et al., 2014, Optimization of 4-(N-cycloamino)phenylquinazolines as a novel class of tubulin-polymerization inhibitors targeting the colchicine site., J Med Chem
Minegishi H et al., 2015, Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate (GN39482) as a tubulin polymerization inhibitor identified by MorphoBase and ChemProteoBase profiling methods., J Med Chem
Canela MD et al., 2014, Novel colchicine-site binders with a cyclohexanedione scaffold identified through a ligand-based virtual screening approach., J Med Chem
Kawaratani Y et al., 2011, New microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group., Bioorg Med Chem
Buey RM et al., 2007, Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites., Nat Chem Biol
Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem
Field JJ et al., 2009, Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis., J Med Chem
Kamal A et al., 2011, Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents., Eur J Med Chem
Kuroiwa K et al., 2015, Synthesis and Structure-Activity Relationship Study of 1-Phenyl-1-(quinazolin-4-yl)ethanols as Anticancer Agents., ACS Med Chem Lett
Guan Q et al., 2014, Synthesis and evaluation of benzimidazole carbamates bearing indole moieties for antiproliferative and antitubulin activities., Eur J Med Chem
Cheng YY et al., 2013, Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl)-6-pyrrolidinylquinolin-4-one as a potent anticancer lead., Bioorg Med Chem Lett
Gasparotto V et al., 2006, Synthesis and biological activity of 7-phenyl-6,9-dihydro-3H-pyrrolo[3,2-f]quinolin-9-ones: a new class of antimitotic agents devoid of aromatase activity., J Med Chem
Zheng J et al., 2013, Elaboration of thorough simplified vinca alkaloids as antimitotic agents based on pharmacophore similarity., Eur J Med Chem
Galli U et al., 2015, Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents., J Med Chem
Kamal A et al., 2014, Synthesis and biological evaluation of 1,2,3-triazole linked aminocombretastatin conjugates as mitochondrial mediated apoptosis inducers., Bioorg Med Chem
Zheng S et al., 2014, Design, synthesis, and biological evaluation of novel pyridine-bridged analogues of combretastatin-A4 as anticancer agents., J Med Chem
Pirali T et al., 2006, Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents., J Med Chem
Kamal A et al., 2014, Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents., Bioorg Med Chem

COMBRETASTATIN A4 TUBB3

Interaction Score: 0.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23631389 25584687 17765552 25192811 24669888 22543234 16913727

Sources:
DTC
NOCODAZOLE TUBB3

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25369367 21194809 25815147 23313639 25262051

Sources:
DTC
IXABEPILONE TUBB3

Interaction Score: 0.35

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name ixabepilone, BMS-247550,Ixempra

Mechanism of Interaction Tubulin inhibitor

PMIDs:
18378531 18945860 18321240

Sources:
TdgClinicalTrial ChemblInteractions
COLCHICINE TUBB3

Interaction Score: 0.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions
PODOFILOX TUBB3

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21402478 17765552 24953821

Sources:
DTC
PACLITAXEL TUBB3

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23631389 17887662 22595423 25369367 24457094 23725535 24953821 23313639 25768699 19758808 23387901

Sources:
DTC ClearityFoundationBiomarkers ChemblInteractions
ZAMPANOLIDE TUBB3

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19877653

Sources:
DTC
CHEMBL2036124 TUBB3

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22543234

Sources:
DTC
MAYTANSINOL TUBB3

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
563462

Sources:
DTC
CYCLOSTREPTIN TUBB3

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17206139

Sources:
DTC
CHEMBL1795737 TUBB3

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21664138

Sources:
DTC
CHEMBL2036119 TUBB3

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22543234

Sources:
DTC
MAYTANSINE TUBB3

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
563462

Sources:
DTC
CHEMBL453818 TUBB3

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12141877

Sources:
DTC
CHEMBL1935538 TUBB3

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22435708

Sources:
DTC
ABT-751 TUBB3

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25468039

Sources:
DTC
VINBLASTINE TUBB3

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23708010 23916255

Sources:
DTC
VINORELBINE TUBB3

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25768699

Sources:
DTC
FOSBRETABULIN DISODIUM TUBB3

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PACLITAXEL POLIGLUMEX TUBB3

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin stabiliser

PMIDs:
None found

Sources:
ChemblInteractions
DAVUNETIDE TUBB3

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin stabiliser

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DOCETAXEL TUBB3

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VERUBULIN TUBB3

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin disrupting agent

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PLINABULIN TUBB3

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FOSBRETABULIN TROMETHAMINE TUBB3

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin disrupting agent

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LEXIBULIN TUBB3

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CROLIBULIN TUBB3

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VINFLUNINE TUBB3

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SAGOPILONE TUBB3

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin stabiliser

PMIDs:
None found

Sources:
ChemblInteractions
VINCRISTINE TUBB3

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21664138 23916255 16539377

Sources:
DTC
LARGAZOLE TUBB3

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440

Sources:
DTC
INDIBULIN TUBB3

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
TRASTUZUMAB EMTANSINE TUBB3

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ERIBULIN MESYLATE TUBB3

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
BRENTUXIMAB VEDOTIN TUBB3

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VINORELBINE TARTRATE TUBB3

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
CABAZITAXEL TUBB3

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VINCRISTINE SULFATE TUBB3

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VINBLASTINE SULFATE TUBB3

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VORINOSTAT TUBB3

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440

Sources:
DTC
CURCUMIN TUBB3

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23830698

Sources:
DTC
DOCETAXEL TUBB3

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
ClearityFoundationBiomarkers

Ensembl: ENSG00000258947
- Version: 101_38
Alternate Names:

TUBB3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000198211
- Version: 26-July-2011
Alternate Names:

TUBULIN BETA-3 CHAIN (TUBULIN BETA-III) (TUBULIN BETA-4). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13509] Description

TUBB3 Display Id

ENSG00000198211 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: Q13509
- Version: January-2014
Alternate Names:

TUBB3 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass StructuralAndAdhesion

Target Subclass Tubulin

Publications:
HopkinsGroom: Q13509
- Version: 11-September-2012
Alternate Names:

10381 Entrez Gene Id

Q13509 Uniprot Accession

ENSG00000198211 Ensembl Gene Id

Gene Info:

Interpro Name Tubulin

Human Readable Name DRUGGABLE GENOME

Interpro Type Family

Gene Categories:

DRUGGABLE GENOME

Publications:

DTC: TUBB3

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Bio M et al., 2013, Site-specific and far-red-light-activatable prodrug of combretastatin A-4 using photo-unclick chemistry., J Med Chem

O'Boyle NM et al., 2014, β-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand., J Med Chem

Parrino B et al., 2015, Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: in vitro antiproliferative activity and molecular mechanism(s) of action., Eur J Med Chem

ChemblInteractions: TUBB4
- Version: chembl_23
Alternate Names:

TUBB4 GENE_SYMBOL

TUBB3 GENE_SYMBOL

Tubulin beta-3 chain UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000258947
- Version: 31-May-2017
Alternate Names:

ENSG00000258947 Gene Symbol

Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HingoraniCasas: ENSG00000198211
- Version: 31-May-2017
Alternate Names:

ENSG00000198211 Gene Symbol

TUBB3 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ClearityFoundationBiomarkers: TUBB3
- Version: 26-July-2013
Alternate Names:

Gene Info:

Publications:

Novel drug target	Established target
Trial Name	ixabepilone, BMS-247550,Ixempra
Mechanism of Interaction	Tubulin inhibitor

Mechanism of Interaction	Tubulin inhibitor
Direct Interaction	yes

Direct Interaction	yes
Mechanism of Interaction	Tubulin stabiliser

Mechanism of Interaction	Tubulin disrupting agent
Direct Interaction	yes

TUBULIN BETA-3 CHAIN (TUBULIN BETA-III) (TUBULIN BETA-4). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13509]	Description
TUBB3	Display Id
ENSG00000198211	Ensembl Gene Id

10381	Entrez Gene Id
Q13509	Uniprot Accession
ENSG00000198211	Ensembl Gene Id

TUBB3 Gene Record

TUBB3 10381 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23631389 25584687 17765552 25192811 24669888 22543234 16913727

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25369367 21194809 25815147 23313639 25262051

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name ixabepilone, BMS-247550,Ixempra Mechanism of Interaction Tubulin inhibitor

PMIDs: 18378531 18945860 18321240

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tubulin inhibitor Direct Interaction yes

PMIDs: 23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21402478 17765552 24953821

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tubulin inhibitor Direct Interaction yes

PMIDs: 23631389 17887662 22595423 25369367 24457094 23725535 24953821 23313639 25768699 19758808 23387901

Sources: DTC ClearityFoundationBiomarkers ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19877653

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22543234

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 563462

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17206139

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21664138

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22543234

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 563462

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12141877

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22435708

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25468039

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23708010 23916255

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25768699

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tubulin inhibitor Direct Interaction yes

Interaction Types & Directionality:

n/a

PMIDs:
23631389 25584687 17765552 25192811 24669888 22543234 16913727

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25369367 21194809 25815147 23313639 25262051

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name ixabepilone, BMS-247550,Ixempra

Mechanism of Interaction Tubulin inhibitor

PMIDs:
18378531 18945860 18321240

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
21402478 17765552 24953821

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23631389 17887662 22595423 25369367 24457094 23725535 24953821 23313639 25768699 19758808 23387901

Sources:
DTC ClearityFoundationBiomarkers ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
19877653

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22543234

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
563462

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17206139

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21664138

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22543234

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
563462

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
12141877

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22435708

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25468039

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23708010 23916255

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25768699

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin stabiliser

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin stabiliser

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin disrupting agent

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found