DGIdb - TUBB4B Gene Record

TUBB4B 10383 Druggable Genome

Alternate Names:

10383
TUBULIN BETA 4B CLASS IVB
TUBB4B
Beta2
TUBB2
TUBB2C
602660
20771
ENSG00000188229
OTTHUMG00000131783
TBB4B_HUMAN
P68371
TUBULIN BETA-4B CHAIN
Tubulin beta-2C chain
Tubulin beta-2 chain
TBBX_HUMAN
TUBULIN BETA-? CHAIN (TUBULIN BETA-2 CHAIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P68371]
T28661
LCAEOD

Gene Info:

Uniprot Status	Swiss-Prot
Interpro Name	Tubulin
Interpro Acc	IPR000217
Interpro Short Name	Tubulin
Human Readable Name	DRUGGABLE GENOME
Interpro Type	Family
Uniprot Evidence	1: Evidence at protein level
Target Class	Miscellaneous
Target Subclass	StructuralAndAdhesion
Target Subclass	Cytoskeleton
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Kupchan SM et al., 1978, Structural requirements for antileukemic activity among the naturally occurring and semisynthetic maytansinoids., J Med Chem
Arslanian RL et al., 2002, A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus., J Nat Prod
Zheng J et al., 2013, Elaboration of thorough simplified vinca alkaloids as antimitotic agents based on pharmacophore similarity., Eur J Med Chem
Cheng YY et al., 2013, Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl)-6-pyrrolidinylquinolin-4-one as a potent anticancer lead., Bioorg Med Chem Lett
Reddy MV et al., 2013, Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents., J Med Chem
Wang F et al., 2015, Synthesis and biological evaluation of diarylthiazole derivatives as antimitotic and antivascular agents with potent antitumor activity., Bioorg Med Chem
Zhu C et al., 2014, Discovery of potent cytotoxic ortho-aryl chalcones as new scaffold targeting tubulin and mitosis with affinity-based fluorescence., J Med Chem
Zhang X et al., 2015, Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors., Eur J Med Chem
Wang XF et al., 2014, Optimization of 4-(N-cycloamino)phenylquinazolines as a novel class of tubulin-polymerization inhibitors targeting the colchicine site., J Med Chem
Minegishi H et al., 2015, Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate (GN39482) as a tubulin polymerization inhibitor identified by MorphoBase and ChemProteoBase profiling methods., J Med Chem
Canela MD et al., 2014, Novel colchicine-site binders with a cyclohexanedione scaffold identified through a ligand-based virtual screening approach., J Med Chem
Oxberry et al., 2001, Assessment of benzimidazole binding to individual recombinant tubulin isotypes from Haemonchus contortus., Parasitology
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Wampande et al., 2007, Classical ligands interact with native and recombinant tubulin from Onchocerca volvulus with similar rank order of magnitude., Protein Expr. Purif.
Lubega et al., 1993, Expression of cloned beta-tubulin genes of Haemonchus contortus in Escherichia coli: interaction of recombinant beta-tubulin with native tubulin and mebendazole., Mol. Biochem. Parasitol.
Ochola et al., 2002, Classical ligands bind tubulin of trypanosomes and inhibit their growth in vitro., J. Parasitol.
MacDonald et al., 2004, Characterisation of benzimidazole binding with recombinant tubulin from Giardia duodenalis, Encephalitozoon intestinalis, and Cryptosporidium parvum., Mol. Biochem. Parasitol.
Kawaratani Y et al., 2011, New microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group., Bioorg Med Chem
Gasparotto V et al., 2006, Synthesis and biological activity of 7-phenyl-6,9-dihydro-3H-pyrrolo[3,2-f]quinolin-9-ones: a new class of antimitotic agents devoid of aromatase activity., J Med Chem
Bio M et al., 2013, Site-specific and far-red-light-activatable prodrug of combretastatin A-4 using photo-unclick chemistry., J Med Chem
Galli U et al., 2015, Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents., J Med Chem
Imperio D et al., 2007, Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry., Bioorg Med Chem
Kamal A et al., 2014, Synthesis and biological evaluation of 1,2,3-triazole linked aminocombretastatin conjugates as mitochondrial mediated apoptosis inducers., Bioorg Med Chem
Zheng S et al., 2014, Design, synthesis, and biological evaluation of novel pyridine-bridged analogues of combretastatin-A4 as anticancer agents., J Med Chem
Kamal A et al., 2012, Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents., Bioorg Med Chem
Pirali T et al., 2006, Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents., J Med Chem
Vine KL et al., 2007, An investigation into the cytotoxicity and mode of action of some novel N-alkyl-substituted isatins., J Med Chem
Asami Y et al., 2012, Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells., Bioorg Med Chem
O'Boyle NM et al., 2014, β-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand., J Med Chem
Sathish Kumar B et al., 2014, Synthesis of neolignans as microtubule stabilisers., Bioorg Med Chem
Zhao Y et al., 2013, Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation., J Med Chem
Kamal A et al., 2014, Synthesis and biological evaluation of 4-aza-2,3-dihydropyridophenanthrolines as tubulin polymerization inhibitors., Bioorg Med Chem Lett
Kumar AS et al., 2013, Design and synthesis of biaryl aryl stilbenes/ethylenes as antimicrotubule agents., Eur J Med Chem
Parrino B et al., 2015, Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: in vitro antiproliferative activity and molecular mechanism(s) of action., Eur J Med Chem
Tu HY et al., 2009, Ursolic acid derivatives induce cell cycle arrest and apoptosis in NTUB1 cells associated with reactive oxygen species., Bioorg Med Chem
Kumar M et al., 2013, Tubulin inhibitors from an endophytic fungus isolated from Cedrus deodara., J Nat Prod
Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem
Kamal A et al., 2011, Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents., Bioorg Med Chem
Yi X et al., 2012, Identification of a class of novel tubulin inhibitors., J Med Chem
Kamal A et al., 2014, Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents., Bioorg Med Chem
Field JJ et al., 2009, Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis., J Med Chem
Kamal A et al., 2011, Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents., Eur J Med Chem
Kuroiwa K et al., 2015, Synthesis and Structure-Activity Relationship Study of 1-Phenyl-1-(quinazolin-4-yl)ethanols as Anticancer Agents., ACS Med Chem Lett
Guan Q et al., 2014, Synthesis and evaluation of benzimidazole carbamates bearing indole moieties for antiproliferative and antitubulin activities., Eur J Med Chem
Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem
Buey RM et al., 2007, Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites., Nat Chem Biol

MEBENDAZOLE TUBB4B

Interaction Score: 2.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Mebendazole

Novel drug target Established target

PMIDs:
11444621 10592235 17662615 8139621 12099434 15500920

Sources:
TdgClinicalTrial
COMBRETASTATIN A4 TUBB4B

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23631389 25584687 17765552 25192811 24669888 22543234 16913727

Sources:
DTC
DOLASTATIN-10 TUBB4B

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
NOCODAZOLE TUBB4B

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25369367 21194809 25815147 23313639 25262051

Sources:
DTC
COLCHICINE TUBB4B

Interaction Score: 0.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions
PODOFILOX TUBB4B

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21402478 17765552 24953821

Sources:
DTC
PACLITAXEL TUBB4B

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23631389 17887662 22595423 25369367 24457094 23725535 24953821 23313639 25768699 19758808 23387901

Sources:
DTC ChemblInteractions
VINBLASTINE TUBB4B

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23708010 23916255

Sources:
DTC TTD
CYCLOSTREPTIN TUBB4B

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17206139

Sources:
DTC
CHEMBL1795737 TUBB4B

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21664138

Sources:
DTC
CHEMBL2036124 TUBB4B

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22543234

Sources:
DTC
ZAMPANOLIDE TUBB4B

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19877653

Sources:
DTC
MAYTANSINOL TUBB4B

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
563462

Sources:
DTC
CHEMBL2036119 TUBB4B

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22543234

Sources:
DTC
CHEMBL453818 TUBB4B

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12141877

Sources:
DTC
MAYTANSINE TUBB4B

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
563462

Sources:
DTC
CHEMBL1935538 TUBB4B

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22435708

Sources:
DTC
ABT-751 TUBB4B

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25468039

Sources:
DTC
VINORELBINE TUBB4B

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25768699

Sources:
DTC
FOSBRETABULIN TROMETHAMINE TUBB4B

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin disrupting agent

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LEXIBULIN TUBB4B

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PLINABULIN TUBB4B

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VINFLUNINE TUBB4B

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CROLIBULIN TUBB4B

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DAVUNETIDE TUBB4B

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin stabiliser

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FOSBRETABULIN DISODIUM TUBB4B

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DOCETAXEL TUBB4B

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
SAGOPILONE TUBB4B

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin stabiliser

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PACLITAXEL POLIGLUMEX TUBB4B

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin stabiliser

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VERUBULIN TUBB4B

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin disrupting agent

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LARGAZOLE TUBB4B

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440

Sources:
DTC
VINCRISTINE TUBB4B

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21664138 23916255 16539377

Sources:
DTC
BRENTUXIMAB VEDOTIN TUBB4B

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TRASTUZUMAB EMTANSINE TUBB4B

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
INDIBULIN TUBB4B

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ERIBULIN MESYLATE TUBB4B

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VINORELBINE TARTRATE TUBB4B

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
CABAZITAXEL TUBB4B

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
VINCRISTINE SULFATE TUBB4B

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VINBLASTINE SULFATE TUBB4B

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
IXABEPILONE TUBB4B

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VORINOSTAT TUBB4B

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440

Sources:
DTC
CURCUMIN TUBB4B

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23830698

Sources:
DTC

Ensembl: ENSG00000188229
- Version: 101_38
Alternate Names:

TUBB4B Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P68371
- Version: January-2014
Alternate Names:

TUBB2C Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass StructuralAndAdhesion

Target Subclass Cytoskeleton

Publications:
HopkinsGroom: P68371
- Version: 11-September-2012
Alternate Names:

ENSG00000188229 Ensembl Gene Id

TUBULIN BETA-4B CHAIN Uniprot Protein Name

TUBB4B Uniprot Gene Name

Gene Info:

Uniprot Status Swiss-Prot

Interpro Name Tubulin

Interpro Acc IPR000217

Gene Categories:

DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000188229
- Version: 26-July-2011
Alternate Names:

TUBULIN BETA-? CHAIN (TUBULIN BETA-2 CHAIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P68371] Description

ENSG00000188229 Ensembl Gene Id

TBBX_HUMAN Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

DTC: TUBB4B

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Gasparotto V et al., 2006, Synthesis and biological activity of 7-phenyl-6,9-dihydro-3H-pyrrolo[3,2-f]quinolin-9-ones: a new class of antimitotic agents devoid of aromatase activity., J Med Chem

Kawaratani Y et al., 2011, New microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group., Bioorg Med Chem

Cheng YY et al., 2013, Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl)-6-pyrrolidinylquinolin-4-one as a potent anticancer lead., Bioorg Med Chem Lett

ChemblInteractions: TUBB2C
- Version: chembl_23
Alternate Names:

TUBB2C GENE_SYMBOL

TUBB4B GENE_SYMBOL

Tubulin beta-4B chain UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000188229
- Version: 31-May-2017
Alternate Names:

ENSG00000188229 Gene Symbol

TUBB4B Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Tubulin beta-2 chain
- Version: 2020.06.01
Alternate Names:

TUBB2 TTD Gene Abbreviation

T28661 TTD Target ID

Gene Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Tubulin inhibitor

Mechanism of Interaction	Tubulin disrupting agent
Direct Interaction	yes

Mechanism of Interaction	Tubulin stabiliser
Direct Interaction	yes

ENSG00000188229	Ensembl Gene Id
TUBULIN BETA-4B CHAIN	Uniprot Protein Name
TUBB4B	Uniprot Gene Name

TUBULIN BETA-? CHAIN (TUBULIN BETA-2 CHAIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P68371]	Description
ENSG00000188229	Ensembl Gene Id
TBBX_HUMAN	Display Id

TUBB2C	GENE_SYMBOL
TUBB4B	GENE_SYMBOL
Tubulin beta-4B chain	UNIPROT

Trial Name	Mebendazole
Novel drug target	Established target

TUBB4B Gene Record

TUBB4B 10383 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Mebendazole Novel drug target Established target

PMIDs: 11444621 10592235 17662615 8139621 12099434 15500920

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23631389 25584687 17765552 25192811 24669888 22543234 16913727

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25369367 21194809 25815147 23313639 25262051

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Tubulin inhibitor

PMIDs: 23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21402478 17765552 24953821

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tubulin inhibitor Direct Interaction yes

PMIDs: 23631389 17887662 22595423 25369367 24457094 23725535 24953821 23313639 25768699 19758808 23387901

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23708010 23916255

Sources: DTC TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17206139

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21664138

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22543234

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19877653

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 563462

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22543234

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12141877

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 563462

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22435708

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25468039

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Mebendazole

Novel drug target Established target

PMIDs:
11444621 10592235 17662615 8139621 12099434 15500920

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
23631389 25584687 17765552 25192811 24669888 22543234 16913727

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
25369367 21194809 25815147 23313639 25262051

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
21402478 17765552 24953821

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23631389 17887662 22595423 25369367 24457094 23725535 24953821 23313639 25768699 19758808 23387901

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
23708010 23916255

Sources:
DTC TTD

Interaction Types & Directionality:

n/a

PMIDs:
17206139

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21664138

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22543234

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19877653

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
563462

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22543234

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
12141877

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
563462

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22435708

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25468039

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25768699

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin disrupting agent

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions