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TUBB4B Gene Record

  • Summary
  • Interactions
  • Claims
  • TUBB4B 10383 Druggable Genome

    Alternate Names:

    10383
    TUBULIN BETA 4B CLASS IVB
    TUBB4B
    Beta2
    TUBB2
    TUBB2C
    602660
    20771
    ENSG00000188229
    OTTHUMG00000131783
    TBB4B_HUMAN
    P68371
    TUBULIN BETA-4B CHAIN
    Tubulin beta-2C chain
    Tubulin beta-2 chain
    TBBX_HUMAN
    TUBULIN BETA-? CHAIN (TUBULIN BETA-2 CHAIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P68371]
    T28661
    LCAEOD

    Gene Info:

    Uniprot Status Swiss-Prot
    Interpro Name Tubulin
    Interpro Acc IPR000217
    Interpro Short Name Tubulin
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Family
    Uniprot Evidence 1: Evidence at protein level
    Target Class Miscellaneous
    Target Subclass StructuralAndAdhesion
    Target Subclass Cytoskeleton
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Kupchan SM et al., 1978, Structural requirements for antileukemic activity among the naturally occurring and semisynthetic maytansinoids., J Med Chem
    Arslanian RL et al., 2002, A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus., J Nat Prod
    Zheng J et al., 2013, Elaboration of thorough simplified vinca alkaloids as antimitotic agents based on pharmacophore similarity., Eur J Med Chem
    Cheng YY et al., 2013, Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl)-6-pyrrolidinylquinolin-4-one as a potent anticancer lead., Bioorg Med Chem Lett
    Reddy MV et al., 2013, Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents., J Med Chem
    Wang F et al., 2015, Synthesis and biological evaluation of diarylthiazole derivatives as antimitotic and antivascular agents with potent antitumor activity., Bioorg Med Chem
    Zhu C et al., 2014, Discovery of potent cytotoxic ortho-aryl chalcones as new scaffold targeting tubulin and mitosis with affinity-based fluorescence., J Med Chem
    Zhang X et al., 2015, Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors., Eur J Med Chem
    Wang XF et al., 2014, Optimization of 4-(N-cycloamino)phenylquinazolines as a novel class of tubulin-polymerization inhibitors targeting the colchicine site., J Med Chem
    Minegishi H et al., 2015, Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate (GN39482) as a tubulin polymerization inhibitor identified by MorphoBase and ChemProteoBase profiling methods., J Med Chem
    Canela MD et al., 2014, Novel colchicine-site binders with a cyclohexanedione scaffold identified through a ligand-based virtual screening approach., J Med Chem
    Oxberry et al., 2001, Assessment of benzimidazole binding to individual recombinant tubulin isotypes from Haemonchus contortus., Parasitology
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Wampande et al., 2007, Classical ligands interact with native and recombinant tubulin from Onchocerca volvulus with similar rank order of magnitude., Protein Expr. Purif.
    Lubega et al., 1993, Expression of cloned beta-tubulin genes of Haemonchus contortus in Escherichia coli: interaction of recombinant beta-tubulin with native tubulin and mebendazole., Mol. Biochem. Parasitol.
    Ochola et al., 2002, Classical ligands bind tubulin of trypanosomes and inhibit their growth in vitro., J. Parasitol.
    MacDonald et al., 2004, Characterisation of benzimidazole binding with recombinant tubulin from Giardia duodenalis, Encephalitozoon intestinalis, and Cryptosporidium parvum., Mol. Biochem. Parasitol.
    Kawaratani Y et al., 2011, New microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group., Bioorg Med Chem
    Gasparotto V et al., 2006, Synthesis and biological activity of 7-phenyl-6,9-dihydro-3H-pyrrolo[3,2-f]quinolin-9-ones: a new class of antimitotic agents devoid of aromatase activity., J Med Chem
    Bio M et al., 2013, Site-specific and far-red-light-activatable prodrug of combretastatin A-4 using photo-unclick chemistry., J Med Chem
    Galli U et al., 2015, Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents., J Med Chem
    Imperio D et al., 2007, Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry., Bioorg Med Chem
    Kamal A et al., 2014, Synthesis and biological evaluation of 1,2,3-triazole linked aminocombretastatin conjugates as mitochondrial mediated apoptosis inducers., Bioorg Med Chem
    Zheng S et al., 2014, Design, synthesis, and biological evaluation of novel pyridine-bridged analogues of combretastatin-A4 as anticancer agents., J Med Chem
    Kamal A et al., 2012, Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents., Bioorg Med Chem
    Pirali T et al., 2006, Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents., J Med Chem
    Vine KL et al., 2007, An investigation into the cytotoxicity and mode of action of some novel N-alkyl-substituted isatins., J Med Chem
    Asami Y et al., 2012, Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells., Bioorg Med Chem
    O'Boyle NM et al., 2014, β-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand., J Med Chem
    Sathish Kumar B et al., 2014, Synthesis of neolignans as microtubule stabilisers., Bioorg Med Chem
    Zhao Y et al., 2013, Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation., J Med Chem
    Kamal A et al., 2014, Synthesis and biological evaluation of 4-aza-2,3-dihydropyridophenanthrolines as tubulin polymerization inhibitors., Bioorg Med Chem Lett
    Kumar AS et al., 2013, Design and synthesis of biaryl aryl stilbenes/ethylenes as antimicrotubule agents., Eur J Med Chem
    Parrino B et al., 2015, Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: in vitro antiproliferative activity and molecular mechanism(s) of action., Eur J Med Chem
    Tu HY et al., 2009, Ursolic acid derivatives induce cell cycle arrest and apoptosis in NTUB1 cells associated with reactive oxygen species., Bioorg Med Chem
    Kumar M et al., 2013, Tubulin inhibitors from an endophytic fungus isolated from Cedrus deodara., J Nat Prod
    Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem
    Kamal A et al., 2011, Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents., Bioorg Med Chem
    Yi X et al., 2012, Identification of a class of novel tubulin inhibitors., J Med Chem
    Kamal A et al., 2014, Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents., Bioorg Med Chem
    Field JJ et al., 2009, Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis., J Med Chem
    Kamal A et al., 2011, Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents., Eur J Med Chem
    Kuroiwa K et al., 2015, Synthesis and Structure-Activity Relationship Study of 1-Phenyl-1-(quinazolin-4-yl)ethanols as Anticancer Agents., ACS Med Chem Lett
    Guan Q et al., 2014, Synthesis and evaluation of benzimidazole carbamates bearing indole moieties for antiproliferative and antitubulin activities., Eur J Med Chem
    Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem
    Buey RM et al., 2007, Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites., Nat Chem Biol
  • MEBENDAZOLE   TUBB4B

    Interaction Score: 2.01

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name Mebendazole
    Novel drug target Established target

    PMIDs:
    11444621 10592235 17662615 8139621 12099434 15500920


    Sources:
    TdgClinicalTrial

  • COMBRETASTATIN A4   TUBB4B

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23631389 25584687 17765552 25192811 24669888 22543234 16913727


    Sources:
    DTC

  • DOLASTATIN-10   TUBB4B

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • NOCODAZOLE   TUBB4B

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25369367 21194809 25815147 23313639 25262051


    Sources:
    DTC

  • COLCHICINE   TUBB4B

    Interaction Score: 0.28

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tubulin inhibitor

    PMIDs:
    23750455 25937236 25061803 25805446 24502232 25938266 24773591


    Sources:
    DTC ChemblInteractions

  • PODOFILOX   TUBB4B

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21402478 17765552 24953821


    Sources:
    DTC

  • PACLITAXEL   TUBB4B

    Interaction Score: 0.19

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    23631389 17887662 22595423 25369367 24457094 23725535 24953821 23313639 25768699 19758808 23387901


    Sources:
    DTC ChemblInteractions

  • VINBLASTINE   TUBB4B

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23708010 23916255


    Sources:
    DTC TTD

  • CYCLOSTREPTIN   TUBB4B

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17206139


    Sources:
    DTC

  • CHEMBL1795737   TUBB4B

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21664138


    Sources:
    DTC

  • CHEMBL2036124   TUBB4B

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22543234


    Sources:
    DTC

  • ZAMPANOLIDE   TUBB4B

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19877653


    Sources:
    DTC

  • MAYTANSINOL   TUBB4B

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    563462


    Sources:
    DTC

  • CHEMBL2036119   TUBB4B

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22543234


    Sources:
    DTC

  • CHEMBL453818   TUBB4B

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12141877


    Sources:
    DTC

  • MAYTANSINE   TUBB4B

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    563462


    Sources:
    DTC

  • CHEMBL1935538   TUBB4B

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22435708


    Sources:
    DTC

  • ABT-751   TUBB4B

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25468039


    Sources:
    DTC

  • VINORELBINE   TUBB4B

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25768699


    Sources:
    DTC

  • FOSBRETABULIN TROMETHAMINE   TUBB4B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Tubulin disrupting agent
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LEXIBULIN   TUBB4B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PLINABULIN   TUBB4B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VINFLUNINE   TUBB4B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CROLIBULIN   TUBB4B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DAVUNETIDE   TUBB4B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Tubulin stabiliser
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FOSBRETABULIN DISODIUM   TUBB4B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DOCETAXEL   TUBB4B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tubulin inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SAGOPILONE   TUBB4B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Tubulin stabiliser
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PACLITAXEL POLIGLUMEX   TUBB4B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Tubulin stabiliser
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VERUBULIN   TUBB4B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Tubulin disrupting agent
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LARGAZOLE   TUBB4B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20491440


    Sources:
    DTC

  • VINCRISTINE   TUBB4B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21664138 23916255 16539377


    Sources:
    DTC

  • BRENTUXIMAB VEDOTIN   TUBB4B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TRASTUZUMAB EMTANSINE   TUBB4B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tubulin inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INDIBULIN   TUBB4B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ERIBULIN MESYLATE   TUBB4B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VINORELBINE TARTRATE   TUBB4B

    Interaction Score: 0.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tubulin inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CABAZITAXEL   TUBB4B

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tubulin inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VINCRISTINE SULFATE   TUBB4B

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VINBLASTINE SULFATE   TUBB4B

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • IXABEPILONE   TUBB4B

    Interaction Score: 0.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VORINOSTAT   TUBB4B

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20491440


    Sources:
    DTC

  • CURCUMIN   TUBB4B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23830698


    Sources:
    DTC

  • Ensembl: ENSG00000188229

    • Version: 101_38

    Alternate Names:
    TUBB4B Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P68371

    • Version: January-2014

    Alternate Names:
    TUBB2C Gene Symbol

    Gene Info:
    Target Class Miscellaneous
    Target Subclass StructuralAndAdhesion
    Target Subclass Cytoskeleton

    Publications:

  • HopkinsGroom: P68371

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000188229 Ensembl Gene Id
    TUBULIN BETA-4B CHAIN Uniprot Protein Name
    TUBB4B Uniprot Gene Name

    Gene Info:
    Uniprot Status Swiss-Prot
    Interpro Name Tubulin
    Interpro Acc IPR000217

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000188229

    • Version: 26-July-2011

    Alternate Names:
    TUBULIN BETA-? CHAIN (TUBULIN BETA-2 CHAIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P68371] Description
    ENSG00000188229 Ensembl Gene Id
    TBBX_HUMAN Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • DTC: TUBB4B

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Gasparotto V et al., 2006, Synthesis and biological activity of 7-phenyl-6,9-dihydro-3H-pyrrolo[3,2-f]quinolin-9-ones: a new class of antimitotic agents devoid of aromatase activity., J Med Chem
    Kawaratani Y et al., 2011, New microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group., Bioorg Med Chem
    Cheng YY et al., 2013, Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl)-6-pyrrolidinylquinolin-4-one as a potent anticancer lead., Bioorg Med Chem Lett

  • ChemblInteractions: TUBB2C

    • Version: chembl_23

    Alternate Names:
    TUBB2C GENE_SYMBOL
    TUBB4B GENE_SYMBOL
    Tubulin beta-4B chain UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000188229

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000188229 Gene Symbol
    TUBB4B Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Tubulin beta-2 chain

    • Version: 2020.06.01

    Alternate Names:
    TUBB2 TTD Gene Abbreviation
    T28661 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21