DGIdb - TYMP Gene Record

TYMP 1890 Druggable Genome

Alternate Names:

1890
THYMIDINE PHOSPHORYLASE
TYMP
ECGF
ECGF1
MEDPS1
MNGIE
MTDPS1
PDECGF
TP
hPD-ECGF
131222
3148
ENSG00000025708
OTTHUMG00000150249
P19971
THYMIDINE PHOSPHORYLASE PRECURSOR (EC 2.4.2.4) (TDRPASE) (TP) (PLATELET-DERIVED ENDOTHELIAL CELL GROWTH FACTOR) (PD-ECGF) (GLIOSTATIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P19971]
PA162407502
TYPH_HUMAN
PD-ECGF
TdRPase
Platelet-derived endothelial cell growth factor
Gliostatin
T59929

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Interpro Acc	IPR000312
Interpro Name	Glycosyl transferase, family 3
Interpro Type	Domain
Interpro Short Name	Glycosyl_Trfase_fam3
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

GROWTH FACTOR
DRUGGABLE GENOME

Publications:

Hirano et al., Thymidine phosphorylase activity in transitional cell cancer: relation to histological parameters and chemosensitivity to fluorouracil-related drugs., Anticancer Res.
Jennings BA et al., 2013, Evaluating predictive pharmacogenetic signatures of adverse events in colorectal cancer patients treated with fluoropyrimidines., PLoS One
Aoki et al., 2003, Effects of various steroids on platelet-derived endothelial cell growth factor (PD-ECGF) and its mRNA expression in uterine endometrial cancer cells., J. Steroid Biochem. Mol. Biol.
de Bruin et al., 2004, Sulfasalazine down-regulates the expression of the angiogenic factors platelet-derived endothelial cell growth factor/thymidine phosphorylase and interleukin-8 in human monocytic-macrophage THP1 and U937 cells., Mol. Pharmacol.

TIPIRACIL HYDROCHLORIDE TYMP

Interaction Score: 10.3

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thymidine phosphorylase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
URIDINE TYMP

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
SULFASALAZINE TYMP

Interaction Score: 0.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15269287

Sources:
NCI
CAPECITABINE TYMP

Interaction Score: 0.57

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24167597

Sources:
PharmGKB
FLUOROURACIL TYMP

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11205264 24167597

Sources:
NCI PharmGKB
PROGESTERONE TYMP

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12711006

Sources:
NCI

Ensembl: ENSG00000025708
- Version: 101_38
Alternate Names:

TYMP Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000025708

Version: 26-July-2011

Alternate Names:

ECGF1 Display Id

ENSG00000025708 Ensembl Gene Id

THYMIDINE PHOSPHORYLASE PRECURSOR (EC 2.4.2.4) (TDRPASE) (TP) (PLATELET-DERIVED ENDOTHELIAL CELL GROWTH FACTOR) (PD-ECGF) (GLIOSTATIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P19971] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P19971
- Version: 11-September-2012
Alternate Names:

1890 Entrez Gene Id

ENSG00000025708 Ensembl Gene Id

TYPH_HUMAN Uniprot Id

Gene Info:

Interpro Acc IPR000312

Human Readable Name DRUGGABLE GENOME

Interpro Name Glycosyl transferase, family 3

Gene Categories:

DRUGGABLE GENOME

Publications:
PharmGKB: TYMP
- Version: 18-August-2020
Alternate Names:

PA162407502 PharmGKB ID

Gene Info:

Publications:

Jennings BA et al., 2013, Evaluating predictive pharmacogenetic signatures of adverse events in colorectal cancer patients treated with fluoropyrimidines., PLoS One

NCI: TYMP

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

de Bruin et al., 2004, Sulfasalazine down-regulates the expression of the angiogenic factors platelet-derived endothelial cell growth factor/thymidine phosphorylase and interleukin-8 in human monocytic-macrophage THP1 and U937 cells., Mol. Pharmacol.

Harada et al., 2006, Thymidylate synthase expression in oral squamous cell carcinoma predicts response to S-1., Oncol. Rep.

Nishimura et al., Thymidine phosphorylase and dihydropyrimidine dehydrogenase levels in primary colorectal cancer show a relationship to clinical effects of 5'-deoxy-5-fluorouridine as adjuvant chemotherapy., Oncol. Rep.

HingoraniCasas: ENSG00000025708
- Version: 31-May-2017
Alternate Names:

ENSG00000025708 Gene Symbol

TYMP Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: ECGF1
- Version: chembl_23
Alternate Names:

ECGF1 GENE_SYMBOL

TYMP GENE_SYMBOL

Thymidine phosphorylase UNIPROT

Gene Info:

Publications:
GO: TYMP
- Version: 01-February-2022
Alternate Names:

ECGF1 GO Gene Synonym

Gene Info:

Gene Categories:

GROWTH FACTOR

Publications:
TTD: Thymidine phosphorylase
- Version: 2020.06.01
Alternate Names:

TYMP TTD Gene Abbreviation

T59929 TTD Target ID

Gene Info:

Publications:

Mechanism of Interaction	Thymidine phosphorylase inhibitor
Direct Interaction	yes

ECGF1	Display Id
ENSG00000025708	Ensembl Gene Id
THYMIDINE PHOSPHORYLASE PRECURSOR (EC 2.4.2.4) (TDRPASE) (TP) (PLATELET-DERIVED ENDOTHELIAL CELL GROWTH FACTOR) (PD-ECGF) (GLIOSTATIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P19971]	Description

1890	Entrez Gene Id
ENSG00000025708	Ensembl Gene Id
TYPH_HUMAN	Uniprot Id

ECGF1	GENE_SYMBOL
TYMP	GENE_SYMBOL
Thymidine phosphorylase	UNIPROT

TYMP Gene Record

TYMP 1890 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

TIPIRACIL HYDROCHLORIDE TYMP

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Thymidine phosphorylase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

URIDINE TYMP

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

SULFASALAZINE TYMP

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15269287

Sources: NCI

CAPECITABINE TYMP

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24167597

Sources: PharmGKB

FLUOROURACIL TYMP

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11205264 24167597

Sources: NCI PharmGKB

PROGESTERONE TYMP

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12711006

Sources: NCI

Ensembl: ENSG00000025708

Alternate Names: TYMP Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000025708

Alternate Names: ECGF1 Display Id ENSG00000025708 Ensembl Gene Id THYMIDINE PHOSPHORYLASE PRECURSOR (EC 2.4.2.4) (TDRPASE) (TP) (PLATELET-DERIVED ENDOTHELIAL CELL GROWTH FACTOR) (PD-ECGF) (GLIOSTATIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P19971] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: P19971

Alternate Names: 1890 Entrez Gene Id ENSG00000025708 Ensembl Gene Id TYPH_HUMAN Uniprot Id

Gene Info: Interpro Acc IPR000312 Human Readable Name DRUGGABLE GENOME Interpro Name Glycosyl transferase, family 3

Gene Categories: DRUGGABLE GENOME

Publications:

PharmGKB: TYMP

Alternate Names: PA162407502 PharmGKB ID

Gene Info:

Publications: Jennings BA et al., 2013, Evaluating predictive pharmacogenetic signatures of adverse events in colorectal cancer patients treated with fluoropyrimidines., PLoS One

NCI: TYMP

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000025708

Alternate Names: ENSG00000025708 Gene Symbol TYMP Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: ECGF1

Alternate Names: ECGF1 GENE_SYMBOL TYMP GENE_SYMBOL Thymidine phosphorylase UNIPROT

Gene Info:

Publications:

GO: TYMP

Alternate Names: ECGF1 GO Gene Synonym

Gene Info:

Gene Categories: GROWTH FACTOR

Publications:

TTD: Thymidine phosphorylase

Alternate Names: TYMP TTD Gene Abbreviation T59929 TTD Target ID

Gene Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thymidine phosphorylase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
15269287

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
24167597

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
11205264 24167597

Sources:
NCI PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
12711006

Sources:
NCI

Alternate Names:

TYMP Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ECGF1 Display Id

ENSG00000025708 Ensembl Gene Id

THYMIDINE PHOSPHORYLASE PRECURSOR (EC 2.4.2.4) (TDRPASE) (TP) (PLATELET-DERIVED ENDOTHELIAL CELL GROWTH FACTOR) (PD-ECGF) (GLIOSTATIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P19971] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

1890 Entrez Gene Id

ENSG00000025708 Ensembl Gene Id

TYPH_HUMAN Uniprot Id

Gene Info:

Interpro Acc IPR000312

Human Readable Name DRUGGABLE GENOME

Interpro Name Glycosyl transferase, family 3

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PA162407502 PharmGKB ID

Publications:

Jennings BA et al., 2013, Evaluating predictive pharmacogenetic signatures of adverse events in colorectal cancer patients treated with fluoropyrimidines., PLoS One

Alternate Names:

ENSG00000025708 Gene Symbol

TYMP Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ECGF1 GENE_SYMBOL

TYMP GENE_SYMBOL

Thymidine phosphorylase UNIPROT

Alternate Names:

ECGF1 GO Gene Synonym

Gene Categories:

GROWTH FACTOR

Alternate Names:

TYMP TTD Gene Abbreviation

T59929 TTD Target ID