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TYMP Gene Record

  • Summary
  • Interactions
  • Claims
  • TYMP 1890 Druggable Genome

    Alternate Names:

    1890
    THYMIDINE PHOSPHORYLASE
    TYMP
    ECGF
    ECGF1
    MEDPS1
    MNGIE
    MTDPS1
    PDECGF
    TP
    hPD-ECGF
    131222
    3148
    ENSG00000025708
    OTTHUMG00000150249
    P19971
    THYMIDINE PHOSPHORYLASE PRECURSOR (EC 2.4.2.4) (TDRPASE) (TP) (PLATELET-DERIVED ENDOTHELIAL CELL GROWTH FACTOR) (PD-ECGF) (GLIOSTATIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P19971]
    PA162407502
    TYPH_HUMAN
    PD-ECGF
    TdRPase
    Platelet-derived endothelial cell growth factor
    Gliostatin
    T59929

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR000312
    Interpro Name Glycosyl transferase, family 3
    Interpro Type Domain
    Interpro Short Name Glycosyl_Trfase_fam3
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    GROWTH FACTOR
    DRUGGABLE GENOME

    Publications:

    Hirano et al., Thymidine phosphorylase activity in transitional cell cancer: relation to histological parameters and chemosensitivity to fluorouracil-related drugs., Anticancer Res.
    Jennings BA et al., 2013, Evaluating predictive pharmacogenetic signatures of adverse events in colorectal cancer patients treated with fluoropyrimidines., PLoS One
    Aoki et al., 2003, Effects of various steroids on platelet-derived endothelial cell growth factor (PD-ECGF) and its mRNA expression in uterine endometrial cancer cells., J. Steroid Biochem. Mol. Biol.
    de Bruin et al., 2004, Sulfasalazine down-regulates the expression of the angiogenic factors platelet-derived endothelial cell growth factor/thymidine phosphorylase and interleukin-8 in human monocytic-macrophage THP1 and U937 cells., Mol. Pharmacol.
  • TIPIRACIL HYDROCHLORIDE   TYMP

    Interaction Score: 10.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Thymidine phosphorylase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • URIDINE   TYMP

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • SULFASALAZINE   TYMP

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15269287


    Sources:
    NCI

  • CAPECITABINE   TYMP

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24167597


    Sources:
    PharmGKB

  • FLUOROURACIL   TYMP

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11205264 24167597


    Sources:
    NCI PharmGKB

  • PROGESTERONE   TYMP

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12711006


    Sources:
    NCI

  • Ensembl: ENSG00000025708

    • Version: 101_38

    Alternate Names:
    TYMP Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000025708

    • Version: 26-July-2011

    Alternate Names:
    ECGF1 Display Id
    ENSG00000025708 Ensembl Gene Id
    THYMIDINE PHOSPHORYLASE PRECURSOR (EC 2.4.2.4) (TDRPASE) (TP) (PLATELET-DERIVED ENDOTHELIAL CELL GROWTH FACTOR) (PD-ECGF) (GLIOSTATIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P19971] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P19971

    • Version: 11-September-2012

    Alternate Names:
    1890 Entrez Gene Id
    ENSG00000025708 Ensembl Gene Id
    TYPH_HUMAN Uniprot Id

    Gene Info:
    Interpro Acc IPR000312
    Human Readable Name DRUGGABLE GENOME
    Interpro Name Glycosyl transferase, family 3

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: TYMP

    • Version: 18-August-2020

    Alternate Names:
    PA162407502 PharmGKB ID

    Gene Info:

    Publications:
    Jennings BA et al., 2013, Evaluating predictive pharmacogenetic signatures of adverse events in colorectal cancer patients treated with fluoropyrimidines., PLoS One

  • NCI: TYMP

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    de Bruin et al., 2004, Sulfasalazine down-regulates the expression of the angiogenic factors platelet-derived endothelial cell growth factor/thymidine phosphorylase and interleukin-8 in human monocytic-macrophage THP1 and U937 cells., Mol. Pharmacol.
    Harada et al., 2006, Thymidylate synthase expression in oral squamous cell carcinoma predicts response to S-1., Oncol. Rep.
    Nishimura et al., Thymidine phosphorylase and dihydropyrimidine dehydrogenase levels in primary colorectal cancer show a relationship to clinical effects of 5'-deoxy-5-fluorouridine as adjuvant chemotherapy., Oncol. Rep.

  • HingoraniCasas: ENSG00000025708

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000025708 Gene Symbol
    TYMP Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: ECGF1

    • Version: chembl_23

    Alternate Names:
    ECGF1 GENE_SYMBOL
    TYMP GENE_SYMBOL
    Thymidine phosphorylase UNIPROT

    Gene Info:

    Publications:

  • GO: TYMP

    • Version: 01-February-2022

    Alternate Names:
    ECGF1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    GROWTH FACTOR

    Publications:

  • TTD: Thymidine phosphorylase

    • Version: 2020.06.01

    Alternate Names:
    TYMP TTD Gene Abbreviation
    T59929 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21