DGIdb - TYMS Gene Record

TYMS 7298 Druggable GenomeDrug Resistance

Alternate Names:

7298
THYMIDYLATE SYNTHETASE
TYMS
HST422
TMS
TS
188350
12441
ENSG00000176890
OTTHUMG00000131473
Thymidylate synthase
TSase
PA359
TYSY_HUMAN
P04818
5971
THYMIDYLATE SYNTHASE (EC 2.1.1.45) (TS) (TSASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P04818]
T98397

Gene Info:

Target Main Class	Enzymes
Target Subclass	2.1.1.45
Human Readable Name	DRUGGABLE GENOME
Target Class	Enzymes
Target Subclass	EC:2.1.1.45
Interpro Short Name	Thymidylate_synthase
Interpro Name	Thymidylate synthase
Uniprot Status	Swiss-Prot
Interpro Acc	IPR000398
Interpro Type	Family
Uniprot Evidence	1: Evidence at protein level
Gene Biotype	PROTEIN_CODING

(12 More Sources)

Gene Categories: Category Details

DRUG RESISTANCE
DRUGGABLE GENOME
ENZYME

Publications:

Fischel et al., 2006, Synergistic cytotoxic interaction in hormone-refractory prostate cancer with the triple combination docetaxel-erlotinib and 5-fluoro-5'-deoxyuridine., Anticancer Drugs
Carlini et al., 2005, UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan., Clin. Cancer Res.
Li et al., 2005, Rapid quantitation of plasma 2'-deoxyuridine by high-performance liquid chromatography/atmospheric pressure chemical ionization mass spectrometry and its application to pharmacodynamic studies in cancer patients., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Patel et al., 2004, Enzyme expression profiles suggest the novel tumor-activated fluoropyrimidine carbamate capecitabine (Xeloda) might be effective against papillary thyroid cancers of children and young adults., Cancer Chemother. Pharmacol.
Eliason et al., 2004, Potential for predicting toxicity and response of fluoropyrimidines in patients., Curr Drug Targets
Radtke et al., 2013, Germline genetic variations in methotrexate candidate genes are associated with pharmacokinetics, toxicity, and outcome in childhood acute lymphoblastic leukemia., Blood
Inoue K et al., 2014, Molecular basis for pharmacokinetics and pharmacodynamics of methotrexate in rheumatoid arthritis therapy., Drug Metab Pharmacokinet
Freyer G et al., 2011, Pharmacogenetic tailoring of irinotecan-based first-line chemotherapy in metastatic colorectal cancer: results of a pilot study., Anticancer Res
Massacesi et al., 2006, Uridine diphosphate glucuronosyl transferase 1A1 promoter polymorphism predicts the risk of gastrointestinal toxicity and fatigue induced by irinotecan-based chemotherapy., Cancer
Martinez-Balibrea et al., 2010, UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapy., Br. J. Cancer
Tsukamoto et al., 1989, Effect of glucocorticoid on liver regeneration after partial hepatectomy in the rat., Gut
Pelà M et al., 2014, Optimization of peptides that target human thymidylate synthase to inhibit ovarian cancer cell growth., J Med Chem
Huang et al., 2006, Tailor-made chemotherapy for non-small cell lung cancer patients., Future Oncol
Garcia et al., 2006, Thymidylate synthase messenger RNA expression in plasma from patients with colon cancer: prognostic potential., Clin. Cancer Res.
Fernández-Contreras et al., 2006, Thymidylate synthase expression pattern, expression level and single nucleotide polymorphism are predictors for disease-free survival in patients of colorectal cancer treated with 5-fluorouracil., Int. J. Oncol.
Formentini et al., 2007, Thymidylate synthase expression in resectable and unresectable pancreatic cancer: role as predictive or prognostic marker?, Int J Colorectal Dis
Ploylearmsaeng et al., 2006, How may anticancer chemotherapy with fluorouracil be individualised?, Clin Pharmacokinet
Rustum, 2004, Thymidylate synthase: a critical target in cancer therapy?, Front. Biosci.
Singh V et al., 2015, The complex mechanism of antimycobacterial action of 5-fluorouracil., Chem Biol
Chen et al., 2011, Thymidylate synthase and dihydrofolate reductase expression in non-small cell lung carcinoma: the association with treatment efficacy of pemetrexed., Lung Cancer
Kasai et al., 2013, Thymidylate synthase gene copy number as a predictive marker for response to pemetrexed treatment of lung adenocarcinoma., Anticancer Res.
Shimizu et al., 2012, Association between expression of thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase and efficacy of pemetrexed in advanced non-small cell lung cancer., Anticancer Res.
Chamizo et al., 2015, Thymidylate synthase expression as a predictive biomarker of pemetrexed sensitivity in advanced non-small cell lung cancer., BMC Pulm Med
Pivot et al., 2001, Pemetrexed disodium in recurrent locally advanced or metastatic squamous cell carcinoma of the head and neck., Br. J. Cancer
Kindler, 2002, Pemetrexed in pancreatic cancer., Semin. Oncol.
Hanauske et al., 2001, Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors., Oncologist
Adjei, 2001, Gemcitabine and Pemetrexed disodium in treating breast cancer., Oncology (Williston Park, N.Y.)
Adjei, 2002, Pemetrexed in the treatment of selected solid tumors., Semin. Oncol.
Giovannetti et al., 2005, Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small-cell lung cancer cells., Mol. Pharmacol.
Norman, 2001, Pemetrexed disodium (Eli Lilly)., Curr Opin Investig Drugs
Schultz et al., Sequence dependence of Alimta (LY231514, MTA) combined with doxorubicin in ZR-75-1 human breast carcinoma cells., Anticancer Res.
Molina et al., 2003, The role of Pemetrexed (Alimta , LY231514) in lung cancer therapy., Clin Lung Cancer
Adjei, 2001, Gemcitabine and pemetrexed disodium combinations in vitro and in vivo., Lung Cancer
Cao et al., 1999, Antitumor activity of ZD1694 (tomudex) against human head and neck cancer in nude mouse models: role of dosing schedule and plasma thymidine., Clin. Cancer Res.
Orlandi et al., 1999, Involvement of bcl-2 and p21waf1 proteins in response of human breast cancer cell clones to Tomudex., Br. J. Cancer
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Chen et al., 1999, Cellular pharmacology of MTA: a correlation of MTA-induced cellular toxicity and in vitro enzyme inhibition with its effect on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells., Semin. Oncol.
Ferguson et al., 1999, Antisense down-regulation of thymidylate synthase to suppress growth and enhance cytotoxicity of 5-FUdR, 5-FU and Tomudex in HeLa cells., Br. J. Pharmacol.
Yang et al., 2008, DNA damage and homologous recombination signaling induced by thymidylate deprivation., Biochem. Pharmacol.
Grem et al., 1999, A Phase I study of raltitrexed, an antifolate thymidylate synthase inhibitor, in adult patients with advanced solid tumors., Clin. Cancer Res.
Yin et al., 1999, Cyclin E-cdk2 activation is associated with cell cycle arrest and inhibition of DNA replication induced by the thymidylate synthase inhibitor Tomudex., Exp. Cell Res.
Salgado J et al., 2007, Polymorphisms in the thymidylate synthase and dihydropyrimidine dehydrogenase genes predict response and toxicity to capecitabine-raltitrexed in colorectal cancer., Oncol Rep
Suzuki et al., Effects of tamoxifen on mammary tumors and bone in 7,12-dimethylbenz-(a)anthracene-treated rats., Anticancer Res.
Barbour et al., 1988, Glucocorticoid regulation of the genes encoding thymidine kinase, thymidylate synthase, and ornithine decarboxylase in P1798 cells., Mol. Endocrinol.
James HM et al., 2008, Common polymorphisms in the folate pathway predict efficacy of combination regimens containing methotrexate and sulfasalazine in early rheumatoid arthritis., J Rheumatol
FitzGerald et al., 1987, Inhibition of thymidylate synthase in intact L1210 cells by ara-C, daunomycin, hydroxyurea and 3,4-dihydroxybenzylamine., Anticancer Drug Des.
Newman et al., 1988, Mechanisms of cross-resistance to methotrexate and 5-fluorouracil in an A2780 human ovarian carcinoma cell subline resistant to cisplatin., Biochem. Pharmacol.
Goldstein S et al., 1984, Interaction of N4-hydroxy-2'-deoxycytidylic acid with thymidylate synthetase., J Med Chem
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Lee MN et al., 2015, Impact of Genetic Polymorphisms on 6-Thioguanine Nucleotide Levels and Toxicity in Pediatric Patients with IBD Treated with Azathioprine., Inflamm Bowel Dis
Kubota, 1999, [Theoretical basis for low-dose CDDP/5-FU therapy]., Gan To Kagaku Ryoho
Murakami et al., 2000, Different mechanisms of acquired resistance to fluorinated pyrimidines in human colorectal cancer cells., Int. J. Oncol.
Kuwa et al., Effects of a low dose leucovorin with 5-fluorouracil derivative on colorectal tumors induced with 1,2-dimethylhydrazine in rats., Anticancer Res.
Kuwa et al., Effects of long-term administration of UFT plus leucovorin on colorectal tumors induced with 1,2-dimethylhydrazine in rats., Anticancer Res.
Voeller et al., 2000, Identification and proposed mechanism of action of thymidine kinase inhibition associated with cellular exposure to camptothecin analogs., Cancer Chemother. Pharmacol.
Joerger M et al., 2015, Germline TYMS genotype is highly predictive in patients with metastatic gastrointestinal malignancies receiving capecitabine-based chemotherapy., Cancer Chemother Pharmacol
Berne et al., 1988, Inhibition of thymidylate synthase after administration of doxifluridine in a transplantable colon carcinoma in the rat., Cancer Invest.
Nakata et al., 1985, Alpha-adrenergic regulation of the activity of thymidylate synthetase and thymidine kinase during liver regeneration after partial hepatectomy., Eur. J. Pharmacol.
Visani G et al., 2018, MTHFR, TS and XRCC1 genetic variants may affect survival in patients with myelodysplastic syndromes treated with supportive care or azacitidine., Pharmacogenomics J
Cao et al., 2000, alpha-fluoro-beta-alanine: effects on the antitumor activity and toxicity of 5-fluorouracil., Biochem. Pharmacol.
Kamm et al., 2003, Correlation between 5-fluorouracil metabolism and treatment response in two variants of C26 murine colon carcinoma., Br. J. Cancer
Tsukamoto et al., 1989, Effect of colchicine and vincristine on DNA synthesis in regenerating rat liver., Biochim. Biophys. Acta
Tsukamoto et al., 1987, Effect of calcium channel blockers and trifluoperazine on rat liver regeneration., Eur. J. Pharmacol.

DEOXYURIDINE MONOPHOSPHATE TYMS

Interaction Score: 8.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6434741 17139284 17016423 10592235

Sources:
DTC
THYMIDINE MONOPHOSPHATE TYMS

Interaction Score: 6.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6434741 17139284 17016423

Sources:
DTC
RALTITREXED TYMS

Interaction Score: 3.58

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name raltitrexed, ZD-1694,Tomudex

PMIDs:
10430100 10496350 10592235 10598555 10482907 18773878 10499608 11752352 10047461 17203168 16456808 15353299

Sources:
TdgClinicalTrial TEND PharmGKB
CARBOGEN TYMS

Interaction Score: 3.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12915890

Sources:
NCI
DOXIFLURIDINE TYMS

Interaction Score: 3.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2972339

Sources:
NCI
PEMETREXED TYMS

Interaction Score: 2.27

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Alimta

Novel drug target Established target

Trial Name -

PMIDs:
21367480 23645741 23060591 26502926 11531245 12571811 11524555 11252887 12023793 15795320 11752352 11763166 11848474 14596699 11742712

Sources:
ClearityFoundationBiomarkers TdgClinicalTrial TEND CIViC
ENILURACIL TYMS

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10692560

Sources:
NCI
ARFOLITIXORIN TYMS

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Modufolin

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
OSI-7904 TYMS

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name OSI-7904L

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
FLOXURIDINE TYMS

Interaction Score: 1.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name CPX-1

Mechanism of Interaction Thymidylate synthase inhibitor

PMIDs:
10553409 10482907 10891536 10697524 10697523

Sources:
TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions TEND
TEGAFUR TYMS

Interaction Score: 0.42

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name UFT

Novel drug target Established target

Trial Name S-1, TS1

PMIDs:
None found

Sources:
TdgClinicalTrial
CAPECITABINE TYMS

Interaction Score: 0.42

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thymidylate synthase inhibitor

Direct Interaction yes

PMIDs:
16926630 15709193 15866500 11752352 15132128 15134221

Sources:
ClearityFoundationBiomarkers ClearityFoundationClinicalTrial ChemblInteractions
PHENTOLAMINE TYMS

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2866100

Sources:
NCI
9-AMINOCAMPTOTHECIN TYMS

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10803925

Sources:
NCI
HYDROXYCHLOROQUINE TYMS

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18322994

Sources:
PharmGKB
PLATINUM TYMS

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25677447

Sources:
PharmGKB
TOPOTECAN TYMS

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10803925

Sources:
NCI
FLUOROURACIL TYMS

Interaction Score: 0.22

Interaction Types & Directionality:

other/unknown

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thymidylate synthase inhibitor

Direct Interaction yes

PMIDs:
24450514 16563096 16609021 16596248 16538493 16719540 11752352 15353299 20628391 25544046

Sources:
DTC ClearityFoundationClinicalTrial ChemblInteractions CIViC
IRINOTECAN TYMS

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21273624 16456808 20628391

Sources:
CIViC PharmGKB
SULFASALAZINE TYMS

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18322994

Sources:
PharmGKB
RESERPINE TYMS

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2866100

Sources:
NCI
AZATHIOPRINE TYMS

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26332308

Sources:
PharmGKB
LEUCOVORIN TYMS

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Fusilev

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
ASPARAGINASE TYMS

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
VERAPAMIL TYMS

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3436366

Sources:
NCI
AZACITIDINE TYMS

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29205204

Sources:
PharmGKB
INDOMETHACIN TYMS

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2707640

Sources:
NCI
HYDROCORTISONE TYMS

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2707640

Sources:
NCI
DEXAMETHASONE TYMS

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3398844 2707640

Sources:
NCI PharmGKB
DAUNORUBICIN TYMS

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2967076

Sources:
NCI PharmGKB
VINCRISTINE TYMS

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2804079

Sources:
NCI
TAMOXIFEN TYMS

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9615734

Sources:
NCI
PREDNISONE TYMS

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
METHOTREXATE TYMS

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
23652803 24284432

Sources:
CIViC
CYTARABINE TYMS

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ETOPOSIDE TYMS

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CISPLATIN TYMS

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3337743

Sources:
NCI

Ensembl: ENSG00000176890
- Version: 101_38
Alternate Names:

TYMS Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P04818
- Version: 11-September-2012
Alternate Names:

ENSG00000176890 Ensembl Gene Id

7298 Entrez Gene Id

P04818 Uniprot Accession

Gene Info:

Interpro Short Name Thymidylate_synthase

Human Readable Name DRUGGABLE GENOME

Interpro Name Thymidylate synthase

Gene Categories:

DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000176890
- Version: 26-July-2011
Alternate Names:

ENSG00000176890 Ensembl Gene Id

TYMS Display Id

THYMIDYLATE SYNTHASE (EC 2.1.1.45) (TS) (TSASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P04818] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P04818
- Version: January-2014
Alternate Names:

TYMS Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.1.1.45

Publications:
TEND: P04818
- Version: 01-August-2011
Alternate Names:

TYMS Gene Symbol

7298 Entrez Gene Id

ENSG00000176890 Ensembl Gene Id

Gene Info:

Target Main Class Enzymes

Target Subclass 2.1.1.45

Publications:

PharmGKB: TYMS

Version: 18-August-2020

Alternate Names:

PA359 PharmGKB ID

Gene Info:

Publications:

James HM et al., 2008, Common polymorphisms in the folate pathway predict efficacy of combination regimens containing methotrexate and sulfasalazine in early rheumatoid arthritis., J Rheumatol

Joerger M et al., 2015, Germline TYMS genotype is highly predictive in patients with metastatic gastrointestinal malignancies receiving capecitabine-based chemotherapy., Cancer Chemother Pharmacol

Visani G et al., 2018, MTHFR, TS and XRCC1 genetic variants may affect survival in patients with myelodysplastic syndromes treated with supportive care or azacitidine., Pharmacogenomics J

CIViC: TYMS

Version: 14-September-2020

Alternate Names:

7298 Entrez Gene ID

5971 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Kasai et al., 2013, Thymidylate synthase gene copy number as a predictive marker for response to pemetrexed treatment of lung adenocarcinoma., Anticancer Res.

Shimizu et al., 2012, Association between expression of thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase and efficacy of pemetrexed in advanced non-small cell lung cancer., Anticancer Res.

Chen et al., 2011, Thymidylate synthase and dihydrofolate reductase expression in non-small cell lung carcinoma: the association with treatment efficacy of pemetrexed., Lung Cancer

NCI: TYMS

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Tsukamoto et al., 1989, Effect of glucocorticoid on liver regeneration after partial hepatectomy in the rat., Gut

Voeller et al., 2000, Identification and proposed mechanism of action of thymidine kinase inhibition associated with cellular exposure to camptothecin analogs., Cancer Chemother. Pharmacol.

Barbour et al., 1988, Glucocorticoid regulation of the genes encoding thymidine kinase, thymidylate synthase, and ornithine decarboxylase in P1798 cells., Mol. Endocrinol.

DTC: TYMS

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Pelà M et al., 2014, Optimization of peptides that target human thymidylate synthase to inhibit ovarian cancer cell growth., J Med Chem

Goldstein S et al., 1984, Interaction of N4-hydroxy-2'-deoxycytidylic acid with thymidylate synthetase., J Med Chem

HingoraniCasas: ENSG00000176890
- Version: 31-May-2017
Alternate Names:

ENSG00000176890 Gene Symbol

TYMS Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: TS
- Version: chembl_23
Alternate Names:

TS GENE_SYMBOL

TYMS GENE_SYMBOL

Thymidylate synthase UNIPROT

Gene Info:

Publications:
Tempus: TYMS
- Version: 11-November-2018
Alternate Names:

TYMS Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
TTD: Thymidylate synthase
- Version: 2020.06.01
Alternate Names:

TYMS TTD Gene Abbreviation

T98397 TTD Target ID

Gene Info:

Publications:
Pharos: TYMS
- Version: 01-February-2022
Alternate Names:

Thymidylate synthase Gene Name

P04818 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
ClearityFoundationClinicalTrial: TYMS
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:
ClearityFoundationBiomarkers: TYMS
- Version: 26-July-2013
Alternate Names:

Gene Info:

Publications:

Novel drug target	Established target
Trial Name	raltitrexed, ZD-1694,Tomudex

Trial Name	Alimta
Novel drug target	Established target
Trial Name	-

Mechanism of Interaction	Thymidylate synthase inhibitor
Direct Interaction	yes

ENSG00000176890	Ensembl Gene Id
7298	Entrez Gene Id
P04818	Uniprot Accession

TYMS	Gene Symbol
7298	Entrez Gene Id
ENSG00000176890	Ensembl Gene Id

other/unknown
inhibitor (inhibitory)

TYMS Gene Record

TYMS 7298 Druggable GenomeDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6434741 17139284 17016423 10592235

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6434741 17139284 17016423

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name raltitrexed, ZD-1694,Tomudex

PMIDs: 10430100 10496350 10592235 10598555 10482907 18773878 10499608 11752352 10047461 17203168 16456808 15353299

Sources: TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12915890

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2972339

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Alimta Novel drug target Established target Trial Name -

PMIDs: 21367480 23645741 23060591 26502926 11531245 12571811 11524555 11252887 12023793 15795320 11752352 11763166 11848474 14596699 11742712

Sources: ClearityFoundationBiomarkers TdgClinicalTrial TEND CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10692560

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Modufolin Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name OSI-7904L Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name CPX-1 Mechanism of Interaction Thymidylate synthase inhibitor

PMIDs: 10553409 10482907 10891536 10697524 10697523

Sources: TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name UFT Novel drug target Established target Trial Name S-1, TS1

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Thymidylate synthase inhibitor Direct Interaction yes

PMIDs: 16926630 15709193 15866500 11752352 15132128 15134221

Sources: ClearityFoundationBiomarkers ClearityFoundationClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2866100

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10803925

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18322994

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25677447

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10803925

Sources: NCI

Interaction Types & Directionality: other/unknown inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Thymidylate synthase inhibitor Direct Interaction yes

PMIDs: 24450514 16563096 16609021 16596248 16538493 16719540 11752352 15353299 20628391 25544046

Sources: DTC ClearityFoundationClinicalTrial ChemblInteractions CIViC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
6434741 17139284 17016423 10592235

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
6434741 17139284 17016423

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name raltitrexed, ZD-1694,Tomudex

PMIDs:
10430100 10496350 10592235 10598555 10482907 18773878 10499608 11752352 10047461 17203168 16456808 15353299

Sources:
TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
12915890

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2972339

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Alimta

Novel drug target Established target

Trial Name -

PMIDs:
21367480 23645741 23060591 26502926 11531245 12571811 11524555 11252887 12023793 15795320 11752352 11763166 11848474 14596699 11742712

Sources:
ClearityFoundationBiomarkers TdgClinicalTrial TEND CIViC

Interaction Types & Directionality:

n/a

PMIDs:
10692560

Sources:
NCI

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Modufolin

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name OSI-7904L

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name CPX-1

Mechanism of Interaction Thymidylate synthase inhibitor

PMIDs:
10553409 10482907 10891536 10697524 10697523

Sources:
TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name UFT

Novel drug target Established target

Trial Name S-1, TS1

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thymidylate synthase inhibitor

Direct Interaction yes

PMIDs:
16926630 15709193 15866500 11752352 15132128 15134221

Sources:
ClearityFoundationBiomarkers ClearityFoundationClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
2866100

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10803925

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18322994

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
25677447

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
10803925

Sources:
NCI

Interaction Types & Directionality:

other/unknown

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thymidylate synthase inhibitor

Direct Interaction yes

PMIDs:
24450514 16563096 16609021 16596248 16538493 16719540 11752352 15353299 20628391 25544046

Sources:
DTC ClearityFoundationClinicalTrial ChemblInteractions CIViC

Interaction Types & Directionality:

n/a

PMIDs:
21273624 16456808 20628391

Sources:
CIViC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
18322994

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
2866100

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
26332308

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Fusilev

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found