DGIdb - TYR Gene Record

TYR 7299 Druggable Genome

Alternate Names:

7299
TYROSINASE
TYR
ATN
CMM8
OCA1
OCA1A
OCAIA
SHEP3
606933
12442
ENSG00000077498
OTTHUMG00000167294
Tumor rejection antigen AB
SK29-AB
LB24-AB
Monophenol monooxygenase
TYROSINASE PRECURSOR (EC 1.14.18.1) (MONOPHENOL MONOOXYGENASE) (TUMOR REJECTION ANTIGEN AB) (SK29-AB) (LB24-AB). [SOURCE:UNIPROT/SWISSPROT;ACC:P14679]
P14679
BE0000252
T97035
NP_000363
NM_000372
2643

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	1.-.-.- Oxidoreductases
GuideToPharmacology Gene Category ID	840

(5 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Chen et al., 2009, Identification of an Alkylhydroquinone from Rhus succedanea as an Inhibitor of Tyrosinase and Melanogenesis., J. Agric. Food Chem.
Yoshimori A et al., 2014, Structure-activity relationships of the thujaplicins for inhibition of human tyrosinase., Bioorg Med Chem
Patil et al., 2016, Interaction of small molecules with human tyrosinase: A surface plasmon resonance and molecular docking study., Int. J. Biol. Macromol.
Wang HM et al., 2010, (-)-N-Formylanonaine from Michelia alba as a human tyrosinase inhibitor and antioxidant., Bioorg Med Chem
Zafar et al., 2006, A potential role for cyclized quinones derived from dopamine, DOPA, and 3,4-dihydroxyphenylacetic acid in proteasomal inhibition., Mol. Pharmacol.
Jadhav et al., 2007, Decolourization of azo dye methyl red by Saccharomyces cerevisiae MTCC 463., Chemosphere
Ahmad et al., 2004, Tyrosinase inhibitors from Rhododendron collettianum and their structure-activity relationship (SAR) studies., Chem. Pharm. Bull.
Sugumaran, 1986, Tyrosinase catalyzes an unusual oxidative decarboxylation of 3,4-dihydroxymandelate., Biochemistry
Woolery et al., 1984, Extended X-ray absorption fine structure study of the coupled binuclear copper active site of tyrosinase from Neurospora crassa., Biochim. Biophys. Acta
Khan et al., 2006, Oxazolones: new tyrosinase inhibitors; synthesis and their structure-activity relationships., Bioorg. Med. Chem.
Potter E et al., 2015, Investigation of fatty acid conjugates of 3,5-bisarylmethylene-4-piperidone derivatives as antitumor agents and human topoisomerase-IIα inhibitors., Bioorg Med Chem
Chakraborty AK et al., 1998, Effect of arbutin on melanogenic proteins in human melanocytes., Pigment Cell Res
Maeda K et al., 1996, Arbutin: mechanism of its depigmenting action in human melanocyte culture., J Pharmacol Exp Ther

ARBUTIN TYR

Interaction Score: 14.2

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
9711535 8632348

Sources:
DrugBank
PHENYLTHIOUREA TYR

Interaction Score: 9.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20584613

Sources:
DTC
ALPHA-THUJAPLICIN TYR

Interaction Score: 9.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25288494

Sources:
DTC
MIMOSINE TYR

Interaction Score: 7.89

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
15577244 3094574 6234942 16750372

Sources:
DrugBank
KOJIC ACID TYR

Interaction Score: 7.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20584613 25577711

Sources:
DTC
MONOBENZONE TYR

Interaction Score: 6.31

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tyrosinase inhibitor

PMIDs:
19159217

Sources:
DrugBank ChemblInteractions TTD
MEQUINOL TYR

Interaction Score: 4.73

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tyrosinase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HYDROQUINONE TYR

Interaction Score: 0.84

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
27519292

Sources:
DrugBank TTD
HEXYLRESORCINOL TYR

Interaction Score: 0.68

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
CHRYSIN TYR

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LUTEOLIN TYR

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1161866 TYR

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16790533 17292452

Sources:
DrugBank

Ensembl: ENSG00000077498
- Version: 101_38
Alternate Names:

TYR Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000077498

Version: 26-July-2011

Alternate Names:

TYR Display Id

ENSG00000077498 Ensembl Gene Id

TYROSINASE PRECURSOR (EC 1.14.18.1) (MONOPHENOL MONOOXYGENASE) (TUMOR REJECTION ANTIGEN AB) (SK29-AB) (LB24-AB). [SOURCE:UNIPROT/SWISSPROT;ACC:P14679] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

GuideToPharmacology: 7299
- Version: 29-September-2020
Alternate Names:

12442 HUGO Gene ID

12442 HUGO Gene Symbol

tyrosinase HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name 1.-.-.- Oxidoreductases

GuideToPharmacology Gene Category ID 840

Gene Categories:

ENZYME

Publications:

DrugBank: BE0000252

Version: 5.1.7

Alternate Names:

TYR DrugBank Gene Name

P14679 UniProt Accession

7299 Entrez Gene Id

Gene Info:

Publications:

Zafar et al., 2006, A potential role for cyclized quinones derived from dopamine, DOPA, and 3,4-dihydroxyphenylacetic acid in proteasomal inhibition., Mol. Pharmacol.

Jadhav et al., 2007, Decolourization of azo dye methyl red by Saccharomyces cerevisiae MTCC 463., Chemosphere

Picardo et al., 1985, Activity of azelaic acid on cultures of lymphoma- and leukemia-derived cell lines, normal resting and stimulated lymphocytes and 3T3 fibroblasts., Biochem. Pharmacol.

TTD: Tyrosinase

Version: 2020.06.01

Alternate Names:

TYR TTD Gene Abbreviation

T97035 TTD Target ID

Gene Info:

Publications:

Tarhini AA et al., 2012, Safety and immunogenicity of vaccination with MART-1 (26-35, 27L), gp100 (209-217, 210M), and tyrosinase (368-376, 370D) in adjuvant with PF-3512676 and GM-CSF in metastatic melanoma., J Immunother

DTC: TYR

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Wang HM et al., 2010, (-)-N-Formylanonaine from Michelia alba as a human tyrosinase inhibitor and antioxidant., Bioorg Med Chem

Potter E et al., 2015, Investigation of fatty acid conjugates of 3,5-bisarylmethylene-4-piperidone derivatives as antitumor agents and human topoisomerase-IIα inhibitors., Bioorg Med Chem

Yoshimori A et al., 2014, Structure-activity relationships of the thujaplicins for inhibition of human tyrosinase., Bioorg Med Chem

ChemblInteractions: TYR
- Version: chembl_23
Alternate Names:

TYR GENE_SYMBOL

Tyrosinase UNIPROT

LB24-AB UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000077498
- Version: 31-May-2017
Alternate Names:

ENSG00000077498 Gene Symbol

TYR Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: TYR
- Version: 03-September-2020
Alternate Names:

Tyrosinase Gene Name

P14679 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

Direct Interaction	yes
Mechanism of Interaction	Tyrosinase inhibitor

TYR	Display Id
ENSG00000077498	Ensembl Gene Id
TYROSINASE PRECURSOR (EC 1.14.18.1) (MONOPHENOL MONOOXYGENASE) (TUMOR REJECTION ANTIGEN AB) (SK29-AB) (LB24-AB). [SOURCE:UNIPROT/SWISSPROT;ACC:P14679]	Description

12442	HUGO Gene ID
12442	HUGO Gene Symbol
tyrosinase	HUGO Gene Name

TYR	DrugBank Gene Name
P14679	UniProt Accession
7299	Entrez Gene Id

TYR Gene Record

TYR 7299 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 9711535 8632348

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20584613

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25288494

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 15577244 3094574 6234942 16750372

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20584613 25577711

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Tyrosinase inhibitor

PMIDs: 19159217

Sources: DrugBank ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tyrosinase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 27519292

Sources: DrugBank TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16790533 17292452

Sources: DrugBank

Ensembl: ENSG00000077498

Alternate Names: TYR Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000077498

Alternate Names: TYR Display Id ENSG00000077498 Ensembl Gene Id TYROSINASE PRECURSOR (EC 1.14.18.1) (MONOPHENOL MONOOXYGENASE) (TUMOR REJECTION ANTIGEN AB) (SK29-AB) (LB24-AB). [SOURCE:UNIPROT/SWISSPROT;ACC:P14679] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

GuideToPharmacology: 7299

Alternate Names: 12442 HUGO Gene ID 12442 HUGO Gene Symbol tyrosinase HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name 1.-.-.- Oxidoreductases GuideToPharmacology Gene Category ID 840

Gene Categories: ENZYME

Publications:

DrugBank: BE0000252

Alternate Names: TYR DrugBank Gene Name P14679 UniProt Accession 7299 Entrez Gene Id

Gene Info:

TTD: Tyrosinase

Alternate Names: TYR TTD Gene Abbreviation T97035 TTD Target ID

Gene Info:

Publications: Tarhini AA et al., 2012, Safety and immunogenicity of vaccination with MART-1 (26-35, 27L), gp100 (209-217, 210M), and tyrosinase (368-376, 370D) in adjuvant with PF-3512676 and GM-CSF in metastatic melanoma., J Immunother

DTC: TYR

Alternate Names:

Gene Info:

ChemblInteractions: TYR

Alternate Names: TYR GENE_SYMBOL Tyrosinase UNIPROT LB24-AB UNIPROT

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
9711535 8632348

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
20584613

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25288494

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
15577244 3094574 6234942 16750372

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
20584613 25577711

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tyrosinase inhibitor

PMIDs:
19159217

Sources:
DrugBank ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tyrosinase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
27519292

Sources:
DrugBank TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16790533 17292452

Sources:
DrugBank

Alternate Names:

TYR Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

TYR Display Id

ENSG00000077498 Ensembl Gene Id

TYROSINASE PRECURSOR (EC 1.14.18.1) (MONOPHENOL MONOOXYGENASE) (TUMOR REJECTION ANTIGEN AB) (SK29-AB) (LB24-AB). [SOURCE:UNIPROT/SWISSPROT;ACC:P14679] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

12442 HUGO Gene ID

12442 HUGO Gene Symbol

tyrosinase HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name 1.-.-.- Oxidoreductases

GuideToPharmacology Gene Category ID 840

Gene Categories:

ENZYME

Alternate Names:

TYR DrugBank Gene Name

P14679 UniProt Accession

7299 Entrez Gene Id

Alternate Names:

TYR TTD Gene Abbreviation

T97035 TTD Target ID

Publications:

Tarhini AA et al., 2012, Safety and immunogenicity of vaccination with MART-1 (26-35, 27L), gp100 (209-217, 210M), and tyrosinase (368-376, 370D) in adjuvant with PF-3512676 and GM-CSF in metastatic melanoma., J Immunother

Alternate Names:

TYR GENE_SYMBOL

Tyrosinase UNIPROT

LB24-AB UNIPROT

Alternate Names:

ENSG00000077498 Gene Symbol

TYR Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

Tyrosinase Gene Name

P14679 UniProt ID

Gene Categories:

ENZYME