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TYR Gene Record

  • Summary
  • Interactions
  • Claims
  • TYR 7299 Druggable Genome

    Alternate Names:

    7299
    TYROSINASE
    TYR
    ATN
    CMM8
    OCA1
    OCA1A
    OCAIA
    SHEP3
    606933
    12442
    ENSG00000077498
    OTTHUMG00000167294
    Tumor rejection antigen AB
    SK29-AB
    LB24-AB
    Monophenol monooxygenase
    TYROSINASE PRECURSOR (EC 1.14.18.1) (MONOPHENOL MONOOXYGENASE) (TUMOR REJECTION ANTIGEN AB) (SK29-AB) (LB24-AB). [SOURCE:UNIPROT/SWISSPROT;ACC:P14679]
    P14679
    BE0000252
    T97035
    NP_000363
    NM_000372
    2643

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name 1.-.-.- Oxidoreductases
    GuideToPharmacology Gene Category ID 840
    (5 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Chen et al., 2009, Identification of an Alkylhydroquinone from Rhus succedanea as an Inhibitor of Tyrosinase and Melanogenesis., J. Agric. Food Chem.
    Yoshimori A et al., 2014, Structure-activity relationships of the thujaplicins for inhibition of human tyrosinase., Bioorg Med Chem
    Patil et al., 2016, Interaction of small molecules with human tyrosinase: A surface plasmon resonance and molecular docking study., Int. J. Biol. Macromol.
    Wang HM et al., 2010, (-)-N-Formylanonaine from Michelia alba as a human tyrosinase inhibitor and antioxidant., Bioorg Med Chem
    Zafar et al., 2006, A potential role for cyclized quinones derived from dopamine, DOPA, and 3,4-dihydroxyphenylacetic acid in proteasomal inhibition., Mol. Pharmacol.
    Jadhav et al., 2007, Decolourization of azo dye methyl red by Saccharomyces cerevisiae MTCC 463., Chemosphere
    Khan et al., 2006, Oxazolones: new tyrosinase inhibitors; synthesis and their structure-activity relationships., Bioorg. Med. Chem.
    Woolery et al., 1984, Extended X-ray absorption fine structure study of the coupled binuclear copper active site of tyrosinase from Neurospora crassa., Biochim. Biophys. Acta
    Sugumaran, 1986, Tyrosinase catalyzes an unusual oxidative decarboxylation of 3,4-dihydroxymandelate., Biochemistry
    Ahmad et al., 2004, Tyrosinase inhibitors from Rhododendron collettianum and their structure-activity relationship (SAR) studies., Chem. Pharm. Bull.
    Potter E et al., 2015, Investigation of fatty acid conjugates of 3,5-bisarylmethylene-4-piperidone derivatives as antitumor agents and human topoisomerase-IIα inhibitors., Bioorg Med Chem
    Chakraborty AK et al., 1998, Effect of arbutin on melanogenic proteins in human melanocytes., Pigment Cell Res
    Maeda K et al., 1996, Arbutin: mechanism of its depigmenting action in human melanocyte culture., J Pharmacol Exp Ther
  • ARBUTIN   TYR

    Interaction Score: 14.2

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    9711535 8632348


    Sources:
    DrugBank

  • PHENYLTHIOUREA   TYR

    Interaction Score: 9.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20584613


    Sources:
    DTC

  • ALPHA-THUJAPLICIN   TYR

    Interaction Score: 9.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25288494


    Sources:
    DTC

  • MIMOSINE   TYR

    Interaction Score: 7.89

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    16750372 6234942 3094574 15577244


    Sources:
    DrugBank

  • KOJIC ACID   TYR

    Interaction Score: 7.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25577711 20584613


    Sources:
    DTC

  • MONOBENZONE   TYR

    Interaction Score: 6.31

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tyrosinase inhibitor

    PMIDs:
    19159217


    Sources:
    TTD DrugBank ChemblInteractions

  • MEQUINOL   TYR

    Interaction Score: 4.73

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tyrosinase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • HYDROQUINONE   TYR

    Interaction Score: 0.84

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    27519292


    Sources:
    TTD DrugBank

  • HEXYLRESORCINOL   TYR

    Interaction Score: 0.68

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • CHRYSIN   TYR

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LUTEOLIN   TYR

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL1161866   TYR

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16790533 17292452


    Sources:
    DrugBank

  • Ensembl: ENSG00000077498

    • Version: 101_38

    Alternate Names:
    TYR Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000077498

    • Version: 26-July-2011

    Alternate Names:
    TYR Display Id
    ENSG00000077498 Ensembl Gene Id
    TYROSINASE PRECURSOR (EC 1.14.18.1) (MONOPHENOL MONOOXYGENASE) (TUMOR REJECTION ANTIGEN AB) (SK29-AB) (LB24-AB). [SOURCE:UNIPROT/SWISSPROT;ACC:P14679] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 7299

    • Version: 29-September-2020

    Alternate Names:
    12442 HUGO Gene ID
    12442 HUGO Gene Symbol
    tyrosinase HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name 1.-.-.- Oxidoreductases
    GuideToPharmacology Gene Category ID 840

    Gene Categories:
    ENZYME

    Publications:

  • DrugBank: BE0000252

    • Version: 5.1.7

    Alternate Names:
    TYR DrugBank Gene Name
    P14679 UniProt Accession
    7299 Entrez Gene Id

    Gene Info:

    Publications:
    Zafar et al., 2006, A potential role for cyclized quinones derived from dopamine, DOPA, and 3,4-dihydroxyphenylacetic acid in proteasomal inhibition., Mol. Pharmacol.
    Jadhav et al., 2007, Decolourization of azo dye methyl red by Saccharomyces cerevisiae MTCC 463., Chemosphere
    Schallreuter et al., 1990, A possible mechanism of action for azelaic acid in the human epidermis., Arch. Dermatol. Res.

  • TTD: Tyrosinase

    • Version: 2020.06.01

    Alternate Names:
    TYR TTD Gene Abbreviation
    T97035 TTD Target ID

    Gene Info:

    Publications:
    Tarhini AA et al., 2012, Safety and immunogenicity of vaccination with MART-1 (26-35, 27L), gp100 (209-217, 210M), and tyrosinase (368-376, 370D) in adjuvant with PF-3512676 and GM-CSF in metastatic melanoma., J Immunother

  • DTC: TYR

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Wang HM et al., 2010, (-)-N-Formylanonaine from Michelia alba as a human tyrosinase inhibitor and antioxidant., Bioorg Med Chem
    Potter E et al., 2015, Investigation of fatty acid conjugates of 3,5-bisarylmethylene-4-piperidone derivatives as antitumor agents and human topoisomerase-IIα inhibitors., Bioorg Med Chem
    Yoshimori A et al., 2014, Structure-activity relationships of the thujaplicins for inhibition of human tyrosinase., Bioorg Med Chem

  • ChemblInteractions: TYR

    • Version: chembl_23

    Alternate Names:
    TYR GENE_SYMBOL
    Tyrosinase UNIPROT
    LB24-AB UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000077498

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000077498 Gene Symbol
    TYR Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: TYR

    • Version: 03-September-2020

    Alternate Names:
    Tyrosinase Gene Name
    P14679 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21