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UCP1 Gene Record

  • Summary
  • Interactions
  • Claims
  • UCP1 7350 Druggable Genome

    Alternate Names:

    7350
    UNCOUPLING PROTEIN 1
    UCP1
    SLC25A7
    UCP
    113730
    12517
    ENSG00000109424
    OTTHUMG00000133415
    P25874
    MITOCHONDRIAL BROWN FAT UNCOUPLING PROTEIN 1 (UCP 1) (THERMOGENIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P25874]
    Mitochondrial uncoupling protein 1
    T88729
    Mitochondrial brown fat uncoupling protein 1

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    ION CHANNEL
    DRUGGABLE GENOME

    Publications:

    Burcelin et al., 1993, Changes in uncoupling protein and GLUT4 glucose transporter expressions in interscapular brown adipose tissue of diabetic rats: relative roles of hyperglycaemia and hypoinsulinaemia., Biochem. J.
    Sivitz et al., 1999, Sympathetic inhibition, leptin, and uncoupling protein subtype expression in normal fasting rats., Am. J. Physiol.
    Urhammer et al., 1997, Studies of genetic variability of the uncoupling protein 1 gene in Caucasian subjects with juvenile-onset obesity., J. Clin. Endocrinol. Metab.
    Urhammer et al., 2000, Studies of the synergistic effect of the Trp/Arg64 polymorphism of the beta3-adrenergic receptor gene and the -3826 A-->G variant of the uncoupling protein-1 gene on features of obesity and insulin resistance in a population-based sample of 379 young Danish subjects., J. Clin. Endocrinol. Metab.
  • METYROSINE   UCP1

    Interaction Score: 3.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10516126


    Sources:
    NCI

  • INSULIN   UCP1

    Interaction Score: 1.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9398715 10999801


    Sources:
    NCI

  • STREPTOZOCIN   UCP1

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8471028


    Sources:
    NCI

  • Ensembl: ENSG00000109424

    • Version: 101_38

    Alternate Names:
    UCP1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000109424

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000109424 Ensembl Gene Id
    UCP1 Display Id
    MITOCHONDRIAL BROWN FAT UNCOUPLING PROTEIN 1 (UCP 1) (THERMOGENIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P25874] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • NCI: UCP1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Sivitz et al., 1999, Sympathetic inhibition, leptin, and uncoupling protein subtype expression in normal fasting rats., Am. J. Physiol.
    Urhammer et al., 1997, Studies of genetic variability of the uncoupling protein 1 gene in Caucasian subjects with juvenile-onset obesity., J. Clin. Endocrinol. Metab.
    Urhammer et al., 2000, Studies of the synergistic effect of the Trp/Arg64 polymorphism of the beta3-adrenergic receptor gene and the -3826 A-->G variant of the uncoupling protein-1 gene on features of obesity and insulin resistance in a population-based sample of 379 young Danish subjects., J. Clin. Endocrinol. Metab.

  • TTD: Mitochondrial uncoupling protein 1

    • Version: 2020.06.01

    Alternate Names:
    UCP1 TTD Gene Abbreviation
    T88729 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: UCP1

    • Version: 01-February-2022

    Alternate Names:
    Mitochondrial brown fat uncoupling protein 1 Gene Name
    P25874 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER, ION CHANNEL

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21