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UMPS Gene Record

  • Summary
  • Interactions
  • Claims
  • UMPS 7372 Druggable Genome

    Alternate Names:

    7372
    URIDINE MONOPHOSPHATE SYNTHETASE
    UMPS
    OPRT
    613891
    12563
    ENSG00000114491
    OTTHUMG00000159431
    UMPS_HUMAN
    P11172
    URIDINE 5'-MONOPHOSPHATE SYNTHASE (UMP SYNTHASE) [INCLUDES: OROTATE PHOSPHORIBOSYLTRANSFERASE (EC 2.4.2.10) (OPRTASE); OROTIDINE 5'- PHOSPHATE DECARBOXYLASE (EC 4.1.1.23) (OMPDECASE)]. [SOURCE:UNIPROT/SWISSPROT;ACC:P11172]
    OROTATE PHOSPHORIBOSYLTRANSFERASE
    PA363
    Uridine 5'-monophosphate synthase

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Type Domain
    Interpro Short Name PRibTrfase
    Uniprot Status Swiss-Prot
    Interpro Acc IPR000836
    Interpro Name Phosphoribosyltransferase
    Uniprot Evidence 1: Evidence at protein level
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Pellicer M et al., 2017, Identification of new SNPs associated with severe toxicity to capecitabine., Pharmacol Res
    Tsunoda A et al., 2011, Associations of various gene polymorphisms with toxicity in colorectal cancer patients receiving oral uracil and tegafur plus leucovorin: a prospective study., Ann Oncol
    Ichikawa W et al., 2006, Orotate phosphoribosyltransferase gene polymorphism predicts toxicity in patients treated with bolus 5-fluorouracil regimen., Clin Cancer Res
    Meza-Avina ME et al., 2010, Structural determinants for the inhibitory ligands of orotidine-5'-monophosphate decarboxylase., Bioorg Med Chem
  • CHEMBL1164954   UMPS

    Interaction Score: 24.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20452222


    Sources:
    DTC

  • TEGAFUR   UMPS

    Interaction Score: 9.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20647221 16818689


    Sources:
    PharmGKB

  • CAPECITABINE   UMPS

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28347776 20647221 16818689


    Sources:
    PharmGKB

  • LEUCOVORIN   UMPS

    Interaction Score: 1.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20647221 16818689


    Sources:
    PharmGKB

  • FLUOROURACIL   UMPS

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20647221 16818689


    Sources:
    PharmGKB

  • Ensembl: ENSG00000114491

    • Version: 101_38

    Alternate Names:
    UMPS Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000114491

    • Version: 26-July-2011

    Alternate Names:
    UMPS Display Id
    ENSG00000114491 Ensembl Gene Id
    URIDINE 5'-MONOPHOSPHATE SYNTHASE (UMP SYNTHASE) [INCLUDES: OROTATE PHOSPHORIBOSYLTRANSFERASE (EC 2.4.2.10) (OPRTASE); OROTIDINE 5'- PHOSPHATE DECARBOXYLASE (EC 4.1.1.23) (OMPDECASE)]. [SOURCE:UNIPROT/SWISSPROT;ACC:P11172] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P11172

    • Version: 11-September-2012

    Alternate Names:
    7372 Entrez Gene Id
    OROTATE PHOSPHORIBOSYLTRANSFERASE Uniprot Protein Name
    P11172 Uniprot Accession

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Domain
    Interpro Short Name PRibTrfase

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: UMPS

    • Version: 18-August-2020

    Alternate Names:
    PA363 PharmGKB ID

    Gene Info:

    Publications:
    Tsunoda A et al., 2011, Associations of various gene polymorphisms with toxicity in colorectal cancer patients receiving oral uracil and tegafur plus leucovorin: a prospective study., Ann Oncol
    Ichikawa W et al., 2006, Orotate phosphoribosyltransferase gene polymorphism predicts toxicity in patients treated with bolus 5-fluorouracil regimen., Clin Cancer Res
    Pellicer M et al., 2017, Identification of new SNPs associated with severe toxicity to capecitabine., Pharmacol Res

  • DTC: UMPS

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Meza-Avina ME et al., 2010, Structural determinants for the inhibitory ligands of orotidine-5'-monophosphate decarboxylase., Bioorg Med Chem

  • HingoraniCasas: ENSG00000114491

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000114491 Gene Symbol
    UMPS Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: UMPS

    • Version: 19.3

    Alternate Names:
    P11172 UniProt ID
    ENSG00000114491 Ensembl Gene ID
    Uridine monophosphate synthetase Human Protein Atlas Gene Description

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • Tempus: UMPS

    • Version: 11-November-2018

    Alternate Names:
    UMPS Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Pharos: UMPS

    • Version: 01-February-2022

    Alternate Names:
    Uridine 5'-monophosphate synthase Gene Name
    P11172 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21