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VWF Gene Record

  • Summary
  • Interactions
  • Claims
  • VWF 7450 Druggable Genome

    Alternate Names:

    7450
    VON WILLEBRAND FACTOR
    VWF
    F8VWF
    VWD
    613160
    12726
    ENSG00000110799
    OTTHUMG00000168265
    von Willebrand antigen II
    von Willebrand antigen 2
    P04275
    VON WILLEBRAND FACTOR PRECURSOR (VWF) [CONTAINS: VON WILLEBRAND ANTIGEN II]. [SOURCE:UNIPROT/SWISSPROT;ACC:P04275]
    T23348

    Gene Info:

    Target Class Miscellaneous
    Target Subclass StructuralAndAdhesion
    Target Subclass Collagen
    Target Subclass F8
    Target Subclass F2
    Human Readable Name DRUGGABLE GENOME
    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Monteagudo et al., 1990, Investigation of plasma von Willebrand factor and circulating platelet aggregating activity in mitomycin C-related hemolytic-uremic syndrome., Am. J. Hematol.
    Minnema et al., 2003, Extremely high levels of von Willebrand factor antigen and of procoagulant factor VIII found in multiple myeloma patients are associated with activity status but not with thalidomide treatment., J. Thromb. Haemost.
    Randi et al., 1992, Recombinant von Willebrand factor Arg578-->Gln. A type IIB von Willebrand disease mutation affects binding to glycoprotein Ib but not to collagen or heparin., J. Biol. Chem.
    Zhou et al., 2003, Effects of angiogenesis inhibitor TNP-470 on the development of uterine adenomyosis in mice., Fertil. Steril.
    Pui et al., 1985, Altered von Willebrand factor molecule in children with thrombosis following asparaginase-prednisone-vincristine therapy for leukemia., J. Clin. Oncol.
    Knudsen et al., 2005, Effect of intravenous N-acetylcysteine infusion on haemostatic parameters in healthy subjects., Gut
    Tranquille et al., 1991, The effect of pentoxifylline (Trental) and two analogues, BL 194 and HWA 448, on the release of plasminogen activators and von Willebrand factor in rats., J. Cardiovasc. Pharmacol.
    Hinokiyama et al., 2006, Vein graft harvesting induces inflammation and impairs vessel reactivity., Ann. Thorac. Surg.
    Winocour et al., 1985, Effect of insulin treatment in streptozocin-induced diabetic rats on in vitro platelet function and plasma von Willebrand factor activity and factor VIII-related antigen., J. Lab. Clin. Med.
    Bivalacqua et al., 2005, Superoxide anion production in the rat penis impairs erectile function in diabetes: influence of in vivo extracellular superoxide dismutase gene therapy., J Sex Med
    Lip et al., 1995, Increased markers of thrombogenesis in chronic atrial fibrillation: effects of warfarin treatment., Br Heart J
    Casonato et al., 1988, Factor VIII/von Willebrand factor abnormalities during L-asparaginase treatment in patients with acute lymphoblastic leukemia., Acta Haematol.
    Homoncik et al., 2005, Short- and long-term effects of therapy with interferon-alpha and pegylated interferon-alpha/ribavirin on platelet plug formation and von Willebrand factor release in patients with chronic hepatitis C., Aliment. Pharmacol. Ther.
  • CAPLACIZUMAB   VWF

    Interaction Score: 13.25

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction von Willebrand factor inhibitor
    Direct Interaction yes
    Trial Name ALX-0081, ALX-0681, anti-von Willebrand factor nanobodies

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • EGAPTIVON PEGOL   VWF

    Interaction Score: 4.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name ARC1779

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • O-CHLOROACETYLCARBAMOYLFUMAGILLOL   VWF

    Interaction Score: 2.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14505755


    Sources:
    NCI

  • MITOMYCIN   VWF

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2104558


    Sources:
    NCI

  • PHENYLEPHRINE   VWF

    Interaction Score: 0.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16996954


    Sources:
    NCI

  • ACETYLCYSTEINE   VWF

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15753537


    Sources:
    NCI

  • HEPARIN   VWF

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1400429


    Sources:
    NCI

  • STREPTOZOCIN   VWF

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3928783 16422885


    Sources:
    NCI

  • RIBAVIRIN   VWF

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15644045


    Sources:
    NCI

  • PREDNISONE   VWF

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3146197


    Sources:
    NCI

  • PENTOXIFYLLINE   VWF

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1719289


    Sources:
    NCI

  • THALIDOMIDE   VWF

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12871448


    Sources:
    NCI

  • WARFARIN   VWF

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7626351


    Sources:
    NCI

  • VINCRISTINE   VWF

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3875694


    Sources:
    NCI

  • Ensembl: ENSG00000110799

    • Version: 101_38

    Alternate Names:
    VWF Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000110799

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000110799 Ensembl Gene Id
    VON WILLEBRAND FACTOR PRECURSOR (VWF) [CONTAINS: VON WILLEBRAND ANTIGEN II]. [SOURCE:UNIPROT/SWISSPROT;ACC:P04275] Description
    VWF Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P04275

    • Version: January-2014

    Alternate Names:
    VWF Gene Symbol

    Gene Info:
    Target Class Miscellaneous
    Target Subclass StructuralAndAdhesion
    Target Subclass Collagen

    Publications:

  • TTD: von Willebrand factor

    • Version: 2020.06.01

    Alternate Names:
    VWF TTD Gene Abbreviation
    T23348 TTD Target ID

    Gene Info:

    Publications:
    2009, 6 Factor VIII Concentrates, Factor VIII/von Willebrand Factor Concentrates, Factor IX Concentrates, Activated Prothrombin Complex Concentrates., Transfus Med Hemother

  • NCI: VWF

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Monteagudo et al., 1990, Investigation of plasma von Willebrand factor and circulating platelet aggregating activity in mitomycin C-related hemolytic-uremic syndrome., Am. J. Hematol.
    Wheeler-Jones et al., 1996, Protein tyrosine kinases regulate agonist-stimulated prostacyclin release but not von Willebrand factor secretion from human umbilical vein endothelial cells., Biochem. J.
    Vermeulen et al., 2003, Homocysteine-lowering treatment with folic acid plus vitamin B6 lowers urinary albumin excretion but not plasma markers of endothelial function or C-reactive protein: further analysis of secondary end-points of a randomized clinical trial., Eur. J. Clin. Invest.

  • ChemblInteractions: F8VWF

    • Version: chembl_23

    Alternate Names:
    F8VWF GENE_SYMBOL
    VWF GENE_SYMBOL
    von Willebrand factor UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000110799

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000110799 Gene Symbol
    VWF Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21