DGIdb - VWF Gene Record

VWF 7450 Druggable Genome

Alternate Names:

7450
VON WILLEBRAND FACTOR
VWF
F8VWF
VWD
613160
12726
ENSG00000110799
OTTHUMG00000168265
von Willebrand antigen II
von Willebrand antigen 2
P04275
VON WILLEBRAND FACTOR PRECURSOR (VWF) [CONTAINS: VON WILLEBRAND ANTIGEN II]. [SOURCE:UNIPROT/SWISSPROT;ACC:P04275]
T23348

Gene Info:

Target Class	Miscellaneous
Target Subclass	StructuralAndAdhesion
Target Subclass	Collagen
Target Subclass	F8
Target Subclass	F2
Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Monteagudo et al., 1990, Investigation of plasma von Willebrand factor and circulating platelet aggregating activity in mitomycin C-related hemolytic-uremic syndrome., Am. J. Hematol.
Minnema et al., 2003, Extremely high levels of von Willebrand factor antigen and of procoagulant factor VIII found in multiple myeloma patients are associated with activity status but not with thalidomide treatment., J. Thromb. Haemost.
Randi et al., 1992, Recombinant von Willebrand factor Arg578-->Gln. A type IIB von Willebrand disease mutation affects binding to glycoprotein Ib but not to collagen or heparin., J. Biol. Chem.
Zhou et al., 2003, Effects of angiogenesis inhibitor TNP-470 on the development of uterine adenomyosis in mice., Fertil. Steril.
Pui et al., 1985, Altered von Willebrand factor molecule in children with thrombosis following asparaginase-prednisone-vincristine therapy for leukemia., J. Clin. Oncol.
Knudsen et al., 2005, Effect of intravenous N-acetylcysteine infusion on haemostatic parameters in healthy subjects., Gut
Tranquille et al., 1991, The effect of pentoxifylline (Trental) and two analogues, BL 194 and HWA 448, on the release of plasminogen activators and von Willebrand factor in rats., J. Cardiovasc. Pharmacol.
Hinokiyama et al., 2006, Vein graft harvesting induces inflammation and impairs vessel reactivity., Ann. Thorac. Surg.
Winocour et al., 1985, Effect of insulin treatment in streptozocin-induced diabetic rats on in vitro platelet function and plasma von Willebrand factor activity and factor VIII-related antigen., J. Lab. Clin. Med.
Bivalacqua et al., 2005, Superoxide anion production in the rat penis impairs erectile function in diabetes: influence of in vivo extracellular superoxide dismutase gene therapy., J Sex Med
Lip et al., 1995, Increased markers of thrombogenesis in chronic atrial fibrillation: effects of warfarin treatment., Br Heart J
Casonato et al., 1988, Factor VIII/von Willebrand factor abnormalities during L-asparaginase treatment in patients with acute lymphoblastic leukemia., Acta Haematol.
Homoncik et al., 2005, Short- and long-term effects of therapy with interferon-alpha and pegylated interferon-alpha/ribavirin on platelet plug formation and von Willebrand factor release in patients with chronic hepatitis C., Aliment. Pharmacol. Ther.

CAPLACIZUMAB VWF

Interaction Score: 13.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction von Willebrand factor inhibitor

Direct Interaction yes

Trial Name ALX-0081, ALX-0681, anti-von Willebrand factor nanobodies

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
EGAPTIVON PEGOL VWF

Interaction Score: 4.42

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name ARC1779

PMIDs:
None found

Sources:
TdgClinicalTrial
O-CHLOROACETYLCARBAMOYLFUMAGILLOL VWF

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14505755

Sources:
NCI
MITOMYCIN VWF

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2104558

Sources:
NCI
PHENYLEPHRINE VWF

Interaction Score: 0.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16996954

Sources:
NCI
ACETYLCYSTEINE VWF

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15753537

Sources:
NCI
HEPARIN VWF

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1400429

Sources:
NCI
STREPTOZOCIN VWF

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3928783 16422885

Sources:
NCI
RIBAVIRIN VWF

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15644045

Sources:
NCI
PREDNISONE VWF

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3146197

Sources:
NCI
PENTOXIFYLLINE VWF

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1719289

Sources:
NCI
THALIDOMIDE VWF

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12871448

Sources:
NCI
WARFARIN VWF

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7626351

Sources:
NCI
VINCRISTINE VWF

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3875694

Sources:
NCI

Ensembl: ENSG00000110799
- Version: 101_38
Alternate Names:

VWF Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000110799
- Version: 26-July-2011
Alternate Names:

ENSG00000110799 Ensembl Gene Id

VON WILLEBRAND FACTOR PRECURSOR (VWF) [CONTAINS: VON WILLEBRAND ANTIGEN II]. [SOURCE:UNIPROT/SWISSPROT;ACC:P04275] Description

VWF Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P04275
- Version: January-2014
Alternate Names:

VWF Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass StructuralAndAdhesion

Target Subclass Collagen

Publications:
TTD: von Willebrand factor
- Version: 2020.06.01
Alternate Names:

VWF TTD Gene Abbreviation

T23348 TTD Target ID

Gene Info:

Publications:

2009, 6 Factor VIII Concentrates, Factor VIII/von Willebrand Factor Concentrates, Factor IX Concentrates, Activated Prothrombin Complex Concentrates., Transfus Med Hemother

NCI: VWF

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Monteagudo et al., 1990, Investigation of plasma von Willebrand factor and circulating platelet aggregating activity in mitomycin C-related hemolytic-uremic syndrome., Am. J. Hematol.

Wheeler-Jones et al., 1996, Protein tyrosine kinases regulate agonist-stimulated prostacyclin release but not von Willebrand factor secretion from human umbilical vein endothelial cells., Biochem. J.

Vermeulen et al., 2003, Homocysteine-lowering treatment with folic acid plus vitamin B6 lowers urinary albumin excretion but not plasma markers of endothelial function or C-reactive protein: further analysis of secondary end-points of a randomized clinical trial., Eur. J. Clin. Invest.

ChemblInteractions: F8VWF
- Version: chembl_23
Alternate Names:

F8VWF GENE_SYMBOL

VWF GENE_SYMBOL

von Willebrand factor UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000110799
- Version: 31-May-2017
Alternate Names:

ENSG00000110799 Gene Symbol

VWF Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:

Mechanism of Interaction	von Willebrand factor inhibitor
Direct Interaction	yes
Trial Name	ALX-0081, ALX-0681, anti-von Willebrand factor nanobodies

ENSG00000110799	Ensembl Gene Id
VON WILLEBRAND FACTOR PRECURSOR (VWF) [CONTAINS: VON WILLEBRAND ANTIGEN II]. [SOURCE:UNIPROT/SWISSPROT;ACC:P04275]	Description
VWF	Display Id

Novel drug target	Established target
Trial Name	ARC1779

VWF Gene Record

VWF 7450 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction von Willebrand factor inhibitor Direct Interaction yes Trial Name ALX-0081, ALX-0681, anti-von Willebrand factor nanobodies

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name ARC1779

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14505755

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2104558

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16996954

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15753537

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1400429

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3928783 16422885

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15644045

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3146197

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1719289

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12871448

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7626351

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3875694

Sources: NCI

Ensembl: ENSG00000110799

Alternate Names: VWF Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000110799

Alternate Names: ENSG00000110799 Ensembl Gene Id VON WILLEBRAND FACTOR PRECURSOR (VWF) [CONTAINS: VON WILLEBRAND ANTIGEN II]. [SOURCE:UNIPROT/SWISSPROT;ACC:P04275] Description VWF Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P04275

Alternate Names: VWF Gene Symbol

Gene Info: Target Class Miscellaneous Target Subclass StructuralAndAdhesion Target Subclass Collagen

Publications:

TTD: von Willebrand factor

Alternate Names: VWF TTD Gene Abbreviation T23348 TTD Target ID

Gene Info:

Publications: 2009, 6 Factor VIII Concentrates, Factor VIII/von Willebrand Factor Concentrates, Factor IX Concentrates, Activated Prothrombin Complex Concentrates., Transfus Med Hemother

NCI: VWF

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction von Willebrand factor inhibitor

Direct Interaction yes

Trial Name ALX-0081, ALX-0681, anti-von Willebrand factor nanobodies

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name ARC1779

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
14505755

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2104558

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16996954

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15753537

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1400429

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3928783 16422885

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15644045

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3146197

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1719289

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12871448

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7626351

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3875694

Sources:
NCI

Alternate Names:

VWF Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000110799 Ensembl Gene Id

VON WILLEBRAND FACTOR PRECURSOR (VWF) [CONTAINS: VON WILLEBRAND ANTIGEN II]. [SOURCE:UNIPROT/SWISSPROT;ACC:P04275] Description

VWF Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

VWF Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass StructuralAndAdhesion

Target Subclass Collagen

Alternate Names:

VWF TTD Gene Abbreviation

T23348 TTD Target ID

Publications:

2009, 6 Factor VIII Concentrates, Factor VIII/von Willebrand Factor Concentrates, Factor IX Concentrates, Activated Prothrombin Complex Concentrates., Transfus Med Hemother

Alternate Names:

F8VWF GENE_SYMBOL

VWF GENE_SYMBOL

von Willebrand factor UNIPROT

Alternate Names:

ENSG00000110799 Gene Symbol

VWF Ensembl Id

Gene Categories:

DRUGGABLE GENOME