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XRCC3 Gene Record

  • Summary
  • Interactions
  • Claims
  • XRCC3 7517

    Alternate Names:

    7517
    X-RAY REPAIR CROSS COMPLEMENTING 3
    XRCC3
    CMM6
    600675
    12830
    ENSG00000126215
    OTTHUMG00000169228
    PA37422

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (0 More Sources)

    Gene Categories: Category Details

    DNA REPAIR

    Publications:

    Ruzzo A et al., 2008, Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFIRI chemotherapy., Pharmacogenomics J
  • LEUCOVORIN   XRCC3

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17549067


    Sources:
    PharmGKB

  • IRINOTECAN   XRCC3

    Interaction Score: 0.78

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17549067


    Sources:
    PharmGKB

  • FLUOROURACIL   XRCC3

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17549067


    Sources:
    PharmGKB

  • Ensembl: ENSG00000126215

    • Version: 101_38

    Alternate Names:
    XRCC3 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: XRCC3

    • Version: 18-August-2020

    Alternate Names:
    PA37422 PharmGKB ID

    Gene Info:

    Publications:
    Ruzzo A et al., 2008, Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFIRI chemotherapy., Pharmacogenomics J
    Shen XY et al., 2013, XRCC3 Thr241Met polymorphism and clinical outcomes of NSCLC patients receiving platinum-based chemotherapy: a systematic review and meta-analysis., PLoS One
    Chen J et al., 2016, Pharmacogenomics of platinum-based chemotherapy response in NSCLC: a genotyping study and a pooled analysis., Oncotarget

  • Tempus: XRCC3

    • Version: 11-November-2018

    Alternate Names:
    XRCC3 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • GO: XRCC3

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    DNA REPAIR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21