7525 |
YES PROTO-ONCOGENE 1, SRC FAMILY TYROSINE KINASE |
YES1 |
HsT441 |
P61-YES |
Yes |
c-yes |
164880 |
12841 |
ENSG00000176105 |
OTTHUMG00000131472 |
PROTO-ONCOGENE TYROSINE-PROTEIN KINASE YES (EC 2.7.1.112) (P61-YES) (C-YES). [SOURCE:UNIPROT/SWISSPROT;ACC:P07947] |
P07947 |
YES_HUMAN |
TYROSINE-PROTEIN KINASE YES |
Proto-oncogene c-Yes |
Yes tyrosine kinase |
T75570 |
Human Readable Name | DRUGGABLE GENOME |
Initial Gene Query | YES |
Counted Citations from 1950-2000 | 581 |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Acc | IPR001245 |
Human Readable Name | KINASE |
Interpro Type | Domain |
Interpro Short Name | Ser-Thr/Tyr_kinase_cat_dom |
Uniprot Status | Swiss-Prot |
Interpro Name | Serine-threonine/tyrosine-protein kinase catalytic domain |
Target Class | Enzymes |
Target Subclass | EC:2.7.10.2 |
Target Main Class | Enzymes |
Target Subclass | 2.7.10.2 |
Gene Biotype | PROTEIN_CODING |
KINASE |
TYROSINE KINASE |
DRUGGABLE GENOME |
CLINICALLY ACTIONABLE |
inhibitor (inhibitory) |
Mechanism of Interaction | Tyrosine-protein kinase YES inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
Trial Name | dasatinib, BMS-354825,Sprycel |
Novel drug target | Established target |
Mechanism of Interaction | SRC inhibitor |
inhibitor (inhibitory) |
Notes |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | SRC inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | SRC inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Notes |
n/a |
Trial Name | ENMD-2076 |
Novel drug target | Established target |
inhibitor (inhibitory) |
Mechanism of Interaction | SRC inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | SRC inhibitor |
Direct Interaction | yes |
YES1 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
PROTO-ONCOGENE TYROSINE-PROTEIN KINASE YES (EC 2.7.1.112) (P61-YES) (C-YES). [SOURCE:UNIPROT/SWISSPROT;ACC:P07947] | Description |
ENSG00000176105 | Ensembl Gene Id |
YES1 | Display Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
7525 | Entrez Gene ID |
Initial Gene Query | YES |
Counted Citations from 1950-2000 | 581 |
KINASE |
YES1 | Uniprot Gene Name |
P07947 | Uniprot Accession |
TYROSINE-PROTEIN KINASE YES | Uniprot Protein Name |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Acc | IPR001245 |
Human Readable Name | KINASE |
KINASE, DRUGGABLE GENOME |
YES_HUMAN | Uniprot Id |
ENSG00000176105 | Ensembl Gene Id |
P07947 | Uniprot Accession |
Target Main Class | Enzymes |
Target Subclass | 2.7.10.2 |
YES1 | Gene Symbol |
Target Class | Enzymes |
Target Subclass | EC:2.7.10.2 |
YES | GENE_SYMBOL |
YES1 | GENE_SYMBOL |
Tyrosine-protein kinase Yes | UNIPROT |
ENSG00000176105 | Gene Symbol |
YES1 | Ensembl Id |
DRUGGABLE GENOME |
YES | Gene Symbol |
YES | GO Gene Synonym |
TYROSINE KINASE |
7525 | Gene ID |
HsT441 | dGene Synonym |
P61-YES | dGene Synonym |
KINASE, TYROSINE KINASE |
YES | TTD Gene Abbreviation |
T75570 | TTD Target ID |
Tyrosine-protein kinase Yes | Gene Name |
P07947 | UniProt ID |
KINASE |
CLINICALLY ACTIONABLE |