DGIdb 3.0 released June 30, 2017

DGIdb 3.0 is here, and brings with it several major improvements:
  • New and updated sources
  • New Preset interaction search filters now available
    • FDA-approved drugs
    • Anti-neoplastic drugs
    • Immunotherapy drugs
    • Clinically actionable genes
    • Druggable genome genes
    • Drug resistance genes
  • Improved grouping of gene and drug claims
    • Iterative updating of Entrez genes
    • Transition to ChEMBL for primary drug concepts
    • Interaction groups added
  • Redesigned search
    • Improved search interface with preset filter panel
    • Improved search results interface presents grouped interactions
  • Redesigned gene, drug, and interaction views
  • Faster Interaction Searches
  • Expanded API
  • Framework upgrade
    • Upgraded from Rails 3 to Rails 5
    • Upgraded from Postgres 9.4 to 9.6
    • Added functional indexes to db

DGIdb Amazon Machine Image released May 6, 2017

DGIdb is now available on Amazon's Elastic Compute Cloud (EC2) as an Amazon Machine Image. See the wiki for details on how to get started!

DGIdb 2.0 software demonstration at AGBT 2016 February 15, 2016

DGIdb 2.0 was presented as a software demonstration at the 17th annual Advances in Genome Biology and Technology (AGBT) meeting in Orlando, Florida from February 10th - 13th, 2016.

DGIdb 2.0 publication released January 4, 2016

DGIdb 2.0 has been published (open-access) in the 2016 Nucleic Acids Research Database edition.

DGIdb 2.0 released August 31, 2015

DGIdb 2.0 is here, and brings with it several major improvements:
  • New Sources of Drug-Gene Interactions
    • CIViC, an open access, open source, community-driven web resource for Clinical Interpretation of Variants in Cancer.
    • DoCM, the Database of Curated Mutations, a highly curated database of known, disease-causing mutations.
  • Automatic updating of sources
    • CIViC - drug-gene interactions
    • DoCM - drug-gene interactions
    • Entrez Gene - genes
  • Search drug-gene interactions by drug identifiers

IUPHAR/BPS Guide to Pharmacology added as new source of druggable gene categories May 7, 2015

The IUPHAR/BPD Guide to Pharmacology has been added as a new source of potentially druggable gene categories.

Drug Targets in Clinical Trials added as new source of drug-gene interactions May 7, 2015

IUPHAR/BPS Guide to Pharmacology added as new source of drug-gene interactions Apr 23, 2015

The IUPHAR/BPD Guide to Pharmacology has been added as a new source of drug-gene interactions.

My Cancer Genome Clinical Trials added as new source of drug-gene interactions Jun 9, 2014

Clinical trial data from My Cancer Genome has been added to DGIdb as a new source of drug-gene interactions.

Python DGIdb API example added Feb 25, 2014

A Python example to interrogate DGIdb has been added here Start hacking!

Bader Lab genes added as a new source of potentially druggable genes Feb 13, 2014

Gene category information for the genes in the Bader Lab "Roads not taken" data set have been added to DGIdb.

Foundation One genes added as a new source of potentially druggable gene categories Jan 9, 2014

The list of genes determined to be "Clinically Actionable" has been added as a new category of potentially druggable genes of the same name.

Clearity Clinical Trials added as a new source of drug-gene interactions Jan 9, 2014

The previous ClearityFoundation source of interactions has been renamed to ClearityFoundationBiomarkers and a new source ClearityFoundationClinicalTrial has been added. The former are biomarkers determined by the Clearity Foundation to be relevant for (typically) sensitivity or resistance to a specific therapeutic agent in Ovarian Cancer. The latter are interactions that were manually curated from the list of relevant clinical trials (themselves manually curated) by the Clearity Foundation as of potential relevance to Ovarian Cancer patients.

DGIdb is selected for a software demo at AGBT 2014 Dec 10, 2013

At AGBT in Feb. 12-15 we will present DGIdb as part of the first AGBT software demonstration session.

DGIdb press coverage November 15, 2013

Since the online publication of the DGIdb paper in Nature Methods, various news organizations have described DGIdb. Washington University Newsroom wrote a press release that was picked up by GEN News, Medical Xpress, Science Daily, Medical News Today, and Scicasts. Genome Web and Texchnologist conducted separate interviews and wrote their own articles. Student Life also conducted interviews from a WashU student perspective. Nick Spies gets a shout out! Singularity Hub give their take on DGIdb. Lab Manager Bio-IT World has possibly done the best job of explaining DGIdb for the laymen. The Associated Press wrote a more general interest article which so far has been picked up by the Kansas City Star, The News & Observer, the Columbia Daily Tribune, Sacramento Bee, The Republic and the Modesto Bee.

DGIdb is published online in Nature Methods October 14, 2013

A paper describing this resource is now available online: DGIdb - mining the druggable genome. Nature Methods (2013) doi:10.1038/nmeth.2689

TALC and Clearity Foundation data have been updated September 11, 2013

This version of DGIdb incorporates updates and bug fixes for the Clearity Foundation data. The TALC data has been updated to reflect the new interactions added in the December 2012 publication: "A Tabulated Summary of Targeted and Biologic Therapies for Non-Small-Cell Lung Cancer" (J Thorac Oncol. 2012 Dec;7(16 Suppl 5):S342-68).

Clearity Foundation is added as a source for DGIdb August 7, 2013

Highly curated drug-gene interactions have been mined from the Clearity Foundation and incorporated into DGIdb. The Clearity Foundation is a 501(c)(3) not-for-profit organization that provides patient support services including lab test coordination, tumor blueprint interpretation, and clinical trial identification free of charge. The Clearity Foundation was launched in 2008 to help ovarian cancer patients and their physicians make better-informed treatment decisions, based on molecular profiling of tumors. From this resource we obtained 175 drug-gene interactions involving 34 genes and 64 drugs.

Updated version of the interface is released July 30, 2013

This version of DGIdb incorporates improvements in versioning, the ability to perform drug interaction searches against the gene-gene interactors of a specific gene, and additional minor fixes and improvements.

Cancer Commons is added as a source for DGIdb July 25, 2013

Highly curated drug-gene interactions have been mined from Cancer Commons and incorporated into DGIdb. Cancer Commons is a patient-centered nonprofit uniting patients, clinicians, and researchers in rapid learning communities. From this resource we obtained 109 drug-gene interactions involving 48 genes and 80 drugs.

Updated version of the interface is released May 14, 2013

This version of DGIdb incorporates improvements in gene detail views, source views, the guided tours and the FAQ. Customized browsing and export of druggable gene categories by source is now available. Also included in this release are updates to many Ruby TSV source importers, better coverage in the code test suite, and various minor bug fixes.

Updated version of the interface is released April 15, 2013

Many improvements and fixes have been incorporated into DGIdb. API access has been added along with detailed documentation and examples (see Help -> API Documentation). TSV export functionality has been improved. Results are now characterized by source trust level and results can now be filtered on this attribute. Extensive documentation was added throughout various views in the form of additional help flags.

MyCancerGenome is added as a source for DGIdb April 1, 2013

Highly curated drug-gene interactions have been mined from My Cancer Genome and incorporated into DGIdb. My Cancer Genome is a freely available online personalized cancer medicine resource and decision-making tool for physicians, patients, caregivers and researchers. From this resource we obtained 835 drug-gene interactions involving 169 genes and 226 drugs.

DGIdb beta is launched at AGBT 2013 February 22, 2013

The 14th annual Advances in Genome Biology and Technology (AGBT) meeting was held in Marco Island, Florida, on February 20-23, 2013. A poster describing DGIdb was presented by Obi Griffith and results from DGIdb were described during a talk delivered by Malachi Griffith in the Genomic Medicine session. The first publicly available release of DGIdb includes 2 sources of canonical gene information, 1 source of drug information, 5 sources of drug-gene interactions and 4 sources of potentially druggable gene categories.