DGIdb - ALFUZOSIN Drug Record

ALFUZOSIN chembl:CHEMBL709 Approved

Alternate Names:

ALFUZOSIN
UROXATRAL
ALFUZOSINA
ALFUZOSINE
UROXATRAL®
SL-7749910
SL-77499-10
ALFUZOSINUM
(±)-N-[3-[(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)METHYLAMINO]PROPYL]TETRAHYDRO-2-FURAMIDE
N-[3-[(4-AMINO-6,7-DIMETHOXY-QUINAZOLIN-2-YL)- METHYL-AMINO]PROPYL] TETRAHYDROFURAN- 2-CARBOXAMIDE
chemidplus:81403-80-7
drugbank:00346
pubchem.compound:2092
chembl:CHEMBL709
rxcui:17300

Drug Info:

FDA Approval	approved
Drug Indications	for treatment of benign prostatic hyperplasia
Drug Class	Small Molecule
Year of Approval	2003
Drug Class	antispasmodics, urinary

(1 More Sources)

Publications:

Bèïque et al., 1998, Are the new selective alpha-blockers better than non-selective alpha-blockers for benign prostatic hyperplasia?, Can Fam Physician
Elhilali, 2006, Alfuzosin: an alpha1-receptor blocker for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia., Expert Opin Pharmacother
Faure et al., 1994, Identification of alpha 1-adrenoceptor subtypes present in the human prostate., Life Sci.
Roehrborn, 2001, Alfuzosin: overview of pharmacokinetics, safety, and efficacy of a clinically uroselective alpha-blocker., Urology
McVary, 2006, BPH: epidemiology and comorbidities., Am J Manag Care
Andersson et al., 1997, Prostatic alpha 1-adrenoceptors and uroselectivity., Prostate
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Kenny et al., 1996, Evaluation of the pharmacological selectivity profile of alpha 1 adrenoceptor antagonists at prostatic alpha 1 adrenoceptors: binding, functional and in vivo studies., Br. J. Pharmacol.
Lowe, 2004, Role of the newer alpha, -adrenergic-receptor antagonists in the treatment of benign prostatic hyperplasia-related lower urinary tract symptoms., Clin Ther
Martin et al., 1997, Comparative alpha-1 adrenoceptor subtype selectivity and functional uroselectivity of alpha-1 adrenoceptor antagonists., J. Pharmacol. Exp. Ther.
Lee, 2003, Alfuzosin hydrochloride for the treatment of benign prostatic hyperplasia., Am J Health Syst Pharm

ALFUZOSIN ADRA1D

Interaction Score: 4.36

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name alfuzosin,UroXatral

PMIDs:
16553574 8196478 11750253 16613526 9122046 11752352 8799556 15639685

Sources:
TdgClinicalTrial TEND TTD
ALFUZOSIN ADRA1B

Interaction Score: 1.89

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name alfuzosin,UroXatral

PMIDs:
9870119 16553574 8196478 11750253 16613526 9122046 11752352 8799556 15639685

Sources:
TdgClinicalTrial TEND
ALFUZOSIN ADRA1A

Interaction Score: 1.54

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name alfuzosin,UroXatral

Novel drug target Established target

PMIDs:
9870119 16553574 8196478 11750253 16613526 9223558 9122046 11752352 8799556 12892027 15639685

Sources:
TdgClinicalTrial TEND
ALFUZOSIN GAA

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALFUZOSIN HSD17B10

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALFUZOSIN EHMT2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: ALFUZOSIN
- Version: 01-August-2011
Alternate Names:

ALFUZOSIN Primary Drug Name

Drug Info:

Drug Class antispasmodics, urinary

Year of Approval 2003

Publications:
TdgClinicalTrial: ALFUZOSIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Class Small Molecule

Drug Indications for treatment of benign prostatic hyperplasia

FDA Approval approved

Publications:
TTD: Alfuzosin
- Version: 2020.06.01
Alternate Names:

D09MWJ TTD Drug ID

Drug Info:

Publications:
DTC: ALFUZOSIN
- Version: 02-September-2020
Alternate Names:

CHEMBL709 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL709
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	alfuzosin,UroXatral

ALFUZOSIN Drug Record

ALFUZOSIN chembl:CHEMBL709 Approved

Alternate Names:

Drug Info:

Publications:

ALFUZOSIN ADRA1D

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name alfuzosin,UroXatral

PMIDs: 16553574 8196478 11750253 16613526 9122046 11752352 8799556 15639685

Sources: TdgClinicalTrial TEND TTD

ALFUZOSIN ADRA1B

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name alfuzosin,UroXatral

PMIDs: 9870119 16553574 8196478 11750253 16613526 9122046 11752352 8799556 15639685

Sources: TdgClinicalTrial TEND

ALFUZOSIN ADRA1A

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name alfuzosin,UroXatral Novel drug target Established target

PMIDs: 9870119 16553574 8196478 11750253 16613526 9223558 9122046 11752352 8799556 12892027 15639685

Sources: TdgClinicalTrial TEND

ALFUZOSIN GAA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

ALFUZOSIN HSD17B10

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

ALFUZOSIN EHMT2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: ALFUZOSIN

Alternate Names: ALFUZOSIN Primary Drug Name

Drug Info: Drug Class antispasmodics, urinary Year of Approval 2003

Publications:

TdgClinicalTrial: ALFUZOSIN

Alternate Names:

Drug Info: Drug Class Small Molecule Drug Indications for treatment of benign prostatic hyperplasia FDA Approval approved

Publications:

TTD: Alfuzosin

Alternate Names: D09MWJ TTD Drug ID

Drug Info:

Publications:

DTC: ALFUZOSIN

Alternate Names: CHEMBL709 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL709

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name alfuzosin,UroXatral

PMIDs:
16553574 8196478 11750253 16613526 9122046 11752352 8799556 15639685

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name alfuzosin,UroXatral

PMIDs:
9870119 16553574 8196478 11750253 16613526 9122046 11752352 8799556 15639685

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name alfuzosin,UroXatral

Novel drug target Established target

PMIDs:
9870119 16553574 8196478 11750253 16613526 9223558 9122046 11752352 8799556 12892027 15639685

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

ALFUZOSIN Primary Drug Name

Drug Info:

Drug Class antispasmodics, urinary

Year of Approval 2003

Drug Info:

Drug Class Small Molecule

Drug Indications for treatment of benign prostatic hyperplasia

FDA Approval approved

Alternate Names:

D09MWJ TTD Drug ID

Alternate Names:

CHEMBL709 ChEMBL Drug ID