DGIdb - DICHLORPHENAMIDE Drug Record

DICHLORPHENAMIDE chembl:CHEMBL17 Approved

Alternate Names:

DICHLORPHENAMIDE
KEVEYIS
DARANIDE
DICLOFENAMIDE
ORATROL
4,5-DICHLORO-M-BENZENEDISULFONAMIDE
4,5-DICHLOROBENZENE-1,3-DISULFONAMIDE
4,5-DICHLORO-1,3-BENZENEDISULFONAMIDE
1,3-DISULFAMYL-4,5-DICHLOROBENZENE
DICLOFENAMIDA
GLAUCONIDE
3,4-DICHLORO-5-SULFAMYLBENZENESULFONAMIDE
4,5-DICHLORO-1,3-DISULFAMOYLBENZENE
DICHLOFENAMIDE
4,5-DICHLORO-BENZENE-1,3-DISULFONIC ACID DIAMIDE
DARANIDE®
DICHLOROPHENAMIDE
KEVEYIS®
1,3-DISULFAMOYL-4,5-DICHLOROBENZENE
DICLOFENAMIDUM
drugbank:01144
rxcui:3353
chembl:CHEMBL17
pubchem.compound:3038
chemidplus:120-97-8

Drug Info:

Year of Approval	1958
Drug Class	antiglaucomic agents
FDA Approval	1958
Drug Class	small molecule
Drug Indications	Antiglaucomic Agents

(1 More Sources)

Publications:

Lindskog, 1997, Structure and mechanism of carbonic anhydrase., Pharmacol. Ther.
Winum et al., 2004, Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits., Bioorg. Med. Chem. Lett.
Nishimori et al., 2007, Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors., J. Med. Chem.
Giacomotto et al., 2009, Evaluation of the therapeutic potential of carbonic anhydrase inhibitors in two animal models of dystrophin deficient muscular dystrophy., Hum. Mol. Genet.
Cleland et al., 2008, Treatment of neuromuscular channelopathies: current concepts and future prospects., Neurotherapeutics
Mincione et al., 2008, The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents., Curr. Pharm. Des.

DICHLORPHENAMIDE CA1

Interaction Score: 7.73

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Direct Interaction yes

PMIDs:
9336012 14684332 17228881 19648295 19019313

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
DICHLORPHENAMIDE CA4

Interaction Score: 2.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase IV inhibitor

Direct Interaction yes

PMIDs:
18336310

Sources:
ChemblInteractions
DICHLORPHENAMIDE CA2

Interaction Score: 2.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase II inhibitor

Direct Interaction yes

PMIDs:
18336310

Sources:
ChemblInteractions TTD
DICHLORPHENAMIDE CA12

Interaction Score: 1.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase XII inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

TEND: DICHLORPHENAMIDE
- Version: 01-August-2011
Alternate Names:

DICHLORPHENAMIDE Primary Drug Name

Drug Info:

Drug Class antiglaucomic agents

Year of Approval 1958

Publications:
TdgClinicalTrial: DICHLORPHENAMIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antiglaucomic Agents

Drug Class small molecule

FDA Approval 1958

Publications:
TTD: Dichlorphenamide
- Version: 2020.06.01
Alternate Names:

D0J4GO TTD Drug ID

Drug Info:

Publications:
ChemblInteractions: CHEMBL17
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL17
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target
Direct Interaction	yes

Mechanism of Interaction	Carbonic anhydrase IV inhibitor
Direct Interaction	yes

Mechanism of Interaction	Carbonic anhydrase II inhibitor
Direct Interaction	yes

Mechanism of Interaction	Carbonic anhydrase XII inhibitor
Direct Interaction	yes

DICHLORPHENAMIDE Drug Record

DICHLORPHENAMIDE chembl:CHEMBL17 Approved

Alternate Names:

Drug Info:

Publications:

DICHLORPHENAMIDE CA1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Direct Interaction yes

PMIDs: 9336012 14684332 17228881 19648295 19019313

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

DICHLORPHENAMIDE CA4

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Carbonic anhydrase IV inhibitor Direct Interaction yes

PMIDs: 18336310

Sources: ChemblInteractions

DICHLORPHENAMIDE CA2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Carbonic anhydrase II inhibitor Direct Interaction yes

PMIDs: 18336310

Sources: ChemblInteractions TTD

DICHLORPHENAMIDE CA12

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Carbonic anhydrase XII inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

TEND: DICHLORPHENAMIDE

Alternate Names: DICHLORPHENAMIDE Primary Drug Name

Drug Info: Drug Class antiglaucomic agents Year of Approval 1958

Publications:

TdgClinicalTrial: DICHLORPHENAMIDE

Alternate Names:

Drug Info: Drug Indications Antiglaucomic Agents Drug Class small molecule FDA Approval 1958

Publications:

TTD: Dichlorphenamide

Alternate Names: D0J4GO TTD Drug ID

Drug Info:

Publications:

ChemblInteractions: CHEMBL17

Alternate Names:

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL17

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Direct Interaction yes

PMIDs:
9336012 14684332 17228881 19648295 19019313

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase IV inhibitor

Direct Interaction yes

PMIDs:
18336310

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase II inhibitor

Direct Interaction yes

PMIDs:
18336310

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase XII inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

DICHLORPHENAMIDE Primary Drug Name

Drug Info:

Drug Class antiglaucomic agents

Year of Approval 1958

Drug Info:

Drug Indications Antiglaucomic Agents

Drug Class small molecule

FDA Approval 1958

Alternate Names:

D0J4GO TTD Drug ID