DGIdb - DOXAZOSIN Drug Record

DOXAZOSIN chembl:CHEMBL707 Approved

Alternate Names:

DOXAZOSIN
UK-33274
C02CA04
CARDURA
DOXAZOSINUM
1-(4-AMINO-6,7-DIMETHOXY-2-CHINAZOLINYL)-4-(2,3-DIHYDRO-1,4-BENZODIOXIXIN-2-YLCARBONYL)PIPERAZIN
1-(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)-4-(1,4-BENZODIOXAN-2-YLCARBONYL)PIPERAZIN
CARDURA®
UK-3327427
DOXAZOSINA
DOXAZOSINE
chemidplus:74191-85-8
drugbank:00590
rxcui:49276
pubchem.compound:3157
chembl:CHEMBL707

Drug Info:

Drug Class	vasodilator agents
Drug Class	antihypertensive agents
Year of Approval	1990
Drug Class	anticholesteremic agents
FDA Approval	1990
Drug Class	small molecule
Drug Indications	Vasodilator Agents
Drug Indications	Antihypertensive Agents
Drug Indications	Anticholesteremic Agents

(1 More Sources)

Publications:

Greco et al., 2008, The role of combination medical therapy in benign prostatic hyperplasia., Int. J. Impot. Res.
Martin, 1999, Preclinical pharmacology of alpha1-adrenoceptor antagonists., Eur. Urol.
Lepor, 2007, Alpha blockers for the treatment of benign prostatic hyperplasia., Rev Urol
Shannon et al., 2006, Effect of alpha1-adrenergic receptors in cardiac pathophysiology., Am. Heart J.
Schwinn DA et al., 2008, Alpha1-adrenoceptor subtypes and lower urinary tract symptoms., Int J Urol
Martin et al., 1997, Comparative alpha-1 adrenoceptor subtype selectivity and functional uroselectivity of alpha-1 adrenoceptor antagonists., J. Pharmacol. Exp. Ther.
Michel et al., 1996, Drugs for treatment of benign prostatic hyperplasia: affinity comparison at cloned alpha 1-adrenoceptor subtypes and in human prostate., J Auton Pharmacol
Roehrborn et al., 2004, Alpha1-adrenergic receptors and their inhibitors in lower urinary tract symptoms and benign prostatic hyperplasia., J. Urol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Yono et al., 2004, Doxazosin-induced up-regulation of alpha 1A-adrenoceptor mRNA in the rat lower urinary tract., Can. J. Physiol. Pharmacol.
Bae et al., 2005, The effects of alpha-adrenoceptor antagonists on the urethral perfusion pressure of the female rat., BJU Int.
Ishizuka et al., 1997, Stimulation of bladder activity by volume, L-dopa and capsaicin in normal conscious rats--effects of spinal alpha 1-adrenoceptor blockade., Naunyn Schmiedebergs Arch. Pharmacol.

DOXAZOSIN ADRA1D

Interaction Score: 4.28

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
19002123 10393471 18231614 17070143 9223558 18304211

Sources:
TdgClinicalTrial TEND TTD
DOXAZOSIN ADRA1A

Interaction Score: 1.85

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8736427 19002123 17070143 10393471 14767264 11752352 15573147 16225542 9205965 9223558 18304211

Sources:
TdgClinicalTrial TEND
DOXAZOSIN ADRA1B

Interaction Score: 1.65

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
19002123 10393471 18231614 17070143 18304211 9223558

Sources:
TdgClinicalTrial TEND
DOXAZOSIN MTOR

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DOXAZOSIN ATAD5

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: DOXAZOSIN
- Version: 01-August-2011
Alternate Names:

DOXAZOSIN Primary Drug Name

Drug Info:

Drug Class anticholesteremic agents

Year of Approval 1990

Drug Class antihypertensive agents

Publications:
TdgClinicalTrial: DOXAZOSIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Anticholesteremic Agents

Drug Indications Antihypertensive Agents

Drug Indications Vasodilator Agents

Publications:
DTC: DOXAZOSIN
- Version: 02-September-2020
Alternate Names:

CHEMBL707 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Doxazosin
- Version: 2020.06.01
Alternate Names:

D03MIR TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL707
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

Novel drug target	Established target
Trial Name	-

DOXAZOSIN Drug Record

DOXAZOSIN chembl:CHEMBL707 Approved

Alternate Names:

Drug Info:

Publications:

DOXAZOSIN ADRA1D

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 19002123 10393471 18231614 17070143 9223558 18304211

Sources: TdgClinicalTrial TEND TTD

DOXAZOSIN ADRA1A

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 8736427 19002123 17070143 10393471 14767264 11752352 15573147 16225542 9205965 9223558 18304211

Sources: TdgClinicalTrial TEND

DOXAZOSIN ADRA1B

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 19002123 10393471 18231614 17070143 18304211 9223558

Sources: TdgClinicalTrial TEND

DOXAZOSIN MTOR

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DOXAZOSIN ATAD5

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: DOXAZOSIN

Alternate Names: DOXAZOSIN Primary Drug Name

Drug Info: Drug Class anticholesteremic agents Year of Approval 1990 Drug Class antihypertensive agents

Publications:

TdgClinicalTrial: DOXAZOSIN

Alternate Names:

Drug Info: Drug Indications Anticholesteremic Agents Drug Indications Antihypertensive Agents Drug Indications Vasodilator Agents

Publications:

DTC: DOXAZOSIN

Alternate Names: CHEMBL707 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Doxazosin

Alternate Names: D03MIR TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL707

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
19002123 10393471 18231614 17070143 9223558 18304211

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8736427 19002123 17070143 10393471 14767264 11752352 15573147 16225542 9205965 9223558 18304211

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
19002123 10393471 18231614 17070143 18304211 9223558

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

DOXAZOSIN Primary Drug Name

Drug Info:

Drug Class anticholesteremic agents

Year of Approval 1990

Drug Class antihypertensive agents

Drug Info:

Drug Indications Anticholesteremic Agents

Drug Indications Antihypertensive Agents

Drug Indications Vasodilator Agents

Alternate Names:

CHEMBL707 ChEMBL Drug ID

Alternate Names:

D03MIR TTD Drug ID