DGIdb - ETHOXZOLAMIDE Drug Record

ETHOXZOLAMIDE chembl:CHEMBL18 Approved

Alternate Names:

ETHOXZOLAMIDE
ETHAMIDE
CARDRASE
6-ETHOXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE
6-ETHOXY-2-BENZOTHIAZOLESULFONAMIDE
ETHOXAZOLAMIDE
ETHOXYZOLAMIDE
ETHAMIDE®
6-ETHOXYBENZOTHIAZOLE-2-SULFONAMIDE
CARDRASE®
chemidplus:452-35-7
drugbank:00311
pubchem.compound:3295
chembl:CHEMBL18

Drug Info:

FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Antiglaucoma agents
Drug Indications	Antihypertensive Agents, Diuretics
Drug Class	antiglaucoma agents
Year of Approval	approved before 1982
Drug Class	antihypertensive agents, diuretics

(2 More Sources)

Publications:

Mincione et al., 2008, The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents., Curr. Pharm. Des.
Scozzafava et al., 2000, Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes., J. Med. Chem.
Köhling et al., 2000, Ictal epileptiform activity is facilitated by hippocampal GABAA receptor-mediated oscillations., J. Neurosci.
Heck et al., 1994, Catalytic properties of mouse carbonic anhydrase V., J. Biol. Chem.
Bertucci et al., 2009, Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides., Bioorg. Med. Chem.
Siffert et al., 1982, Carbonic anhydrase C in white-skeletal-muscle tissue., Biochem. J.
Perez Velazquez, 2003, Bicarbonate-dependent depolarizing potentials in pyramidal cells and interneurons during epileptiform activity., Eur. J. Neurosci.
Jogaitė V et al., 2013, Characterization of human carbonic anhydrase XII stability and inhibitor binding., Bioorg Med Chem
Yang B et al., 2008, Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides., Bioorg Med Chem
Nishimori I et al., 2007, Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides., Bioorg Med Chem

ETHOXZOLAMIDE CA5B

Interaction Score: 4.76

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ETHOXZOLAMIDE CA13

Interaction Score: 4.76

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ETHOXZOLAMIDE CA7

Interaction Score: 4.76

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase inhibitor

Direct Interaction yes

PMIDs:
18336310

Sources:
ChemblInteractions
ETHOXZOLAMIDE CA5A

Interaction Score: 4.76

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ETHOXZOLAMIDE CA3

Interaction Score: 3.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase inhibitor

Direct Interaction yes

PMIDs:
17826101

Sources:
ChemblInteractions
ETHOXZOLAMIDE CA1

Interaction Score: 2.64

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Carbonic anhydrase inhibitor

Trial Name -

PMIDs:
10649985 10995826 7929150 19520577 6816217 12956733

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
ETHOXZOLAMIDE AQP4

Interaction Score: 1.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18572411

Sources:
DTC
ETHOXZOLAMIDE CA12

Interaction Score: 1.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase inhibitor

Direct Interaction yes

PMIDs:
23159038

Sources:
DTC ChemblInteractions
ETHOXZOLAMIDE CA6

Interaction Score: 0.95

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ETHOXZOLAMIDE CA14

Interaction Score: 0.79

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ETHOXZOLAMIDE CA4

Interaction Score: 0.68

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Carbonic anhydrase inhibitor

PMIDs:
18336310

Sources:
ChemblInteractions
ETHOXZOLAMIDE CA2

Interaction Score: 0.62

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase inhibitor

Direct Interaction yes

PMIDs:
18336310

Sources:
ChemblInteractions TTD
ETHOXZOLAMIDE CA9

Interaction Score: 0.43

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Carbonic anhydrase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

TEND: ETHOXZOLAMIDE
- Version: 01-August-2011
Alternate Names:

ETHOXZOLAMIDE Primary Drug Name

Drug Info:

Drug Class antihypertensive agents, diuretics

Year of Approval approved before 1982

Drug Class antiglaucoma agents

Publications:
TdgClinicalTrial: ETHOXZOLAMIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypertensive Agents, Diuretics

Drug Indications Antiglaucoma agents

Drug Class small molecule

Publications:

DTC: ETHOXZOLAMIDE

Version: 02-September-2020

Alternate Names:

CHEMBL18 ChEMBL Drug ID

Drug Info:

Publications:

Yang B et al., 2008, Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides., Bioorg Med Chem

Jogaitė V et al., 2013, Characterization of human carbonic anhydrase XII stability and inhibitor binding., Bioorg Med Chem

TTD: Ethoxzolamide
- Version: 2020.06.01
Alternate Names:

D07INV TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL18
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL18
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Carbonic anhydrase inhibitor
Direct Interaction	yes

ETHOXZOLAMIDE Drug Record

ETHOXZOLAMIDE chembl:CHEMBL18 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Carbonic anhydrase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Carbonic anhydrase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Carbonic anhydrase inhibitor Direct Interaction yes

PMIDs: 18336310

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Carbonic anhydrase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Carbonic anhydrase inhibitor Direct Interaction yes

PMIDs: 17826101

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Carbonic anhydrase inhibitor Trial Name -

PMIDs: 10649985 10995826 7929150 19520577 6816217 12956733

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18572411

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Carbonic anhydrase inhibitor Direct Interaction yes

PMIDs: 23159038

Sources: DTC ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Carbonic anhydrase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Carbonic anhydrase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Carbonic anhydrase inhibitor

PMIDs: 18336310

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Carbonic anhydrase inhibitor Direct Interaction yes

PMIDs: 18336310

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Carbonic anhydrase inhibitor

PMIDs: None found

Sources: ChemblInteractions

TEND: ETHOXZOLAMIDE

Alternate Names: ETHOXZOLAMIDE Primary Drug Name

Drug Info: Drug Class antihypertensive agents, diuretics Year of Approval approved before 1982 Drug Class antiglaucoma agents

Publications:

TdgClinicalTrial: ETHOXZOLAMIDE

Alternate Names:

Drug Info: Drug Indications Antihypertensive Agents, Diuretics Drug Indications Antiglaucoma agents Drug Class small molecule

Publications:

DTC: ETHOXZOLAMIDE

Alternate Names: CHEMBL18 ChEMBL Drug ID

Drug Info:

Publications: Yang B et al., 2008, Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides., Bioorg Med Chem Jogaitė V et al., 2013, Characterization of human carbonic anhydrase XII stability and inhibitor binding., Bioorg Med Chem

TTD: Ethoxzolamide

Alternate Names: D07INV TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL18

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL18

Alternate Names:

Drug Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase inhibitor

Direct Interaction yes

PMIDs:
18336310

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase inhibitor

Direct Interaction yes

PMIDs:
17826101

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Carbonic anhydrase inhibitor

Trial Name -

PMIDs:
10649985 10995826 7929150 19520577 6816217 12956733

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
18572411

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase inhibitor

Direct Interaction yes

PMIDs:
23159038

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Carbonic anhydrase inhibitor

PMIDs:
18336310

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase inhibitor

Direct Interaction yes

PMIDs:
18336310

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Carbonic anhydrase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

ETHOXZOLAMIDE Primary Drug Name

Drug Info:

Drug Class antihypertensive agents, diuretics

Year of Approval approved before 1982

Drug Class antiglaucoma agents

Drug Info:

Drug Indications Antihypertensive Agents, Diuretics

Drug Indications Antiglaucoma agents

Drug Class small molecule

Alternate Names:

CHEMBL18 ChEMBL Drug ID

Publications:

Yang B et al., 2008, Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides., Bioorg Med Chem

Jogaitė V et al., 2013, Characterization of human carbonic anhydrase XII stability and inhibitor binding., Bioorg Med Chem

Alternate Names:

D07INV TTD Drug ID