DGIdb - HYPERICIN Drug Record

HYPERICIN chembl:CHEMBL286494 AntineoplasticImmunotherapy

Alternate Names:

HYPERICIN
SGX301
NSC-407313

Drug Info:

(0 More Sources)

Publications:

Kocanova et al., 2007, Induction of heme-oxygenase 1 requires the p38MAPK and PI3K pathways and suppresses apoptotic cell death following hypericin-mediated photodynamic therapy., Apoptosis
Schwarz et al., 2003, St. John's wort extracts and some of their constituents potently inhibit ultimate carcinogen formation from benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1., Cancer Res.
Komoroski et al., 2004, Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures., Drug Metab. Dispos.

HYPERICIN CYP1A1

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14633740

Sources:
NCI
HYPERICIN ALOX15B

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYPERICIN THRB

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYPERICIN BLM

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYPERICIN KAT2A

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYPERICIN RECQL

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYPERICIN APEX1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYPERICIN HPGD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYPERICIN POLK

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYPERICIN CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15100173

Sources:
NCI
HYPERICIN NFE2L2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17219054

Sources:
NCI
HYPERICIN MAPT

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYPERICIN EHMT2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

NCI: HYPERICIN

Version: 14-September-2017

Alternate Names:

C37456 NCI drug code

Drug Info:

Publications:

Kocanova et al., 2007, Induction of heme-oxygenase 1 requires the p38MAPK and PI3K pathways and suppresses apoptotic cell death following hypericin-mediated photodynamic therapy., Apoptosis

Komoroski et al., 2004, Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures., Drug Metab. Dispos.

Schwarz et al., 2003, St. John's wort extracts and some of their constituents potently inhibit ultimate carcinogen formation from benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1., Cancer Res.

DTC: HYPERICIN
- Version: 02-September-2020
Alternate Names:

CHEMBL286494 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL286494
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

HYPERICIN Drug Record

HYPERICIN chembl:CHEMBL286494 AntineoplasticImmunotherapy

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14633740

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15100173

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17219054

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

NCI: HYPERICIN

Alternate Names: C37456 NCI drug code

Drug Info:

DTC: HYPERICIN

Alternate Names: CHEMBL286494 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL286494

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
14633740

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
15100173

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17219054

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

C37456 NCI drug code

Alternate Names:

CHEMBL286494 ChEMBL Drug ID