DGIdb - MEPROBAMATE Drug Record

MEPROBAMATE chembl:CHEMBL979 Approved

Alternate Names:

MILTOWN
TRANMEP
EQUANIL
AMOSENE
MEPROBAMATE
MEPRIAM
NEURAMATE
TENAVOID
BAMATE
MEPROSPAN
MEPROBAMATUM
MEPROBAMIC ACID
EQUANIL®
MEPROBAMAT
MEPROBAMATO
MILTOWN®
MEPROSPAN®
chemidplus:57-53-4
pubchem.compound:4064
rxcui:6760
chembl:CHEMBL979
drugbank:00371

Drug Info:

FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Hypnotics and Sedatives
Drug Indications	Anticonvulsants
Drug Class	anticonvulsants
Drug Class	hypnotics and sedatives
Year of Approval	approved before 1982

(1 More Sources)

Publications:

Rho et al., 1997, Barbiturate-like actions of the propanediol dicarbamates felbamate and meprobamate., J. Pharmacol. Exp. Ther.
Gonzalez et al., 2009, Carisoprodol-mediated modulation of GABAA receptors: in vitro and in vivo studies., J. Pharmacol. Exp. Ther.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Mochly-Rosen D et al., 2012, Protein kinase C, an elusive therapeutic target?, Nat Rev Drug Discov

MEPROBAMATE PRKCE

Interaction Score: 0.57

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23197040

Sources:
TTD
MEPROBAMATE PDF

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
MEPROBAMATE GABRA1

Interaction Score: 0.26

Interaction Types & Directionality:

positive modulator (activating)

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel agonist

Trial Name -

PMIDs:
9067327 19244096 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
MEPROBAMATE GABRA4

Interaction Score: 0.26

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel agonist

Trial Name -

PMIDs:
9067327 19244096

Sources:
TdgClinicalTrial ChemblInteractions TEND
MEPROBAMATE GABRA6

Interaction Score: 0.26

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel agonist

Trial Name -

PMIDs:
9067327 19244096

Sources:
TdgClinicalTrial ChemblInteractions TEND
MEPROBAMATE GABRA5

Interaction Score: 0.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction GABA-A receptor; anion channel agonist

PMIDs:
9067327 19244096

Sources:
TdgClinicalTrial ChemblInteractions TEND
MEPROBAMATE GABRA3

Interaction Score: 0.23

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel agonist

Direct Interaction yes

Trial Name -

PMIDs:
9067327 19244096

Sources:
TdgClinicalTrial ChemblInteractions TEND
MEPROBAMATE GABRA2

Interaction Score: 0.22

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction GABA-A receptor; anion channel agonist

PMIDs:
9067327 19244096

Sources:
TdgClinicalTrial ChemblInteractions TEND
MEPROBAMATE GABRQ

Interaction Score: 0.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel agonist

PMIDs:
None found

Sources:
ChemblInteractions
MEPROBAMATE GABRP

Interaction Score: 0.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEPROBAMATE GABRE

Interaction Score: 0.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel agonist

PMIDs:
None found

Sources:
ChemblInteractions
MEPROBAMATE GABRD

Interaction Score: 0.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEPROBAMATE GABRB3

Interaction Score: 0.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel agonist

PMIDs:
None found

Sources:
ChemblInteractions
MEPROBAMATE GABRG1

Interaction Score: 0.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEPROBAMATE GABRB1

Interaction Score: 0.05

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEPROBAMATE GABRG2

Interaction Score: 0.05

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEPROBAMATE GABRB2

Interaction Score: 0.05

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEPROBAMATE GABRG3

Interaction Score: 0.05

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel agonist

PMIDs:
None found

Sources:
ChemblInteractions

TEND: MEPROBAMATE
- Version: 01-August-2011
Alternate Names:

MEPROBAMATE Primary Drug Name

Drug Info:

Year of Approval approved before 1982

Drug Class hypnotics and sedatives

Drug Class anticonvulsants

Publications:
TdgClinicalTrial: MEPROBAMATE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Anticonvulsants

Drug Indications Hypnotics and Sedatives

Drug Class small molecule

Publications:
TTD: Meprobamate
- Version: 2020.06.01
Alternate Names:

D0Y4AW TTD Drug ID

Drug Info:

Publications:

Mochly-Rosen D et al., 2012, Protein kinase C, an elusive therapeutic target?, Nat Rev Drug Discov
ChemblInteractions: CHEMBL979
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL979
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	GABA-A receptor; anion channel agonist
Trial Name	-

Novel drug target	Established target
Trial Name	-
Mechanism of Interaction	GABA-A receptor; anion channel agonist

positive modulator (activating)
agonist (activating)

MEPROBAMATE Drug Record

MEPROBAMATE chembl:CHEMBL979 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23197040

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: positive modulator (activating) agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction GABA-A receptor; anion channel agonist Trial Name -

PMIDs: 9067327 19244096 11752352

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction GABA-A receptor; anion channel agonist Trial Name -

PMIDs: 9067327 19244096

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction GABA-A receptor; anion channel agonist Trial Name -

PMIDs: 9067327 19244096

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name - Mechanism of Interaction GABA-A receptor; anion channel agonist

PMIDs: 9067327 19244096

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction GABA-A receptor; anion channel agonist Direct Interaction yes Trial Name -

PMIDs: 9067327 19244096

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction GABA-A receptor; anion channel agonist

PMIDs: 9067327 19244096

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction GABA-A receptor; anion channel agonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction GABA-A receptor; anion channel agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction GABA-A receptor; anion channel agonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction GABA-A receptor; anion channel agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction GABA-A receptor; anion channel agonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction GABA-A receptor; anion channel agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction GABA-A receptor; anion channel agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction GABA-A receptor; anion channel agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction GABA-A receptor; anion channel agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction GABA-A receptor; anion channel agonist

PMIDs: None found

Sources: ChemblInteractions

TEND: MEPROBAMATE

Alternate Names: MEPROBAMATE Primary Drug Name

Drug Info: Year of Approval approved before 1982 Drug Class hypnotics and sedatives Drug Class anticonvulsants

Interaction Types & Directionality:

n/a

PMIDs:
23197040

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

positive modulator (activating)

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel agonist

Trial Name -

PMIDs:
9067327 19244096 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel agonist

Trial Name -

PMIDs:
9067327 19244096

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel agonist

Trial Name -

PMIDs:
9067327 19244096

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction GABA-A receptor; anion channel agonist

PMIDs:
9067327 19244096

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel agonist

Direct Interaction yes

Trial Name -

PMIDs:
9067327 19244096

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction GABA-A receptor; anion channel agonist

PMIDs:
9067327 19244096

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel agonist

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

MEPROBAMATE Primary Drug Name

Drug Info:

Year of Approval approved before 1982

Drug Class hypnotics and sedatives

Drug Class anticonvulsants

Drug Info:

Drug Indications Anticonvulsants

Drug Indications Hypnotics and Sedatives

Drug Class small molecule

Alternate Names:

D0Y4AW TTD Drug ID

Publications:

Mochly-Rosen D et al., 2012, Protein kinase C, an elusive therapeutic target?, Nat Rev Drug Discov