DGIdb - METHOXAMINE Drug Record

METHOXAMINE chembl:CHEMBL524 Approved

Alternate Names:

NRL-001
METHOXAMINE
VASOXYL
NRL001
METOSSAMINA
MÉTHOXAMÉDRINE
METHOXAMIN
2,5-DIMETHOXYNOREPHEDRINE
MÉTHOXAMINE
METHOXAMINUM
METOXAMINA
PSEUDOMETHOXAMINE
drugbank:00723
chemidplus:390-28-3
rxcui:6853
chembl:CHEMBL524
pubchem.compound:6082

Drug Info:

FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Vasoconstrictor Agents
Drug Indications	Antihypotensive Agents
Drug Class	vasoconstrictor agents
Year of Approval	approved before 1982
Drug Class	antihypotensive agents

(1 More Sources)

Publications:

Simpson, 1985, Stimulation of hypertrophy of cultured neonatal rat heart cells through an alpha 1-adrenergic receptor and induction of beating through an alpha 1- and beta 1-adrenergic receptor interaction. Evidence for independent regulation of growth and beating., Circ. Res.
Oleksa et al., 1996, Alpha 1-adrenergic inhibition of the beta-adrenergically activated Cl- current in guinea pig ventricular myocytes., Circ. Res.
Waugh et al., 2001, Phe-308 and Phe-312 in transmembrane domain 7 are major sites of alpha 1-adrenergic receptor antagonist binding. Imidazoline agonists bind like antagonists., J. Biol. Chem.
Tsujimoto et al., 1989, Glycogen phosphorylase activation by two different alpha 1-adrenergic receptor subtypes: methoxamine selectively stimulates a putative alpha 1-adrenergic receptor subtype (alpha 1a) that couples with Ca2+ influx., Mol. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Zeng et al., 2009, Frontal analysis of cell-membrane chromatography for determination of drug-alpha(1D) adrenergic receptor affinity., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
Suzuki et al., 1990, Two pharmacologically distinct alpha 1-adrenoceptor subtypes in the contraction of rabbit aorta: each subtype couples with a different Ca2+ signalling mechanism and plays a different physiological role., Mol. Pharmacol.
Satoh et al., 1994, Alpha 1-adrenoceptor subtypes mediating the regulation and modulation of Ca2+ sensitization in rabbit thoracic aorta., Eur. J. Pharmacol.
Hoang et al., 1996, Characterization of alpha-adrenoceptor activity in the preterm piglet mesentery., J. Pediatr. Surg.
Sattar et al., 1994, Evidence for an alpha 1-adrenoceptor subtype mediating adrenergic vasoconstriction in Wistar normotensive and stroke-prone spontaneously hypertensive rat kidney., J. Cardiovasc. Pharmacol.
Piascik et al., 1991, Evidence for a complex interaction between the subtypes of the alpha 1-adrenoceptor., Eur. J. Pharmacol.

METHOXAMINE ADRA1B

Interaction Score: 3.09

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2988814 8635240 11331292 2546049 11752352

Sources:
TdgClinicalTrial TEND PharmGKB TTD
METHOXAMINE ADRA1A

Interaction Score: 1.9

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1978244 7875228 8986981 7511752 1680715

Sources:
TdgClinicalTrial TEND PharmGKB
METHOXAMINE ADRA1D

Interaction Score: 1.59

Interaction Types & Directionality:

agonist (activating)

binder

Interaction Info:

PMIDs:
19493707

Sources:
PharmGKB

TEND: METHOXAMINE
- Version: 01-August-2011
Alternate Names:

METHOXAMINE Primary Drug Name

Drug Info:

Drug Class antihypotensive agents

Year of Approval approved before 1982

Drug Class vasoconstrictor agents

Publications:
TdgClinicalTrial: METHOXAMINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypotensive Agents

Drug Indications Vasoconstrictor Agents

Drug Class small molecule

Publications:
TTD: Methoxamine
- Version: 2020.06.01
Alternate Names:

D09GYT TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL524
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
PharmGKB: methoxamine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

agonist (activating)
binder

METHOXAMINE Drug Record

METHOXAMINE chembl:CHEMBL524 Approved

Alternate Names:

Drug Info:

Publications:

METHOXAMINE ADRA1B

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 2988814 8635240 11331292 2546049 11752352

Sources: TdgClinicalTrial TEND PharmGKB TTD

METHOXAMINE ADRA1A

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 1978244 7875228 8986981 7511752 1680715

Sources: TdgClinicalTrial TEND PharmGKB

METHOXAMINE ADRA1D

Interaction Types & Directionality: agonist (activating) binder

Interaction Info:

PMIDs: 19493707

Sources: PharmGKB

TEND: METHOXAMINE

Alternate Names: METHOXAMINE Primary Drug Name

Drug Info: Drug Class antihypotensive agents Year of Approval approved before 1982 Drug Class vasoconstrictor agents

Publications:

TdgClinicalTrial: METHOXAMINE

Alternate Names:

Drug Info: Drug Indications Antihypotensive Agents Drug Indications Vasoconstrictor Agents Drug Class small molecule

Publications:

TTD: Methoxamine

Alternate Names: D09GYT TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL524

Alternate Names:

Drug Info:

Publications:

PharmGKB: methoxamine

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2988814 8635240 11331292 2546049 11752352

Sources:
TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1978244 7875228 8986981 7511752 1680715

Sources:
TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality:

agonist (activating)

binder

PMIDs:
19493707

Sources:
PharmGKB

Alternate Names:

METHOXAMINE Primary Drug Name

Drug Info:

Drug Class antihypotensive agents

Year of Approval approved before 1982

Drug Class vasoconstrictor agents

Drug Info:

Drug Indications Antihypotensive Agents

Drug Indications Vasoconstrictor Agents

Drug Class small molecule

Alternate Names:

D09GYT TTD Drug ID