DGIdb - PEGFILGRASTIM Drug Record

PEGFILGRASTIM chembl:CHEMBL1201568 Approved

Alternate Names:

NEULASTA SURECLICK
PEGFILGRASTIM
MYL-1401H
NEULASTA
PEGFILGRASTIM FOR BIOASSAY
N-(3-HYDROXYPROPYL)METHIONYLCOLONY-STIMULATING FACTOR (HUMAN), 1-ETHER WITH .ALPHA.-METHYL-.OMEGA.-HYDROXYPOLY(OXYETHYLENE)
G-CSF
LENOGRASTIM
PLURIPOIETIN
GRANULOCYTE COLONY-STIMULATING FACTOR PRECURSOR
rxcui:338036
chembl:CHEMBL1201568
drugbank:00019
chemidplus:208265-92-3

Drug Info:

FDA Approval	2002
Drug Class	recombinant protein
Drug Indications	Antineutropenic Agents
FDA Approval	approved
Drug Class	protein
Drug Indications	for treatment of neutropenia
Year of Approval	2002
Drug Class	antineutropenic agents

(1 More Sources)

Publications:

Zhuang et al., 2005, Tyrosine 729 of the G-CSF receptor controls the duration of receptor signaling: involvement of SOCS3 and SOCS1., J. Leukoc. Biol.
Kotto-Kome et al., 2004, Evidence that the granulocyte colony-stimulating factor (G-CSF) receptor plays a role in the pharmacokinetics of G-CSF and PegG-CSF using a G-CSF-R KO model., Pharmacol. Res.
Erkeland et al., 2007, Novel role of WD40 and SOCS box protein-2 in steady-state distribution of granulocyte colony-stimulating factor receptor and G-CSF-controlled proliferation and differentiation signaling., Oncogene
Cao et al., 2005, [The response of bone marrow hematopoietic cells to G-CSF in paroxysmal nocturnal hemoglobinuria patients]., Zhonghua Xue Ye Xue Za Zhi
Ward, 2007, The role of the granulocyte colony-stimulating factor receptor (G-CSF-R) in disease., Front. Biosci.
Elsässer et al., 2003, The fusion protein AML1-ETO in acute myeloid leukemia with translocation t(8;21) induces c-jun protein expression via the proximal AP-1 site of the c-jun promoter in an indirect, JNK-dependent manner., Oncogene

PEGFILGRASTIM CSF3R

Interaction Score: 88.33

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Granulocyte colony stimulating factor receptor agonist

Trial Name pegfilgrastim,N/

PMIDs:
16033816 15082029 17001306 15949269 17127322 12944913

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

TEND: PEGFILGRASTIM
- Version: 01-August-2011
Alternate Names:

PEGFILGRASTIM Primary Drug Name

Drug Info:

Drug Class antineutropenic agents

Year of Approval 2002

Publications:
TdgClinicalTrial: PEGFILGRASTIM
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of neutropenia

Drug Class protein

FDA Approval approved

Publications:
TTD: Pegfilgrastim
- Version: 2020.06.01
Alternate Names:

D0AT8C TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1201568
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1201568
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Granulocyte colony stimulating factor receptor agonist
Trial Name	pegfilgrastim,N/

PEGFILGRASTIM Drug Record

PEGFILGRASTIM chembl:CHEMBL1201568 Approved

Alternate Names:

Drug Info:

Publications:

PEGFILGRASTIM CSF3R

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Granulocyte colony stimulating factor receptor agonist Trial Name pegfilgrastim,N/

PMIDs: 16033816 15082029 17001306 15949269 17127322 12944913

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

TEND: PEGFILGRASTIM

Alternate Names: PEGFILGRASTIM Primary Drug Name

Drug Info: Drug Class antineutropenic agents Year of Approval 2002

Publications:

TdgClinicalTrial: PEGFILGRASTIM

Alternate Names:

Drug Info: Drug Indications for treatment of neutropenia Drug Class protein FDA Approval approved

Publications:

TTD: Pegfilgrastim

Alternate Names: D0AT8C TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1201568

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1201568

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Granulocyte colony stimulating factor receptor agonist

Trial Name pegfilgrastim,N/

PMIDs:
16033816 15082029 17001306 15949269 17127322 12944913

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Alternate Names:

PEGFILGRASTIM Primary Drug Name

Drug Info:

Drug Class antineutropenic agents

Year of Approval 2002

Drug Info:

Drug Indications for treatment of neutropenia

Drug Class protein

FDA Approval approved

Alternate Names:

D0AT8C TTD Drug ID