DGIdb - PHENFORMIN Drug Record

PHENFORMIN chembl:CHEMBL170988 Antineoplastic

Alternate Names:

PHENFORMIN
PHENFORMINE
DBI
FENFORMIN
FENFORMINA
Β-PHENETHYBIGUANIDE
PHENFORMINUM
pubchem.compound:8249
chembl:CHEMBL170988
rxcui:8129
drugbank:00914
chemidplus:114-86-3

Drug Info:

Year of Approval	approved before 1982
Drug Class	hypoglycemic agents
FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Hypoglycemic Agents

(0 More Sources)

Publications:

Momcilovic et al., 2015, Heightening Energetic Stress Selectively Targets LKB1-Deficient Non-Small Cell Lung Cancers., Cancer Res.
Zhang et al., 2007, Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration., Am. J. Physiol. Heart Circ. Physiol.
Chen et al., 2008, Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators., Biochem. J.
Woollhead et al., 2007, Pharmacological activators of AMP-activated protein kinase have different effects on Na+ transport processes across human lung epithelial cells., Br. J. Pharmacol.

PHENFORMIN PRKAA1

Interaction Score: 3.96

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17369473 17995453 17603555

Sources:
TdgClinicalTrial TEND
PHENFORMIN STK11

Interaction Score: 1.79

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy MLN0128 + Phenformin

Indication/Tumor Type lung adenocarcinoma

Response Type sensitive

PMIDs:
26574479

Sources:
JAX-CKB
PHENFORMIN KRAS

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy MLN0128 + Phenformin

Indication/Tumor Type lung adenocarcinoma

Response Type sensitive

PMIDs:
26574479

Sources:
JAX-CKB

TEND: PHENFORMIN
- Version: 01-August-2011
Alternate Names:

PHENFORMIN Primary Drug Name

Drug Info:

Drug Class hypoglycemic agents

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: PHENFORMIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Hypoglycemic Agents

Drug Class small molecule

FDA Approval Approved before 1982

Publications:
JAX-CKB: Phenformin
- Version: 27-September-2017
Alternate Names:

Drug Info:

Publications:

Momcilovic et al., 2015, Heightening Energetic Stress Selectively Targets LKB1-Deficient Non-Small Cell Lung Cancers., Cancer Res.
ChemblDrugs: chembl:CHEMBL170988
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

combination therapy	MLN0128 + Phenformin
Indication/Tumor Type	lung adenocarcinoma
Response Type	sensitive

Trial Name	-
Novel drug target	Established target

PHENFORMIN Drug Record

PHENFORMIN chembl:CHEMBL170988 Antineoplastic

Alternate Names:

Drug Info:

Publications:

PHENFORMIN PRKAA1

Interaction Types & Directionality: activator (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17369473 17995453 17603555

Sources: TdgClinicalTrial TEND

PHENFORMIN STK11

Interaction Types & Directionality: n/a

Interaction Info: combination therapy MLN0128 + Phenformin Indication/Tumor Type lung adenocarcinoma Response Type sensitive

PMIDs: 26574479

Sources: JAX-CKB

PHENFORMIN KRAS

Interaction Types & Directionality: n/a

Interaction Info: combination therapy MLN0128 + Phenformin Indication/Tumor Type lung adenocarcinoma Response Type sensitive

PMIDs: 26574479

Sources: JAX-CKB

TEND: PHENFORMIN

Alternate Names: PHENFORMIN Primary Drug Name

Drug Info: Drug Class hypoglycemic agents Year of Approval approved before 1982

Publications:

TdgClinicalTrial: PHENFORMIN

Alternate Names:

Drug Info: Drug Indications Hypoglycemic Agents Drug Class small molecule FDA Approval Approved before 1982

Publications:

JAX-CKB: Phenformin

Alternate Names:

Drug Info:

Publications: Momcilovic et al., 2015, Heightening Energetic Stress Selectively Targets LKB1-Deficient Non-Small Cell Lung Cancers., Cancer Res.

ChemblDrugs: chembl:CHEMBL170988

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17369473 17995453 17603555

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy MLN0128 + Phenformin

Indication/Tumor Type lung adenocarcinoma

Response Type sensitive

PMIDs:
26574479

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy MLN0128 + Phenformin

Indication/Tumor Type lung adenocarcinoma

Response Type sensitive

PMIDs:
26574479

Sources:
JAX-CKB

Alternate Names:

PHENFORMIN Primary Drug Name

Drug Info:

Drug Class hypoglycemic agents

Year of Approval approved before 1982

Drug Info:

Drug Indications Hypoglycemic Agents

Drug Class small molecule

FDA Approval Approved before 1982

Publications:

Momcilovic et al., 2015, Heightening Energetic Stress Selectively Targets LKB1-Deficient Non-Small Cell Lung Cancers., Cancer Res.