DGIdb - PICROTOXIN Drug Record

PICROTOXIN chembl:CHEMBL1908342

Alternate Names:

PICROTOXIN

Drug Info:

Drug Class	convulsants
Drug Class	central nervous system stimulants
Year of Approval	not approved by the fda
FDA Approval	not approved by the FDA
Drug Class	small molecule
Drug Indications	Central Nervous System Stimulants
Drug Indications	Convulsants

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Publications:

Yang et al., 2007, A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore., J. Neurochem.
Wang et al., 2007, Mechanisms for picrotoxinin and picrotin blocks of alpha2 homomeric glycine receptors., J. Biol. Chem.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Richter et al., 2010, Intrinsic activation of GABA(A) receptors suppresses epileptiform activity in the cerebral cortex of immature mice., Epilepsia
Law et al., 2008, Gaba receptor insecticide non-competitive antagonists may bind at allosteric modulator sites., Int. J. Neurosci.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

PICROTOXIN GLRA3

Interaction Score: 30.91

Interaction Types & Directionality:

antagonist (inhibitory)

blocker (inhibitory)

Interaction Info:

PMIDs:
17714449

Sources:
TEND
PICROTOXIN GLRA2

Interaction Score: 11.59

Interaction Types & Directionality:

antagonist (inhibitory)

blocker (inhibitory)

Interaction Info:

PMIDs:
17714449 17405877

Sources:
TEND
PICROTOXIN GABRR1

Interaction Score: 3.43

Interaction Types & Directionality:

antagonist (inhibitory)

blocker (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 20491873 18446586

Sources:
TdgClinicalTrial TEND
PICROTOXIN GABRA1

Interaction Score: 1.36

Interaction Types & Directionality:

antagonist (inhibitory)

blocker (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752352 17016423 17139284 20491873 18446586

Sources:
TdgClinicalTrial TEND TTD

TEND: PICROTOXIN
- Version: 01-August-2011
Alternate Names:

PICROTOXIN Primary Drug Name

Drug Info:

Year of Approval not approved by the fda

Drug Class central nervous system stimulants

Drug Class convulsants

Publications:
TdgClinicalTrial: PICROTOXIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Convulsants

Drug Indications Central Nervous System Stimulants

Drug Class small molecule

Publications:
TTD: Picrotoxin
- Version: 2020.06.01
Alternate Names:

D0KR9U TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1908342
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

antagonist (inhibitory)
blocker (inhibitory)

antagonist (inhibitory)
blocker (inhibitory)

antagonist (inhibitory)
blocker (inhibitory)

Trial Name	-
Novel drug target	Established target

PICROTOXIN Drug Record

PICROTOXIN chembl:CHEMBL1908342

Alternate Names:

Drug Info:

Publications:

PICROTOXIN GLRA3

Interaction Types & Directionality: antagonist (inhibitory) blocker (inhibitory)

Interaction Info:

PMIDs: 17714449

Sources: TEND

PICROTOXIN GLRA2

Interaction Types & Directionality: antagonist (inhibitory) blocker (inhibitory)

Interaction Info:

PMIDs: 17714449 17405877

Sources: TEND

PICROTOXIN GABRR1

Interaction Types & Directionality: antagonist (inhibitory) blocker (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284 20491873 18446586

Sources: TdgClinicalTrial TEND

PICROTOXIN GABRA1

Interaction Types & Directionality: antagonist (inhibitory) blocker (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11752352 17016423 17139284 20491873 18446586

Sources: TdgClinicalTrial TEND TTD

TEND: PICROTOXIN

Alternate Names: PICROTOXIN Primary Drug Name

Drug Info: Year of Approval not approved by the fda Drug Class central nervous system stimulants Drug Class convulsants

Publications:

TdgClinicalTrial: PICROTOXIN

Alternate Names:

Drug Info: Drug Indications Convulsants Drug Indications Central Nervous System Stimulants Drug Class small molecule

Publications:

TTD: Picrotoxin

Alternate Names: D0KR9U TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1908342

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

blocker (inhibitory)

PMIDs:
17714449

Sources:
TEND

Interaction Types & Directionality:

antagonist (inhibitory)

blocker (inhibitory)

PMIDs:
17714449 17405877

Sources:
TEND

Interaction Types & Directionality:

antagonist (inhibitory)

blocker (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 20491873 18446586

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

blocker (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752352 17016423 17139284 20491873 18446586

Sources:
TdgClinicalTrial TEND TTD

Alternate Names:

PICROTOXIN Primary Drug Name

Drug Info:

Year of Approval not approved by the fda

Drug Class central nervous system stimulants

Drug Class convulsants

Drug Info:

Drug Indications Convulsants

Drug Indications Central Nervous System Stimulants

Drug Class small molecule

Alternate Names:

D0KR9U TTD Drug ID