DGIdb - PROCYCLIDINE Drug Record

PROCYCLIDINE chembl:CHEMBL86715 Approved

Alternate Names:

PROCYCLIDINE
1-CYCLOHEXYL-1-PHENYL-3-PYRROLIDINO-1-PROPANOL
PROCYCLIDINUM
PROCYCLIDINE HYDROCHLORIDE
1-CYCLOHEXYL-1-PHENYL-3-PYRROLIDIN-1-YL-PROPAN-1-OL HYDROCHLORIDE
1-CYCLOHEXYL-1-PHENYL-3-PYRROLIDIN-1-YLPROPAN-1-OL
KEMADRIN®
PROCYCLIDIN
ARPICOLIN®
TRICYCLAMOL
1-CYCLOHEXYL-1-PHENYL-3-PYRROLIDINO-PROPAN-1-OL
1-CYCLOHEXYL-1-PHENYL-3-PYRROLIDIN-1-YL-PROPAN-1-OL
PROCICLIDINA
1-CYCLOHEXYL-1-PHENYL-3-(1-PYRROLIDINYL)-1-PROPANOL
drugbank:00387
rxcui:8718
chembl:CHEMBL86715
chemidplus:77-37-2
pubchem.compound:4919

Drug Info:

FDA Approval	1955
Drug Class	small molecule
Drug Indications	Antiparkinson Agents
Drug Indications	Antidyskinetics
Year of Approval	1955
Drug Class	antidyskinetics
Drug Class	antiparkinson agents

(0 More Sources)

Publications:

Larson et al., 1991, Selectivity of antimuscarinic compounds for muscarinic receptors of human brain and heart., Psychopharmacology (Berl.)
Waelbroeck et al., 1992, Stereoselective interaction of procyclidine, hexahydro-difenidol, hexbutinol and oxyphencyclimine, and of related antagonists, with four muscarinic receptors., Eur. J. Pharmacol.
Waelbroeck et al., 1990, Stereoselectivity of procyclidine binding to muscarinic receptor subtypes M1, M2 and M4., Eur. J. Pharmacol.
Myhrer, 2010, Identification of neuronal target areas for nerve agents and specification of receptors for pharmacological treatment., Neurotoxicology
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Alberts, 1995, Classification of the presynaptic muscarinic receptor subtype that regulates 3H-acetylcholine secretion in the guinea pig urinary bladder in vitro., J. Pharmacol. Exp. Ther.

PROCYCLIDINE CHRM4

Interaction Score: 5.62

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
1426023 2253700 20624420 7616431 17016423 17139284

Sources:
TdgClinicalTrial TEND
PROCYCLIDINE CHRM2

Interaction Score: 2.42

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2027917 1426023 2253700 20624420 17016423 17139284

Sources:
TdgClinicalTrial TEND
PROCYCLIDINE CHRM1

Interaction Score: 1.47

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2027917 1426023 2253700 20624420 17016423 17139284

Sources:
TdgClinicalTrial TEND
PROCYCLIDINE CHRM5

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

TEND: PROCYCLIDINE
- Version: 01-August-2011
Alternate Names:

PROCYCLIDINE Primary Drug Name

Drug Info:

Drug Class antiparkinson agents

Drug Class antidyskinetics

Year of Approval 1955

Publications:
TdgClinicalTrial: PROCYCLIDINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antidyskinetics

Drug Indications Antiparkinson Agents

Drug Class small molecule

Publications:
TTD: Procyclidine
- Version: 2020.06.01
Alternate Names:

D0R1WR TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL86715
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	-

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

PROCYCLIDINE Drug Record

PROCYCLIDINE chembl:CHEMBL86715 Approved

Alternate Names:

Drug Info:

Publications:

PROCYCLIDINE CHRM4

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 1426023 2253700 20624420 7616431 17016423 17139284

Sources: TdgClinicalTrial TEND

PROCYCLIDINE CHRM2

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 2027917 1426023 2253700 20624420 17016423 17139284

Sources: TdgClinicalTrial TEND

PROCYCLIDINE CHRM1

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 2027917 1426023 2253700 20624420 17016423 17139284

Sources: TdgClinicalTrial TEND

PROCYCLIDINE CHRM5

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

TEND: PROCYCLIDINE

Alternate Names: PROCYCLIDINE Primary Drug Name

Drug Info: Drug Class antiparkinson agents Drug Class antidyskinetics Year of Approval 1955

Publications:

TdgClinicalTrial: PROCYCLIDINE

Alternate Names:

Drug Info: Drug Indications Antidyskinetics Drug Indications Antiparkinson Agents Drug Class small molecule

Publications:

TTD: Procyclidine

Alternate Names: D0R1WR TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL86715

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
1426023 2253700 20624420 7616431 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2027917 1426023 2253700 20624420 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2027917 1426023 2253700 20624420 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Alternate Names:

PROCYCLIDINE Primary Drug Name

Drug Info:

Drug Class antiparkinson agents

Drug Class antidyskinetics

Year of Approval 1955

Drug Info:

Drug Indications Antidyskinetics

Drug Indications Antiparkinson Agents

Drug Class small molecule

Alternate Names:

D0R1WR TTD Drug ID