DGIdb - PROTRIPTYLINE Drug Record

PROTRIPTYLINE chembl:CHEMBL668 Approved

Alternate Names:

PROTRIPTYLINE
7-(3-METHYLAMINOPROPYL)-1,2:5,6-DIBENZOCYCLOHEPTATRIENE
VIVACTIL®
N-METHYL-5H-DIBENZO[A,D]CYCLOHEPTENE-5-PROPYLAMINE
5-(3-METHYLAMINOPROPYL)-5H-DIBENZO[A,D]CYCLOHEPTENE
N-METHYL-5H-DIBENZO[A,D]CYCLOHEPTENE-5-PROPANAMINE
MK-240
AMIMETILINA
3-(5H-DIBENZO[A,D]CYCLOHEPTEN-5-YL)-N-METHYL-1-PROPANAMINE
pubchem.compound:4976
chemidplus:438-60-8
chembl:CHEMBL668
drugbank:00344
rxcui:8886

Drug Info:

FDA Approval	1967
Drug Class	small molecule
Drug Indications	Antidepressive Agents, Tricyclic
Year of Approval	1967
Drug Class	antidepressive agents, tricyclic

(3 More Sources)

Publications:

Frazer et al., 1998, Serotonin transporter function in vivo: assessment by chronoamperometry., Ann. N. Y. Acad. Sci.
Kovachich et al., 1992, Effect of repeated administration of antidepressants on serotonin uptake sites in limbic and neocortical structures of rat brain determined by quantitative autoradiography., Neuropsychopharmacology
McDougle et al., 1998, Evidence for linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and obsessive compulsive disorder., Mol. Psychiatry
Tatsumi et al., 1997, Pharmacological profile of antidepressants and related compounds at human monoamine transporters., Eur. J. Pharmacol.
Daws et al., 1998, In vivo chronoamperometric measures of extracellular serotonin clearance in rat dorsal hippocampus: contribution of serotonin and norepinephrine transporters., J. Pharmacol. Exp. Ther.
Rouillon et al., 1996, [Pharmaco-epidemiologic study of the use of antidepressant drugs in the general population]., Encephale
Cheetham et al., 1996, [3H]nisoxetine--a radioligand for noradrenaline reuptake sites: correlation with inhibition of [3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments., Neuropharmacology
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

PROTRIPTYLINE SLC6A2

Interaction Score: 1.36

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8684598 17016423 17139284 9537821

Sources:
TdgClinicalTrial TEND
PROTRIPTYLINE SLC6A4

Interaction Score: 1.36

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9928259 1476595 9672904 9537821 9694957 8767026

Sources:
TdgClinicalTrial TEND
PROTRIPTYLINE THPO

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROTRIPTYLINE NFKB1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROTRIPTYLINE DRD1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROTRIPTYLINE CYP2D6

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC PharmGKB FDA
PROTRIPTYLINE HSD17B10

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: PROTRIPTYLINE
- Version: 01-August-2011
Alternate Names:

PROTRIPTYLINE Primary Drug Name

Drug Info:

Drug Class antidepressive agents, tricyclic

Year of Approval 1967

Publications:
TdgClinicalTrial: PROTRIPTYLINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antidepressive Agents, Tricyclic

Drug Class small molecule

FDA Approval 1967

Publications:
DTC: PROTRIPTYLINE
- Version: 02-September-2020
Alternate Names:

CHEMBL668 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Protriptyline
- Version: 2020.06.01
Alternate Names:

D00MYQ TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL668
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
PharmGKB: protriptyline
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:
FDA: Protriptyline
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

PROTRIPTYLINE Drug Record

PROTRIPTYLINE chembl:CHEMBL668 Approved

Alternate Names:

Drug Info:

Publications:

PROTRIPTYLINE SLC6A2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 8684598 17016423 17139284 9537821

Sources: TdgClinicalTrial TEND

PROTRIPTYLINE SLC6A4

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 9928259 1476595 9672904 9537821 9694957 8767026

Sources: TdgClinicalTrial TEND

PROTRIPTYLINE THPO

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

PROTRIPTYLINE NFKB1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

PROTRIPTYLINE DRD1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

PROTRIPTYLINE CYP2D6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC PharmGKB FDA

PROTRIPTYLINE HSD17B10

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: PROTRIPTYLINE

Alternate Names: PROTRIPTYLINE Primary Drug Name

Drug Info: Drug Class antidepressive agents, tricyclic Year of Approval 1967

Publications:

TdgClinicalTrial: PROTRIPTYLINE

Alternate Names:

Drug Info: Drug Indications Antidepressive Agents, Tricyclic Drug Class small molecule FDA Approval 1967

Publications:

DTC: PROTRIPTYLINE

Alternate Names: CHEMBL668 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Protriptyline

Alternate Names: D00MYQ TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL668

Alternate Names:

Drug Info:

Publications:

PharmGKB: protriptyline

Alternate Names:

Drug Info:

Publications:

FDA: Protriptyline

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8684598 17016423 17139284 9537821

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9928259 1476595 9672904 9537821 9694957 8767026

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

PROTRIPTYLINE Primary Drug Name

Drug Info:

Drug Class antidepressive agents, tricyclic

Year of Approval 1967

Drug Info:

Drug Indications Antidepressive Agents, Tricyclic

Drug Class small molecule

FDA Approval 1967

Alternate Names:

CHEMBL668 ChEMBL Drug ID

Alternate Names:

D00MYQ TTD Drug ID