DGIdb - RAMELTEON Drug Record

RAMELTEON chembl:CHEMBL1218 Approved

Alternate Names:

TAK375
ROZEREM
TAK-375
RAMELTEON
ROZEREM®
chembl:CHEMBL1218
drugbank:00980
rxcui:596205
pubchem.compound:208902
chemidplus:196597-26-9

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	for treatment of insomnia
Year of Approval	2005
Drug Class	hypnotics and sedatives

(1 More Sources)

Publications:

Greenblatt et al., 2007, Age and gender effects on the pharmacokinetics and pharmacodynamics of ramelteon, a hypnotic agent acting via melatonin receptors MT1 and MT2., J Clin Pharmacol
Borja et al., 2006, Ramelteon for the treatment of insomnia., Clin Ther
Miyamoto, 2009, [A novel therapeutic drug: ramelteon]., Nippon Rinsho
Pandi-Perumal et al., 2009, Ramelteon: a review of its therapeutic potential in sleep disorders., Adv Ther
Miyamoto, 2006, Effect of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist, on motor performance in mice., Neurosci. Lett.
Zammit et al., 2007, Evaluation of the efficacy and safety of ramelteon in subjects with chronic insomnia., J Clin Sleep Med
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Karim et al., 2006, Disposition kinetics and tolerance of escalating single doses of ramelteon, a high-affinity MT1 and MT2 melatonin receptor agonist indicated for treatment of insomnia., J Clin Pharmacol
Kato et al., 2005, Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist., Neuropharmacology
Roth et al., 2005, Ramelteon (TAK-375), a selective MT1/MT2-receptor agonist, reduces latency to persistent sleep in a model of transient insomnia related to a novel sleep environment., Sleep
Johnson et al., 2006, Ramelteon: a novel hypnotic lacking abuse liability and sedative adverse effects., Arch. Gen. Psychiatry
Miyamoto, 2009, Pharmacology of ramelteon, a selective MT1/MT2 receptor agonist: a novel therapeutic drug for sleep disorders., CNS Neurosci Ther
2005, Ramelteon: TAK 375., Drugs R D

RAMELTEON MTNR1B

Interaction Score: 131.39

Interaction Types & Directionality:

agonist (activating)

multitarget

Interaction Info:

Mechanism of Interaction Melatonin receptor agonist

Direct Interaction yes

Trial Name ramelteon, TAK-375,Rozerem

PMIDs:
17389558 17157111 19768947 19568703 16730121 17803013 11752352 16432265 15695169 16173650 17015817 19228178 15869323

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
RAMELTEON MTNR1A

Interaction Score: 105.11

Interaction Types & Directionality:

agonist (activating)

multitarget

Interaction Info:

Mechanism of Interaction Melatonin receptor agonist

Direct Interaction yes

Trial Name ramelteon, TAK-375,Rozerem

PMIDs:
17389558 17157111 19768947 19568703 16730121 17803013 11752352 16432265 15695169 16173650 17015817 19228178 15869323

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

TEND: RAMELTEON
- Version: 01-August-2011
Alternate Names:

RAMELTEON Primary Drug Name

Drug Info:

Drug Class hypnotics and sedatives

Year of Approval 2005

Publications:
TdgClinicalTrial: RAMELTEON
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of insomnia

Drug Class Small Molecule

FDA Approval approved

Publications:
TTD: Ramelteon
- Version: 2020.06.01
Alternate Names:

D0U0KW TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1218
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1218
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Melatonin receptor agonist
Direct Interaction	yes
Trial Name	ramelteon, TAK-375,Rozerem

agonist (activating)
multitarget

agonist (activating)
multitarget

RAMELTEON Drug Record

RAMELTEON chembl:CHEMBL1218 Approved

Alternate Names:

Drug Info:

Publications:

RAMELTEON MTNR1B

Interaction Types & Directionality: agonist (activating) multitarget

Interaction Info: Mechanism of Interaction Melatonin receptor agonist Direct Interaction yes Trial Name ramelteon, TAK-375,Rozerem

PMIDs: 17389558 17157111 19768947 19568703 16730121 17803013 11752352 16432265 15695169 16173650 17015817 19228178 15869323

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

RAMELTEON MTNR1A

Interaction Types & Directionality: agonist (activating) multitarget

Interaction Info: Mechanism of Interaction Melatonin receptor agonist Direct Interaction yes Trial Name ramelteon, TAK-375,Rozerem

PMIDs: 17389558 17157111 19768947 19568703 16730121 17803013 11752352 16432265 15695169 16173650 17015817 19228178 15869323

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

TEND: RAMELTEON

Alternate Names: RAMELTEON Primary Drug Name

Drug Info: Drug Class hypnotics and sedatives Year of Approval 2005

Publications:

TdgClinicalTrial: RAMELTEON

Alternate Names:

Drug Info: Drug Indications for treatment of insomnia Drug Class Small Molecule FDA Approval approved

Publications:

TTD: Ramelteon

Alternate Names: D0U0KW TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1218

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1218

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

multitarget

Interaction Info:

Mechanism of Interaction Melatonin receptor agonist

Direct Interaction yes

Trial Name ramelteon, TAK-375,Rozerem

PMIDs:
17389558 17157111 19768947 19568703 16730121 17803013 11752352 16432265 15695169 16173650 17015817 19228178 15869323

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

agonist (activating)

multitarget

Interaction Info:

Mechanism of Interaction Melatonin receptor agonist

Direct Interaction yes

Trial Name ramelteon, TAK-375,Rozerem

PMIDs:
17389558 17157111 19768947 19568703 16730121 17803013 11752352 16432265 15695169 16173650 17015817 19228178 15869323

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Alternate Names:

RAMELTEON Primary Drug Name

Drug Info:

Drug Class hypnotics and sedatives

Year of Approval 2005

Drug Info:

Drug Indications for treatment of insomnia

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

D0U0KW TTD Drug ID