DGIdb - RILUZOLE Drug Record

RILUZOLE chembl:CHEMBL744 Approved

Alternate Names:

RP-54274
RILUTEK
RILUZOLE
TIGLUTIK KIT
TEGLUTIK
BHV-0223
RILUZOLUM
RILUZOL
RILUTEK®
chembl:CHEMBL744
chemidplus:1744-22-5
rxcui:35623
pubchem.compound:5070
drugbank:00740

Drug Info:

Drug Indications	for treatment of ALS
FDA Approval	approved
Drug Class	Small Molecule

(1 More Sources)

Publications:

Weiss et al., 2010, Riluzole protects against cardiac ischaemia and reperfusion damage via block of the persistent sodium current., Br. J. Pharmacol.
Schwartz et al., 2002, Secondary injury mechanisms of spinal cord trauma: a novel therapeutic approach for the management of secondary pathophysiology with the sodium channel blocker riluzole., Prog. Brain Res.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Song et al., 1997, Differential action of riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels., J. Pharmacol. Exp. Ther.
Azbill et al., 2000, Riluzole increases high-affinity glutamate uptake in rat spinal cord synaptosomes., Brain Res.
Hayashida et al., 2010, Activation of glutamate transporters in the locus coeruleus paradoxically activates descending inhibition in rats., Brain Res.
Dunlop et al., 2003, Impaired spinal cord glutamate transport capacity and reduced sensitivity to riluzole in a transgenic superoxide dismutase mutant rat model of amyotrophic lateral sclerosis., J. Neurosci.
Wokke, 1996, Riluzole., Lancet
Gosselin et al., 2010, Riluzole normalizes early-life stress-induced visceral hypersensitivity in rats: role of spinal glutamate reuptake mechanisms., Gastroenterology

RILUZOLE SLC7A11

Interaction Score: 23.19

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Trial Name riluzole,Rilutek

Novel drug target Established target

PMIDs:
10899284 20059984 12629173 8813989 20226190

Sources:
TdgClinicalTrial
RILUZOLE SCN5A

Interaction Score: 0.32

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name riluzole,Rilutek

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
20590601 12440368 17016423 17139284 9262334

Sources:
TdgClinicalTrial ChemblInteractions
RILUZOLE SCN11A

Interaction Score: 0.13

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
RILUZOLE SCN7A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RILUZOLE SCN8A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RILUZOLE SCN3A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RILUZOLE SCN2A

Interaction Score: 0.06

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RILUZOLE SCN1A

Interaction Score: 0.06

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RILUZOLE SCN4A

Interaction Score: 0.06

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RILUZOLE SCN9A

Interaction Score: 0.06

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RILUZOLE SCN10A

Interaction Score: 0.05

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RILUZOLE TARDBP

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RILUZOLE NPC1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RILUZOLE RAB9A

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RILUZOLE CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RILUZOLE CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TdgClinicalTrial: RILUZOLE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Class Small Molecule

FDA Approval approved

Drug Indications for treatment of ALS

Publications:
TTD: Riluzole
- Version: 2020.06.01
Alternate Names:

D0H0KB TTD Drug ID

Drug Info:

Publications:
DTC: RILUZOLE
- Version: 02-September-2020
Alternate Names:

CHEMBL744 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL744
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL744
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	riluzole,Rilutek
Novel drug target	Established target

Mechanism of Interaction	Sodium channel alpha subunit blocker
Direct Interaction	yes

blocker (inhibitory)
inhibitor (inhibitory)

RILUZOLE Drug Record

RILUZOLE chembl:CHEMBL744 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inducer (activating)

Interaction Info: Trial Name riluzole,Rilutek Novel drug target Established target

PMIDs: 10899284 20059984 12629173 8813989 20226190

Sources: TdgClinicalTrial

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name riluzole,Rilutek Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs: 20590601 12440368 17016423 17139284 9262334

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TdgClinicalTrial: RILUZOLE

Alternate Names:

Drug Info: Drug Class Small Molecule FDA Approval approved Drug Indications for treatment of ALS

Publications:

TTD: Riluzole

Alternate Names: D0H0KB TTD Drug ID

Drug Info:

Publications:

DTC: RILUZOLE

Alternate Names: CHEMBL744 ChEMBL Drug ID

Drug Info:

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Trial Name riluzole,Rilutek

Novel drug target Established target

PMIDs:
10899284 20059984 12629173 8813989 20226190

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name riluzole,Rilutek

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
20590601 12440368 17016423 17139284 9262334

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Drug Info:

Drug Class Small Molecule

FDA Approval approved

Drug Indications for treatment of ALS

Alternate Names:

D0H0KB TTD Drug ID

Alternate Names:

CHEMBL744 ChEMBL Drug ID