DGIdb - SAPROPTERIN Drug Record

SAPROPTERIN chembl:CHEMBL1201774 Approved

Alternate Names:

SAPROPTERIN
DAPROTERIN

Drug Info:

Year of Approval	err:520
Drug Class	pku-treatment
FDA Approval	2007
Drug Class	small molecule
Drug Indications	PKU-treatment

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Publications:

Zekanowski et al., 1998, Identification of Mutations Causing 6-Pyruvoyl- Tetrahydrobiopterin Synthase Deficiency in Polish Patients With Variant Hyperphenylalaninemia., Mol. Diagn.
Werner et al., 2000, Contrasting effects of N5-substituted tetrahydrobiopterin derivatives on phenylalanine hydroxylase, dihydropteridine reductase and nitric oxide synthase., Biochem. J.
Jennings et al., 2001, Essential role of the N-terminal autoregulatory sequence in the regulation of phenylalanine hydroxylase., FEBS Lett.
Ayling et al., 2000, Hyperphenylalaninemia and 7-pterin excretion associated with mutations in 4a-hydroxy-tetrahydrobiopterin dehydratase/DCoH: analysis of enzyme activity in intestinal biopsies., Mol. Genet. Metab.
Fitzpatrick, 1999, Tetrahydropterin-dependent amino acid hydroxylases., Annu. Rev. Biochem.

SAPROPTERIN PAH

Interaction Score: 86.56

Interaction Types & Directionality:

activator (activating)

cofactor (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10089284 10839989 11163771 10924272 10872454

Sources:
TdgClinicalTrial TEND

TEND: SAPROPTERIN
- Version: 01-August-2011
Alternate Names:

SAPROPTERIN Primary Drug Name

Drug Info:

Drug Class pku-treatment

Year of Approval err:520

Publications:
TdgClinicalTrial: SAPROPTERIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications PKU-treatment

Drug Class small molecule

FDA Approval 2007

Publications:
ChemblDrugs: chembl:CHEMBL1201774
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications: