DGIdb - SUCRALFATE Drug Record

SUCRALFATE chembl:CHEMBL2367706 Approved

Alternate Names:

SUCRALFATE
SUCRALFATE HYDRATE
CARAFATE
ANTEPSIN
ULCERLMIN

Drug Info:

Drug Class	gi anti-ulcer agents, antimuscarinics
Year of Approval	1981
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antiulcer agent

(1 More Sources)

Publications:

Szabo et al., 1995, Growth factors: new 'endogenous drugs' for ulcer healing., Scand. J. Gastroenterol. Suppl.
Szabo, 1991, The mode of action of sucralfate: the 1 x 1 x 1 mechanism of action., Scand. J. Gastroenterol. Suppl.
Tarnawski et al., 1995, Cellular and molecular mechanisms of gastric ulcer healing. Is the quality of mucosal scar affected by treatment?, Scand. J. Gastroenterol. Suppl.
Korman et al., Sucralfate: the Bangkok review., J. Gastroenterol. Hepatol.
Konturek, 1990, Role of growth factors in gastroduodenal protection and healing of peptic ulcers., Gastroenterol. Clin. North Am.
Peterson, 1990, Pathogenesis and therapy of peptic ulcer disease., J. Clin. Gastroenterol.
Hollander et al., 1990, The protective and therapeutic mechanisms of sucralfate., Scand. J. Gastroenterol. Suppl.
Jensen et al., 1992, Role of sucralfate in peptic disease., Dig Dis

SUCRALFATE PGA5

Interaction Score: 82.44

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Pepsin A inhibitor

Direct Interaction yes

PMIDs:
1978840 2190304 1611711

Sources:
ChemblInteractions
SUCRALFATE PGA3

Interaction Score: 20.61

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name sucralfate,Ulcermin

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
SUCRALFATE FGF2

Interaction Score: 5.89

Interaction Types & Directionality:

agonist (activating)

inducer (activating)

Interaction Info:

PMIDs:
8578198 1957124 8578218 7948825 1970337

Sources:
TTD

TEND: SUCRALFATE
- Version: 01-August-2011
Alternate Names:

SUCRALFATE Primary Drug Name

Drug Info:

Year of Approval 1981

Drug Class gi anti-ulcer agents, antimuscarinics

Publications:
TdgClinicalTrial: SUCRALFATE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antiulcer agent

Drug Class Small Molecule

FDA Approval approved

Publications:
TTD: Sucralfate
- Version: 2020.06.01
Alternate Names:

D06ULU TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL2367706
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL2367706
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Pepsin A inhibitor
Direct Interaction	yes

Trial Name	sucralfate,Ulcermin
Novel drug target	Established target

agonist (activating)
inducer (activating)

SUCRALFATE Drug Record

SUCRALFATE chembl:CHEMBL2367706 Approved

Alternate Names:

Drug Info:

Publications:

SUCRALFATE PGA5

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Pepsin A inhibitor Direct Interaction yes

PMIDs: 1978840 2190304 1611711

Sources: ChemblInteractions

SUCRALFATE PGA3

Interaction Types & Directionality: n/a

Interaction Info: Trial Name sucralfate,Ulcermin Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND

SUCRALFATE FGF2

Interaction Types & Directionality: agonist (activating) inducer (activating)

Interaction Info:

PMIDs: 8578198 1957124 8578218 7948825 1970337

Sources: TTD

TEND: SUCRALFATE

Alternate Names: SUCRALFATE Primary Drug Name

Drug Info: Year of Approval 1981 Drug Class gi anti-ulcer agents, antimuscarinics

Publications:

TdgClinicalTrial: SUCRALFATE

Alternate Names:

Drug Info: Drug Indications antiulcer agent Drug Class Small Molecule FDA Approval approved

Publications:

TTD: Sucralfate

Alternate Names: D06ULU TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL2367706

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL2367706

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Pepsin A inhibitor

Direct Interaction yes

PMIDs:
1978840 2190304 1611711

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name sucralfate,Ulcermin

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

inducer (activating)

PMIDs:
8578198 1957124 8578218 7948825 1970337

Sources:
TTD

Alternate Names:

SUCRALFATE Primary Drug Name

Drug Info:

Year of Approval 1981

Drug Class gi anti-ulcer agents, antimuscarinics

Drug Info:

Drug Indications antiulcer agent

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

D06ULU TTD Drug ID