DGIdb - TALOTREXIN Drug Record

TALOTREXIN chembl:CHEMBL590985 Antineoplastic

Alternate Names:

TALOTREXIN
NSC-623017

Drug Info:

FDA Approval	not approved
Drug Class	small molecule
Drug Indications	antineoplastic agent

(0 More Sources)

Publications:

Hagner N et al., 2010, Cancer chemotherapy: targeting folic acid synthesis., Cancer Manag Res
Wang L et al., 2011, Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide formyltransferase., J Med Chem

TALOTREXIN FOLR1

Interaction Score: 4.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21301589

Sources:
TTD
TALOTREXIN SLC19A1

Interaction Score: 3.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21879757

Sources:
DTC
TALOTREXIN DHFR

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name talotrexin, PT-523,Talvesta

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

TdgClinicalTrial: TALOTREXIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antineoplastic agent

Drug Class small molecule

FDA Approval not approved

Publications:

DTC: TALOTREXIN

Version: 02-September-2020

Alternate Names:

CHEMBL590985 ChEMBL Drug ID

Drug Info:

Publications:

Wang L et al., 2011, Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide formyltransferase., J Med Chem

TTD: Talotrexin
- Version: 2020.06.01
Alternate Names:

D0GL7H TTD Drug ID

Drug Info:

Publications:

Hagner N et al., 2010, Cancer chemotherapy: targeting folic acid synthesis., Cancer Manag Res
ChemblDrugs: chembl:CHEMBL590985
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	talotrexin, PT-523,Talvesta
Novel drug target	Established target

TALOTREXIN Drug Record

TALOTREXIN chembl:CHEMBL590985 Antineoplastic

Alternate Names:

Drug Info:

Publications:

TALOTREXIN FOLR1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21301589

Sources: TTD

TALOTREXIN SLC19A1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21879757

Sources: DTC

TALOTREXIN DHFR

Interaction Types & Directionality: n/a

Interaction Info: Trial Name talotrexin, PT-523,Talvesta Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

TdgClinicalTrial: TALOTREXIN

Alternate Names:

Drug Info: Drug Indications antineoplastic agent Drug Class small molecule FDA Approval not approved

Publications:

DTC: TALOTREXIN

Alternate Names: CHEMBL590985 ChEMBL Drug ID

Drug Info:

TTD: Talotrexin

Alternate Names: D0GL7H TTD Drug ID

Drug Info:

Publications: Hagner N et al., 2010, Cancer chemotherapy: targeting folic acid synthesis., Cancer Manag Res

ChemblDrugs: chembl:CHEMBL590985

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
21301589

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
21879757

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name talotrexin, PT-523,Talvesta

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Drug Info:

Drug Indications antineoplastic agent

Drug Class small molecule

FDA Approval not approved

Alternate Names:

CHEMBL590985 ChEMBL Drug ID

Alternate Names:

D0GL7H TTD Drug ID

Publications:

Hagner N et al., 2010, Cancer chemotherapy: targeting folic acid synthesis., Cancer Manag Res