DGIdb - TARANABANT Drug Record

TARANABANT chembl:CHEMBL220360

Alternate Names:

MK-0634
TARANABANT
MK-0364

Drug Info:

FDA Approval	not approved
Drug Class	small molecule
Drug Indications	antiobesity agent,smoking-cessation agent

(0 More Sources)

Publications:

Yan L et al., 2010, Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity., J Med Chem

TARANABANT CNR1

Interaction Score: 3.86

Interaction Types & Directionality:

inverse agonist (inhibitory)

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Cannabinoid CB1 receptor inverse agonist

Direct Interaction yes

Trial Name taranabant, MK-0364

PMIDs:
20423086

Sources:
DTC TdgClinicalTrial ChemblInteractions
TARANABANT CNR2

Interaction Score: 3.43

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
20423086

Sources:
DTC

TdgClinicalTrial: TARANABANT
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antiobesity agent,smoking-cessation agent

Drug Class small molecule

FDA Approval not approved

Publications:

DTC: TARANABANT

Version: 02-September-2020

Alternate Names:

CHEMBL220360 ChEMBL Drug ID

Drug Info:

Publications:

Yan L et al., 2010, Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity., J Med Chem

ChemblDrugs: chembl:CHEMBL220360
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL220360
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Cannabinoid CB1 receptor inverse agonist
Direct Interaction	yes
Trial Name	taranabant, MK-0364

inverse agonist (inhibitory)
antagonist (inhibitory)

TARANABANT Drug Record

TARANABANT chembl:CHEMBL220360

Alternate Names:

Drug Info:

Publications:

TARANABANT CNR1

Interaction Types & Directionality: inverse agonist (inhibitory) antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Cannabinoid CB1 receptor inverse agonist Direct Interaction yes Trial Name taranabant, MK-0364

PMIDs: 20423086

Sources: DTC TdgClinicalTrial ChemblInteractions

TARANABANT CNR2

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 20423086

Sources: DTC

TdgClinicalTrial: TARANABANT

Alternate Names:

Drug Info: Drug Indications antiobesity agent,smoking-cessation agent Drug Class small molecule FDA Approval not approved

Publications:

DTC: TARANABANT

Alternate Names: CHEMBL220360 ChEMBL Drug ID

Drug Info:

Publications: Yan L et al., 2010, Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity., J Med Chem

ChemblDrugs: chembl:CHEMBL220360

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL220360

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inverse agonist (inhibitory)

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Cannabinoid CB1 receptor inverse agonist

Direct Interaction yes

Trial Name taranabant, MK-0364

PMIDs:
20423086

Sources:
DTC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

PMIDs:
20423086

Sources:
DTC

Drug Info:

Drug Indications antiobesity agent,smoking-cessation agent

Drug Class small molecule

FDA Approval not approved

Alternate Names:

CHEMBL220360 ChEMBL Drug ID

Publications:

Yan L et al., 2010, Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity., J Med Chem