DGIdb - TIAGABINE Drug Record

TIAGABINE chembl:CHEMBL1027 Approved

Alternate Names:

ABBOTT-70569
NNC-050328 FREE BASE
TIAGABINE
NO-05-0328
ABBOTT-705691 FREE BASE
ABT-569
NO-050328 FREE BASE
GABITRIL
ABT-569 FREE BASE
NNC-05-0328
A-70569-1
ABBOTT-70569-1
ABBOTT-70569 FREE BASE
TIAGABINA
GABITRIL®
TIAGABINUM
TIAGABINE HYDROCHLORIDE
chemidplus:115103-54-3
drugbank:00906
rxcui:31914
chembl:CHEMBL1027
pubchem.compound:60648

Drug Info:

Year of Approval	1997
Drug Class	anticonvulsants
FDA Approval	1997
Drug Class	small molecule
Drug Indications	Anticonvulsants

(0 More Sources)

Publications:

Suñol et al., 2010, A possible role of the non-GAT1 GABA transporters in transfer of GABA from GABAergic to glutamatergic neurons in mouse cerebellar neuronal cultures., Neurochem. Res.
Henjum et al., 2007, High-affinity GABA uptake and GABA-metabolizing enzymes in pig forebrain white matter: a quantitative study., Neurochem. Int.
Pollack et al., 2005, The selective GABA reuptake inhibitor tiagabine for the treatment of generalized anxiety disorder: results of a placebo-controlled study., J Clin Psychiatry
Sheehan et al., 2007, An open-label study of tiagabine in panic disorder., Psychopharmacol Bull
Foster et al., 2006, Glutamate- and GABA-based CNS therapeutics., Curr Opin Pharmacol
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

TIAGABINE SLC6A1

Interaction Score: 55.65

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
20512624 17069932 16420077 18007567 16377242 11752352

Sources:
TdgClinicalTrial TEND TTD
TIAGABINE ABAT

Interaction Score: 10.3

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

TEND: TIAGABINE
- Version: 01-August-2011
Alternate Names:

TIAGABINE Primary Drug Name

Drug Info:

Drug Class anticonvulsants

Year of Approval 1997

Publications:
TdgClinicalTrial: TIAGABINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Anticonvulsants

Drug Class small molecule

FDA Approval 1997

Publications:
TTD: Tiagabine
- Version: 2020.06.01
Alternate Names:

D0ED7U TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1027
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	-

Novel drug target	Established target
Trial Name	-

TIAGABINE Drug Record

TIAGABINE chembl:CHEMBL1027 Approved

Alternate Names:

Drug Info:

Publications:

TIAGABINE SLC6A1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 20512624 17069932 16420077 18007567 16377242 11752352

Sources: TdgClinicalTrial TEND TTD

TIAGABINE ABAT

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: None found

Sources: TdgClinicalTrial TEND

TEND: TIAGABINE

Alternate Names: TIAGABINE Primary Drug Name

Drug Info: Drug Class anticonvulsants Year of Approval 1997

Publications:

TdgClinicalTrial: TIAGABINE

Alternate Names:

Drug Info: Drug Indications Anticonvulsants Drug Class small molecule FDA Approval 1997

Publications:

TTD: Tiagabine

Alternate Names: D0ED7U TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1027

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
20512624 17069932 16420077 18007567 16377242 11752352

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Alternate Names:

TIAGABINE Primary Drug Name

Drug Info:

Drug Class anticonvulsants

Year of Approval 1997

Drug Info:

Drug Indications Anticonvulsants

Drug Class small molecule

FDA Approval 1997

Alternate Names:

D0ED7U TTD Drug ID