DGIdb - TRIHEXYPHENIDYL Drug Record

TRIHEXYPHENIDYL chembl:CHEMBL1490 Approved

Alternate Names:

TRIHEXYPHENIDYL
NSC-12268
TRIHEXYPHENIDYLUM
CYCLODOLE
CYCLODOL
BENZHEXOL HYDROCHLORIDE
APO-TRIHEX
BENZHEXOL
TRIHEXIFENIDILO
TRIHEXYPHÉNIDYLE
ARTANE®
(RS)-1-CYCLOHEXYL-1-PHENYL-3-(1-PIPERIDYL)PROPAN-1-OL
drugbank:00376
chembl:CHEMBL1490
rxcui:10811
pubchem.compound:5572
chemidplus:144-11-6

Drug Info:

Year of Approval	approved before 1982
Drug Class	antiparkinson agents
FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Antiparkinson Agents

(1 More Sources)

Publications:

Dörje et al., 1991, Antagonist binding profiles of five cloned human muscarinic receptor subtypes., J. Pharmacol. Exp. Ther.
Prus et al., 2009, The role of M1 muscarinic cholinergic receptors in the discriminative stimulus properties of N-desmethylclozapine and the atypical antipsychotic drug clozapine in rats., Psychopharmacology (Berl.)
Tanda et al., 2007, Muscarinic preferential M(1) receptor antagonists enhance the discriminative-stimulus effects of cocaine in rats., Pharmacol. Biochem. Behav.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Freedman et al., 1988, Muscarinic M1, M2 receptor binding. Relationship with functional efficacy., Eur. J. Pharmacol.
Giachetti et al., 1986, Binding and functional profiles of the selective M1 muscarinic receptor antagonists trihexyphenidyl and dicyclomine., Br. J. Pharmacol.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

TRIHEXYPHENIDYL CHRM1

Interaction Score: 2.7

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1994002 18685832 17631384 11752352 3208836 2432979 17016423 17139284

Sources:
TdgClinicalTrial TEND TTD
TRIHEXYPHENIDYL ADRB3

Interaction Score: 0.71

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TRIHEXYPHENIDYL COMT

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

TEND: TRIHEXYPHENIDYL
- Version: 01-August-2011
Alternate Names:

TRIHEXYPHENIDYL Primary Drug Name

Drug Info:

Drug Class antiparkinson agents

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: TRIHEXYPHENIDYL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antiparkinson Agents

Drug Class small molecule

FDA Approval Approved before 1982

Publications:
TTD: Trihexyphenidyl
- Version: 2020.06.01
Alternate Names:

D09GFL TTD Drug ID

Drug Info:

Publications:
PharmGKB: trihexyphenidyl
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1490
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

TRIHEXYPHENIDYL Drug Record

TRIHEXYPHENIDYL chembl:CHEMBL1490 Approved

Alternate Names:

Drug Info:

Publications:

TRIHEXYPHENIDYL CHRM1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1994002 18685832 17631384 11752352 3208836 2432979 17016423 17139284

Sources:
TdgClinicalTrial TEND TTD

TRIHEXYPHENIDYL ADRB3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

TRIHEXYPHENIDYL COMT

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

TEND: TRIHEXYPHENIDYL

Alternate Names:

TRIHEXYPHENIDYL Primary Drug Name

Drug Info:

Drug Class antiparkinson agents

Year of Approval approved before 1982

Publications:

TdgClinicalTrial: TRIHEXYPHENIDYL

Alternate Names:

Drug Info:

Drug Indications Antiparkinson Agents

Drug Class small molecule

FDA Approval Approved before 1982

Publications:

TTD: Trihexyphenidyl

Alternate Names:

D09GFL TTD Drug ID

Drug Info:

Publications:

PharmGKB: trihexyphenidyl

Alternate Names:

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1490

Alternate Names:

Drug Info:

Publications:

TRIHEXYPHENIDYL Drug Record

TRIHEXYPHENIDYL chembl:CHEMBL1490 Approved

Alternate Names:

Drug Info:

Publications:

TRIHEXYPHENIDYL CHRM1

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 1994002 18685832 17631384 11752352 3208836 2432979 17016423 17139284

Sources: TdgClinicalTrial TEND TTD

TRIHEXYPHENIDYL ADRB3

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

TRIHEXYPHENIDYL COMT

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

TEND: TRIHEXYPHENIDYL

Alternate Names: TRIHEXYPHENIDYL Primary Drug Name

Drug Info: Drug Class antiparkinson agents Year of Approval approved before 1982

Publications:

TdgClinicalTrial: TRIHEXYPHENIDYL

Alternate Names:

Drug Info: Drug Indications Antiparkinson Agents Drug Class small molecule FDA Approval Approved before 1982

Publications:

TTD: Trihexyphenidyl

Alternate Names: D09GFL TTD Drug ID

Drug Info:

Publications:

PharmGKB: trihexyphenidyl

Alternate Names:

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1490

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1994002 18685832 17631384 11752352 3208836 2432979 17016423 17139284

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Alternate Names:

TRIHEXYPHENIDYL Primary Drug Name

Drug Info:

Drug Class antiparkinson agents

Year of Approval approved before 1982

Drug Info:

Drug Indications Antiparkinson Agents

Drug Class small molecule

FDA Approval Approved before 1982

Alternate Names:

D09GFL TTD Drug ID