DGIdb - ACAT1 Gene Record

ACAT1 38

Alternate Names:

38
ACETYL-COA ACETYLTRANSFERASE 1
ACAT1
ACAT
MAT
T2
THIL
607809
93
ENSG00000075239
OTTHUMG00000166381
P24752
THIL_HUMAN
ACETOACETYL-COA THIOLASE
T11487
Acetyl-CoA acetyltransferase, mitochondrial

Gene Info:

Target Subclass	2.3.1.9
Target Main Class	Enzymes
Target Class	Enzymes
Target Subclass	EC:2.3.1.9
Gene Biotype	PROTEIN_CODING

(2 More Sources)

Gene Categories: Category Details

ENZYME

Publications:

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Faison et al., 1992, Sulfasalazine inhibits lyso-PAF: acetyl-COA acetyltransferase., Prostaglandins

SULFASALAZINE ACAT1

Interaction Score: 13.44

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name sulfasalazine,Azulfidine, Salazopyrin

Novel drug target Established target

PMIDs:
17016423 17139284 1357724

Sources:
TdgClinicalTrial TEND

Ensembl: ENSG00000075239
- Version: 101_38
Alternate Names:

ACAT1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P24752
- Version: January-2014
Alternate Names:

ACAT1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.3.1.9

Publications:
TEND: P24752
- Version: 01-August-2011
Alternate Names:

38 Entrez Gene Id

P24752 Uniprot Accession

ACAT1 Gene Symbol

Gene Info:

Target Subclass 2.3.1.9

Target Main Class Enzymes

Publications:
HumanProteinAtlas: ACAT1
- Version: 19.3
Alternate Names:

ENSG00000075239 Ensembl Gene ID

ACAT Human Protein Atlas Gene Synonym

THIL Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
TTD: Acetoacetyl-CoA thiolase
- Version: 2020.06.01
Alternate Names:

ACAT1 TTD Gene Abbreviation

T11487 TTD Target ID

Gene Info:

Publications:
Pharos: ACAT1
- Version: 01-February-2022
Alternate Names:

Acetyl-CoA acetyltransferase, mitochondrial Gene Name

P24752 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

Trial Name	sulfasalazine,Azulfidine, Salazopyrin
Novel drug target	Established target

ENSG00000075239	Ensembl Gene ID
ACAT	Human Protein Atlas Gene Synonym
THIL	Human Protein Atlas Gene Synonym

Acetyl-CoA acetyltransferase, mitochondrial	Gene Name
P24752	UniProt ID

38	Entrez Gene Id
P24752	Uniprot Accession
ACAT1	Gene Symbol

ACAT1 Gene Record

ACAT1 38

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

SULFASALAZINE ACAT1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name sulfasalazine,Azulfidine, Salazopyrin Novel drug target Established target

PMIDs: 17016423 17139284 1357724

Sources: TdgClinicalTrial TEND

Ensembl: ENSG00000075239

Alternate Names: ACAT1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P24752

Alternate Names: ACAT1 Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:2.3.1.9

Publications:

TEND: P24752

Alternate Names: 38 Entrez Gene Id P24752 Uniprot Accession ACAT1 Gene Symbol

Gene Info: Target Subclass 2.3.1.9 Target Main Class Enzymes

Publications:

HumanProteinAtlas: ACAT1

Alternate Names: ENSG00000075239 Ensembl Gene ID ACAT Human Protein Atlas Gene Synonym THIL Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories: ENZYME

Publications:

TTD: Acetoacetyl-CoA thiolase

Alternate Names: ACAT1 TTD Gene Abbreviation T11487 TTD Target ID

Gene Info:

Publications:

Pharos: ACAT1

Alternate Names: Acetyl-CoA acetyltransferase, mitochondrial Gene Name P24752 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name sulfasalazine,Azulfidine, Salazopyrin

Novel drug target Established target

PMIDs:
17016423 17139284 1357724

Sources:
TdgClinicalTrial TEND

Alternate Names:

ACAT1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ACAT1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.3.1.9

Alternate Names:

38 Entrez Gene Id

P24752 Uniprot Accession

ACAT1 Gene Symbol

Gene Info:

Target Subclass 2.3.1.9

Target Main Class Enzymes

Alternate Names:

ENSG00000075239 Ensembl Gene ID

ACAT Human Protein Atlas Gene Synonym

THIL Human Protein Atlas Gene Synonym

Gene Categories:

ENZYME

Alternate Names:

ACAT1 TTD Gene Abbreviation

T11487 TTD Target ID

Alternate Names:

Acetyl-CoA acetyltransferase, mitochondrial Gene Name

P24752 UniProt ID

Gene Categories:

ENZYME