AURKC Gene Record

  • AURKC 6795 Druggable Genome

    Alternate Names:

    6795
    AURORA KINASE C
    AURKC
    AIE2
    AIK3
    ARK3
    AurC
    HEL-S-90
    SPGF5
    STK13
    aurora-C
    603495
    11391
    ENSG00000105146
    OTTHUMG00000183106
    Aurora/IPL1-related kinase 3
    Aurora-related kinase 3
    ARK-3
    Serine/threonine-protein kinase aurora-C
    Serine/threonine-protein kinase 13
    Aurora/IPL1/Eg2 protein 2
    Aurora 3
    AIRK3
    Q9UQB9
    AURKC_HUMAN
    SERINE/THREONINE-PROTEIN KINASE 13 (EC 2.7.1.37) (AURORA/IPL1/EG2 PROTEIN 2) (AURORA/IPL1-RELATED KINASE 3) (AURORA-C). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9UQB9]
    Aurora C
    Aurora A/B/C
    T97592

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Target Class Enzymes
    Target Subclass EC:2.7.11.1
    Uniprot Status Swiss-Prot
    Human Readable Name KINASE
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Interpro Type Domain
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR002290
    Gene Biotype PROTEIN_CODING
    (10 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    HISTONE MODIFICATION
    DRUGGABLE GENOME
    ENZYME

    Publications:

  • GSK-1070916   AURKC

    Interaction Score: 12.37

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Mechanism of Interaction Serine/threonine-protein kinase Aurora-C inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    TALC MyCancerGenome ChemblInteractions TTD

  • AMG-900   AURKC

    Interaction Score: 4.95

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor
    Direct Interaction yes
    Notes

    PMIDs:
    None found


    Sources:
    TALC MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions

  • DANUSERTIB   AURKC

    Interaction Score: 4.64

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    MyCancerGenome ChemblInteractions TTD

  • TTP-607   AURKC

    Interaction Score: 2.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MK-6592   AURKC

    Interaction Score: 2.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SNS-314   AURKC

    Interaction Score: 0.74

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor
    Direct Interaction yes

    PMIDs:
    10592235


    Sources:
    TALC MyCancerGenome ChemblInteractions TTD

  • TOZASERTIB   AURKC

    Interaction Score: 0.26

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name VX-680, MK-0457
    Novel drug target Novel Target
    Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

    PMIDs:
    None found


    Sources:
    TALC TdgClinicalTrial ChemblInteractions

  • ILORASERTIB   AURKC

    Interaction Score: 0.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • CYC-116   AURKC

    Interaction Score: 0.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CENISERTIB   AURKC

    Interaction Score: 0.05

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • Ensembl: ENSG00000105146

    • Version: 101_38

    Alternate Names:
    AURKC Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000105146

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000105146 Ensembl Gene Id
    SERINE/THREONINE-PROTEIN KINASE 13 (EC 2.7.1.37) (AURORA/IPL1/EG2 PROTEIN 2) (AURORA/IPL1-RELATED KINASE 3) (AURORA-C). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9UQB9] Description
    AURKC Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: Q9UQB9

    • Version: 11-September-2012

    Alternate Names:
    AURKC Uniprot Gene Name
    AURKC_HUMAN Uniprot Id
    Q9UQB9 Uniprot Accession

    Gene Info:
    Uniprot Status Swiss-Prot
    Human Readable Name KINASE
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: Q9UQB9

    • Version: January-2014

    Alternate Names:
    AURKC Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.1

    Publications:

  • HingoraniCasas: ENSG00000105146

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000105146 Gene Symbol
    AURKC Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TALC: AURORA C

    • Version: 12-May-2016

    Alternate Names:
    AURORA C Gene Symbol

    Gene Info:

    Publications:

  • MyCancerGenome: AURKC

    • Version: 20-Jun-2017

    Alternate Names:
    6795 Entrez Gene Id
    AURKC MyCancerGenome Gene Symbol
    Aurora A/B/C MyCancerGenome Reported Gene Name

    Gene Info:

    Publications:

  • ChemblInteractions: AIE2

    • Version: chembl_23

    Alternate Names:
    AIK3 GENE_SYMBOL
    AIRK3 GENE_SYMBOL
    ARK3 GENE_SYMBOL

    Gene Info:

    Publications:

  • HumanProteinAtlas: AURKC

    • Version: 19.3

    Alternate Names:
    ENSG00000105146 Ensembl Gene ID
    ARK3 Human Protein Atlas Gene Synonym
    AurC Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • GO: AURKC

    • Version: 01-February-2022

    Alternate Names:
    AIE2 GO Gene Synonym
    AIK3 GO Gene Synonym
    AIRK3 GO Gene Synonym

    Gene Info:

    Gene Categories:
    HISTONE MODIFICATION

    Publications:

  • dGene: AURKC

    • Version: 27-Jun-2013

    Alternate Names:
    6795 Gene ID
    AIE2 dGene Synonym
    AIK3 dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

  • TTD: Aurora kinase C

    • Version: 2020.06.01

    Alternate Names:
    AURKC TTD Gene Abbreviation
    T97592 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: AURKC

    • Version: 01-February-2022

    Alternate Names:
    Aurora kinase C Gene Name
    Q9UQB9 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • ClearityFoundationClinicalTrial: AURKC

    • Version: 15-June-2013

    Alternate Names:

    Gene Info:

    Publications: