DGIdb - AVPR2 Gene Record

AVPR2 554 Druggable Genome

Alternate Names:

554
ARGININE VASOPRESSIN RECEPTOR 2
AVPR2
ADHR
DI1
DIR
DIR3
NDI
V2R
300538
897
ENSG00000126895
OTTHUMG00000024227
P30518
V2R_HUMAN
Renal-type arginine vasopressin receptor
Vasopressin V2 receptor
Antidiuretic hormone receptor
AVPR V2
VASOPRESSIN V2 RECEPTOR (RENAL-TYPE ARGININE VASOPRESSIN RECEPTOR) (ANTIDIURETIC HORMONE RECEPTOR) (AVPR V2). [SOURCE:UNIPROT/SWISSPROT;ACC:P30518]
T66237
NDI1

Gene Info:

Human Readable Name	G PROTEIN COUPLED RECEPTOR
Transmembrane Helix Count	7
Target Subclass	Rhodopsin
Target Main Class	Receptors
Target Subclass	GPCR
Uniprot Status	Swiss-Prot
Interpro Name	GPCR, rhodopsin-like, 7TM
Interpro Type	Family
Interpro Short Name	7TM_GPCR_Rhodpsn
Interpro Acc	IPR000276
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	DRUGGABLE GENOME
Target Class	Receptors
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Dixon et al., 2008, Tolvaptan and its potential in the treatment of hyponatremia., Ther Clin Risk Manag
Aperis et al., 2011, Tolvaptan: a new therapeutic agent., Rev Recent Clin Trials
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Slusarz et al., 2006, Investigation of mechanism of desmopressin binding in vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors: molecular dynamics simulation of the agonist-bound state in the membrane-aqueous system., Biopolymers
Del Tredici et al., 2008, Identification of novel selective V2 receptor non-peptide agonists., Biochem. Pharmacol.
Boson et al., 2006, Novel vasopressin type 2 (AVPR2) gene mutations in Brazilian nephrogenic diabetes insipidus patients., Genet. Test.
Yi et al., 2007, Alix (AIP1) is a vasopressin receptor (V2R)-interacting protein that increases lysosomal degradation of the V2R., Am. J. Physiol. Renal Physiol.
Bouley et al., 2006, Aquaporin 2 (AQP2) and vasopressin type 2 receptor (V2R) endocytosis in kidney epithelial cells: AQP2 is located in 'endocytosis-resistant' membrane domains after vasopressin treatment., Biol. Cell
Palm et al., 2006, Vasopressin antagonists as aquaretic agents for the treatment of hyponatremia., Am. J. Med.
Annane et al., 2009, Efficacy and safety of oral conivaptan, a vasopressin-receptor antagonist, evaluated in a randomized, controlled trial in patients with euvolemic or hypervolemic hyponatremia., Am. J. Med. Sci.
Ali et al., 2007, Therapeutic potential of vasopressin receptor antagonists., Drugs
Wada et al., 2005, Intravenous administration of conivaptan hydrochloride improves cardiac hemodynamics in rats with myocardial infarction-induced congestive heart failure., Eur. J. Pharmacol.
Ghali et al., 2009, Conivaptan and its role in the treatment of hyponatremia., Drug Des Devel Ther
Hoque et al., 2009, Conivaptan: promise of treatment in heart failure., Expert Opin Pharmacother
Ali et al., 2007, Conivaptan: a dual vasopressin receptor v1a/v2 antagonist [corrected]., Cardiovasc Drug Rev
Wada et al., 2007, A novel vasopressin dual V1A/V2 receptor antagonist, conivaptan hydrochloride, improves hyponatremia in rats with syndrome of inappropriate secretion of antidiuretic hormone (SIADH)., Biol. Pharm. Bull.
Walter, 2007, Conivaptan: new treatment for hyponatremia., Am J Health Syst Pharm
Mao et al., 2009, Pharmacokinetics of conivaptan hydrochloride, a vasopressin V(1A)/V(2)-receptor antagonist, in patients with euvolemic or hypervolemic hyponatremia and with or without congestive heart failure from a prospective, 4-day open-label study., Clin Ther
Ghali et al., 2006, Efficacy and safety of oral conivaptan: a V1A/V2 vasopressin receptor antagonist, assessed in a randomized, placebo-controlled trial in patients with euvolemic or hypervolemic hyponatremia., J. Clin. Endocrinol. Metab.
Sassano MF et al., 2013, Colloidal aggregation causes inhibition of G protein-coupled receptors., J Med Chem
Akerlund et al., 1999, Receptor binding of oxytocin and vasopressin antagonists and inhibitory effects on isolated myometrium from preterm and term pregnant women., Br J Obstet Gynaecol

CONIVAPTAN AVPR2

Interaction Score: 24.41

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name conivaptan, YM-087,Vaprisol

PMIDs:
16843091 19057376 17428103 15659304 20054444 19663609 17919259 17202666 11752352 17592003 19695403 16522696

Sources:
TdgClinicalTrial TEND TTD
TOLVAPTAN AVPR2

Interaction Score: 9.76

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vasopressin V2 receptor antagonist

Trial Name tolvaptan, OPC-41061,Samsca

PMIDs:
19337422 20868352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
TETRA-IODOPHENOLPHTHALEIN AVPR2

Interaction Score: 6.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23437772

Sources:
DTC
LYPRESSIN AVPR2

Interaction Score: 6.51

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Vasopressin receptor agonist

Direct Interaction yes

PMIDs:
16333859 17020465 17287200 11752352 16563128

Sources:
ChemblInteractions
SATAVAPTAN AVPR2

Interaction Score: 6.51

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vasopressin V2 receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions TTD
TERLIPRESSIN AVPR2

Interaction Score: 6.51

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name terlipressin,Lucassin

Novel drug target Established target

PMIDs:
17020465 17287200 16333859 16563128

Sources:
TdgClinicalTrial TEND
LIXIVAPTAN AVPR2

Interaction Score: 4.88

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Vasopressin V2 receptor antagonist

Direct Interaction yes

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
DESMOPRESSIN AVPR2

Interaction Score: 4.07

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name OX 19, sublingual desmopressin

Novel drug target Established target

PMIDs:
11752352 16333859 18761325

Sources:
TdgClinicalTrial TTD
FEDOVAPAGON AVPR2

Interaction Score: 3.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
VASOPRESSIN AVPR2

Interaction Score: 1.83

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Vasopressin receptor agonist

PMIDs:
17020465 17287200 11752352 16333859 16563128

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
ATOSIBAN AVPR2

Interaction Score: 1.63

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
10519430

Sources:
TTD
CONIVAPTAN HYDROCHLORIDE AVPR2

Interaction Score: 1.63

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vasopressin V2 receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions
DESMOPRESSIN ACETATE AVPR2

Interaction Score: 1.08

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Vasopressin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MOZAVAPTAN AVPR2

Interaction Score: 1.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
VASOPRESSIN TANNATE AVPR2

Interaction Score: 1.08

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Vasopressin V2 receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ITRACONAZOLE AVPR2

Interaction Score: 0.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23437772

Sources:
DTC
OXYTOCIN AVPR2

Interaction Score: 0.36

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
None found

Sources:
TTD
CLOTRIMAZOLE AVPR2

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23437772

Sources:
DTC
QUERCETIN AVPR2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23437772

Sources:
DTC

Ensembl: ENSG00000126895
- Version: 101_38
Alternate Names:

AVPR2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P30518
- Version: January-2014
Alternate Names:

AVPR2 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:

RussLampel: ENSG00000126895

Version: 26-July-2011

Alternate Names:

VASOPRESSIN V2 RECEPTOR (RENAL-TYPE ARGININE VASOPRESSIN RECEPTOR) (ANTIDIURETIC HORMONE RECEPTOR) (AVPR V2). [SOURCE:UNIPROT/SWISSPROT;ACC:P30518] Description

ENSG00000126895 Ensembl Gene Id

AVPR2 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TEND: P30518
- Version: 01-August-2011
Alternate Names:

ENSG00000126895 Ensembl Gene Id

AVPR2 Gene Symbol

V2R_HUMAN Uniprot Id

Gene Info:

Transmembrane Helix Count 7

Target Subclass Rhodopsin

Target Main Class Receptors

Publications:
HopkinsGroom: P30518
- Version: 11-September-2012
Alternate Names:

V2R_HUMAN Uniprot Id

P30518 Uniprot Accession

ENSG00000126895 Ensembl Gene Id

Gene Info:

Interpro Name GPCR, rhodopsin-like, 7TM

Interpro Type Family

Human Readable Name G PROTEIN COUPLED RECEPTOR

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
DTC: AVPR2
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Sassano MF et al., 2013, Colloidal aggregation causes inhibition of G protein-coupled receptors., J Med Chem
HingoraniCasas: ENSG00000126895
- Version: 31-May-2017
Alternate Names:

ENSG00000126895 Gene Symbol

AVPR2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: ADHR
- Version: chembl_23
Alternate Names:

DIR GENE_SYMBOL

DIR3 GENE_SYMBOL

V2R GENE_SYMBOL

Gene Info:

Publications:
GO: AVPR2
- Version: 01-February-2022
Alternate Names:

ADHR GO Gene Synonym

DIR GO Gene Synonym

DIR3 GO Gene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
dGene: AVPR2
- Version: 27-Jun-2013
Alternate Names:

554 Gene ID

ADHR dGene Synonym

DI1 dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: Vasopressin V2 receptor
- Version: 2020.06.01
Alternate Names:

V2R TTD Gene Abbreviation

T66237 TTD Target ID

Gene Info:

Publications:
Pharos: AVPR2
- Version: 01-February-2022
Alternate Names:

Vasopressin V2 receptor Gene Name

P30518 UniProt ID

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

Novel drug target	Established target
Trial Name	conivaptan, YM-087,Vaprisol

Direct Interaction	yes
Mechanism of Interaction	Vasopressin V2 receptor antagonist
Trial Name	tolvaptan, OPC-41061,Samsca

Mechanism of Interaction	Vasopressin receptor agonist
Direct Interaction	yes

Trial Name	terlipressin,Lucassin
Novel drug target	Established target

Trial Name	OX 19, sublingual desmopressin
Novel drug target	Established target

Mechanism of Interaction	Vasopressin V2 receptor agonist
Direct Interaction	yes

VASOPRESSIN V2 RECEPTOR (RENAL-TYPE ARGININE VASOPRESSIN RECEPTOR) (ANTIDIURETIC HORMONE RECEPTOR) (AVPR V2). [SOURCE:UNIPROT/SWISSPROT;ACC:P30518]	Description
ENSG00000126895	Ensembl Gene Id
AVPR2	Display Id

V2R_HUMAN	Uniprot Id
P30518	Uniprot Accession
ENSG00000126895	Ensembl Gene Id

AVPR2 Gene Record

AVPR2 554 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name conivaptan, YM-087,Vaprisol

PMIDs: 16843091 19057376 17428103 15659304 20054444 19663609 17919259 17202666 11752352 17592003 19695403 16522696

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Vasopressin V2 receptor antagonist Trial Name tolvaptan, OPC-41061,Samsca

PMIDs: 19337422 20868352

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23437772

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Vasopressin receptor agonist Direct Interaction yes

PMIDs: 16333859 17020465 17287200 11752352 16563128

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Vasopressin V2 receptor antagonist

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name terlipressin,Lucassin Novel drug target Established target

PMIDs: 17020465 17287200 16333859 16563128

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Vasopressin V2 receptor antagonist Direct Interaction yes Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name OX 19, sublingual desmopressin Novel drug target Established target

PMIDs: 11752352 16333859 18761325

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction Vasopressin receptor agonist

PMIDs: 17020465 17287200 11752352 16333859 16563128

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 10519430

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Vasopressin V2 receptor antagonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Vasopressin receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Vasopressin V2 receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23437772

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23437772

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name conivaptan, YM-087,Vaprisol

PMIDs:
16843091 19057376 17428103 15659304 20054444 19663609 17919259 17202666 11752352 17592003 19695403 16522696

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vasopressin V2 receptor antagonist

Trial Name tolvaptan, OPC-41061,Samsca

PMIDs:
19337422 20868352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
23437772

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Vasopressin receptor agonist

Direct Interaction yes

PMIDs:
16333859 17020465 17287200 11752352 16563128

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vasopressin V2 receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name terlipressin,Lucassin

Novel drug target Established target

PMIDs:
17020465 17287200 16333859 16563128

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Vasopressin V2 receptor antagonist

Direct Interaction yes

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name OX 19, sublingual desmopressin

Novel drug target Established target

PMIDs:
11752352 16333859 18761325

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Vasopressin receptor agonist

PMIDs:
17020465 17287200 11752352 16333859 16563128

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
10519430

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vasopressin V2 receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Vasopressin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Vasopressin V2 receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
23437772

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
23437772

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23437772

Sources:
DTC

Alternate Names:

AVPR2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

AVPR2 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Alternate Names:

VASOPRESSIN V2 RECEPTOR (RENAL-TYPE ARGININE VASOPRESSIN RECEPTOR) (ANTIDIURETIC HORMONE RECEPTOR) (AVPR V2). [SOURCE:UNIPROT/SWISSPROT;ACC:P30518] Description

ENSG00000126895 Ensembl Gene Id

AVPR2 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000126895 Ensembl Gene Id

AVPR2 Gene Symbol

V2R_HUMAN Uniprot Id

Gene Info:

Transmembrane Helix Count 7

Target Subclass Rhodopsin

Target Main Class Receptors

Alternate Names:

V2R_HUMAN Uniprot Id

P30518 Uniprot Accession

ENSG00000126895 Ensembl Gene Id

Gene Info:

Interpro Name GPCR, rhodopsin-like, 7TM

Interpro Type Family

Human Readable Name G PROTEIN COUPLED RECEPTOR

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME