DGIdb - CCR2 Gene Record

CCR2 729230 Druggable Genome

Alternate Names:

729230
C-C MOTIF CHEMOKINE RECEPTOR 2
CCR2
CC-CKR-2
CCR-2
CCR2A
CCR2B
CD192
CKR2
CKR2A
CKR2B
CMKBR2
MCP-1-R
601267
1603
ENSG00000121807
OTTHUMG00000156466
MONOCYTE CHEMOATTRACTANT PROTEIN 1 RECEPTOR
C-C CKR-2
C-C CHEMOKINE RECEPTOR TYPE 2
P41597
CD_antigen=CD192
CCR2_HUMAN
ENSG00000188680
C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (MONOCYTE CHEMOATTRACTANT PROTEIN 1 RECEPTOR) (MCP-1-R). [SOURCE:UNIPROT/SWISSPROT;ACC:P41597]
T89988

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Interpro Acc	IPR000276
Uniprot Status	Swiss-Prot
Interpro Type	Family
Interpro Short Name	7TM_GPCR_Rhodpsn
Interpro Name	GPCR, rhodopsin-like, 7TM
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Target Class	Receptors
Target Subclass	GPCR
Target Subclass	Rhodopsin
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

El-Hage et al., 2006, CCR2 mediates increases in glial activation caused by exposure to HIV-1 Tat and opiates., J. Neuroimmunol.
Sohy D et al., 2007, Allosteric transinhibition by specific antagonists in CCR2/CXCR4 heterodimers., J Biol Chem
Han et al., 2005, HMG-CoA reductase inhibition reduces monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated monocyte recruitment in vivo., Circulation

CCX140 CCR2

Interaction Score: 16.86

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction C-C chemokine receptor type 2 antagonist

Direct Interaction yes

Trial Name CCX140

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
CHEMBL41275 CCR2

Interaction Score: 11.24

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
17715128

Sources:
DTC
PLOZALIZUMAB CCR2

Interaction Score: 11.24

Interaction Types & Directionality:

antibody (inhibitory)

antagonist (inhibitory)

Interaction Info:

Trial Name MLN-1202

Novel drug target Novel Target

Mechanism of Interaction C-C chemokine receptor type 2 antagonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
AZD2423 CCR2

Interaction Score: 11.24

Interaction Types & Directionality:

allosteric modulator

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction C-C chemokine receptor type 2 antagonist

PMIDs:
None found

Sources:
ChemblInteractions TTD
CENICRIVIROC CCR2

Interaction Score: 5.62

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction C-C chemokine receptor type 2 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
MK-0812 CCR2

Interaction Score: 5.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PIMAGEDINE CCR2

Interaction Score: 2.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PLERIXAFOR CCR2

Interaction Score: 2.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17715128

Sources:
DTC
PF-04634817 CCR2

Interaction Score: 2.81

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction C-C chemokine receptor type 2 antagonist

PMIDs:
None found

Sources:
ChemblInteractions
MORPHINE CCR2

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16831471

Sources:
NCI
SIMVASTATIN CCR2

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15781755

Sources:
NCI

Ensembl: ENSG00000121807
- Version: 101_38
Alternate Names:

CCR2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P41597
- Version: January-2014
Alternate Names:

CCR2 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:

RussLampel: ENSG00000121807

Version: 26-July-2011

Alternate Names:

CCR2 Display Id

C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (MONOCYTE CHEMOATTRACTANT PROTEIN 1 RECEPTOR) (MCP-1-R). [SOURCE:UNIPROT/SWISSPROT;ACC:P41597] Description

ENSG00000121807 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P41597
- Version: 11-September-2012
Alternate Names:

CCR2_HUMAN Uniprot Id

ENSG00000121807 Ensembl Gene Id

CCR2 Uniprot Gene Name

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Acc IPR000276

Uniprot Status Swiss-Prot

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000188680

Version: 26-July-2011

Alternate Names:

CCR2 Display Id

C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (MONOCYTE CHEMOATTRACTANT PROTEIN 1 RECEPTOR) (MCP-1-R). [SOURCE:UNIPROT/SWISSPROT;ACC:P41597] Description

ENSG00000188680 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TTD: C-C chemokine receptor type 2
- Version: 2020.06.01
Alternate Names:

CCR2 TTD Gene Abbreviation

T89988 TTD Target ID

Gene Info:

Publications:

McIntosh LM et al., 2009, Selective CCR2-targeted macrophage depletion ameliorates experimental mesangioproliferative glomerulonephritis., Clin Exp Immunol

NCI: CCR2

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

El-Hage et al., 2006, CCR2 mediates increases in glial activation caused by exposure to HIV-1 Tat and opiates., J. Neuroimmunol.

Kim et al., 2004, Differential effects of 9-cis retinoic acid on expression of CC chemokine receptors in human monocytes., Biochem. Pharmacol.

Han et al., 2005, HMG-CoA reductase inhibition reduces monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated monocyte recruitment in vivo., Circulation

DTC: CCR2
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Sohy D et al., 2007, Allosteric transinhibition by specific antagonists in CCR2/CXCR4 heterodimers., J Biol Chem
HingoraniCasas: ENSG00000121807
- Version: 31-May-2017
Alternate Names:

ENSG00000121807 Gene Symbol

CCR2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: CMKBR2
- Version: chembl_23
Alternate Names:

CMKBR2 GENE_SYMBOL

CCR2 GENE_SYMBOL

C-C chemokine receptor type 2 UNIPROT

Gene Info:

Publications:
GO: CCR2
- Version: 01-February-2022
Alternate Names:

CMKBR2 GO Gene Synonym

Gene Info:

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
dGene: CCR2
- Version: 27-Jun-2013
Alternate Names:

729230 Gene ID

CC-CKR-2 dGene Synonym

CCR-2 dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

Mechanism of Interaction	C-C chemokine receptor type 2 antagonist
Direct Interaction	yes
Trial Name	CCX140

Trial Name	MLN-1202
Novel drug target	Novel Target
Mechanism of Interaction	C-C chemokine receptor type 2 antagonist

CCR2	Display Id
C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (MONOCYTE CHEMOATTRACTANT PROTEIN 1 RECEPTOR) (MCP-1-R). [SOURCE:UNIPROT/SWISSPROT;ACC:P41597]	Description
ENSG00000121807	Ensembl Gene Id

CCR2_HUMAN	Uniprot Id
ENSG00000121807	Ensembl Gene Id
CCR2	Uniprot Gene Name

CMKBR2	GENE_SYMBOL
CCR2	GENE_SYMBOL
C-C chemokine receptor type 2	UNIPROT

antibody (inhibitory)
antagonist (inhibitory)

allosteric modulator
antagonist (inhibitory)

CCR2 Gene Record

CCR2 729230 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction C-C chemokine receptor type 2 antagonist Direct Interaction yes Trial Name CCX140

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 17715128

Sources: DTC

Interaction Types & Directionality: antibody (inhibitory) antagonist (inhibitory)

Interaction Info: Trial Name MLN-1202 Novel drug target Novel Target Mechanism of Interaction C-C chemokine receptor type 2 antagonist

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: allosteric modulator antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction C-C chemokine receptor type 2 antagonist

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction C-C chemokine receptor type 2 antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17715128

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction C-C chemokine receptor type 2 antagonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16831471

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15781755

Sources: NCI

Ensembl: ENSG00000121807

Alternate Names: CCR2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P41597

Alternate Names: CCR2 Gene Symbol

Gene Info: Target Class Receptors Target Subclass GPCR Target Subclass Rhodopsin

Publications:

RussLampel: ENSG00000121807

Alternate Names: CCR2 Display Id C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (MONOCYTE CHEMOATTRACTANT PROTEIN 1 RECEPTOR) (MCP-1-R). [SOURCE:UNIPROT/SWISSPROT;ACC:P41597] Description ENSG00000121807 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: P41597

Alternate Names: CCR2_HUMAN Uniprot Id ENSG00000121807 Ensembl Gene Id CCR2 Uniprot Gene Name

Gene Info: Human Readable Name DRUGGABLE GENOME Interpro Acc IPR000276 Uniprot Status Swiss-Prot

Gene Categories: G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000188680

Alternate Names: CCR2 Display Id C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (MONOCYTE CHEMOATTRACTANT PROTEIN 1 RECEPTOR) (MCP-1-R). [SOURCE:UNIPROT/SWISSPROT;ACC:P41597] Description ENSG00000188680 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TTD: C-C chemokine receptor type 2

Alternate Names: CCR2 TTD Gene Abbreviation T89988 TTD Target ID

Gene Info:

Publications: McIntosh LM et al., 2009, Selective CCR2-targeted macrophage depletion ameliorates experimental mesangioproliferative glomerulonephritis., Clin Exp Immunol

NCI: CCR2

Alternate Names:

Gene Info:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction C-C chemokine receptor type 2 antagonist

Direct Interaction yes

Trial Name CCX140

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
17715128

Sources:
DTC

Interaction Types & Directionality:

antibody (inhibitory)

antagonist (inhibitory)

Interaction Info:

Trial Name MLN-1202

Novel drug target Novel Target

Mechanism of Interaction C-C chemokine receptor type 2 antagonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

allosteric modulator

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction C-C chemokine receptor type 2 antagonist

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction C-C chemokine receptor type 2 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
17715128

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction C-C chemokine receptor type 2 antagonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
16831471

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15781755

Sources:
NCI

Alternate Names:

CCR2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

CCR2 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Alternate Names:

CCR2 Display Id

C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (MONOCYTE CHEMOATTRACTANT PROTEIN 1 RECEPTOR) (MCP-1-R). [SOURCE:UNIPROT/SWISSPROT;ACC:P41597] Description

ENSG00000121807 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CCR2_HUMAN Uniprot Id

ENSG00000121807 Ensembl Gene Id

CCR2 Uniprot Gene Name

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Acc IPR000276

Uniprot Status Swiss-Prot

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Alternate Names:

CCR2 Display Id

C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (MONOCYTE CHEMOATTRACTANT PROTEIN 1 RECEPTOR) (MCP-1-R). [SOURCE:UNIPROT/SWISSPROT;ACC:P41597] Description

ENSG00000188680 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CCR2 TTD Gene Abbreviation

T89988 TTD Target ID

Publications:

McIntosh LM et al., 2009, Selective CCR2-targeted macrophage depletion ameliorates experimental mesangioproliferative glomerulonephritis., Clin Exp Immunol

Publications:

Sohy D et al., 2007, Allosteric transinhibition by specific antagonists in CCR2/CXCR4 heterodimers., J Biol Chem

Alternate Names:

ENSG00000121807 Gene Symbol

CCR2 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CMKBR2 GENE_SYMBOL

CCR2 GENE_SYMBOL

C-C chemokine receptor type 2 UNIPROT

Alternate Names:

CMKBR2 GO Gene Synonym

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Alternate Names:

729230 Gene ID

CC-CKR-2 dGene Synonym

CCR-2 dGene Synonym

Gene Categories:

G PROTEIN COUPLED RECEPTOR