DGIdb - CD40 Gene Record

CD40 958 Druggable Genome

Alternate Names:

958
CD40 MOLECULE
CD40
Bp50
CDW40
TNFRSF5
p50
109535
11919
ENSG00000101017
OTTHUMG00000033053
P25942
CD_antigen=CD40
Tumor necrosis factor receptor superfamily member 5
B-cell surface antigen CD40
CD40L receptor
T45758

Gene Info:

Target Class	Receptors
Target Subclass	Receptors
Target Subclass	TNFNGF
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

CELL SURFACE
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME
TRANSCRIPTION FACTOR

Publications:

Miyazawa et al., 2007, Phenotypic alterations and cytokine production in THP-1 cells in response to allergens., Toxicol In Vitro
Kover et al., 2001, CD40/154 blockade and rejection of islet allografts in the streptozotocin and autoimmune diabetic rat., Pediatr Diabetes
Nierkens et al., 2002, Selective requirement for CD40-CD154 in drug-induced type 1 versus type 2 responses to trinitrophenyl-ovalbumin., J. Immunol.
Tai YT et al., 2004, Mechanisms by which SGN-40, a humanized anti-CD40 antibody, induces cytotoxicity in human multiple myeloma cells: clinical implications., Cancer Res
Younes et al., 1998, Elevated levels of biologically active soluble CD40 ligand in the serum of patients with chronic lymphocytic leukaemia., Br. J. Haematol.

DACETUZUMAB CD40

Interaction Score: 16.86

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tumor necrosis factor receptor superfamily member 5 inhibitor

Direct Interaction yes

Trial Name dacetuzumab, SGN-40

PMIDs:
15087402

Sources:
TdgClinicalTrial ChemblInteractions
BLESELUMAB CD40

Interaction Score: 5.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
APX-005M CD40

Interaction Score: 5.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TENELIXIMAB CD40

Interaction Score: 5.62

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tumor necrosis factor receptor superfamily member 5 partial agonist

PMIDs:
None found

Sources:
ChemblInteractions
ISCALIMAB CD40

Interaction Score: 5.62

Interaction Types & Directionality:

antibody (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
RAVAGALIMAB CD40

Interaction Score: 5.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PG-102 CD40

Interaction Score: 2.81

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tumor necrosis factor receptor superfamily member 5 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LUCATUMUMAB CD40

Interaction Score: 2.81

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name lucatumumab , HCD122, CHIR-12.12

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
HYDROQUINONE CD40

Interaction Score: 0.66

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17118622

Sources:
NCI
FLUDARABINE CD40

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9450802

Sources:
NCI
STREPTOZOCIN CD40

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15016184 11937525

Sources:
NCI

Ensembl: ENSG00000101017
- Version: 101_38
Alternate Names:

CD40 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P25942
- Version: January-2014
Alternate Names:

CD40 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptors

Target Subclass TNFNGF

Publications:

NCI: CD40

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Bugajska et al., 2002, The effects of malignant transformation on susceptibility of human urothelial cells to CD40-mediated apoptosis., J. Natl. Cancer Inst.

Lee et al., 2005, Constitutive expression of functional CD40 on mouse renal cancer cells: induction of Fas and Fas-mediated killing by CD40L., Cell. Immunol.

Kitada et al., 1999, Bryostatin and CD40-ligand enhance apoptosis resistance and induce expression of cell survival genes in B-cell chronic lymphocytic leukaemia., Br. J. Haematol.

HingoraniCasas: ENSG00000101017
- Version: 31-May-2017
Alternate Names:

ENSG00000101017 Gene Symbol

CD40 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: TNFRSF5
- Version: chembl_23
Alternate Names:

TNFRSF5 GENE_SYMBOL

CD40 GENE_SYMBOL

Tumor necrosis factor receptor superfamily member 5 UNIPROT

Gene Info:

Publications:
GO: CD40
- Version: 01-February-2022
Alternate Names:

TNFRSF5 GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
Tempus: CD40
- Version: 11-November-2018
Alternate Names:

CD40 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
TTD: CD40L receptor
- Version: 2020.06.01
Alternate Names:

CD40 TTD Gene Abbreviation

T45758 TTD Target ID

Gene Info:

Publications:
Pharos: CD40
- Version: 01-February-2022
Alternate Names:

Tumor necrosis factor receptor superfamily member 5 Gene Name

P25942 UniProt ID

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR

Publications:

Mechanism of Interaction	Tumor necrosis factor receptor superfamily member 5 inhibitor
Direct Interaction	yes
Trial Name	dacetuzumab, SGN-40

Trial Name	lucatumumab , HCD122, CHIR-12.12
Novel drug target	Novel Target

TNFRSF5	GENE_SYMBOL
CD40	GENE_SYMBOL
Tumor necrosis factor receptor superfamily member 5	UNIPROT

Tumor necrosis factor receptor superfamily member 5	Gene Name
P25942	UniProt ID

CD40 Gene Record

CD40 958 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tumor necrosis factor receptor superfamily member 5 inhibitor Direct Interaction yes Trial Name dacetuzumab, SGN-40

PMIDs: 15087402

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: partial agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Tumor necrosis factor receptor superfamily member 5 partial agonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antibody (inhibitory)

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tumor necrosis factor receptor superfamily member 5 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name lucatumumab , HCD122, CHIR-12.12 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17118622

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9450802

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15016184 11937525

Sources: NCI

Ensembl: ENSG00000101017

Alternate Names: CD40 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P25942

Alternate Names: CD40 Gene Symbol

Gene Info: Target Class Receptors Target Subclass Receptors Target Subclass TNFNGF

Publications:

NCI: CD40

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000101017

Alternate Names: ENSG00000101017 Gene Symbol CD40 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: TNFRSF5

Alternate Names: TNFRSF5 GENE_SYMBOL CD40 GENE_SYMBOL Tumor necrosis factor receptor superfamily member 5 UNIPROT

Gene Info:

Publications:

GO: CD40

Alternate Names: TNFRSF5 GO Gene Synonym

Gene Info:

Gene Categories: CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

Tempus: CD40

Alternate Names: CD40 Gene Symbol

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tumor necrosis factor receptor superfamily member 5 inhibitor

Direct Interaction yes

Trial Name dacetuzumab, SGN-40

PMIDs:
15087402

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tumor necrosis factor receptor superfamily member 5 partial agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antibody (inhibitory)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tumor necrosis factor receptor superfamily member 5 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name lucatumumab , HCD122, CHIR-12.12

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
17118622

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9450802

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15016184 11937525

Sources:
NCI

Alternate Names:

CD40 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

CD40 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptors

Target Subclass TNFNGF

Alternate Names:

ENSG00000101017 Gene Symbol

CD40 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

TNFRSF5 GENE_SYMBOL

CD40 GENE_SYMBOL

Tumor necrosis factor receptor superfamily member 5 UNIPROT

Alternate Names:

TNFRSF5 GO Gene Synonym

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Alternate Names:

CD40 Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

CD40 TTD Gene Abbreviation

T45758 TTD Target ID

Alternate Names:

Tumor necrosis factor receptor superfamily member 5 Gene Name

P25942 UniProt ID

Gene Categories:

TRANSCRIPTION FACTOR