CDK7 Gene Record

  • SELICICLIB   CDK7

    Interaction Score: 1.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Novel Target
    Trial Name seliciclib, R-roscovitine, CYC202
    Mechanism of Interaction Cyclin-dependent kinase 7 inhibitor

    PMIDs:
    17108108


    Sources:
    MyCancerGenome TdgClinicalTrial ChemblInteractions TTD

  • BMS-387032   CDK7

    Interaction Score: 1.03

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Reported Cancer Type Melanoma
    Direct Interaction yes
    Mechanism of Interaction Cyclin-dependent kinase 7 inhibitor

    PMIDs:
    None found


    Sources:
    DTC TdgClinicalTrial ChemblInteractions CancerCommons TTD

  • ALVOCIDIB   CDK7

    Interaction Score: 0.9

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase 7 inhibitor
    Direct Interaction yes
    Trial Name flavopiridol, alvocidib, HMR-1275

    PMIDs:
    18469809 11752352


    Sources:
    DTC MyCancerGenome TdgClinicalTrial ChemblInteractions

  • ZOTIRACICLIB   CDK7

    Interaction Score: 0.45

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase 7 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RGB-286638   CDK7

    Interaction Score: 0.38

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Cyclin-dependent kinase 7 inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • (RS)-ROSCOVITINE   CDK7

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AZD-1080   CDK7

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RONICICLIB   CDK7

    Interaction Score: 0.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AZD-5438   CDK7

    Interaction Score: 0.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PHA-793887   CDK7

    Interaction Score: 0.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AT-7519   CDK7

    Interaction Score: 0.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Cyclin-dependent kinase inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PICTILISIB   CDK7

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FASUDIL   CDK7

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL546797   CDK7

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PAZOPANIB   CDK7

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DACTOLISIB   CDK7

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • JNJ-7706621   CDK7

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ENTRECTINIB   CDK7

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RG-1530   CDK7

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DOVITINIB   CDK7

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TAE-684   CDK7

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PF-00562271   CDK7

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CENISERTIB   CDK7

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000134058

    • Version: 101_38

    Alternate Names:
    CDK7 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P50613

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000134058 Ensembl Gene Id
    1022 Entrez Gene Id
    CDK7_HUMAN Uniprot Id

    Gene Info:
    Uniprot Status Swiss-Prot
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P50613

    • Version: January-2014

    Alternate Names:
    CDK7 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.22
    Target Subclass 2.7.11.23

    Publications:

  • RussLampel: ENSG00000134058

    • Version: 26-July-2011

    Alternate Names:
    CDK7 Display Id
    ENSG00000134058 Ensembl Gene Id
    CELL DIVISION PROTEIN KINASE 7 (EC 2.7.1.37) (CDK-ACTIVATING KINASE) (CAK) (TFIIH BASAL TRANSCRIPTION FACTOR COMPLEX KINASE SUBUNIT) (39 KDA PROTEIN KINASE) (P39 MO15) (STK1) (CAK1). [SOURCE:UNIPROT/SWISSPROT;ACC:P50613] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • CancerCommons: CDK7

    • Version: 25-July-2013

    Alternate Names:
    1022 Entrez Gene ID

    Gene Info:
    CancerCommons Reported Gene Name CDK2,7,9

    Publications:

  • DTC: CDK7

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Montagnoli A et al., 2008, A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity., Nat Chem Biol

  • HingoraniCasas: ENSG00000134058

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000134058 Gene Symbol
    CDK7 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • MyCancerGenome: CDK7

    • Version: 20-Jun-2017

    Alternate Names:
    1022 Entrez Gene Id
    CDK7 MyCancerGenome Gene Symbol
    CDK 1,2,4,5,6,7,9 (pan-CDK) MyCancerGenome Reported Gene Name

    Gene Info:

    Publications:

  • ChemblInteractions: CAK

    • Version: chembl_23

    Alternate Names:
    CAK1 GENE_SYMBOL
    CDKN7 GENE_SYMBOL
    MO15 GENE_SYMBOL

    Gene Info:

    Publications:

  • GO: CDK7

    • Version: 01-February-2022

    Alternate Names:
    CAK GO Gene Synonym
    CAK1 GO Gene Synonym
    CDKN7 GO Gene Synonym

    Gene Info:

    Gene Categories:
    TUMOR SUPPRESSOR, DNA REPAIR, SERINE THREONINE KINASE

    Publications:

  • dGene: CDK7

    • Version: 27-Jun-2013

    Alternate Names:
    1022 Gene ID
    CAK1 dGene Synonym
    CDKN7 dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

  • TTD: Cyclin-dependent kinase 7

    • Version: 2020.06.01

    Alternate Names:
    CDK7 TTD Gene Abbreviation
    T58449 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: CDK7

    • Version: 01-February-2022

    Alternate Names:
    Cyclin-dependent kinase 7 Gene Name
    P50613 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, TRANSCRIPTION FACTOR

    Publications:

  • ClearityFoundationClinicalTrial: CDK7

    • Version: 15-June-2013

    Alternate Names:

    Gene Info:

    Publications: